7.14650 % | Eli Lilly and Company | 5,414,185 | 0 | 4/1/2021 |
5.97480 % | BlackRock Institutional Trust Company, N.A. | 4,526,507 | 21,658 | 9/30/2021 |
5.12959 % | State Street Global Advisors (US) | 3,886,181 | 1,297,119 | 9/30/2021 |
4.89336 % | The Vanguard Group, Inc. | 3,707,210 | 86,857 | 9/30/2021 |
4.06578 % | Bain Capital Life Sciences Investors, LLC | 3,080,237 | 0 | 9/30/2021 |
3.54091 % | T. Rowe Price Associates, Inc. | 2,682,596 | 699,671 | 9/30/2021 |
3.24260 % | Aquilo Capital Management, LLC | 2,456,595 | 643,203 | 9/30/2021 |
2.12232 % | Morgan Stanley & Co. LLC | 1,607,870 | 626,309 | 9/30/2021 |
10.00844 % | RTW Investments L.P. | 7,582,396 | 60,537 | 9/30/2021 |
1.78465 % | Woodline Partners LP | 1,352,048 | 351,723 | 9/30/2021 |
1.78268 % | Assenagon Asset Management S.A. | 1,350,558 | 780,152 | 9/30/2021 |
1.76962 % | Two Sigma Investments, LP | 1,340,661 | 715,555 | 9/30/2021 |
1.72984 % | Maverick Capital, Ltd. | 1,310,530 | 2,454 | 9/30/2021 |
1.71512 % | Polar Capital LLP | 1,299,372 | 214,559 | 9/30/2021 |
1.70572 % | Commodore Capital LP | 1,292,251 | 1,292,251 | 9/30/2021 |
1.68052 % | JPMorgan Asset Management U.K. Limited | 1,273,160 | 208,538 | 9/30/2021 |
1.64970 % | EcoR1 Capital, LLC | 1,249,812 | 1,249,812 | 9/30/2021 |
1.57164 % | Geode Capital Management, L.L.C. | 1,190,676 | 2,981 | 9/30/2021 |
1.45364 % | UBS Financial Services, Inc. | 1,101,275 | -234,545 | 9/30/2021 |
1.12951 % | Palo Alto Investors LP | 855,713 | 523,000 | 9/30/2021 |
1.12496 % | BlackRock Financial Management, Inc. | 852,273 | -5,754 | 9/30/2021 |
1.06519 % | Pictet Asset Management Ltd. | 806,987 | 803,987 | 9/30/2021 |
1.05596 % | Great Point Partners, LLC | 799,999 | 799,999 | 9/30/2021 |
0.93674 % | Eagle Asset Management, Inc. | 709,674 | -608,373 | 9/30/2021 |
0.92569 % | Banque Lombard Odier & Cie SA | 701,305 | 65,294 | 9/30/2021 |
0.92397 % | Invus Public Equities Advisors, LLC | 700,000 | -100,000 | 9/30/2021 |
0.87741 % | Northern Trust Investments, Inc. | 664,723 | -6,796 | 9/30/2021 |
0.83870 % | Point72 Asset Management, L.P. | 635,400 | -85,000 | 9/30/2021 |
0.78114 % | Marshall Wace LLP | 591,790 | 591,790 | 9/30/2021 |
0.77542 % | Dafna Capital Management, LLC | 587,456 | 76,700 | 9/30/2021 |
0.72377 % | Goldman Sachs & Company, Inc. | 548,327 | 15,627 | 9/30/2021 |
0.70433 % | Wellington Management Company, LLP | 533,604 | -2,765,749 | 9/30/2021 |
0.68277 % | Charles Schwab Investment Management, Inc. | 517,263 | 17,340 | 9/30/2021 |
0.67795 % | Fidelity Management & Research Company LLC | 513,612 | -105,100 | 9/30/2021 |
0.54440 % | Nuveen LLC | 412,439 | 8,187 | 9/30/2021 |
0.53660 % | Eagle Health Investments LP | 406,525 | 245,400 | 9/30/2021 |
0.52852 % | Invesco Capital Management LLC | 400,406 | 234,317 | 9/30/2021 |
0.51926 % | Candriam Belgium S.A. | 393,390 | -24,855 | 9/30/2021 |
0.47680 % | Millennium Management LLC | 361,222 | 25,736 | 9/30/2021 |
0.43429 % | Voloridge Investment Management, LLC | 329,016 | 266,797 | 9/30/2021 |
0.41788 % | Medical Strategy GmbH | 316,588 | -58,160 | 6/30/2021 |
0.36688 % | Balyasny Asset Management LP | 277,949 | 191,393 | 9/30/2021 |
0.34477 % | Citadel Advisors LLC | 261,200 | -72,328 | 9/30/2021 |
0.33028 % | Goldman Sachs Asset Management, L.P. | 250,217 | 172,463 | 9/30/2021 |
0.30710 % | UBS Asset Management (Americas), Inc. | 232,658 | -5,076 | 9/30/2021 |
0.29988 % | Federated Hermes MDTA LLC | 227,187 | -167,114 | 9/30/2021 |
0.29463 % | Emerald Advisers LLC | 223,213 | -734,271 | 9/30/2021 |
0.29182 % | APG Asset Management N.V. | 221,083 | 221,083 | 6/30/2020 |
0.28586 % | Carson Wealth Management Group | 216,565 | 71,374 | 6/30/2021 |
0.28085 % | BlackRock Investment Management, LLC | 212,773 | -19,851 | 9/30/2021 |
0.27910 % | AXA Investment Managers UK Ltd. | 211,448 | -31,320 | 9/30/2021 |
0.27678 % | Parkman Healthcare Partners LLC | 209,686 | -95,000 | 9/30/2021 |
0.27303 % | Russell Investments Trust Company | 206,845 | 28,079 | 9/30/2021 |
0.26984 % | Mirae Asset Global Investments (USA) LLC | 204,430 | 39,179 | 9/30/2021 |
0.26885 % | Schonfeld Strategic Advisors LLC | 203,680 | 158,795 | 9/30/2021 |
0.23826 % | Silvercrest Asset Management Group LLC | 180,502 | 33,686 | 9/30/2021 |
0.22114 % | Connor, Clark & Lunn Investment Management Ltd. | 167,538 | 79,527 | 9/30/2021 |
0.21626 % | BNY Mellon Asset Management | 163,841 | 1,444 | 9/30/2021 |
0.20229 % | JP Morgan Asset Management | 153,256 | -36,590 | 9/30/2021 |
0.20182 % | Schweizerische Nationalbank | 152,900 | 4,000 | 9/30/2021 |
0.19943 % | Voya Investment Management LLC | 151,085 | -3,274 | 9/30/2021 |
0.19860 % | AllianceBernstein L.P. | 150,459 | -35,398 | 9/30/2021 |
0.18953 % | Rafferty Asset Management LLC | 143,589 | 73,769 | 9/30/2021 |
0.17766 % | First Trust Advisors L.P. | 134,599 | 44,222 | 9/30/2021 |
0.17305 % | Renaissance Technologies LLC | 131,100 | -100 | 9/30/2021 |
0.16935 % | Bank J. Safra Sarasin AG (Asset Management) | 128,296 | 28,148 | 9/30/2021 |
0.16821 % | Citi Investment Research (US) | 127,437 | -14,431 | 9/30/2021 |
0.15958 % | Alphacrest Capital Management LLC | 120,900 | 120,900 | 9/30/2021 |
0.15819 % | Duality Group | 119,842 | 119,842 | 9/30/2021 |
0.15667 % | Mellon Investments Corporation | 118,692 | 20,761 | 9/30/2021 |
0.15328 % | Morgan Stanley Investment Management Inc. (US) | 116,123 | 1,157 | 9/30/2021 |
0.14845 % | JPMorgan Private Bank (United States) | 112,466 | -4,894 | 9/30/2021 |
0.14652 % | Susquehanna International Group, LLP | 111,005 | -41,688 | 9/30/2021 |
0.14520 % | Hudson Bay Capital Management LP | 110,000 | 25,024 | 9/30/2021 |
0.13651 % | D. E. Shaw & Co., L.P. | 103,422 | 103,422 | 9/30/2021 |
0.12576 % | Alps Advisors, Inc. | 95,276 | 86,586 | 9/30/2021 |
0.12566 % | PanAgora Asset Management Inc. | 95,203 | 57,365 | 9/30/2021 |
0.12449 % | California State Teachers Retirement System | 94,311 | -642 | 9/30/2021 |
0.12262 % | Evolutionary Tree Capital Management, LLC | 92,898 | -48,426 | 9/30/2021 |
0.12130 % | Lyxor Asset Management | 91,895 | -450 | 10/31/2021 |
0.12108 % | AQR Capital Management, LLC | 91,733 | 52,741 | 9/30/2021 |
0.11855 % | Arctic Fund Management AS | 89,814 | -67,000 | 9/30/2021 |
0.11720 % | BlackRock Advisors (UK) Limited | 88,793 | 2,580 | 10/31/2021 |
0.11708 % | State of Wisconsin Investment Board | 88,700 | 0 | 9/30/2021 |
0.10733 % | BofA Global Research (US) | 81,313 | -66,797 | 9/30/2021 |
0.10486 % | Foord Asset Management (Pty) Limited | 79,445 | 79,445 | 6/30/2021 |
0.10359 % | BlackRock Asset Management Ireland Limited | 78,478 | -7,240 | 9/30/2021 |
0.10322 % | Deka Investment GmbH | 78,200 | 78,200 | 12/31/2020 |
0.10288 % | Rhumbline Advisers Ltd. Partnership | 77,944 | -1,119 | 9/30/2021 |
0.10123 % | Northern Trust Global Investments | 76,689 | -768 | 9/30/2021 |
0.10037 % | Parametric Portfolio Associates LLC | 76,037 | -9,834 | 9/30/2021 |
0.09792 % | TD Asset Management Inc. | 74,186 | 0 | 9/30/2021 |
0.09556 % | Foord Asset Management (Singapore) Pte. Ltd. | 72,399 | 72,399 | 6/30/2021 |
0.09522 % | UBS Asset Management (Switzerland) | 72,137 | -5,674 | 9/30/2021 |
0.09244 % | Advisors Asset Management, Inc. | 70,029 | 22,425 | 9/30/2021 |
0.09073 % | BlackRock Investment Management (UK) Ltd. | 68,736 | 5,581 | 9/30/2021 |
0.08787 % | Credit Suisse Asset Management | 66,572 | 129 | 9/30/2021 |
0.08678 % | Manchester Capital Management LLC | 65,742 | 0 | 9/30/2021 |
0.07971 % | Legal & General Investment Management Ltd. | 60,386 | 44,332 | 9/30/2021 |
0.07787 % | Cubist Systematic Strategies, LLC | 58,993 | 44,923 | 9/30/2021 |