9.43 % | Federated Hermes Global Investment Management Corp. | 1,956,488 | -301,636 | 12/31/2022 |
8.47 % | Perceptive Advisors LLC | 1,757,160 | -182,563 | 12/31/2022 |
8.21 % | Deep Track Capital LP | 1,704,000 | 579,579 | 12/31/2022 |
7.15 % | Beryl Capital Management, LLC | 1,483,599 | 1,483,599 | 2/16/2023 |
6.57 % | Chicago Capital, LLC | 1,362,484 | 242,710 | 12/31/2022 |
5.59 % | BlackRock Institutional Trust Company, N.A. | 1,159,924 | 91,388 | 12/31/2022 |
5.18 % | Carlson Capital, L.P. | 1,075,000 | 1,075,000 | 2/17/2023 |
4.82 % | Millennium Management LLC | 999,363 | 611,796 | 2/21/2023 |
4.56 % | The Vanguard Group, Inc. | 945,227 | 31,052 | 12/31/2022 |
4.46 % | Franklin Advisers, Inc. | 924,773 | -487 | 12/31/2022 |
3.79 % | ArrowMark Colorado Holdings, LLC | 786,664 | -4,585 | 12/31/2022 |
3.68 % | Medical Strategy GmbH | 763,135 | 0 | 9/30/2022 |
3.06 % | GW&K Investment Management, LLC | 634,701 | -9,091 | 12/31/2022 |
3.00 % | Decheng Capital Management III (Cayman) LLC | 623,342 | 0 | 12/31/2022 |
2.48 % | Rice Hall James & Associates, LLC | 513,525 | 9,387 | 12/31/2022 |
2.35 % | Prosight Capital | 486,726 | -4,518 | 12/31/2022 |
2.24 % | Sphera Funds Management Ltd. | 463,828 | 104,828 | 12/31/2022 |
1.99 % | Tang Capital Management, LLC | 411,968 | -687,548 | 12/31/2022 |
1.68 % | State Street Global Advisors (US) | 348,114 | -2,430 | 12/31/2022 |
1.65 % | Saturn V Capital Management LLC | 341,827 | 341,827 | 12/31/2022 |
1.61 % | Geode Capital Management, L.L.C. | 333,211 | 20,467 | 12/31/2022 |
1.48 % | Platinum Asset Management | 306,834 | 39,917 | 12/31/2022 |
1.45 % | Privium Fund Management BV | 300,252 | 0 | 12/31/2022 |
1.30 % | Dimensional Fund Advisors, L.P. | 269,731 | 5,195 | 12/31/2022 |
1.29 % | Great Point Partners, LLC | 267,283 | 267,283 | 12/31/2022 |
1.28 % | MAI Capital Management, LLC | 265,364 | -141,469 | 12/31/2022 |
1.05 % | Endurant Capital Management LP | 217,209 | 44,588 | 12/31/2022 |
0.89 % | Cooper (Ronald Harold Wilfred) | 184,641 | -33,094 | 3/2/2023 |
0.76 % | Northern Trust Investments, Inc. | 157,275 | 6,165 | 12/31/2022 |
0.61 % | Fiera Capital Corporation | 126,109 | -2,377 | 12/31/2022 |
0.57 % | Streck (Paul) | 118,966 | 55,000 | 1/19/2023 |
0.56 % | Birchview Capital, LP | 117,000 | 0 | 12/31/2022 |
0.56 % | EQT Life Sciences | 116,376 | 11,500 | 6/30/2021 |
0.48 % | Samsara BioCapital, LLC | 100,000 | 0 | 12/31/2022 |
0.43 % | Renaissance Technologies LLC | 89,683 | -50,000 | 12/31/2022 |
0.42 % | BlackRock Financial Management, Inc. | 86,540 | 32,390 | 12/31/2022 |
0.40 % | Morgan Stanley & Co. LLC | 82,277 | -7,959 | 12/31/2022 |
0.36 % | Mattsson (Jan P) | 73,950 | -35,524 | 3/2/2023 |
0.31 % | Duncan (Jason G) | 64,490 | -3,296 | 3/2/2023 |
0.29 % | Parametric Portfolio Associates LLC | 60,726 | 29,482 | 12/31/2022 |
0.27 % | Stephenson (Pamela) | 56,763 | -22,242 | 3/2/2023 |
0.25 % | BNY Mellon Asset Management | 51,894 | 2,145 | 12/31/2022 |
0.25 % | Carter (Martha J) | 51,268 | -3,656 | 3/2/2023 |
0.25 % | Graham (Michelle) | 50,950 | -5,543 | 3/2/2023 |
0.24 % | Charles Schwab Investment Management, Inc. | 49,296 | 2,462 | 12/31/2022 |
0.23 % | BlackRock Investment Management, LLC | 47,565 | 1,062 | 12/31/2022 |
0.22 % | Harford Simon N R | 46,671 | -13,739 | 3/2/2023 |
0.22 % | Deka Vermögensmanagement GmbH | 45,000 | 0 | 12/31/2022 |
0.22 % | Manulife Investment Management (North America) Limited | 44,811 | 37,853 | 1/31/2023 |
0.21 % | Schweizerische Nationalbank | 42,600 | 1,700 | 12/31/2022 |
0.21 % | Jacobs Levy Equity Management, Inc. | 42,538 | 42,538 | 12/31/2022 |
0.20 % | Brandywine Global Investment Management, LLC | 42,168 | 0 | 12/31/2022 |
0.19 % | Nuveen LLC | 40,260 | -52,803 | 12/31/2022 |
0.18 % | International Biotechnology Trust PLC | 38,000 | 21,907 | 12/31/2022 |
0.17 % | Aperio Group, LLC | 35,366 | 4,138 | 12/31/2022 |
0.17 % | Weiss Multi-Strategy Advisers LLC | 35,322 | 322 | 12/31/2022 |
0.17 % | Deka Investment GmbH | 35,000 | 35,000 | 6/30/2022 |
0.14 % | Wilmington Trust Investment Advisors, Inc. | 29,524 | 4,562 | 12/31/2022 |
0.12 % | AllianceBernstein L.P. | 25,200 | 2,300 | 12/31/2022 |
0.12 % | Point72 Asset Management, L.P. | 24,200 | -53,900 | 12/31/2022 |
0.11 % | Northern Trust Global Investments | 23,841 | 719 | 12/31/2022 |
0.11 % | PDT Partners, LLC | 23,587 | 23,587 | 12/31/2022 |
0.11 % | California State Teachers Retirement System | 22,599 | 645 | 12/31/2022 |
0.11 % | Rhumbline Advisers Ltd. Partnership | 22,452 | 1,155 | 12/31/2022 |
0.09 % | ARIAD Asset Management GmbH | 19,099 | 0 | 12/31/2022 |
0.09 % | Schonfeld Strategic Advisors LLC | 18,393 | 18,393 | 12/31/2022 |
0.08 % | Granite Investment Partners, LLC | 16,162 | -734 | 1/31/2023 |
0.08 % | Apo Asset Management GmbH | 15,964 | 0 | 1/31/2023 |
0.08 % | State of Wisconsin Investment Board | 15,802 | -1,081 | 12/31/2022 |
0.07 % | William Blair & Company, L.L.C. (Research) | 15,456 | 75 | 12/31/2022 |
0.07 % | State Street Global Advisors Ireland Limited | 14,594 | 0 | 1/31/2023 |
0.07 % | Mellon Investments Corporation | 14,191 | 1,057 | 12/31/2022 |
0.07 % | Alps Advisors, Inc. | 14,058 | 3,310 | 12/31/2022 |
0.07 % | BlackRock Advisors (UK) Limited | 13,743 | 291 | 2/28/2023 |
0.06 % | Cheyne Capital Management (UK) LLP | 13,364 | 13,364 | 12/31/2022 |
0.06 % | Ensign Peak Advisors, Inc. | 13,090 | 6,450 | 12/31/2022 |
0.06 % | Fidelity Management & Research Company LLC | 13,049 | 11,657 | 12/31/2022 |
0.06 % | Goldman Sachs Asset Management, L.P. | 12,706 | 12,706 | 12/31/2022 |
0.06 % | BofA Global Research (US) | 12,342 | 6,108 | 12/31/2022 |
0.06 % | New York State Common Retirement Fund | 11,751 | -13 | 12/31/2022 |
0.06 % | Jump Financial, LLC | 11,700 | 11,700 | 12/31/2022 |
0.05 % | Credit Suisse Asset Management | 11,279 | 0 | 12/31/2022 |
0.05 % | Dimensional Fund Advisors, Ltd. | 11,256 | 0 | 1/31/2023 |
0.05 % | BlackRock Asset Management Ireland Limited | 11,164 | 513 | 12/31/2022 |
0.05 % | Two Sigma Investments, LP | 11,000 | -900 | 12/31/2022 |
0.05 % | JPMorgan Private Bank (United States) | 10,637 | 1,232 | 12/31/2022 |
0.05 % | Hopkinson (Craig C M.D.) | 10,495 | 10,495 | 12/1/2022 |
0.05 % | MetLife Investment Management, LLC | 9,864 | 0 | 12/31/2022 |
0.05 % | Connor, Clark & Lunn Investment Management Ltd. | 9,724 | -337 | 12/31/2022 |
0.04 % | Russell Investments Trust Company | 9,289 | 8,513 | 12/31/2022 |
0.04 % | Cubist Systematic Strategies, LLC | 8,640 | 4,930 | 12/31/2022 |
0.04 % | SunAmerica Asset Management, LLC | 8,613 | 442 | 12/31/2022 |
0.04 % | DWS Investments UK Limited | 7,848 | 990 | 12/31/2022 |
0.03 % | Legal & General Investment Management Ltd. | 6,990 | 434 | 12/31/2022 |
0.03 % | E Fund Management Co. Ltd. | 6,623 | 4,498 | 6/30/2022 |
0.03 % | UBS Financial Services, Inc. | 6,164 | 5,399 | 12/31/2022 |
0.03 % | Barclays Bank PLC | 6,163 | 4,160 | 12/31/2022 |
0.03 % | Horn Patrick Taylor | 6,086 | 2,066 | 4/1/2022 |
0.03 % | Perinvest (UK) Ltd. | 6,000 | 0 | 6/30/2022 |
0.03 % | Zürcher Kantonalbank (Asset Management) | 5,713 | 813 | 12/31/2022 |