10.46402 % | The Vanguard Group, Inc. | 40,181,847 | 101,254 | 12/31/2024 |
10.12749 % | Baillie Gifford & Co. | 38,889,571 | -3,568,512 | 12/31/2024 |
4.78712 % | Fidelity Management & Research Company LLC | 18,382,536 | 1,283,446 | 12/31/2024 |
4.69820 % | BlackRock Institutional Trust Company, N.A. | 18,041,090 | 471,487 | 12/31/2024 |
4.57741 % | State Street Global Advisors (US) | 17,577,236 | 730,024 | 12/31/2024 |
2.99723 % | Langer (Robert S Jr.) | 11,509,357 | 0 | 3/7/2024 |
2.35687 % | Boston Biotech Ventures, L.L.C. | 9,050,372 | 0 | 3/7/2024 |
1.90283 % | Theleme Partners LLP | 7,306,861 | 80,000 | 12/31/2024 |
1.88577 % | Geode Capital Management, L.L.C. | 7,241,354 | 171,774 | 12/31/2024 |
1.70960 % | OCHA, L.L.C. | 6,564,880 | 0 | 3/7/2024 |
1.43070 % | Bancel (Stephane J) | 5,493,897 | 6,833 | 2/12/2025 |
1.20629 % | Flagship Ventures | 4,632,149 | 0 | 12/31/2024 |
1.13668 % | Invesco Capital Management LLC | 4,364,840 | 854,900 | 12/31/2024 |
1.02609 % | Norges Bank Investment Management (NBIM) | 3,940,194 | 589,401 | 12/31/2024 |
1.01956 % | Wellington Management Company, LLP | 3,915,092 | -1,309,593 | 12/31/2024 |
0.94142 % | Jane Street Capital, L.L.C. | 3,615,060 | 2,984,881 | 12/31/2024 |
0.91306 % | UBS Financial Services, Inc. | 3,506,159 | 1,792,435 | 12/31/2024 |
0.87029 % | Manulife Investment Management (North America) Limited | 3,341,924 | 267,990 | 12/31/2024 |
0.81588 % | Banque Pictet & Cie S.A. | 3,132,974 | -22,425 | 12/31/2024 |
0.70275 % | BlackRock Asset Management Ireland Limited | 2,698,561 | -240,106 | 12/31/2024 |
0.67470 % | Voloridge Investment Management, LLC | 2,590,831 | 1,996,003 | 12/31/2024 |
0.61449 % | Northern Trust Investments, Inc. | 2,359,650 | 401,450 | 12/31/2024 |
0.61047 % | Charles Schwab Investment Management, Inc. | 2,344,203 | 211,426 | 12/31/2024 |
0.60109 % | Merck & Co Inc | 2,308,190 | 2,308,190 | 12/31/2024 |
0.56175 % | Legal & General Investment Management Ltd. | 2,157,121 | -426,059 | 12/31/2024 |
0.55305 % | Susquehanna International Group, LLP | 2,123,708 | 815,129 | 12/31/2024 |
0.52904 % | Morgan Stanley & Co. LLC | 2,031,516 | 593,878 | 12/31/2024 |
0.48465 % | Goldman Sachs Bank AG | 1,861,040 | 111,277 | 12/31/2024 |
0.47967 % | Afeyan (Noubar Boghos) | 1,841,931 | -60,000 | 7/31/2024 |
0.46060 % | D. E. Shaw & Co., L.P. | 1,768,715 | 1,509,591 | 12/31/2024 |
0.46000 % | Pictet Asset Management Ltd. | 1,766,398 | 1,113,455 | 12/31/2024 |
0.44042 % | Citi Investment Research (US) | 1,691,205 | 1,099,295 | 12/31/2024 |
0.43471 % | Dimensional Fund Advisors, L.P. | 1,669,287 | -156,747 | 12/31/2024 |
0.42545 % | Baillie Gifford Overseas Ltd. | 1,633,716 | -37,186 | 12/31/2024 |
0.41749 % | Hoge (Stephen) | 1,603,158 | 3,205 | 2/12/2025 |
0.41690 % | Bellevue Asset Management AG | 1,600,877 | 41 | 12/31/2024 |
0.40538 % | UBS Switzerland AG | 1,556,650 | 1,093,447 | 12/31/2024 |
0.38019 % | DWS Investments UK Limited | 1,459,922 | 683,036 | 12/31/2024 |
0.35718 % | Capital Fund Management S.A. | 1,371,558 | 741,929 | 12/31/2024 |
0.34273 % | UBS Asset Management (Americas), Inc. | 1,316,072 | 211,233 | 12/31/2024 |
0.32240 % | BNP Paribas Securities Corp. North America | 1,238,017 | 13,840 | 12/31/2024 |
0.31519 % | UBS Asset Management (Switzerland) | 1,210,318 | -394,737 | 12/31/2024 |
0.31376 % | Amundi Asset Management, SAS | 1,204,857 | 569,317 | 12/31/2024 |
0.30604 % | Parametric Portfolio Associates LLC | 1,175,201 | 237,042 | 12/31/2024 |
0.29398 % | Millennium Management LLC | 1,128,868 | 978,550 | 12/31/2024 |
0.29247 % | Goldman Sachs Asset Management, L.P. | 1,123,070 | 458,414 | 12/31/2024 |
0.27355 % | Mellon Investments Corporation | 1,050,445 | -209,964 | 12/31/2024 |
0.26322 % | Renaissance Technologies LLC | 1,010,758 | 700,458 | 12/31/2024 |
0.26227 % | BlackRock Investment Management (UK) Ltd. | 1,007,111 | -17,077 | 12/31/2024 |
0.25555 % | BlackRock (Netherlands) B.V. | 981,304 | 368,247 | 12/31/2024 |
0.24852 % | BlackRock Financial Management, Inc. | 954,321 | 97,801 | 12/31/2024 |
0.24045 % | Letko, Brosseau & Associates Inc. | 923,345 | 412,200 | 12/31/2024 |
0.24036 % | Schweizerische Nationalbank | 923,000 | -43,800 | 12/31/2024 |
0.23493 % | Barclays Bank PLC | 902,138 | 36,177 | 12/31/2024 |
0.23252 % | Squarepoint Capital LLP | 892,868 | 491,235 | 12/31/2024 |
0.21103 % | UBS Asset Management (UK) Ltd. | 810,339 | -168,418 | 12/31/2024 |
0.20151 % | Douglas C. Lane & Associates | 773,804 | 298,715 | 12/31/2024 |
0.20101 % | Citadel Advisors LLC | 771,892 | 519,516 | 12/31/2024 |
0.19993 % | Two Sigma Investments, LP | 767,740 | -216,242 | 12/31/2024 |
0.19679 % | Sumitomo Mitsui Trust Bank, Limited | 755,691 | -858,622 | 12/31/2024 |
0.19248 % | BNY Mellon Asset Management | 739,114 | -32,492 | 12/31/2024 |
0.18020 % | Candriam Luxembourg S.A. | 691,985 | 8,760 | 12/31/2024 |
0.17408 % | First Trust Advisors L.P. | 668,467 | 31,645 | 12/31/2024 |
0.17030 % | Nuveen LLC | 653,952 | -11,571 | 12/31/2024 |
0.16234 % | Invesco Advisers, Inc. | 623,391 | 137,065 | 12/31/2024 |
0.16150 % | Mitsubishi UFJ Trust and Banking Corporation | 620,171 | -26,060 | 12/31/2024 |
0.15960 % | Candriam Belgium S.A. | 612,862 | -14,804 | 12/31/2024 |
0.15776 % | Bridgewater Associates, LP | 605,782 | 605,782 | 12/31/2024 |
0.15273 % | T. Rowe Price Associates, Inc. | 586,500 | -399,392 | 12/31/2024 |
0.14718 % | HSBC Global Asset Management (UK) Limited | 565,187 | 73,040 | 12/31/2024 |
0.14457 % | BlackRock Asset Management Canada Limited | 555,153 | 137,333 | 12/31/2024 |
0.14266 % | Grantham Mayo Van Otterloo & Co LLC | 547,812 | 547,812 | 12/31/2024 |
0.14076 % | BofA Global Research (US) | 540,525 | -249,193 | 12/31/2024 |
0.13794 % | Pictet & Cie (Europe) S.A. | 529,686 | 0 | 12/31/2024 |
0.13672 % | Rhumbline Advisers Ltd. Partnership | 525,003 | -20,902 | 12/31/2024 |
0.13561 % | National Pension Service | 520,738 | -293,155 | 12/31/2024 |
0.13333 % | Mitsubishi UFJ Asset Management Co., Ltd. | 511,983 | -6,744 | 12/31/2024 |
0.13291 % | Morgan Stanley Smith Barney LLC | 510,390 | -122,943 | 12/31/2024 |
0.13184 % | HRT Financial LP | 506,280 | 506,280 | 12/31/2024 |
0.13154 % | Pictet Asset Management (Japan) Ltd. | 505,105 | -44,777 | 10/31/2024 |
0.13043 % | California State Teachers Retirement System | 500,867 | -16,129 | 12/31/2024 |
0.13021 % | Hudson Bay Capital Management LP | 500,019 | 500,019 | 12/31/2024 |
0.12841 % | RBC Capital Markets Wealth Management | 493,105 | 125,567 | 12/31/2024 |
0.12671 % | T. Rowe Price International Ltd | 486,555 | 12,468 | 12/31/2024 |
0.12669 % | BlackRock Investment Management, LLC | 486,471 | -839 | 12/31/2024 |
0.12045 % | Sagan (Paul L) | 462,513 | 0 | 3/7/2024 |
0.11834 % | CPP Investment Board | 454,407 | 89,235 | 12/31/2024 |
0.10951 % | BlackRock Japan Co., Ltd. | 420,529 | -46,454 | 12/31/2024 |
0.10735 % | Northern Trust Global Investments Limited | 412,229 | 290,688 | 12/31/2024 |
0.10368 % | New York State Common Retirement Fund | 398,132 | -2,600 | 12/31/2024 |
0.10202 % | California Public Employees' Retirement System | 391,759 | -483,267 | 12/31/2024 |
0.10044 % | Susquehanna Fundamental Investments, LLC | 385,677 | 351,690 | 12/31/2024 |
0.09726 % | Principal Global Investors (Equity) | 373,484 | -5,967 | 12/31/2024 |
0.09716 % | Lingotto Investment Management LLP | 373,095 | 0 | 12/31/2024 |
0.09580 % | LPL Financial LLC | 367,878 | 265,982 | 12/31/2024 |
0.09273 % | Rafferty Asset Management LLC | 356,095 | -104,869 | 12/31/2024 |
0.09215 % | Tudor Investment Corporation | 353,865 | 200,767 | 12/31/2024 |
0.08975 % | Boston Management and Research | 344,651 | 0 | 12/31/2024 |
0.08782 % | Banco Bilbao Vizcaya Argentaria S.A.(Asset Management). | 337,230 | 167,902 | 12/31/2024 |
0.08692 % | Aperio Group, LLC | 333,764 | 97,294 | 12/31/2024 |