9,75349 % | Soleus Capital Management, L.P. | 4 327 622 | 40 528 | 31. 12. 2023 |
9,43200 % | Morgan Stanley & Co. LLC | 4 184 978 | 3 795 | 31. 12. 2023 |
7,35294 % | PFM Health Sciences, LP | 3 262 500 | -936 753 | 31. 12. 2023 |
5,18067 % | RTW Investments L.P. | 2 298 662 | 2 298 662 | 31. 12. 2023 |
2,56013 % | Adage Capital Management, L.P. | 1 135 931 | 93 400 | 31. 12. 2023 |
2,45545 % | Janus Henderson Investors | 1 089 482 | 1 089 482 | 31. 12. 2023 |
19,71744 % | BVF Partners L.P. | 8 748 629 | 0 | 31. 12. 2023 |
17,80163 % | Bellevue Asset Management AG | 7 898 583 | 0 | 31. 12. 2023 |
1,76787 % | Berger (Franklin Milan) | 784 404 | 22 770 | 16. 1. 2024 |
1,52582 % | Rock Springs Capital Management LP | 677 005 | 0 | 31. 12. 2023 |
0,80347 % | Rhenman & Partners Asset Management AB | 356 500 | 0 | 31. 12. 2023 |
0,59411 % | Citadel Advisors LLC | 263 607 | 258 132 | 31. 12. 2023 |
0,44997 % | D. E. Shaw & Co., L.P. | 199 653 | 31 603 | 31. 12. 2023 |
0,25175 % | CIBC World Markets Inc. | 111 700 | -37 443 | 31. 12. 2023 |
0,14822 % | Parkinson (David Ross M.D.) | 65 765 | 0 | 16. 1. 2024 |
0,12952 % | BNP Paribas Securities Corp. North America | 57 466 | 35 771 | 31. 12. 2023 |
0,12714 % | Glickman (Richard M) | 56 410 | 8 460 | 16. 1. 2024 |
0,10407 % | Avantis Investors | 46 176 | 26 132 | 31. 3. 2024 |
0,07515 % | Wood (David Sidney) | 33 343 | 0 | 16. 1. 2024 |
0,06762 % | Requadt (Scott) | 30 002 | 0 | 16. 1. 2024 |
0,06761 % | RBC Capital Markets Wealth Management | 30 000 | 30 000 | 31. 12. 2023 |
0,06053 % | Geode Capital Management, L.L.C. | 26 858 | 7 819 | 31. 12. 2023 |
0,05462 % | Renaissance Technologies LLC | 24 234 | 24 234 | 31. 12. 2023 |
0,04517 % | American Century Investment Management, Inc. | 20 044 | 20 044 | 31. 12. 2023 |
0,04515 % | Privium Fund Management (UK) Ltd | 20 032 | 0 | 31. 12. 2023 |
0,03207 % | Martin (John Alexander) | 14 229 | 0 | 16. 1. 2024 |
0,02691 % | Virsik (Peter) | 11 940 | -694 | 5. 4. 2024 |
0,02519 % | Group One Trading, L.P. | 11 175 | -30 685 | 31. 12. 2023 |
0,01730 % | BlackRock Financial Management, Inc. | 7 677 | 0 | 31. 12. 2023 |
0,01352 % | Osaic Holdings, Inc. | 6 000 | -6 000 | 31. 12. 2023 |
0,01155 % | Cesano (Alessandra) | 5 124 | 0 | 16. 1. 2024 |
0,01103 % | UBS Financial Services, Inc. | 4 895 | 4 730 | 31. 12. 2023 |
0,00943 % | Simplex Trading, LLC | 4 182 | 513 | 31. 12. 2023 |
0,00902 % | Blackstone Alternative Investment Advisors LLC | 4 000 | 800 | 31. 3. 2023 |
0,00649 % | Thorell (Marella) | 2 881 | 0 | 16. 1. 2024 |
0,00361 % | Morgan Stanley Smith Barney LLC | 1 600 | 100 | 31. 12. 2023 |
0,00219 % | Barclays Bank PLC | 971 | -317 | 31. 12. 2023 |
0,00203 % | TD Waterhouse Canada, Inc. | 900 | 0 | 31. 12. 2023 |
0,00175 % | RBC Dominion Securities, Inc. | 775 | 0 | 31. 12. 2023 |
0,00135 % | Laurel Wealth Advisors, LLC | 600 | 0 | 31. 12. 2023 |
0,00011 % | TD Securities, Inc. | 48 | 0 | 31. 12. 2023 |
0,00005 % | J.P. Morgan Securities plc | 21 | 0 | 31. 12. 2023 |
0,00002 % | BofA Global Research (US) | 8 | 0 | 31. 12. 2023 |
0 % | ACCI Capital Investments SGIIC, SA | 0 | -47 500 | 31. 3. 2023 |
0 % | Qube Research & Technologies Ltd | 0 | -11 353 | 30. 9. 2022 |
0 % | One Wealth Advisors, LLC | 0 | -8 333 | 31. 3. 2023 |
0 % | Crewe Advisors LLC | 0 | -265 | 30. 6. 2023 |
0 % | Trexquant Investment LP | 0 | -19 147 | 30. 9. 2022 |
0 % | HRT Financial LP | 0 | -53 443 | 30. 9. 2022 |
0 % | Cubist Systematic Strategies, LLC | 0 | -34 086 | 31. 3. 2023 |
0 % | Hunting Hill Global Capital, LLC | 0 | -10 000 | 31. 12. 2023 |
0 % | Omega Fund Management, LLC | 0 | -328 196 | 31. 12. 2022 |
0 % | Kapitalo Investimentos Ltda | 0 | -33 400 | 31. 3. 2023 |
0 % | Quantbot Technologies, LP | 0 | -1 751 | 31. 3. 2023 |
0 % | KLP Fondsforvaltning AS | 0 | -3 200 | 31. 7. 2022 |
0 % | Boxer Capital, L.L.C. | 0 | -724 500 | 30. 9. 2022 |
0 % | Eventide Asset Management, LLC | 0 | -1 561 251 | 31. 12. 2022 |
0 % | Managed Account Advisors LLC | 0 | -6 968 | 30. 9. 2022 |
0 % | Alps Advisors, Inc. | 0 | -24 052 | 31. 12. 2022 |
0 % | Clarus Ventures, LLC | 0 | -2 003 103 | 30. 9. 2022 |
0 % | Jane Street Capital, L.L.C. | 0 | -40 421 | 30. 9. 2022 |
0 % | Susquehanna International Group, LLP | 0 | -95 758 | 31. 12. 2023 |
0 % | Tower Research Capital LLC | 0 | -27 | 30. 9. 2023 |
0 % | Frazier Healthcare Partners | 0 | -605 141 | 31. 3. 2023 |
0 % | Northern Trust Global Investments | 0 | -4 661 | 30. 9. 2023 |
0 % | Newbridge Capital Management | 0 | -31 | 31. 12. 2023 |
0 % | Two Sigma Investments, LP | 0 | -72 088 | 31. 12. 2023 |
0 % | Apo Asset Management GmbH | 0 | -11 423 | 31. 8. 2022 |
0 % | AlpInvest Partners B.V. | 0 | -39 930 | 31. 12. 2022 |
0 % | RBC Capital Partners | 0 | -723 | 31. 12. 2023 |
0 % | Medical Strategy GmbH | 0 | -413 492 | 31. 8. 2022 |
0 % | Marshall Wace LLP | 0 | -115 122 | 31. 12. 2022 |
0 % | Millennium Management LLC | 0 | -473 556 | 31. 12. 2023 |
0 % | OrbiMed Advisors, LLC | 0 | -842 366 | 31. 12. 2023 |
0 % | City National Rochdale, LLC | 0 | -5 000 | 31. 12. 2022 |
0 % | Acadian Asset Management LLC | 0 | -15 903 | 31. 12. 2023 |
0 % | Driehaus Capital Management, LLC | 0 | -28 300 | 30. 9. 2023 |
0 % | APG Asset Management N.V. | 0 | -332 761 | 30. 9. 2022 |
0 % | Candriam Belgium S.A. | 0 | -417 532 | 31. 12. 2022 |
0 % | Candriam Luxembourg S.A. | 0 | -417 497 | 31. 10. 2022 |
0 % | Wellington Management Company, LLP | 0 | -562 | 30. 6. 2023 |
0 % | State Street Global Advisors (US) | 0 | -24 414 | 30. 9. 2023 |
0 % | Citi Investment Research (US) | 0 | -599 | 30. 9. 2022 |
0 % | Rockefeller Capital Management | 0 | -132 | 30. 9. 2022 |
0 % | Raymond James & Associates, Inc. | 0 | -40 619 | 31. 12. 2022 |
0 % | T. Rowe Price Associates, Inc. | 0 | -44 832 | 31. 12. 2022 |
0 % | Ensign Peak Advisors, Inc. | 0 | -26 282 | 30. 9. 2022 |
0 % | Morgan Stanley Investment Management Inc. (US) | 0 | -7 | 30. 6. 2023 |
0 % | Thrivent Asset Management, LLC | 0 | -33 389 | 31. 3. 2023 |
0 % | Goldman Sachs & Company, Inc. | 0 | -24 531 | 31. 12. 2022 |
0 % | JPMorgan Private Bank (United States) | 0 | -2 950 | 30. 9. 2022 |
0 % | Bessemer Trust Company, N.A. (US) | 0 | -6 852 | 30. 6. 2023 |
0 % | Northern Trust Investments, Inc. | 0 | -7 828 | 30. 9. 2023 |
0 % | Parametric Portfolio Associates LLC | 0 | -799 | 31. 12. 2022 |
0 % | J.P. Morgan Securities LLC | 0 | -29 406 | 31. 12. 2023 |
0 % | JP Morgan Asset Management | 0 | -73 643 | 31. 12. 2022 |
0 % | Values First Advisors, Inc. | 0 | -14 605 | 30. 9. 2022 |
0 % | Aquatic Capital Management LLC | 0 | -3 300 | 31. 12. 2022 |
0 % | Alta Wealth Advisors LLC | 0 | -11 285 | 31. 12. 2022 |
0 % | Ally Bridge Group NY LLC | 0 | -236 583 | 30. 6. 2023 |