8.60464 % | Johnson & Johnson Innovation-JJDC, Inc. | 6,641,064 | 0 | 12/31/2023 |
6.85620 % | Adage Capital Management, L.P. | 5,291,618 | 620,601 | 12/31/2023 |
6.08673 % | Sanofi SA | 4,697,737 | 4,697,737 | 10/30/2023 |
5.24840 % | Prosight Capital | 4,050,714 | -28,090 | 2/13/2024 |
4.23271 % | Adena Estate Inc. | 3,266,806 | 3,266,806 | 12/31/2023 |
3.23918 % | 683 Capital Management LLC | 2,500,000 | 42,391 | 12/31/2023 |
2.56277 % | BlackRock Institutional Trust Company, N.A. | 1,977,943 | 115,709 | 12/31/2023 |
14.68140 % | Perceptive Advisors LLC | 11,331,103 | 0 | 12/31/2023 |
1.81587 % | Forbes (Alexandria) | 1,401,489 | -1,000 | 4/5/2024 |
1.21285 % | Giroux (Richard) | 936,078 | -13,500 | 2/29/2024 |
0.87084 % | Royce Investment Partners | 672,115 | -5,600 | 12/31/2023 |
0.73119 % | Naylor (Stuart) | 564,329 | 73,537 | 1/14/2024 |
0.72799 % | Medical Strategy GmbH | 561,860 | -54,391 | 12/31/2023 |
0.72767 % | State Street Global Advisors (US) | 561,618 | 349 | 12/31/2023 |
0.56135 % | Dimensional Fund Advisors, L.P. | 433,249 | 68,433 | 12/31/2023 |
0.50214 % | Geode Capital Management, L.L.C. | 387,548 | 23,123 | 12/31/2023 |
0.47673 % | Laurion Capital Management LP | 367,937 | 0 | 12/31/2023 |
0.42781 % | Alyeska Investment Group, L.P. | 330,182 | 0 | 12/31/2023 |
0.41946 % | JP Morgan Asset Management | 323,740 | -19,447 | 12/31/2023 |
0.40480 % | The Vanguard Group, Inc. | 312,421 | 11,832 | 12/31/2023 |
0.30619 % | Citadel Advisors LLC | 236,316 | 202,333 | 12/31/2023 |
0.27274 % | Northern Trust Investments, Inc. | 210,503 | 1,982 | 12/31/2023 |
0.20404 % | Shenk (Thomas E) | 157,476 | -15,000 | 3/31/2023 |
0.20084 % | Russell Investments Trust Company | 155,005 | -37,461 | 12/31/2023 |
0.18976 % | Wellington Management Company, LLP | 146,456 | 145,405 | 12/31/2023 |
0.17488 % | Millennium Management LLC | 134,975 | 134,975 | 12/31/2023 |
0.17211 % | Nuveen LLC | 132,833 | 0 | 12/31/2023 |
0.17120 % | William Blair & Company, L.L.C. (Research) | 132,133 | 0 | 12/31/2023 |
0.15586 % | BlackRock Financial Management, Inc. | 120,289 | -9,684 | 12/31/2023 |
0.15069 % | Los Angeles Capital Management LLC | 116,303 | 116,303 | 3/31/2024 |
0.13986 % | Morgan Stanley & Co. LLC | 107,942 | 42,475 | 12/31/2023 |
0.12782 % | Barclays Bank PLC | 98,652 | 31,317 | 12/31/2023 |
0.12239 % | Zeldin (Robert K) | 94,458 | 43,971 | 1/14/2024 |
0.11409 % | Bellecapital Partners AG | 88,056 | 0 | 9/30/2023 |
0.11286 % | BlackRock Investment Management, LLC | 87,103 | -835 | 12/31/2023 |
0.10417 % | Renaissance Technologies LLC | 80,400 | 80,400 | 12/31/2023 |
0.10073 % | Jane Street Capital, L.L.C. | 77,741 | 77,741 | 12/31/2023 |
0.09969 % | CreativeOne Wealth, LLC | 76,942 | -4,067 | 12/31/2023 |
0.09658 % | Charles Schwab Investment Management, Inc. | 74,544 | 0 | 12/31/2023 |
0.09509 % | Fort Sheridan Advisors LLC | 73,388 | -28,749 | 12/31/2023 |
0.09179 % | BNY Mellon Asset Management | 70,840 | -221 | 12/31/2023 |
0.07820 % | Davenport Asset Management | 60,355 | -4,000 | 12/31/2023 |
0.07059 % | Goldman Sachs & Company, Inc. | 54,485 | 14,514 | 12/31/2023 |
0.06910 % | Mellon Investments Corporation | 53,329 | -3,637 | 12/31/2023 |
0.06859 % | Jump Financial, LLC | 52,938 | 52,938 | 12/31/2023 |
0.06374 % | BofA Global Research (US) | 49,196 | 13,048 | 12/31/2023 |
0.06261 % | JPMorgan Private Bank (United States) | 48,321 | 24,549 | 12/31/2023 |
0.06197 % | Goldman Sachs Asset Management, L.P. | 47,830 | -49,206 | 12/31/2023 |
0.06020 % | Rhumbline Advisers Ltd. Partnership | 46,466 | -154 | 12/31/2023 |
0.05584 % | Assenagon Asset Management S.A. | 43,094 | 3,138 | 2/29/2024 |
0.05499 % | AllianceBernstein L.P. | 42,440 | -2,050 | 12/31/2023 |
0.05468 % | State of Wisconsin Investment Board | 42,200 | -24,900 | 12/31/2023 |
0.05383 % | Polen Capital Management, LLC | 41,549 | 0 | 2/29/2024 |
0.05034 % | Squarepoint Capital LLP | 38,854 | 14,506 | 12/31/2023 |
0.04740 % | D. E. Shaw & Co., L.P. | 36,584 | 36,584 | 12/31/2023 |
0.04726 % | UBS Financial Services, Inc. | 36,477 | 20,765 | 12/31/2023 |
0.04649 % | Sierra Summit Advisors LLC | 35,884 | 35,884 | 12/31/2023 |
0.04588 % | BlackRock Advisors (UK) Limited | 35,410 | 1,695 | 3/31/2024 |
0.04411 % | Northern Trust Global Investments | 34,046 | -4,021 | 12/31/2023 |
0.04399 % | Tocqueville Asset Management LP | 33,950 | 13,800 | 12/31/2023 |
0.04346 % | Dimensional Fund Advisors, Ltd. | 33,546 | 0 | 1/31/2024 |
0.04252 % | BlackRock Asset Management Ireland Limited | 32,818 | 8,147 | 12/31/2023 |
0.04237 % | Letko, Brosseau & Associates Inc. | 32,700 | 10,000 | 12/31/2023 |
0.04200 % | Simplex Trading, LLC | 32,414 | 32,414 | 12/31/2023 |
0.04158 % | Rhenman & Partners Asset Management AB | 32,091 | -506,895 | 12/31/2023 |
0.04157 % | CornerCap Investment Counsel, Inc. | 32,083 | 217 | 12/31/2023 |
0.04146 % | Hobbs Group Advisors LLC | 32,000 | 32,000 | 12/31/2023 |
0.03951 % | Innovis Asset Management LLC | 30,496 | 0 | 9/30/2023 |
0.03641 % | Avantis Investors | 28,101 | 24,853 | 3/31/2024 |
0.03226 % | Newton Investment Management North America, LLC | 24,900 | -3,292 | 12/31/2023 |
0.03044 % | LSV Asset Management | 23,494 | 21,292 | 3/31/2024 |
0.03026 % | SEI Investments Management Corporation | 23,353 | 21,048 | 3/31/2024 |
0.02874 % | State Street Global Advisors Ireland Limited | 22,179 | -81 | 4/30/2023 |
0.02873 % | Two Sigma Investments, LP | 22,177 | 9,477 | 12/31/2023 |
0.02747 % | Erste Asset Management GmbH | 21,200 | 0 | 12/31/2023 |
0.02691 % | XTX Markets LLC | 20,771 | 20,771 | 12/31/2023 |
0.02591 % | Harris (Keith R) | 20,000 | 20,000 | 6/7/2023 |
0.02332 % | Deka Investment GmbH | 18,000 | 0 | 12/31/2022 |
0.02202 % | Walleye Capital LLC | 16,996 | 16,996 | 12/31/2023 |
0.02158 % | DWS Investments UK Limited | 16,655 | -1,288 | 12/31/2023 |
0.02100 % | SunAmerica Asset Management, LLC | 16,208 | -66 | 12/31/2023 |
0.02069 % | MetLife Investment Management, LLC | 15,970 | 0 | 12/31/2023 |
0.02067 % | SG Americas Securities, L.L.C. | 15,950 | 3,755 | 12/31/2023 |
0.01961 % | Wollin (Robert J) | 15,137 | 9,425 | 1/14/2024 |
0.01944 % | CIBC Private Wealth Management | 15,000 | 0 | 12/31/2023 |
0.01944 % | Indyk (Martin) | 15,000 | 15,000 | 6/7/2023 |
0.01937 % | Susquehanna International Group, LLP | 14,946 | 14,946 | 12/31/2023 |
0.01897 % | Manulife Investment Management (North America) Limited | 14,642 | 0 | 12/31/2023 |
0.01894 % | Voya Investment Management LLC | 14,619 | 759 | 12/31/2023 |
0.01839 % | Cubist Systematic Strategies, LLC | 14,191 | 14,191 | 12/31/2023 |
0.01824 % | Mirae Asset Global Investments (USA) LLC | 14,077 | 189 | 12/31/2023 |
0.01780 % | Deutsche Asset Management Americas | 13,741 | -720 | 12/31/2023 |
0.01676 % | Parametric Portfolio Associates LLC | 12,936 | -4,627 | 12/31/2023 |
0.01669 % | Mendoza (Neil) | 12,883 | 0 | 3/31/2023 |
0.01604 % | J.P. Morgan Securities plc | 12,383 | 977 | 12/31/2023 |
0.01586 % | Florida State Board of Administration | 12,237 | 0 | 12/31/2023 |
0.01553 % | Citi Investment Research (US) | 11,983 | 6,808 | 12/31/2023 |
0.01434 % | BNP Paribas Securities Corp. North America | 11,064 | 5,179 | 12/31/2023 |
0.01336 % | ProShare Advisors LLC | 10,315 | 784 | 3/31/2024 |
0.01327 % | Invesco Advisers, Inc. | 10,242 | -782 | 12/31/2023 |