8.06268 % | The Vanguard Group, Inc. | 13,374,376 | -220,731 | 12/31/2023 |
6.78415 % | RTW Investments L.P. | 11,253,551 | -322,986 | 12/31/2023 |
5.74221 % | BlackRock Institutional Trust Company, N.A. | 9,525,170 | 914,758 | 12/31/2023 |
3.89741 % | State Street Global Advisors (US) | 6,465,026 | 1,251,295 | 12/31/2023 |
3.61194 % | EcoR1 Capital, LLC | 5,991,479 | 0 | 12/31/2023 |
3.17420 % | Fidelity Management & Research Company LLC | 5,265,358 | -36,622 | 12/31/2023 |
3.01234 % | T. Rowe Price Associates, Inc. | 4,996,868 | -47,010 | 12/31/2023 |
25.84074 % | Baker Bros. Advisors LP | 42,864,612 | 0 | 12/31/2023 |
2.26344 % | D. E. Shaw & Co., L.P. | 3,754,598 | -1,034,400 | 12/31/2023 |
1.91510 % | Fred Alger Management, LLC | 3,176,775 | 67,892 | 12/31/2023 |
1.77847 % | Emerald Advisers LLC | 2,950,121 | -34,919 | 12/31/2023 |
1.62295 % | Geode Capital Management, L.L.C. | 2,692,152 | 113,770 | 12/31/2023 |
1.45259 % | Palo Alto Investors LP | 2,409,556 | 3,763 | 12/31/2023 |
1.07144 % | First Trust Advisors L.P. | 1,777,307 | 148,526 | 12/31/2023 |
1.06383 % | Millennium Management LLC | 1,764,678 | -648,786 | 12/31/2023 |
0.88090 % | Pictet Asset Management Ltd. | 1,461,232 | 109,635 | 12/31/2023 |
0.87004 % | Norges Bank Investment Management (NBIM) | 1,443,218 | -510,938 | 12/31/2023 |
0.79718 % | Jupiter Asset Management Ltd. | 1,322,364 | 46,148 | 12/31/2023 |
0.77295 % | Voloridge Investment Management, LLC | 1,282,177 | 237,676 | 12/31/2023 |
0.67995 % | Charles Schwab Investment Management, Inc. | 1,127,907 | 54,814 | 12/31/2023 |
0.64727 % | Northern Trust Investments, Inc. | 1,073,696 | 32,243 | 12/31/2023 |
0.51377 % | Weatherbie Capital, LLC | 852,248 | 77,793 | 2/29/2024 |
0.51002 % | Manulife Investment Management (North America) Limited | 846,028 | -204,366 | 12/31/2023 |
0.49650 % | Frontier Capital Management Company, LLC | 823,586 | 65,973 | 12/31/2023 |
0.48794 % | Eventide Asset Management, LLC | 809,391 | 809,391 | 12/31/2023 |
0.47503 % | BlackRock Financial Management, Inc. | 787,983 | 315,283 | 12/31/2023 |
0.46398 % | Finepoint Capital LP | 769,653 | 213,100 | 12/31/2023 |
0.44063 % | Frazier Healthcare Partners | 730,917 | 100,020 | 12/31/2023 |
0.42365 % | DWS Investments UK Limited | 702,755 | 641,613 | 12/31/2023 |
0.41768 % | Rice Hall James & Associates, LLC | 692,852 | -3,213 | 12/31/2023 |
0.39993 % | Morgan Stanley & Co. LLC | 663,399 | -624,841 | 12/31/2023 |
0.39303 % | Pictet Asset Management (Japan) Ltd. | 651,959 | 220,060 | 10/31/2023 |
0.38879 % | PanAgora Asset Management Inc. | 644,920 | 1,922 | 12/31/2023 |
0.38654 % | Fuller & Thaler Asset Management Inc. | 641,185 | 382,385 | 12/31/2023 |
0.37822 % | Connor, Clark & Lunn Investment Management Ltd. | 627,384 | -6,085 | 12/31/2023 |
0.35327 % | Nordea Funds Oy | 586,002 | -12,401 | 12/31/2023 |
0.35269 % | Alyeska Investment Group, L.P. | 585,036 | 185,036 | 12/31/2023 |
0.33539 % | Rockefeller Capital Management | 556,337 | 51,164 | 12/31/2023 |
0.32160 % | Goldman Sachs & Company, Inc. | 533,478 | 150,207 | 12/31/2023 |
0.29396 % | BlackRock Advisors (UK) Limited | 487,615 | -3,688 | 3/31/2024 |
0.28883 % | BlackRock Asset Management Ireland Limited | 479,114 | -14,209 | 12/31/2023 |
0.28584 % | Woodline Partners LP | 474,159 | 474,159 | 12/31/2023 |
0.28394 % | HOOPP Investment Management | 471,000 | 234,000 | 12/31/2023 |
0.26906 % | Jane Street Capital, L.L.C. | 446,317 | 128,354 | 12/31/2023 |
0.26170 % | Loomis, Sayles & Company, L.P. | 434,114 | 434,114 | 2/29/2024 |
0.25798 % | Rafferty Asset Management LLC | 427,930 | 91,317 | 12/31/2023 |
0.25219 % | Two Sigma Investments, LP | 418,328 | 329,528 | 12/31/2023 |
0.24863 % | Nuveen LLC | 412,426 | -38,876 | 12/31/2023 |
0.24631 % | Columbia Threadneedle Investments (UK) | 408,583 | 26,757 | 12/31/2023 |
0.24461 % | APG Asset Management N.V. | 405,760 | 140,085 | 9/30/2023 |
0.23681 % | Point72 Asset Management, L.P. | 392,827 | 342,184 | 12/31/2023 |
0.23224 % | Cubist Systematic Strategies, LLC | 385,245 | 385,245 | 12/31/2023 |
0.22623 % | Susquehanna International Group, LLP | 375,263 | 52,883 | 12/31/2023 |
0.22040 % | Invesco Capital Management LLC | 365,601 | 97,152 | 12/31/2023 |
0.21125 % | PGIM Quantitative Solutions LLC | 350,416 | 96,800 | 12/31/2023 |
0.20907 % | Barclays Bank PLC | 346,803 | 153,319 | 12/31/2023 |
0.20517 % | BlackRock Investment Management, LLC | 340,328 | 38,498 | 12/31/2023 |
0.20124 % | M&G Investment Management Ltd. | 333,824 | 239,632 | 12/31/2023 |
0.19953 % | Cutter Capital Management, LP | 330,973 | 330,973 | 12/31/2023 |
0.19796 % | BNY Mellon Asset Management | 328,375 | 1,091 | 12/31/2023 |
0.19410 % | JP Morgan Asset Management | 321,969 | -83,228 | 12/31/2023 |
0.19100 % | DWS Investment S.A. | 316,830 | 316,830 | 12/31/2023 |
0.18722 % | HRT Financial LP | 310,562 | 281,165 | 12/31/2023 |
0.18657 % | Managed Account Advisors LLC | 309,485 | -37,656 | 12/31/2023 |
0.18529 % | UBS Financial Services, Inc. | 307,359 | 162,663 | 12/31/2023 |
0.18138 % | Balyasny Asset Management LP | 300,875 | 284,557 | 12/31/2023 |
0.17423 % | Old Mutual Investment Group (South Africa) (Pty) Limited | 289,011 | 289,011 | 6/30/2023 |
0.17142 % | Voya Investment Management LLC | 284,344 | 28,637 | 12/31/2023 |
0.16895 % | Qube Research & Technologies Ltd | 280,259 | 67,340 | 12/31/2023 |
0.16702 % | Squarepoint Capital LLP | 277,052 | 118,040 | 12/31/2023 |
0.16319 % | Goldman Sachs Asset Management, L.P. | 270,692 | -64,662 | 12/31/2023 |
0.15727 % | Algert Global LLC | 260,877 | 149,343 | 12/31/2023 |
0.15010 % | Morgan Stanley Investment Management Inc. (US) | 248,988 | 131,750 | 12/31/2023 |
0.14910 % | PENN Capital Management Company, Inc. | 247,324 | -41,959 | 12/31/2023 |
0.14698 % | Capital Fund Management S.A. | 243,812 | 68,120 | 12/31/2023 |
0.14631 % | Walleye Capital LLC | 242,705 | 144,104 | 12/31/2023 |
0.14573 % | Parametric Portfolio Associates LLC | 241,737 | 12,207 | 12/31/2023 |
0.14492 % | Birchview Capital, LP | 240,400 | 0 | 12/31/2023 |
0.13851 % | BNP Paribas Securities Corp. North America | 229,765 | -75,403 | 12/31/2023 |
0.13426 % | Citi Investment Research (US) | 222,718 | 75,854 | 12/31/2023 |
0.13257 % | MacKay Shields LLC | 219,900 | 168,389 | 8/31/2022 |
0.12879 % | New York State Common Retirement Fund | 213,639 | -19,870 | 12/31/2023 |
0.12648 % | Schweizerische Nationalbank | 209,804 | -22,600 | 12/31/2023 |
0.12449 % | TD Asset Management Inc. | 206,496 | -19,200 | 12/31/2023 |
0.12068 % | J.P. Morgan Securities LLC | 200,192 | 196,753 | 12/31/2023 |
0.11707 % | Columbia Threadneedle Investments (US) | 194,199 | 15,307 | 12/31/2023 |
0.11562 % | Mellon Investments Corporation | 191,783 | -14,790 | 12/31/2023 |
0.11346 % | BofA Global Research (US) | 188,210 | -236,603 | 12/31/2023 |
0.11340 % | Sector Gamma AS | 188,111 | 8,326 | 12/31/2023 |
0.11133 % | Congress Asset Management Company, LLP | 184,666 | 31,105 | 12/31/2023 |
0.11092 % | Renaissance Technologies LLC | 184,000 | 184,000 | 12/31/2023 |
0.11049 % | Rhumbline Advisers Ltd. Partnership | 183,284 | -1,116 | 12/31/2023 |
0.10950 % | T. Rowe Price International Ltd | 181,641 | -4,642 | 12/31/2023 |
0.10833 % | International Biotechnology Trust PLC | 179,702 | 28,702 | 9/30/2023 |
0.10808 % | BlackRock Investment Management (UK) Ltd. | 179,287 | 92,048 | 12/31/2023 |
0.10539 % | Empire Life Investments Inc. | 174,815 | 467 | 12/31/2023 |
0.09226 % | Citadel Advisors LLC | 153,034 | 147,625 | 12/31/2023 |
0.09099 % | Envestnet Asset Management, Inc. | 150,932 | -20,883 | 12/31/2023 |
0.09049 % | Jennison Associates LLC | 150,100 | 40,500 | 2/29/2024 |
0.08940 % | Erste Asset Management GmbH | 148,300 | 15,700 | 12/31/2023 |