9.99 % | Fidelity Management & Research Company LLC | 11,598,839 | 1,121,528 | 12/31/2023 |
9.48 % | The Vanguard Group, Inc. | 10,997,974 | 273,565 | 12/31/2023 |
5.59 % | Wellington Management Company, LLP | 6,488,500 | -1,497,856 | 12/31/2023 |
5.08 % | State Street Global Advisors (US) | 5,893,358 | 618,872 | 12/31/2023 |
2.75 % | T. Rowe Price Associates, Inc. | 3,192,799 | 2,233,450 | 12/31/2023 |
2.21 % | Janus Henderson Investors | 2,568,405 | 75,079 | 12/31/2023 |
2.18 % | RTW Investments L.P. | 2,525,080 | -49,118 | 12/31/2023 |
12.80 % | BlackRock Institutional Trust Company, N.A. | 14,854,640 | 661,991 | 12/31/2023 |
1.92 % | T. Rowe Price Investment Management, Inc. | 2,229,485 | 413,299 | 12/31/2023 |
1.81 % | Boxer Capital, L.L.C. | 2,100,000 | 0 | 12/31/2023 |
1.80 % | Geode Capital Management, L.L.C. | 2,090,125 | 111,760 | 12/31/2023 |
1.75 % | Morgan Stanley & Co. LLC | 2,025,789 | 1,320,687 | 12/31/2023 |
1.51 % | PFM Health Sciences, LP | 1,757,192 | -642,353 | 12/31/2023 |
1.40 % | Logos Global Management LLC | 1,625,000 | 375,000 | 12/31/2023 |
1.39 % | Lord, Abbett & Co. LLC | 1,607,812 | 1,006,641 | 12/31/2023 |
1.22 % | Polar Capital LLP | 1,417,054 | -1,237,391 | 12/31/2023 |
1.21 % | Fidelity Institutional Asset Management | 1,408,944 | -104,569 | 12/31/2023 |
1.18 % | Pictet Asset Management Ltd. | 1,372,244 | -875,199 | 12/31/2023 |
1.05 % | Invus Public Equities Advisors, LLC | 1,214,284 | -304,547 | 12/31/2023 |
1.03 % | Millennium Management LLC | 1,199,341 | 499,555 | 12/31/2023 |
0.94 % | Farallon Capital Management, L.L.C. | 1,087,772 | 1,066,000 | 12/31/2023 |
0.91 % | Invesco Advisers, Inc. | 1,053,877 | 120,099 | 12/31/2023 |
0.83 % | American Century Investment Management, Inc. | 967,000 | -1,258,762 | 12/31/2023 |
0.76 % | Northern Trust Investments, Inc. | 881,216 | 24,780 | 12/31/2023 |
0.70 % | First Turn Management, LLC | 807,444 | 807,444 | 12/31/2023 |
0.68 % | Charles Schwab Investment Management, Inc. | 789,969 | 33,257 | 12/31/2023 |
0.65 % | Mellon Investments Corporation | 756,882 | -39,906 | 12/31/2023 |
0.62 % | Norges Bank Investment Management (NBIM) | 722,229 | -117,127 | 12/31/2023 |
0.56 % | Fidelity Investments Canada ULC | 652,779 | -70,018 | 12/31/2023 |
0.56 % | Franklin Advisers, Inc. | 651,266 | -471,084 | 12/31/2023 |
0.55 % | Susquehanna International Group, LLP | 635,502 | 470,916 | 12/31/2023 |
0.54 % | Marshall Wace LLP | 626,087 | -907,882 | 12/31/2023 |
0.53 % | Goldman Sachs & Company, Inc. | 616,782 | 77,971 | 12/31/2023 |
0.52 % | Darwin Global Management Ltd | 600,000 | 600,000 | 12/31/2023 |
0.48 % | Hood River Capital Management LLC | 560,981 | 58,455 | 12/31/2023 |
0.48 % | Eventide Asset Management, LLC | 556,000 | 0 | 12/31/2023 |
0.48 % | Assenagon Asset Management S.A. | 554,658 | 554,658 | 12/31/2023 |
0.46 % | Fisher Investments | 536,046 | 536,046 | 12/31/2023 |
0.45 % | Principal Global Investors (Equity) | 521,172 | -4,111 | 12/31/2023 |
0.43 % | Great Point Partners, LLC | 500,000 | -100,000 | 12/31/2023 |
0.40 % | Candriam Luxembourg S.A. | 468,029 | 6,000 | 2/29/2024 |
0.39 % | Saturn V Capital Management LLC | 448,144 | -47,024 | 12/31/2023 |
0.37 % | Finepoint Capital LP | 431,693 | 0 | 12/31/2023 |
0.37 % | BNP Paribas Asset Management USA, Inc. | 430,891 | -141,505 | 12/31/2023 |
0.37 % | Ensign Peak Advisors, Inc. | 425,863 | 0 | 12/31/2023 |
0.36 % | Caption Management, LLC | 420,359 | 405,284 | 12/31/2023 |
0.36 % | BlackRock Financial Management, Inc. | 418,028 | -192,885 | 12/31/2023 |
0.36 % | Sofinnova Investments, Inc | 414,207 | -645,957 | 12/31/2023 |
0.36 % | Balyasny Asset Management LP | 413,137 | -765,741 | 12/31/2023 |
0.35 % | Medical Strategy GmbH | 410,643 | 10,800 | 12/31/2023 |
0.34 % | Dafna Capital Management, LLC | 400,000 | -79,538 | 12/31/2023 |
0.33 % | Ostrum Asset Management | 378,793 | 334,955 | 12/31/2023 |
0.31 % | Putnam Investment Management, L.L.C. | 365,335 | 147,486 | 12/31/2023 |
0.30 % | Qube Research & Technologies Ltd | 350,535 | 340,827 | 12/31/2023 |
0.30 % | DWS Investments UK Limited | 348,712 | 303,878 | 12/31/2023 |
0.30 % | Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 344,484 | 344,484 | 12/31/2023 |
0.29 % | BlackRock Asset Management Ireland Limited | 340,837 | 17,813 | 12/31/2023 |
0.27 % | Columbia Threadneedle Investments (US) | 316,909 | 1,491 | 12/31/2023 |
0.27 % | Nuveen LLC | 314,502 | -5,539 | 12/31/2023 |
0.25 % | Blum (Robert I) | 292,974 | 19,424 | 3/14/2024 |
0.25 % | BlackRock Investment Management, LLC | 291,194 | -1,989 | 12/31/2023 |
0.25 % | Parametric Portfolio Associates LLC | 289,702 | 23,706 | 12/31/2023 |
0.25 % | Deep Track Capital LP | 288,949 | 288,949 | 12/31/2023 |
0.24 % | Rhumbline Advisers Ltd. Partnership | 281,842 | 6,973 | 12/31/2023 |
0.24 % | BNY Mellon Asset Management | 275,689 | 823 | 12/31/2023 |
0.24 % | UBS Financial Services, Inc. | 274,308 | 77,637 | 12/31/2023 |
0.23 % | Citadel Advisors LLC | 272,593 | -959,231 | 12/31/2023 |
0.23 % | Candriam Belgium S.A. | 267,240 | -236,000 | 12/31/2023 |
0.23 % | Legal & General Investment Management Ltd. | 266,487 | -689 | 12/31/2023 |
0.23 % | Rafferty Asset Management LLC | 263,275 | 16,353 | 12/31/2023 |
0.22 % | Pinnacle Associates Ltd. | 258,358 | -971 | 12/31/2023 |
0.22 % | Russell Investments Trust Company | 252,122 | -37,435 | 12/31/2023 |
0.21 % | Barclays Bank PLC | 246,664 | 85,984 | 12/31/2023 |
0.20 % | Checkpoint Capital L.P. | 230,000 | 230,000 | 12/31/2023 |
0.19 % | Sphera Funds Management Ltd. | 223,820 | -10,113 | 12/31/2023 |
0.19 % | Driehaus Capital Management, LLC | 220,384 | 220,384 | 12/31/2023 |
0.19 % | Tekla Capital Management LLC_NLE | 219,025 | 0 | 6/30/2023 |
0.19 % | BlackRock Advisors (UK) Limited | 218,431 | -140,225 | 3/31/2024 |
0.19 % | Barclays Capital Inc. | 216,891 | -193,109 | 12/31/2023 |
0.18 % | Brown Advisory | 208,569 | 208,569 | 2/29/2024 |
0.18 % | Eagle Asset Management, Inc. | 203,547 | -193,223 | 12/31/2023 |
0.18 % | PSP Investments | 203,472 | 84,820 | 12/31/2023 |
0.18 % | BofA Global Research (US) | 203,309 | -22,684 | 12/31/2023 |
0.17 % | Integral Health Asset Management, LLC | 200,000 | -600,000 | 12/31/2023 |
0.17 % | BNP Paribas Securities Corp. North America | 198,886 | 96,081 | 12/31/2023 |
0.17 % | Cantor Fitzgerald, L.P | 197,282 | 197,282 | 12/31/2023 |
0.17 % | Goldman Sachs Asset Management, L.P. | 193,913 | 23,274 | 12/31/2023 |
0.17 % | Victory Capital Management Inc. | 191,654 | 174,848 | 12/31/2023 |
0.16 % | Invesco Capital Management LLC | 189,096 | -60,999 | 12/31/2023 |
0.16 % | JP Morgan Asset Management | 184,155 | -52,972 | 12/31/2023 |
0.16 % | TD Asset Management Inc. | 182,040 | 82,400 | 12/31/2023 |
0.15 % | Two Sigma Investments, LP | 179,462 | -94,101 | 12/31/2023 |
0.15 % | Superstring Capital Management LP | 177,603 | 177,603 | 12/31/2023 |
0.15 % | Voya Investment Management LLC | 176,742 | -677 | 12/31/2023 |
0.15 % | DWS Investment S.A. | 170,647 | 170,647 | 12/31/2023 |
0.15 % | Schweizerische Nationalbank | 170,300 | -29,500 | 12/31/2023 |
0.14 % | HealthCor Management, L.P. | 164,440 | -270,120 | 12/31/2022 |
0.14 % | Affinity Asset Advisors LLC | 160,000 | -70,366 | 12/31/2023 |
0.14 % | Citi Investment Research (US) | 158,974 | 16,260 | 12/31/2023 |
0.14 % | Point72 Asset Management, L.P. | 157,100 | 157,100 | 12/31/2023 |