8,83 % | Franklin Advisers, Inc. | 4 598 127 | 487 708 | 31.12.2023 |
8,58 % | Adage Capital Management, L.P. | 4 466 420 | 2 729 917 | 31.12.2023 |
7,79 % | Suvretta Capital Management, LLC | 4 056 847 | 564 700 | 31.12.2023 |
4,74 % | T. Rowe Price Associates, Inc. | 2 468 513 | 1 099 855 | 31.12.2023 |
4,49 % | EW Healthcare Partners | 2 337 786 | −1 153 135 | 31.12.2023 |
3,91 % | The Vanguard Group, Inc. | 2 034 060 | 593 336 | 31.12.2023 |
3,78 % | BlackRock Institutional Trust Company, N.A. | 1 968 721 | 371 954 | 31.12.2023 |
2,99 % | T. Rowe Price Investment Management, Inc. | 1 558 675 | 1 558 675 | 31.12.2023 |
2,80 % | Columbia Threadneedle Investments (US) | 1 458 367 | 1 448 018 | 31.12.2023 |
2,36 % | Citadel Advisors LLC | 1 227 278 | 168 231 | 31.12.2023 |
2,17 % | Millennium Management LLC | 1 128 638 | 548 009 | 31.12.2023 |
2,17 % | Morgan Stanley & Co. LLC | 1 128 285 | 1 060 344 | 31.12.2023 |
2,05 % | Jennison Associates LLC | 1 066 240 | 1 066 240 | 31.12.2023 |
13,24 % | Cormorant Asset Management, LP | 6 893 235 | 855 000 | 11.1.2024 |
1,31 % | Geode Capital Management, L.L.C. | 682 417 | 146 842 | 31.12.2023 |
1,30 % | Federated MDTA LLC | 674 824 | 445 289 | 31.12.2023 |
1,22 % | Laurion Capital Management LP | 633 409 | 633 409 | 31.12.2023 |
1,13 % | Perceptive Advisors LLC | 589 646 | 589 646 | 31.12.2023 |
1,10 % | UBS Financial Services, Inc. | 574 169 | 47 321 | 31.12.2023 |
1,08 % | DWS Investments UK Limited | 561 958 | 549 824 | 31.12.2023 |
1,06 % | State Street Global Advisors (US) | 550 609 | 17 554 | 31.12.2023 |
1,04 % | Goldman Sachs & Company, Inc. | 541 530 | −34 607 | 31.12.2023 |
0,82 % | Acuta Capital Partners, LLC | 425 128 | 125 000 | 31.12.2023 |
0,77 % | Oracle Investment Management, Inc. | 401 557 | 401 557 | 31.12.2023 |
0,77 % | Woodline Partners LP | 400 000 | 400 000 | 31.12.2023 |
0,71 % | Lord, Abbett & Co. LLC | 370 987 | 370 987 | 31.12.2023 |
0,71 % | Ikarian Capital LLC | 368 130 | 368 130 | 31.12.2023 |
0,61 % | First Turn Management, LLC | 317 010 | 317 010 | 31.12.2023 |
0,60 % | Candriam Luxembourg S.A. | 315 000 | 75 000 | 29.2.2024 |
0,55 % | AXA Investment Managers UK Ltd. | 287 143 | −6 948 | 31.12.2023 |
0,54 % | Invesco Capital Management LLC | 279 872 | 279 872 | 31.12.2023 |
0,53 % | Norges Bank Investment Management (NBIM) | 274 729 | 274 729 | 31.12.2023 |
0,51 % | Susquehanna International Group, LLP | 266 031 | 140 351 | 31.12.2023 |
0,48 % | VR Adviser, LLC | 250 000 | 250 000 | 31.12.2023 |
0,46 % | SEB Investment Management AB | 241 072 | 190 268 | 29.2.2024 |
0,43 % | Northern Trust Investments, Inc. | 222 705 | 29 808 | 31.12.2023 |
0,38 % | DWS Investment S.A. | 198 915 | 198 915 | 31.12.2023 |
0,36 % | Alyeska Investment Group, L.P. | 186 840 | 186 840 | 31.12.2023 |
0,35 % | Schroder Investment Management Ltd. (SIM) | 180 000 | 180 000 | 31.12.2023 |
0,34 % | Monashee Investment Management, LLC | 175 000 | 175 000 | 31.12.2023 |
0,33 % | Two Sigma Investments, LP | 173 682 | 77 252 | 31.12.2023 |
0,33 % | PFM Health Sciences, LP | 170 871 | 170 871 | 31.12.2023 |
0,32 % | Ghost Tree Capital, LLC | 165 000 | −160 000 | 31.12.2023 |
0,31 % | Barclays Bank PLC | 159 642 | 113 983 | 31.12.2023 |
0,28 % | Essex Investment Management Company, LLC | 147 541 | −59 619 | 31.12.2023 |
0,28 % | Paggiarino Dario A | 143 834 | 24 858 | 30.3.2024 |
0,27 % | TD Asset Management Inc. | 142 894 | 71 094 | 31.12.2023 |
0,27 % | Voloridge Investment Management, LLC | 140 705 | 140 705 | 31.12.2023 |
0,27 % | Candriam Belgium S.A. | 140 000 | 140 000 | 31.12.2023 |
0,27 % | EAM Investors, LLC | 138 310 | 138 310 | 31.12.2023 |
0,26 % | HOOPP Investment Management | 137 000 | 137 000 | 31.12.2023 |
0,25 % | Elston (George O) | 130 609 | 7 608 | 9.2.2024 |
0,24 % | Connor, Clark & Lunn Investment Management Ltd. | 123 764 | 123 764 | 31.12.2023 |
0,24 % | Nuveen LLC | 122 997 | −52 865 | 31.12.2023 |
0,22 % | Jones (David Scott) | 116 079 | 6 311 | 9.2.2024 |
0,22 % | PGIM Securities Investment Trust Enterprise | 116 000 | 116 000 | 31.12.2023 |
0,21 % | Affinity Asset Advisors LLC | 109 900 | 109 900 | 31.12.2023 |
0,21 % | Parametric Portfolio Associates LLC | 109 790 | 43 575 | 31.12.2023 |
0,21 % | Ghisallo Capital Management LLC | 108 634 | 108 634 | 31.12.2023 |
0,20 % | BlackRock Financial Management, Inc. | 101 578 | −49 498 | 31.12.2023 |
0,19 % | D. E. Shaw & Co., L.P. | 100 960 | 100 960 | 31.12.2023 |
0,19 % | Ocumension Therapeutics | 100 222 | −1 910 500 | 11.1.2024 |
0,18 % | StemPoint Capital LP | 95 732 | 95 732 | 31.12.2023 |
0,18 % | BNY Mellon Asset Management | 94 582 | 6 394 | 31.12.2023 |
0,18 % | Wellington Management Company, LLP | 94 561 | 94 561 | 31.12.2023 |
0,17 % | Boothbay Fund Management, LLC | 88 443 | 88 443 | 31.12.2023 |
0,16 % | Lurker (Nancy S) | 83 351 | −52 090 | 13.2.2024 |
0,16 % | Sectoral Asset Management Inc. | 81 160 | −94 920 | 31.12.2023 |
0,16 % | PanAgora Asset Management Inc. | 80 780 | 5 541 | 31.12.2023 |
0,15 % | Morgan Stanley Smith Barney LLC | 80 588 | 78 199 | 31.12.2023 |
0,15 % | BofA Global Research (US) | 78 444 | 70 884 | 31.12.2023 |
0,15 % | Charles Schwab Investment Management, Inc. | 78 410 | 6 862 | 31.12.2023 |
0,14 % | Manulife Investment Management (North America) Limited | 74 421 | 21 482 | 31.12.2023 |
0,14 % | Bridgeway Capital Management, LLC | 73 000 | −44 100 | 31.12.2023 |
0,14 % | Legato Capital Management LLC | 71 734 | 12 387 | 31.3.2024 |
0,13 % | BlackRock Investment Management, LLC | 69 957 | 314 | 31.12.2023 |
0,13 % | Jane Street Capital, L.L.C. | 69 895 | 39 672 | 31.12.2023 |
0,11 % | BlackRock Advisors (UK) Limited | 55 624 | 3 006 | 31.3.2024 |
0,10 % | T. Rowe Price International Ltd | 54 191 | 48 503 | 31.12.2023 |
0,10 % | Cubist Systematic Strategies, LLC | 54 022 | −81 137 | 31.12.2023 |
0,10 % | Nicholas Investment Partners, L.P. | 53 236 | 53 236 | 31.12.2023 |
0,10 % | Artia Global Partners LP | 50 000 | 50 000 | 31.12.2023 |
0,09 % | Trexquant Investment LP | 48 760 | −55 858 | 31.12.2023 |
0,09 % | Rhumbline Advisers Ltd. Partnership | 46 140 | 4 388 | 31.12.2023 |
0,09 % | Ratan Capital Management LP | 45 000 | 45 000 | 31.12.2023 |
0,08 % | Jacobs Levy Equity Management, Inc. | 43 761 | 0 | 31.12.2023 |
0,08 % | Franklin Equity Group | 42 524 | 3 300 | 31.12.2023 |
0,07 % | Deka Vermögensmanagement GmbH | 35 000 | 35 000 | 31.12.2023 |
0,06 % | Assenagon Asset Management S.A. | 33 135 | 2 411 | 29.2.2024 |
0,06 % | Fidelity Management & Research Company LLC | 32 485 | 30 088 | 31.12.2023 |
0,06 % | Occudo Quantitative Strategies LP | 32 176 | 32 176 | 31.12.2023 |
0,06 % | Woodstock Corporation | 30 778 | 8 525 | 31.3.2024 |
0,06 % | Hightower Advisors, LLC | 30 007 | −222 965 | 31.12.2023 |
0,06 % | Dimensional Fund Advisors, L.P. | 29 610 | −20 511 | 31.12.2023 |
0,06 % | Duker (Jay S) | 29 420 | −14 066 | 27.2.2024 |
0,05 % | Victory Capital Management Inc. | 28 530 | 28 530 | 31.12.2023 |
0,05 % | Goldman Sachs Asset Management, L.P. | 26 456 | 2 119 | 31.12.2023 |
0,05 % | Exome Asset Management LLC | 26 400 | 26 400 | 31.12.2023 |
0,05 % | BMO Capital Markets (US) | 25 400 | 25 400 | 31.12.2023 |
0,05 % | Simplex Trading, LLC | 24 450 | 24 450 | 31.12.2023 |