٨٫٩١٣٣٠ % | Wellington Management Company, LLP | ٧٬٥٨٥٬٢٢١ | -٥٧٬٢٢٥ | ٣١/١٢/٢٠٢٣ |
٦٫٧٣٧٣١ % | BlackRock Institutional Trust Company, N.A. | ٥٬٧٣٣٬٤٥١ | ٨١١٬٠٥٨ | ٣١/١٢/٢٠٢٣ |
٦٫٦٥١٠٠ % | Kynam Capital Management LP | ٥٬٦٦٠٬٠٠٠ | ٢٬٠٦٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٥٫٨٩٤٥١ % | State Street Global Advisors (US) | ٥٬٠١٦٬٢٢٤ | ١٬٤١٥٬٥٧٦ | ٣١/١٢/٢٠٢٣ |
٥٫٠٧٦٨٤ % | The Vanguard Group, Inc. | ٤٬٣٢٠٬٣٨٨ | ٧١٢٬٧٤٩ | ٣١/١٢/٢٠٢٣ |
٤٫٩٦١٤٨ % | Avoro Capital Advisors LLC | ٤٬٢٢٢٬٢٢٢ | ١٬٦٦٦٬٦٦٧ | ٣١/١٢/٢٠٢٣ |
٤٫٦٤١٦٠ % | Avidity Partners Management LP | ٣٬٩٥٠٬٠٠٠ | ١٬١٢٩٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٣٫٩٧٥٦١ % | Eversept Partners, LP | ٣٬٣٨٣٬٢٤٤ | ٧٨٦٬٩٩٩ | ٣١/١٢/٢٠٢٣ |
٣٫٣٣٠٧٩ % | Point72 Asset Management, L.P. | ٢٬٨٣٤٬٤٩٩ | -٣٢٢٬٤٨٣ | ٣١/١٢/٢٠٢٣ |
٣٫١٨٥٩٦ % | T. Rowe Price Investment Management, Inc. | ٢٬٧١١٬٢٥٣ | ١٬٦٤٤٬٧٠٥ | ٣١/١٢/٢٠٢٣ |
٢٫٤٦٩٩٣ % | Marshall Wace LLP | ٢٬١٠١٬٩١١ | ١٬٤٩٧٬٩٤٩ | ٣١/١٢/٢٠٢٣ |
٢٫٢٠٣٢٩ % | BVF Partners L.P. | ١٬٨٧٥٬٠٠٠ | ١٬٨٧٥٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٢٫٠٥٥٢٣ % | OrbiMed Advisors, LLC | ١٬٧٤٩٬٠٠٠ | ٤٦٥٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
١٫٨١٤٥٩ % | Woodline Partners LP | ١٬٥٤٤٬٢١٦ | ١٬٥١٠٬١٤٩ | ٣١/١٢/٢٠٢٣ |
١٫٨٠٣٨٢ % | Geode Capital Management, L.L.C. | ١٬٥٣٥٬٠٥٥ | ١٧٤٬١٣٥ | ٣١/١٢/٢٠٢٣ |
١٫٦٤٢٣١ % | Morgan Stanley & Co. LLC | ١٬٣٩٧٬٦٠٣ | ٩٤٦٬٠٥٥ | ٣١/١٢/٢٠٢٣ |
١٫٥٦٨١٩ % | Franklin Advisers, Inc. | ١٬٣٣٤٬٥٣١ | ١٬٣٣٤٬٥٣١ | ٣١/١٢/٢٠٢٣ |
١٫٣٨٠٧٣ % | Cormorant Asset Management, LP | ١٬١٧٥٬٠٠٠ | ١٬١٧٥٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
١٫٣٠١٢١ % | Goldman Sachs & Company, Inc. | ١٬١٠٧٬٣٣٠ | -٧٤٬٧٤١ | ٣١/١٢/٢٠٢٣ |
١٫٢٨٦١٣ % | StemPoint Capital LP | ١٬٠٩٤٬٤٩٤ | ١٬٠٩٤٬٤٩٤ | ٣١/١٢/٢٠٢٣ |
١٫٢٦٤١٤ % | Sofinnova Investments, Inc | ١٬٠٧٥٬٧٨٦ | ١٣٣٬٩٦٩ | ٣١/١٢/٢٠٢٣ |
١٫٢٥٨٥٢ % | Candriam Luxembourg S.A. | ١٬٠٧١٬٠٠٠ | 0 | ٢٩/٢/٢٠٢٤ |
١٫٢٠٤٤٧ % | Aisling Capital Management LP | ١٬٠٢٥٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٣ |
١٫١٩٩٨٠ % | Candriam Belgium S.A. | ١٬٠٢١٬٠٣٢ | ٧٨١٬٠٢٢ | ٣١/١٢/٢٠٢٣ |
١٫١١٨٧٥ % | BofA Global Research (US) | ٩٥٢٬٠٥٧ | ٧٥٩٬٢٧٦ | ٣١/١٢/٢٠٢٣ |
١٫١٠٧٦٩ % | Millennium Management LLC | ٩٤٢٬٦٤٢ | ٥٠٢٬٨٧٢ | ٣١/١٢/٢٠٢٣ |
١٫٠٥٧٥٨ % | Adage Capital Management, L.P. | ٩٠٠٬٠٠٠ | -١٠٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
١٫٠٢٨٢٠ % | Foresite Capital Management, LLC | ٨٧٥٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٩٨٤٧٥ % | BlackRock Financial Management, Inc. | ٨٣٨٬٠٢٣ | ٢٥٨٬٣٥٨ | ٣١/١٢/٢٠٢٣ |
٠٫٩١٦٥٧ % | HOOPP Investment Management | ٧٨٠٬٠٠٠ | ٧٨٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٩٠٨٣٠ % | Sphera Funds Management Ltd. | ٧٧٢٬٩٦٤ | -٩٧ | ٣١/١٢/٢٠٢٣ |
٠٫٨٧٦٩٦ % | Kingdon Capital Management, L.L.C. | ٧٤٦٬٢٩٣ | ٧٤٦٬٢٩٣ | ٣١/١٢/٢٠٢٣ |
٠٫٨٧٢٥٩ % | Dafna Capital Management, LLC | ٧٤٢٬٥٧٤ | ٢٨٤٬٢٠١ | ٣١/١٢/٢٠٢٣ |
٠٫٨٦٧٩١ % | Parkman Healthcare Partners LLC | ٧٣٨٬٥٨٩ | ٥٢٦٬١٤١ | ٣١/١٢/٢٠٢٣ |
٠٫٨٠٧٧٤ % | Two Sigma Investments, LP | ٦٨٧٬٣٩٠ | ١٨٨٬٧٧٣ | ٣١/١٢/٢٠٢٣ |
٠٫٧٥٧٢٠ % | JP Morgan Asset Management | ٦٤٤٬٣٧٤ | -٣٬٧٦١ | ٣١/١٢/٢٠٢٣ |
٠٫٧٣١١٨ % | Nuveen LLC | ٦٢٢٬٢٣٧ | ٤٦٢٬٦٣٥ | ٣١/١٢/٢٠٢٣ |
٠٫٧٢١٣٩ % | Northern Trust Investments, Inc. | ٦١٣٬٩٠٤ | ٧٢٬٢٣٩ | ٣١/١٢/٢٠٢٣ |
٠٫٦٩٩٧٩ % | PFM Health Sciences, LP | ٥٩٥٬٥٢٣ | -٢٬١١٩٬٧١٢ | ٣١/١٢/٢٠٢٣ |
٠٫٦٧٨٠٥ % | Charles Schwab Investment Management, Inc. | ٥٧٧٬٠٢٢ | ٧٠٬٥٥٥ | ٣١/١٢/٢٠٢٣ |
٠٫٦٢٠٦٣ % | Algert Global LLC | ٥٢٨٬١٥٧ | ٧١٬٩٣٨ | ٣١/١٢/٢٠٢٣ |
٠٫٦٠٩٦٣ % | Saturn V Capital Management LLC | ٥١٨٬٧٩٩ | -٢٨٩٬١٧٠ | ٣١/١٢/٢٠٢٣ |
٠٫٦٠٥٠٠ % | Ensign Peak Advisors, Inc. | ٥١٤٬٨٥٢ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٦٠٤٠٠ % | Soleus Capital Management, L.P. | ٥١٤٬٠٠٠ | ٣٩٤٬٥٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٥٥٨٩٣ % | Columbia Threadneedle Investments (US) | ٤٧٥٬٦٤٨ | ٤٬٤٥٩ | ٣١/١٢/٢٠٢٣ |
٠٫٥٥٥٣٥ % | Palo Alto Investors LP | ٤٧٢٬٦٠٠ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٥٥٤٠٢ % | Schonfeld Strategic Advisors LLC | ٤٧١٬٤٧٥ | ٢٥٣٬٠٦٢ | ٣١/١٢/٢٠٢٣ |
٠٫٤٨٤١٠ % | Assenagon Asset Management S.A. | ٤١١٬٩٦٥ | ٢١٬٤٢٧ | ٣١/١٢/٢٠٢٣ |
٠٫٤٧٤٠١ % | Rafferty Asset Management LLC | ٤٠٣٬٣٨١ | ١١٩٬٢٥٧ | ٣١/١٢/٢٠٢٣ |
٠٫٤٢٩٢١ % | Nantahala Capital Management, LLC | ٣٦٥٬٢٥٩ | ١٢٥٬٢٢٨ | ٣١/١٢/٢٠٢٣ |
٠٫٤١٥١٠ % | ExodusPoint Capital Management, LP | ٣٥٣٬٢٥٢ | ١٩٧٬٥٣٨ | ٣١/١٢/٢٠٢٣ |
٠٫٣٧٧١٠ % | Granahan Investment Management, LLC | ٣٢٠٬٩١١ | ٣٠٧٬٨٦٢ | ٣١/١٢/٢٠٢٣ |
٠٫٣٤١٧٢ % | UBS Financial Services, Inc. | ٢٩٠٬٨٠١ | ٢١٥٬٤٤٤ | ٣١/١٢/٢٠٢٣ |
٠٫٣٢٣٢٧ % | Zimmer Partners, LP | ٢٧٥٬١٠٠ | ٢٧٥٬١٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٢٩٨٥٤ % | Barclays Bank PLC | ٢٥٤٬٠٦١ | ٦٧٬٠٧٦ | ٣١/١٢/٢٠٢٣ |
٠٫٢٨٦٨٣ % | Macquarie Investment Management | ٢٤٤٬٠٩٠ | ١١٬٦٢٤ | ٣١/١٢/٢٠٢٣ |
٠٫٢٨٥٥٣ % | Citadel Advisors LLC | ٢٤٢٬٩٨٥ | -١٩٢٬٥٠٨ | ٣١/١٢/٢٠٢٣ |
٠٫٢٦٩٠١ % | Parametric Portfolio Associates LLC | ٢٢٨٬٩٢٤ | ١٦٨٬١٤٩ | ٣١/١٢/٢٠٢٣ |
٠٫٢٣٠٣٦ % | Peregrine Capital Management, LLC | ١٩٦٬٠٣٣ | -٢٣٬٩٤١ | ٣١/١٢/٢٠٢٣ |
٠٫٢٢٢٦٨ % | BlackRock Investment Management, LLC | ١٨٩٬٤٩٧ | ١٣٬١٠٤ | ٣١/١٢/٢٠٢٣ |
٠٫٢١٨٣٤ % | BNY Mellon Asset Management | ١٨٥٬٨١٠ | ٢٬٧٨٤ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠٤٦٣ % | PanAgora Asset Management Inc. | ١٧٤٬١٤٤ | ٨٢٬٦٤٥ | ٣١/١٢/٢٠٢٣ |
٠٫١٩٥١٠ % | Voya Investment Management LLC | ١٦٦٬٠٣٣ | ١١٧٬١٤٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٩٣٩١ % | Balyasny Asset Management LP | ١٦٥٬٠١٨ | ١٦٬٤٩٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٩٢٦١ % | Metzger (Michael A) | ١٦٣٬٩٠٩ | ٣٬٧٥٠ | ٨/٣/٢٠٢٤ |
٠٫١٩١٤٣ % | BNP Paribas Securities Corp. North America | ١٦٢٬٩٠٥ | ٤٤٬٩٠٦ | ٣١/١٢/٢٠٢٣ |
٠٫١٩٠٨٤ % | Citi Investment Research (US) | ١٦٢٬٤٠٦ | ٤٢٬١٧٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٨٧٧٨ % | New Jersey Division of Investment | ١٥٩٬٨٠٣ | ٢٦٬٧٦٩ | ٣١/١٢/٢٠٢٣ |
٠٫١٧٦٢٦ % | Casdin Capital, LLC | ١٥٠٬٠٠٠ | ١٥٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٦٨٦٤ % | Trexquant Investment LP | ١٤٣٬٥١٤ | ١٤٣٬٥١٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٦٨٣٥ % | Verition Fund Management LLC | ١٤٣٬٢٦٦ | ١٢٨٬٢٦٦ | ٣١/١٢/٢٠٢٣ |
٠٫١٦٧٣٣ % | Schweizerische Nationalbank | ١٤٢٬٤٠٠ | ٢١٬٤٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٦٤٢٧ % | Allianz Global Investors GmbH | ١٣٩٬٧٩٠ | 0 | ٣١/١/٢٠٢٤ |
٠٫١٦٠٤١ % | JPMorgan Private Bank (United States) | ١٣٦٬٥٠٩ | ٥٥٬٥٤٦ | ٣١/١٢/٢٠٢٣ |
٠٫١٥٥٢٠ % | BlackRock Advisors (UK) Limited | ١٣٢٬٠٧٥ | ٦٬٢٣٧ | ٣١/٣/٢٠٢٤ |
٠٫١٥٢٢٨ % | Goldman Sachs Asset Management, L.P. | ١٢٩٬٥٩٠ | ٥٨٬٦٢٩ | ٣١/١٢/٢٠٢٣ |
٠٫١٥٠٣٣ % | Walleye Capital LLC | ١٢٧٬٩٣٢ | ١٢٧٬٩٣٢ | ٣١/١٢/٢٠٢٣ |
٠٫١٣٤٥٨ % | Yelin Lapidot Mutual Funds Management Ltd | ١١٤٬٥٣٠ | ١١٤٬٥٣٠ | ٣٠/٩/٢٠٢٣ |
٠٫١٣٤٥٨ % | Yelin Lapidot Provident Funds Management Ltd | ١١٤٬٥٣٠ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫١٢٨٤٤ % | Dimensional Fund Advisors, L.P. | ١٠٩٬٣٠٣ | ٣٬١٦٣ | ٣١/١٢/٢٠٢٣ |
٠٫١٢٥٨١ % | Jane Street Capital, L.L.C. | ١٠٧٬٠٦٦ | -٤٣٬٠٦٥ | ٣١/١٢/٢٠٢٣ |
٠٫١٢٠٦٧ % | Victory Capital Management Inc. | ١٠٢٬٦٨٧ | ١٠٢٬٦٨٧ | ٣١/١٢/٢٠٢٣ |
٠٫١١٨٢٧ % | Crestline Investors, Inc. | ١٠٠٬٦٤٩ | -٣٣٬٨١٥ | ٣١/١٢/٢٠٢٣ |
٠٫١١٢٧٥ % | UBS O'Connor LLC | ٩٥٬٩٤٩ | ٩٥٬٩٤٩ | ٣١/١٢/٢٠٢٣ |
٠٫١١٢٠١ % | Rhumbline Advisers Ltd. Partnership | ٩٥٬٣١٧ | -٣٬٦٥٢ | ٣١/١٢/٢٠٢٣ |
٠٫١٠٩٦٧ % | Podlesak (Dennis G) | ٩٣٬٣٣٣ | -٢٬٠٠٠ | ٨/٣/٢٠٢٤ |
٠٫١٠٨١٨ % | Sectoral Asset Management Inc. | ٩٢٬٠٦٠ | ٦٬٠٦٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٠٤٤٨ % | BlackRock Asset Management Ireland Limited | ٨٨٬٩١٠ | ٤٬١٢٥ | ٣١/١٢/٢٠٢٣ |
٠٫١٠١٢٦ % | Axiom Investors | ٨٦٬١٧٥ | ٧٥٬٣٥٥ | ٣١/١٢/٢٠٢٣ |
٠٫١٠٠١٢ % | Wellington Management Japan Pte Ltd | ٨٥٬٢٠٠ | -٥٤٬٨٩١ | ٣٠/٦/٢٠٢٣ |
٠٫٠٩٨٠٧ % | TwinBeech Capital LP | ٨٣٬٤٥٦ | -١٠٤٬٦٥٤ | ٣١/١٢/٢٠٢٣ |
٠٫٠٩٢٥٥ % | State of Wisconsin Investment Board | ٧٨٬٧٥٨ | ٢٤٬٣٠٢ | ٣١/١٢/٢٠٢٣ |
٠٫٠٩١٠٢ % | AllianceBernstein L.P. | ٧٧٬٤٦٠ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٨٦١ % | California State Teachers Retirement System | ٧٥٬٤٠٧ | ١٢٬٢١٥ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٥٥٢ % | Credit Suisse Funds AG | ٧٢٬٧٧٥ | ٣٬٦٠٦ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٢٢٦ % | HealthCor Management, L.P. | ٧٠٬٠٠٠ | -٧٨٩٬٢٤٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٨١٠٦ % | Tudor Investment Corporation | ٦٨٬٩٨١ | ٣٩٬٠٤٢ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٠٤٧ % | Aperio Group, LLC | ٦٨٬٤٧٩ | ٣٧٬٣٤٤ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٠١٤ % | Gyon Technologies Capital Management, LP | ٦٨٬١٩٥ | ٣٥٬٢٢٦ | ٣١/١٢/٢٠٢٢ |
٠٫٠٧٨٨٥ % | Polar Asset Management Partners Inc. | ٦٧٬١٠٠ | ٦٧٬١٠٠ | ٣١/١٢/٢٠٢٣ |