9.82 % | Fidelity Management & Research Company LLC | 8,160,206 | 7,271,997 | 1/31/2024 |
5.72 % | BlackRock Institutional Trust Company, N.A. | 4,755,318 | 752,470 | 12/31/2023 |
4.67 % | Federated Hermes Global Investment Management Corp. | 3,883,600 | 500,000 | 12/31/2023 |
4.27 % | Janus Henderson Investors | 3,551,891 | 1,828,731 | 12/31/2023 |
4.24 % | T. Rowe Price Associates, Inc. | 3,521,999 | 523,472 | 12/31/2023 |
4.17 % | The Vanguard Group, Inc. | 3,465,297 | 504,275 | 12/31/2023 |
3.60 % | State Street Global Advisors (US) | 2,991,899 | 844,399 | 12/31/2023 |
3.52 % | Adage Capital Management, L.P. | 2,925,094 | 638,133 | 12/31/2023 |
3.16 % | Deerfield Management Company, L.P. | 2,630,292 | 361,664 | 12/31/2023 |
2.65 % | Boxer Capital, L.L.C. | 2,202,812 | 0 | 12/31/2023 |
2.38 % | Capital Research Global Investors | 1,976,870 | 600,000 | 12/31/2023 |
2.17 % | Logos Global Management LLC | 1,800,000 | -450,000 | 12/31/2023 |
2.08 % | BVF Partners L.P. | 1,729,043 | -3,554,446 | 12/31/2023 |
2.05 % | Holocene Advisors, LP | 1,700,135 | 667,204 | 12/31/2023 |
1.98 % | Citadel Advisors LLC | 1,643,293 | 898,193 | 12/31/2023 |
1.83 % | Avidity Partners Management LP | 1,520,000 | -624,971 | 12/31/2023 |
1.76 % | Sofinnova Investments, Inc | 1,458,881 | 421,694 | 12/31/2023 |
1.63 % | Geode Capital Management, L.L.C. | 1,351,337 | 190,232 | 12/31/2023 |
1.55 % | Dimensional Fund Advisors, L.P. | 1,286,300 | 144,058 | 12/31/2023 |
1.28 % | Baker Bros. Advisors LP | 1,062,123 | 0 | 12/31/2023 |
1.19 % | Morgan Stanley & Co. LLC | 987,851 | 844,492 | 12/31/2023 |
1.13 % | Redmile Group, LLC | 935,863 | 935,863 | 12/31/2023 |
1.10 % | Driehaus Capital Management, LLC | 912,786 | 215,325 | 12/31/2023 |
1.05 % | Pictet Asset Management Ltd. | 875,747 | 211,657 | 12/31/2023 |
0.82 % | Hata (Yujiro S.) | 677,887 | 0 | 2/9/2024 |
0.80 % | Platinum Asset Management | 662,343 | -104,339 | 12/31/2023 |
0.68 % | Soleus Capital Management, L.P. | 564,700 | 564,700 | 12/31/2023 |
0.65 % | Candriam Luxembourg S.A. | 540,000 | 145,000 | 2/29/2024 |
0.65 % | Fisher Investments | 539,676 | 508,151 | 12/31/2023 |
0.64 % | Boone Capital Management LLC | 531,967 | -38,715 | 12/31/2023 |
0.64 % | D. E. Shaw & Co., L.P. | 529,506 | 93,148 | 12/31/2023 |
0.62 % | Dafna Capital Management, LLC | 516,341 | 16,521 | 12/31/2023 |
0.62 % | Northern Trust Investments, Inc. | 511,956 | 61,264 | 12/31/2023 |
0.60 % | Charles Schwab Investment Management, Inc. | 496,456 | 59,100 | 12/31/2023 |
0.59 % | Ensign Peak Advisors, Inc. | 490,039 | 126,255 | 12/31/2023 |
0.56 % | Balyasny Asset Management LP | 466,271 | 466,271 | 12/31/2023 |
0.54 % | Cormorant Asset Management, LP | 450,000 | -150,000 | 12/31/2023 |
0.50 % | Woodline Partners LP | 414,059 | 173,631 | 12/31/2023 |
0.48 % | Candriam Belgium S.A. | 395,019 | -35,000 | 12/31/2023 |
0.46 % | First Turn Management, LLC | 382,382 | 382,382 | 12/31/2023 |
0.45 % | Nuveen LLC | 376,692 | -169,061 | 12/31/2023 |
0.42 % | Medical Strategy GmbH | 349,447 | -3,400 | 12/31/2023 |
0.42 % | Victory Capital Management Inc. | 346,490 | 346,490 | 12/31/2023 |
0.42 % | First Light Asset Management, LLC | 345,674 | 345,674 | 12/31/2023 |
0.40 % | Eventide Asset Management, LLC | 335,000 | 0 | 12/31/2023 |
0.37 % | Opaleye Management Inc. | 311,500 | 0 | 12/31/2023 |
0.37 % | BlackRock Financial Management, Inc. | 308,979 | 61,814 | 12/31/2023 |
0.30 % | Superstring Capital Management LP | 251,295 | 251,295 | 12/31/2023 |
0.29 % | AXA Investment Managers UK Ltd. | 243,280 | -100,475 | 12/31/2023 |
0.27 % | Columbia Threadneedle Investments (US) | 224,141 | -49,332 | 12/31/2023 |
0.26 % | Voya Investment Management LLC | 219,957 | -71,119 | 12/31/2023 |
0.25 % | Goldman Sachs & Company, Inc. | 208,417 | -109,529 | 12/31/2023 |
0.25 % | BNP Paribas Securities Corp. North America | 207,735 | 155,179 | 12/31/2023 |
0.24 % | Walleye Capital LLC | 199,891 | 115,928 | 12/31/2023 |
0.24 % | UBS Asset Management (Americas), Inc. | 196,329 | -2,262 | 12/31/2023 |
0.23 % | Invesco Capital Management LLC | 194,886 | -72,891 | 12/31/2023 |
0.23 % | Rafferty Asset Management LLC | 193,356 | 64,280 | 12/31/2023 |
0.22 % | BofA Global Research (US) | 182,695 | 100,942 | 12/31/2023 |
0.21 % | Barclays Bank PLC | 176,440 | 90,114 | 12/31/2023 |
0.20 % | BlackRock Investment Management, LLC | 167,656 | 22,622 | 12/31/2023 |
0.19 % | Morgan Stanley Investment Management Inc. (US) | 156,983 | 155,836 | 12/31/2023 |
0.18 % | BNY Mellon Asset Management | 153,513 | 11,507 | 12/31/2023 |
0.18 % | UBS Financial Services, Inc. | 150,702 | 94,167 | 12/31/2023 |
0.17 % | Nantahala Capital Management, LLC | 139,298 | -6,562 | 12/31/2023 |
0.17 % | Jennison Associates LLC | 138,241 | 37,345 | 3/31/2024 |
0.17 % | TD Asset Management Inc. | 137,690 | 24,034 | 12/31/2023 |
0.16 % | BlackRock Advisors (UK) Limited | 133,952 | 9,014 | 3/31/2024 |
0.16 % | Parkman Healthcare Partners LLC | 130,265 | -2,436 | 12/31/2023 |
0.15 % | HighVista Strategies LLC | 126,845 | 0 | 12/31/2023 |
0.15 % | First Trust Advisors L.P. | 120,614 | 1,076 | 12/31/2023 |
0.14 % | Two Sigma Investments, LP | 118,469 | -90,839 | 12/31/2023 |
0.13 % | Nicholas Investment Partners, L.P. | 110,351 | 94,094 | 12/31/2023 |
0.13 % | Allianz Global Investors GmbH | 109,505 | 0 | 1/31/2024 |
0.13 % | EAM Investors, LLC | 108,110 | 20,448 | 12/31/2023 |
0.13 % | BlackRock Asset Management Ireland Limited | 107,277 | 7,750 | 12/31/2023 |
0.11 % | Northern Trust Global Investments | 93,555 | -2,641 | 12/31/2023 |
0.11 % | Manulife Investment Management (North America) Limited | 92,438 | 14,028 | 12/31/2023 |
0.11 % | Citi Investment Research (US) | 89,698 | 34,444 | 12/31/2023 |
0.10 % | Rhumbline Advisers Ltd. Partnership | 85,966 | 7,172 | 12/31/2023 |
0.10 % | Schweizerische Nationalbank | 85,100 | -21,900 | 12/31/2023 |
0.10 % | Hudson Bay Capital Management LP | 84,500 | 49,500 | 12/31/2023 |
0.10 % | Wellington Management Company, LLP | 83,984 | 83,984 | 12/31/2023 |
0.09 % | Qube Research & Technologies Ltd | 77,516 | 42,162 | 12/31/2023 |
0.09 % | Parametric Portfolio Associates LLC | 77,204 | -397 | 12/31/2023 |
0.09 % | UBS O'Connor LLC | 74,575 | -51,574 | 12/31/2023 |
0.09 % | HOOPP Investment Management | 71,000 | 71,000 | 12/31/2023 |
0.08 % | Goldman Sachs Asset Management, L.P. | 69,749 | -32,327 | 12/31/2023 |
0.08 % | MFS Investment Management | 65,001 | -11,145 | 2/29/2024 |
0.08 % | Credit Suisse Funds AG | 62,610 | 1,300 | 12/31/2023 |
0.07 % | Campbell & Company, Inc. | 61,226 | 29,536 | 12/31/2023 |
0.07 % | DWS Investment GmbH | 60,000 | 57,038 | 12/31/2023 |
0.07 % | AllianceBernstein L.P. | 57,680 | 7,140 | 12/31/2023 |
0.07 % | UBS Asset Management (Switzerland) | 56,062 | 5,356 | 12/31/2023 |
0.07 % | Capstone Investment Advisors, LLC | 55,239 | 55,239 | 12/31/2023 |
0.07 % | Mellon Investments Corporation | 54,717 | 7,896 | 12/31/2023 |
0.06 % | State of Wisconsin Investment Board | 52,976 | -11,134 | 12/31/2023 |
0.06 % | Deka Vermögensmanagement GmbH | 50,000 | 0 | 12/31/2023 |
0.06 % | Legal & General Investment Management Ltd. | 49,452 | -1,122 | 12/31/2023 |
0.06 % | Dimensional Fund Advisors, Ltd. | 48,478 | 3,106 | 1/31/2024 |
0.06 % | California State Teachers Retirement System | 48,359 | -6,659 | 12/31/2023 |