8.57 % | EcoR1 Capital, LLC | 5,282,516 | 0 | 12/31/2023 |
5.45 % | T. Rowe Price Associates, Inc. | 3,360,443 | 295,961 | 12/31/2023 |
5.40 % | State Street Global Advisors (US) | 3,326,856 | 348,255 | 12/31/2023 |
4.16 % | Fidelity Management & Research Company LLC | 2,562,691 | -528,990 | 12/31/2023 |
2.43 % | Armistice Capital LLC | 1,500,000 | 22,000 | 12/31/2023 |
2.19 % | T. Rowe Price Investment Management, Inc. | 1,351,367 | -2,426,996 | 12/31/2023 |
2.13 % | Geode Capital Management, L.L.C. | 1,314,943 | 54,991 | 12/31/2023 |
2.07 % | Dimensional Fund Advisors, L.P. | 1,279,077 | -172,270 | 12/31/2023 |
16.34 % | BlackRock Institutional Trust Company, N.A. | 10,073,333 | 637,886 | 12/31/2023 |
14.44 % | PRIMECAP Management Company | 8,901,607 | 717,401 | 12/31/2023 |
10.96 % | The Vanguard Group, Inc. | 6,755,536 | 115,886 | 12/31/2023 |
1.60 % | Loomis, Sayles & Company, L.P. | 988,244 | -518,308 | 12/31/2023 |
1.21 % | Johnson & Johnson Innovation-JJDC, Inc. | 748,062 | 0 | 12/31/2023 |
1.19 % | BlackRock Financial Management, Inc. | 736,235 | 191,124 | 12/31/2023 |
1.16 % | Two Sigma Investments, LP | 714,927 | 255,151 | 12/31/2023 |
1.15 % | Candriam Belgium S.A. | 707,984 | 55,000 | 12/31/2023 |
1.15 % | Candriam Luxembourg S.A. | 707,965 | 0 | 2/29/2024 |
0.95 % | Northern Trust Investments, Inc. | 585,429 | 47,872 | 12/31/2023 |
0.84 % | Charles Schwab Investment Management, Inc. | 520,698 | 32,251 | 12/31/2023 |
0.74 % | Morgan Stanley & Co. LLC | 453,846 | 60,518 | 12/31/2023 |
0.68 % | JP Morgan Asset Management | 420,670 | -45,579 | 12/31/2023 |
0.57 % | Millennium Management LLC | 350,214 | -377,254 | 12/31/2023 |
0.57 % | Goldman Sachs & Company, Inc. | 348,529 | 232,128 | 12/31/2023 |
0.55 % | Principal Global Investors (Equity) | 342,010 | -4,107 | 12/31/2023 |
0.53 % | Norges Bank Investment Management (NBIM) | 325,439 | -213,506 | 12/31/2023 |
0.49 % | Mellon Investments Corporation | 300,376 | -2,407 | 12/31/2023 |
0.47 % | Parametric Portfolio Associates LLC | 289,030 | 133,602 | 12/31/2023 |
0.46 % | ExodusPoint Capital Management, LP | 280,813 | -14,125 | 12/31/2023 |
0.44 % | Dahiyat (Bassil Ishmael) | 270,508 | 39,269 | 3/11/2024 |
0.40 % | Baker Bros. Advisors LP | 245,431 | 122,304 | 12/31/2023 |
0.40 % | Hudson Bay Capital Management LP | 245,000 | 12,500 | 12/31/2023 |
0.38 % | DCF Advisers, LLC | 237,107 | -9,193 | 12/31/2023 |
0.37 % | Columbia Threadneedle Investments (US) | 226,602 | -67,191 | 12/31/2023 |
0.36 % | Rhenman & Partners Asset Management AB | 225,000 | 0 | 12/31/2023 |
0.35 % | PanAgora Asset Management Inc. | 218,288 | 65,568 | 12/31/2023 |
0.31 % | BlackRock Investment Management, LLC | 189,471 | -571 | 12/31/2023 |
0.30 % | Rhumbline Advisers Ltd. Partnership | 184,831 | 4,862 | 12/31/2023 |
0.30 % | Invesco Capital Management LLC | 183,194 | -328,953 | 12/31/2023 |
0.29 % | Renaissance Technologies LLC | 180,300 | 136,000 | 12/31/2023 |
0.29 % | BlackRock Advisors (UK) Limited | 177,066 | 8,982 | 3/31/2024 |
0.28 % | abrdn Inc. | 175,520 | 175,520 | 12/31/2023 |
0.28 % | UBS Asset Management (Americas), Inc. | 171,972 | -2,394 | 12/31/2023 |
0.28 % | Legal & General Investment Management Ltd. | 170,021 | 2,357 | 12/31/2023 |
0.27 % | Citadel Advisors LLC | 169,476 | 141,151 | 12/31/2023 |
0.27 % | Barclays Bank PLC | 168,499 | 63,582 | 12/31/2023 |
0.27 % | Schonfeld Strategic Advisors LLC | 166,111 | 166,111 | 12/31/2023 |
0.27 % | BNY Mellon Asset Management | 165,049 | 6,600 | 12/31/2023 |
0.27 % | Nuveen LLC | 164,881 | 14,789 | 12/31/2023 |
0.25 % | Russell Investments Trust Company | 156,618 | 23,892 | 12/31/2023 |
0.25 % | Segall Bryant & Hamill, LLC | 154,824 | 504 | 12/31/2023 |
0.25 % | BlackRock Asset Management Ireland Limited | 152,613 | 9,465 | 12/31/2023 |
0.24 % | Qube Research & Technologies Ltd | 145,846 | 110,360 | 12/31/2023 |
0.22 % | Silvercrest Asset Management Group LLC | 137,941 | 0 | 12/31/2023 |
0.22 % | Cubist Systematic Strategies, LLC | 137,089 | 113,533 | 12/31/2023 |
0.22 % | Desjarlais (John R) | 135,201 | 12,815 | 3/11/2024 |
0.22 % | New Jersey Division of Investment | 133,752 | 23,399 | 12/31/2023 |
0.21 % | Macquarie Investment Management | 129,191 | 0 | 12/31/2023 |
0.20 % | PSP Investments | 126,331 | 51,414 | 12/31/2023 |
0.20 % | Putnam Investment Management, L.L.C. | 125,833 | -3,000 | 12/31/2023 |
0.20 % | T. Rowe Price International Ltd | 123,332 | 2,880 | 12/31/2023 |
0.20 % | TD Asset Management Inc. | 123,250 | -56,914 | 12/31/2023 |
0.19 % | Rafferty Asset Management LLC | 119,818 | 9,131 | 12/31/2023 |
0.19 % | BofA Global Research (US) | 119,372 | 30,360 | 12/31/2023 |
0.17 % | Schweizerische Nationalbank | 107,500 | -12,000 | 12/31/2023 |
0.16 % | Dimensional Fund Advisors, Ltd. | 100,374 | 1,436 | 1/31/2024 |
0.16 % | Barclays Capital Inc. | 100,000 | 100,000 | 12/31/2023 |
0.16 % | Northern Trust Global Investments | 99,456 | -921 | 12/31/2023 |
0.16 % | Mutual of America Capital Management LLC | 99,335 | 42,364 | 12/31/2023 |
0.16 % | Credit Suisse Funds AG | 96,110 | 10,957 | 12/31/2023 |
0.15 % | Trexquant Investment LP | 93,759 | 58,672 | 12/31/2023 |
0.15 % | Engineers Gate Manager, L.P. | 89,805 | 78,923 | 12/31/2023 |
0.14 % | Goldman Sachs Asset Management, L.P. | 89,371 | 22,409 | 12/31/2023 |
0.14 % | Kuch John J | 87,719 | -5,323 | 3/11/2024 |
0.14 % | Jump Financial, LLC | 84,689 | 61,574 | 12/31/2023 |
0.14 % | Manulife Investment Management (North America) Limited | 83,591 | -553 | 12/31/2023 |
0.13 % | BNP Paribas Securities Corp. North America | 82,488 | 42,403 | 12/31/2023 |
0.13 % | Citi Investment Research (US) | 82,157 | 11,868 | 12/31/2023 |
0.13 % | BlackRock Investment Management (UK) Ltd. | 81,665 | 15,721 | 12/31/2023 |
0.13 % | AllianceBernstein L.P. | 77,700 | 0 | 12/31/2023 |
0.12 % | GWL Investment Management Ltd. | 75,215 | -2,037 | 12/31/2023 |
0.11 % | Avantis Investors | 70,271 | 21,002 | 3/31/2024 |
0.11 % | PGIM Quantitative Solutions LLC | 69,955 | -638 | 12/31/2023 |
0.11 % | JPMorgan Private Bank (United States) | 68,264 | 41,196 | 12/31/2023 |
0.11 % | UBS Asset Management (Switzerland) | 65,492 | -317 | 12/31/2023 |
0.10 % | American Century Investment Management, Inc. | 62,290 | 16,772 | 12/31/2023 |
0.10 % | Valente (Nancy M.D.) | 58,930 | 19,634 | 3/5/2024 |
0.09 % | New York State Teachers' Retirement System | 58,526 | -300 | 12/31/2023 |
0.09 % | California State Teachers Retirement System | 58,086 | -2,758 | 12/31/2023 |
0.09 % | Tekla Capital Management LLC_NLE | 56,675 | 56,675 | 6/30/2023 |
0.09 % | Aperio Group, LLC | 56,519 | 19,359 | 12/31/2023 |
0.09 % | NFJ Investment Group, LLC | 55,538 | 991 | 12/31/2023 |
0.09 % | Thrivent Asset Management, LLC | 54,244 | -1,205 | 12/31/2023 |
0.09 % | Texas Permanent School Fund | 52,587 | 1,109 | 12/31/2023 |
0.08 % | Polen Capital Management, LLC | 52,117 | -9,142 | 2/29/2024 |
0.08 % | Irish Life Investment Managers Ltd. | 48,972 | -2,003 | 9/30/2023 |
0.08 % | Brown Advisory | 48,365 | -752 | 2/29/2024 |
0.08 % | Aigen Investment Management, LP | 47,666 | 37,128 | 12/31/2023 |
0.08 % | State of Wisconsin Investment Board | 46,887 | -349 | 12/31/2023 |
0.07 % | Capula Investment Management LLP | 45,849 | 3,029 | 12/31/2023 |
0.07 % | Invesco Advisers, Inc. | 44,252 | 595 | 12/31/2023 |