6.21585 % | New Enterprise Associates (NEA) | 4,007,977 | -756,463 | 2/28/2024 |
4.65261 % | Octagon Capital Advisors LP | 3,000,000 | 0 | 12/31/2023 |
3.75600 % | The Vanguard Group, Inc. | 2,421,869 | 0 | 12/31/2023 |
2.46169 % | AXA Investment Managers UK Ltd. | 1,587,298 | -38,400 | 12/31/2023 |
14.80190 % | BVF Partners L.P. | 9,544,262 | 0 | 12/31/2023 |
13.32051 % | Invus Public Equities Advisors, LLC | 8,589,064 | 0 | 12/31/2023 |
1.42580 % | Goldman Sachs & Company, Inc. | 919,355 | 124,861 | 12/31/2023 |
1.11403 % | BlackRock Institutional Trust Company, N.A. | 718,329 | 1,577 | 12/31/2023 |
0.98485 % | King (Rachel K) | 635,033 | 25,656 | 3/29/2024 |
0.83929 % | Acadian Asset Management LLC | 541,176 | -302,875 | 12/31/2023 |
0.74268 % | Geode Capital Management, L.L.C. | 478,883 | 19,038 | 12/31/2023 |
0.58220 % | Rock (Edwin) | 375,403 | 0 | 3/15/2024 |
0.53512 % | Magnani (John L) | 345,048 | 45,045 | 11/11/2022 |
0.34898 % | Two Sigma Investments, LP | 225,021 | -108,051 | 12/31/2023 |
0.31171 % | GSA Capital Partners LLP | 200,993 | 107,208 | 12/31/2023 |
0.30583 % | Bridgeway Capital Management, LLC | 197,200 | 25,000 | 12/31/2023 |
0.28965 % | State Street Global Advisors (US) | 186,765 | 0 | 12/31/2023 |
0.24997 % | Rath (Chinmaya) | 161,178 | 161,178 | 3/23/2023 |
0.22233 % | Connor, Clark & Lunn Investment Management Ltd. | 143,359 | -5,747 | 12/31/2023 |
0.21554 % | Johnson (Bruce S) | 138,980 | 13,500 | 5/8/2023 |
0.19300 % | Renaissance Technologies LLC | 124,444 | -76,663 | 12/31/2023 |
0.17291 % | Susquehanna International Group, LLP | 111,491 | 111,491 | 12/31/2023 |
0.17126 % | Welzia Management SGIIC S.A. | 110,429 | 26,650 | 12/31/2023 |
0.15664 % | Taiko | 101,000 | 101,000 | 12/31/2023 |
0.15509 % | Adage Capital Management, L.P. | 100,000 | 100,000 | 12/31/2023 |
0.15499 % | Northern Trust Investments, Inc. | 99,939 | 5,018 | 12/31/2023 |
0.15270 % | Junius (Daniel M) | 98,459 | 5,209 | 3/29/2024 |
0.14851 % | ExodusPoint Capital Management, LP | 95,759 | 95,759 | 12/31/2023 |
0.14850 % | Franklin Advisers, Inc. | 95,751 | -142 | 12/31/2023 |
0.11235 % | Simplex Trading, LLC | 72,445 | 72,445 | 12/31/2023 |
0.09870 % | Avantis Investors | 63,642 | 63,642 | 3/31/2024 |
0.09089 % | Andrews Patricia S | 58,608 | 0 | 3/15/2024 |
0.08995 % | Sargent Investment Group, LLC | 58,000 | 0 | 12/31/2023 |
0.08862 % | Jane Street Capital, L.L.C. | 57,143 | 37,176 | 12/31/2023 |
0.07866 % | Intellectus Partners, LLC | 50,720 | -11,255 | 12/31/2023 |
0.07018 % | Letko, Brosseau & Associates Inc. | 45,250 | 0 | 12/31/2023 |
0.06904 % | Hahn (Brian M) | 44,518 | 17,250 | 3/15/2024 |
0.06359 % | LPL Financial LLC | 41,000 | 28,000 | 12/31/2023 |
0.06031 % | Millennium Management LLC | 38,888 | -25,008 | 12/31/2023 |
0.05950 % | IEQ Capital LLC | 38,363 | 0 | 12/31/2023 |
0.05699 % | Koenig (Scott) | 36,750 | 0 | 3/15/2024 |
0.05634 % | Goldberg (Mark Alan M.D.) | 36,325 | 4,584 | 3/29/2024 |
0.05352 % | Morgan Stanley & Co. LLC | 34,511 | -5,874 | 12/31/2023 |
0.05322 % | Virtu Americas LLC | 34,319 | 34,319 | 12/31/2023 |
0.04847 % | Group One Trading, L.P. | 31,253 | 2,852 | 12/31/2023 |
0.04121 % | Y-Intercept (Hong Kong) Ltd | 26,572 | 26,572 | 12/31/2023 |
0.03877 % | Semerjian (Harout) | 25,000 | 0 | 3/15/2024 |
0.03836 % | BNY Mellon Asset Management | 24,732 | -143 | 12/31/2023 |
0.03823 % | Pearson (Timothy R) | 24,650 | 0 | 3/15/2024 |
0.03468 % | Charles Schwab Investment Management, Inc. | 22,361 | 0 | 12/31/2023 |
0.03339 % | Citi Investment Research (US) | 21,528 | 21,528 | 12/31/2023 |
0.03100 % | BofA Global Research (US) | 19,990 | 11,766 | 12/31/2023 |
0.03006 % | 683 Capital Management LLC | 19,384 | 19,384 | 12/31/2023 |
0.02326 % | Tobias Financial Advisors, Inc. | 15,000 | 0 | 12/31/2023 |
0.01998 % | Marshall Wace LLP | 12,885 | 12,885 | 12/31/2023 |
0.01942 % | Pine Valley Investments LLC | 12,520 | 0 | 12/31/2023 |
0.01933 % | Boothbay Fund Management, LLC | 12,464 | 12,464 | 12/31/2023 |
0.01892 % | Blackstone Alternative Investment Advisors LLC | 12,200 | 9,668 | 3/31/2023 |
0.01755 % | Northern Trust Global Investments | 11,315 | 0 | 12/31/2023 |
0.01720 % | XTX Markets LLC | 11,093 | -21,629 | 12/31/2023 |
0.01360 % | BlackRock Investment Management, LLC | 8,767 | -1,298 | 12/31/2023 |
0.01223 % | BlackRock Investment Management (UK) Ltd. | 7,887 | 0 | 12/31/2023 |
0.01223 % | Citadel Advisors LLC | 7,886 | 7,886 | 12/31/2023 |
0.00814 % | Jackson (Scott Thomas) | 5,250 | 0 | 3/15/2024 |
0.00753 % | Qube Research & Technologies Ltd | 4,853 | 4,454 | 12/31/2023 |
0.00543 % | HFM Wealth Management | 3,500 | 0 | 12/31/2023 |
0.00447 % | Tower Research Capital LLC | 2,882 | -1,780 | 12/31/2023 |
0.00319 % | Truvestments Capital LLC | 2,057 | 0 | 12/31/2023 |
0.00250 % | J.P. Morgan Securities LLC | 1,613 | 1,147 | 12/31/2023 |
0.00162 % | Rhumbline Advisers Ltd. Partnership | 1,044 | 0 | 12/31/2023 |
0.00145 % | Manulife Investment Management (North America) Limited | 933 | 0 | 1/31/2024 |
0.00106 % | UBS Financial Services, Inc. | 683 | 683 | 12/31/2023 |
0.00078 % | ORG Partners LLC | 500 | 500 | 12/31/2023 |
0.00075 % | BNP Paribas Securities Corp. North America | 481 | 0 | 12/31/2023 |
0.00058 % | Wells Fargo Bank, N.A. | 377 | 20 | 12/31/2023 |
0.00012 % | Barclays Capital Inc. | 76 | -76 | 12/31/2023 |
0 % | Susquehanna Fundamental Investments, LLC | 0 | -90,876 | 9/30/2022 |
0 % | AE Wealth Management LLC | 0 | -26,898 | 3/31/2023 |
0 % | Wolverine Trading, LLC | 0 | -11,879 | 6/30/2023 |
0 % | Osaic Holdings, Inc. | 0 | -600 | 3/31/2023 |
0 % | Eversept Partners, LP | 0 | -100,579 | 3/31/2023 |
0 % | MJP Wealth Advisors | 0 | -101,000 | 3/31/2024 |
0 % | Chicago Partners Wealth Advisors | 0 | -20,000 | 12/31/2023 |
0 % | Cubist Systematic Strategies, LLC | 0 | -44,939 | 6/30/2023 |
0 % | Stratos Wealth Partners, Ltd. | 0 | -33,340 | 9/30/2023 |
0 % | DLD Asset Management, LP | 0 | -29,200 | 6/30/2023 |
0 % | Caption Management, LLC | 0 | -6,657 | 6/30/2023 |
0 % | Pura Vida Investments, LLC | 0 | -31,615 | 3/31/2023 |
0 % | Creative Planning, Inc. | 0 | -10,000 | 12/31/2023 |
0 % | Dimensional Fund Advisors, Ltd. | 0 | -2,193 | 2/28/2023 |
0 % | Commonwealth Financial Network | 0 | -10,000 | 12/31/2023 |
0 % | Parallax Volatility Advisers, L.P. | 0 | -37,604 | 6/30/2023 |
0 % | Signaturefd, LLC | 0 | -100 | 12/31/2023 |
0 % | Acuta Capital Partners, LLC | 0 | -27,500 | 12/31/2023 |
0 % | Archer Investment Corporation | 0 | -1,000 | 3/31/2023 |
0 % | Chatham Asset Management, L.L.C. | 0 | -29,200 | 4/30/2023 |
0 % | Apo Asset Management GmbH | 0 | -18,333 | 2/28/2023 |
0 % | RBC Capital Partners | 0 | -167 | 9/30/2023 |
0 % | Medical Strategy GmbH | 0 | -810,578 | 3/31/2023 |
0 % | Prentiss Smith & Company, Inc. | 0 | -15,120 | 3/31/2023 |