٩٫٧٧٠٠٤ % | Wellington Management Company, LLP | ٦٬٤٧٦٬٥٦١ | ١٬٠٤٤٬٧٢٨ | ٣١/١٢/٢٠٢٣ |
٩٫١٦١٥١ % | Fidelity Management & Research Company LLC | ٦٬٠٧٣٬١٦٢ | -٢٠٠٬٨٨٤ | ٣١/١٢/٢٠٢٣ |
٥٫٤٧٥٩٦ % | Eventide Asset Management, LLC | ٣٬٦٣٠٬٠١٣ | ٢٬٠٣٠٬٠١٣ | ٣١/١٢/٢٠٢٣ |
٥٫٢٢٤٣٢ % | RTW Investments L.P. | ٣٬٤٦٣٬٢٠١ | 0 | ٣١/١٢/٢٠٢٣ |
٤٫٩٩٨٤٩ % | BlackRock Institutional Trust Company, N.A. | ٣٬٣١٣٬٥٠٢ | ٤٢٩٬٦٦٨ | ٣١/١٢/٢٠٢٣ |
٤٫٧٣٠٥٣ % | Polar Capital LLP | ٣٬١٣٥٬٨٧١ | ٧٠٩٬١١٥ | ٣١/١٢/٢٠٢٣ |
٤٫٥٧٩٣٩ % | The Vanguard Group, Inc. | ٣٬٠٣٥٬٦٧٥ | ٤٢٥٬٥٠٠ | ٣١/١٢/٢٠٢٣ |
٤٫٥٣٤٤٨ % | Kynam Capital Management LP | ٣٬٠٠٥٬٩٠٤ | -١٩٤٬٠٩٦ | ٣١/١٢/٢٠٢٣ |
٤٫١٥٧٦٧ % | Point72 Asset Management, L.P. | ٢٬٧٥٦٬١٢٢ | -٨٦٦٬٠١٤ | ٣١/١٢/٢٠٢٣ |
٣٫٦٤٥٠٤ % | Bellevue Asset Management AG | ٢٬٤١٦٬٢٩٦ | ٥١٦٬٢٩٦ | ٣١/١٢/٢٠٢٣ |
٣٫٥٨٦٢٥ % | State Street Global Advisors (US) | ٢٬٣٧٧٬٣٢٦ | ٨٤٬٤٧٥ | ٣١/١٢/٢٠٢٣ |
٣٫٣٥٧١٤ % | Pictet Asset Management Ltd. | ٢٬٢٢٥٬٤٤٨ | ٣٧٤٬٤٧٨ | ٣١/١٢/٢٠٢٣ |
١٫٩٣١٠٤ % | Marshall Wace LLP | ١٬٢٨٠٬٠٨٤ | ٧٤١٬٧٦٥ | ٣١/١٢/٢٠٢٣ |
١٫٦٨٦٥٢ % | Geode Capital Management, L.L.C. | ١٬١١٧٬٩٩٤ | ١١٧٬٥٦٩ | ٣١/١٢/٢٠٢٣ |
١٫٤٩٩١٧ % | Redmile Group, LLC | ٩٩٣٬٨٠٣ | -٦٤٢٬١٣٥ | ٣١/١٢/٢٠٢٣ |
١٫٤٧٤٢٠ % | Fidelity Institutional Asset Management | ٩٧٧٬٢٤٧ | ١٦٢٬١٧٣ | ٣١/١٢/٢٠٢٣ |
١٫٤٦٢٧٣ % | Rock Springs Capital Management LP | ٩٦٩٬٦٤٦ | ٤٦٩٬٥٤٥ | ٣١/١٢/٢٠٢٣ |
١٫٢٧٣٢١ % | Sofinnova Investments, Inc | ٨٤٤٬٠٠٨ | ٤١٩٬٧٤٩ | ٣١/١٢/٢٠٢٣ |
١٫١٣٧٥٩ % | Eversept Partners, LP | ٧٥٤٬١٠٧ | ١٦٥٬٩٦٤ | ٣١/١٢/٢٠٢٣ |
١٫٠٦٧٣٢ % | Octagon Capital Advisors LP | ٧٠٧٬٥٢٦ | -٥٢٬٣٧٢ | ٣١/١٢/٢٠٢٣ |
١٫٠٥٨٩٣ % | Commodore Capital LP | ٧٠١٬٩٦٧ | -٤٬٦٩٨ | ٣١/١٢/٢٠٢٣ |
٠٫٩٣٩٥٣ % | Morgan Stanley & Co. LLC | ٦٢٢٬٨١٣ | ١١٩٬٥٤٤ | ٣١/١٢/٢٠٢٣ |
٠٫٧٥٠١٤ % | 5AM Ventures | ٤٩٧٬٢٧٠ | ١٨٧٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٦١٧٥٨ % | Charles Schwab Investment Management, Inc. | ٤٠٩٬٣٩١ | ٤٧٬٨٤٤ | ٣١/١٢/٢٠٢٣ |
٠٫٦٠٣٥٨ % | Northern Trust Investments, Inc. | ٤٠٠٬١١٢ | ٢٧٬٩٢٠ | ٣١/١٢/٢٠٢٣ |
٠٫٦٠٣٤١ % | Affinity Asset Advisors LLC | ٤٠٠٬٠٠٠ | ٢٥٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٥٨٥٩٢ % | Goldman Sachs & Company, Inc. | ٣٨٨٬٤٠٤ | ١٢٬٩٦٤ | ٣١/١٢/٢٠٢٣ |
٠٫٥٨٤٧٨ % | Woodline Partners LP | ٣٨٧٬٦٥٢ | ٢٨٠٬١٥٦ | ٣١/١٢/٢٠٢٣ |
٠٫٥٨٢٠٠ % | T. Rowe Price Associates, Inc. | ٣٨٥٬٨٠٩ | -٤٧٬٨١٤ | ٣١/١٢/٢٠٢٣ |
٠٫٤٧٨٩٧ % | Candriam Luxembourg S.A. | ٣١٧٬٥٠٩ | 0 | ٢٩/٢/٢٠٢٤ |
٠٫٤٧٨٩٧ % | Candriam Belgium S.A. | ٣١٧٬٥٠٩ | -٥٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٤٧٦١٦ % | Sphera Funds Management Ltd. | ٣١٥٬٦٤٤ | ١٣٥٬٦٤٤ | ٣١/١٢/٢٠٢٣ |
٠٫٣٧٩٣٩ % | TSP Capital Management Group, LLC | ٢٥١٬٤٩٥ | -٢٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٣٧٣٥٨ % | Baker Bros. Advisors LP | ٢٤٧٬٦٤٤ | ٢٤٧٬٦٤٤ | ٣١/١٢/٢٠٢٣ |
٠٫٣٧٢٩٣ % | SilverArc Capital Management, LLC | ٢٤٧٬٢١٥ | ٢٤٧٬٢١٥ | ٣١/١٢/٢٠٢٣ |
٠٫٣٦٧٩٩ % | Medical Strategy GmbH | ٢٤٣٬٩٤٢ | ٦٬٤٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٣٥٥٤٣ % | Invesco Capital Management LLC | ٢٣٥٬٦١٢ | ٢١٧٬٧٨٣ | ٣١/١٢/٢٠٢٣ |
٠٫٣٤٧٦٧ % | Dimensional Fund Advisors, L.P. | ٢٣٠٬٤٧١ | -١١٠٬٨٧٩ | ٣١/١٢/٢٠٢٣ |
٠٫٣٢٦٠٤ % | BofA Global Research (US) | ٢١٦٬١٣٣ | ٤٬٦٩٥ | ٣١/١٢/٢٠٢٣ |
٠٫٢٧٠٩٥ % | Ensign Peak Advisors, Inc. | ١٧٩٬٦١١ | ٨٧٬٤٨٢ | ٣١/١٢/٢٠٢٣ |
٠٫٢٥٥٣٤ % | Walleye Capital LLC | ١٦٩٬٢٦٨ | ١٠٬٢٧٥ | ٣١/١٢/٢٠٢٣ |
٠٫٢٤٦٦٥ % | Nomura Asset Management Co., Ltd. | ١٦٣٬٥٠١ | ١٦٣٬٥٠١ | ٣٠/١١/٢٠٢٣ |
٠٫٢٤٢٩٥ % | American Century Investment Management, Inc. | ١٦١٬٠٥١ | ١٩١ | ٣١/١٢/٢٠٢٣ |
٠٫٢٣٨٤٩ % | UBS Financial Services, Inc. | ١٥٨٬٠٩٢ | ١٣٦٬٨٩٧ | ٣١/١٢/٢٠٢٣ |
٠٫٢٢٣٢٨ % | Rafferty Asset Management LLC | ١٤٨٬٠٠٩ | -١٦٬٧٨١ | ٣١/١٢/٢٠٢٣ |
٠٫٢١٧٧٥ % | Barclays Bank PLC | ١٤٤٬٣٤٥ | ٢٬٢٩٥ | ٣١/١٢/٢٠٢٣ |
٠٫٢١٤٤٧ % | AXA Investment Managers UK Ltd. | ١٤٢٬١٧٠ | -٣٬٤٣٩ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠٩٦٩ % | BlackRock Financial Management, Inc. | ١٣٩٬٠٠٦ | ٣٬٩١٦ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠٨٩٨ % | Laurion Capital Management LP | ١٣٨٬٥٣١ | ١٣٨٬٥٣١ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠٦٠٧ % | BNP Paribas Securities Corp. North America | ١٣٦٬٦٠١ | ٤٤٬٨٧٨ | ٣١/١٢/٢٠٢٣ |
٠٫١٩٦٩٣ % | Schonfeld Strategic Advisors LLC | ١٣٠٬٥٤٢ | ١٣٠٬٥٤٢ | ٣١/١٢/٢٠٢٣ |
٠٫١٩٤٣٠ % | MacKay Shields LLC | ١٢٨٬٨٠٣ | 0 | ٣١/٨/٢٠٢٢ |
٠٫١٩٣٣٣ % | Jane Street Capital, L.L.C. | ١٢٨٬١٦١ | ٦٨٬٧٤٧ | ٣١/١٢/٢٠٢٣ |
٠٫١٩٢٨٤ % | BNY Mellon Asset Management | ١٢٧٬٨٣٦ | ٤٬٦٦١ | ٣١/١٢/٢٠٢٣ |
٠٫١٩٠٥٧ % | Citadel Advisors LLC | ١٢٦٬٣٢٨ | ١٢٠٬٤٠٣ | ٣١/١٢/٢٠٢٣ |
٠٫١٨٦١٤ % | BlackRock Investment Management, LLC | ١٢٣٬٣٩٣ | ١٬١١٥ | ٣١/١٢/٢٠٢٣ |
٠٫١٨١١٤ % | Nuveen LLC | ١٢٠٬٠٧٦ | -٢٠٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٦٧٩٠ % | Exome Asset Management LLC | ١١١٬٣٠٠ | ١١١٬٣٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٥٨٠٣ % | Mirador Capital Partners LP | ١٠٤٬٧٥٩ | -٣٬١٥١ | ٣١/٣/٢٠٢٤ |
٠٫١٥١١٧ % | Monashee Investment Management, LLC | ١٠٠٬٢٠٩ | ١٠٠٬٢٠٩ | ٣١/١٢/٢٠٢٣ |
٠٫١٤٦٣٣ % | Schweizerische Nationalbank | ٩٧٬٠٠٠ | ٨٬٧٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٤٢٢٥ % | Polar Asset Management Partners Inc. | ٩٤٬٣٠٠ | -٣٨٬١٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٢١٠٤ % | UBS Switzerland AG | ٨٠٬٢٣٥ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫١١٤٦٨ % | Rhumbline Advisers Ltd. Partnership | ٧٦٬٠٢٢ | -٦٥٢ | ٣١/١٢/٢٠٢٣ |
٠٫١٠٤٦٩ % | Acuta Capital Partners, LLC | ٦٩٬٤٠٠ | -٥٢٬٩٤١ | ٣١/١٢/٢٠٢٣ |
٠٫١٠١٤٤ % | Crestline Investors, Inc. | ٦٧٬٢٤٣ | ٤٬١٣٣ | ٣١/١٢/٢٠٢٣ |
٠٫٠٩٦٣٣ % | BlackRock Advisors (UK) Limited | ٦٣٬٨٥٤ | ١٬٣٦٦ | ٣١/٣/٢٠٢٤ |
٠٫٠٩٤٠٤ % | Citi Investment Research (US) | ٦٢٬٣٤١ | -٧٬٠١٤ | ٣١/١٢/٢٠٢٣ |
٠٫٠٩٣٧٩ % | Kennedy Capital Management LLC | ٦٢٬١٧٢ | -٢٥٬٢٢٢ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٨٧٠ % | OrbiMed Advisors, LLC | ٥٨٬٨٠٠ | ٥٨٬٨٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨١٥٨ % | AllianceBernstein L.P. | ٥٤٬٠٨٠ | -٣٩٬٢٠١ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧٨٩٣ % | TD Asset Management Inc. | ٥٢٬٣٢٢ | -١٢٬٦٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧٨٤٦ % | Legal & General Investment Management Ltd. | ٥٢٬٠١٢ | ١١٬١٦٨ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧٨٢٢ % | Wellington Management Japan Pte Ltd | ٥١٬٨٥٤ | -١٦٬٣٨٤ | ٣٠/٦/٢٠٢٣ |
٠٫٠٧٧٦٥ % | California State Teachers Retirement System | ٥١٬٤٧٤ | ٥٬٧٢١ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧٥٤٣ % | HBM Partners AG | ٥٠٬٠٠٠ | 0 | ٣٠/٩/٢٠٢٣ |
٠٫٠٧٤٤٥ % | Goldman Sachs Asset Management, L.P. | ٤٩٬٣٥٥ | ١٢٬٩٦١ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧٣٧٥ % | Susquehanna International Group, LLP | ٤٨٬٨٨٨ | -٨٬٥٧٢ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧٢٥٦ % | International Biotechnology Trust PLC | ٤٨٬٠٩٩ | 0 | ٣٠/٩/٢٠٢٣ |
٠٫٠٧٢٥٦ % | Schroder Investment Management Ltd. (SIM) | ٤٨٬٠٩٩ | ٤٨٬٠٩٩ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧٢٤١ % | Credit Suisse Funds AG | ٤٧٬٩٩٨ | ٨٬٣٥٢ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧١٠٧ % | Young (Diane C) | ٤٧٬١١٥ | 0 | ٥/٤/٢٠٢٣ |
٠٫٠٧٠٦٣ % | BlackRock Asset Management Ireland Limited | ٤٦٬٨٢١ | ٣٬٥٦٢ | ٣١/١٢/٢٠٢٣ |
٠٫٠٦٩٥٢ % | SG Americas Securities, L.L.C. | ٤٦٬٠٨٣ | -٣١٬٩٢٨ | ٣١/١٢/٢٠٢٣ |
٠٫٠٦٨٦١ % | Monarch Partners Asset Management LLC | ٤٥٬٤٧٩ | ٤٥٬٤٧٩ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦٧٨٤ % | Qube Research & Technologies Ltd | ٤٤٬٩٦٨ | ٤٠٬٦٦٩ | ٣١/١٢/٢٠٢٣ |
٠٫٠٦٥٥١ % | Manulife Investment Management (North America) Limited | ٤٣٬٤٢٧ | -٦٬٤٠٥ | ٣١/١٢/٢٠٢٣ |
٠٫٠٦٢٣٥ % | JPMorgan Private Bank (United States) | ٤١٬٣٣١ | ٣٦٬٧٣٥ | ٣١/١٢/٢٠٢٣ |
٠٫٠٦٢٢٣ % | Mellon Investments Corporation | ٤١٬٢٥٢ | ٣٢١ | ٣١/١٢/٢٠٢٣ |
٠٫٠٦١٦٧ % | Atom Investors LP | ٤٠٬٨٨٢ | ٤٠٬٨٨٢ | ٣١/١٢/٢٠٢٣ |
٠٫٠٦١١٢ % | State of Wisconsin Investment Board | ٤٠٬٥١٨ | ٨٬٥٦٩ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥٩٨٩ % | Caption Management, LLC | ٣٩٬٧٠٠ | ٢٦٬٧٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥٦٧٩ % | Alps Advisors, Inc. | ٣٧٬٦٤٥ | ٢٬٧٩٧ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥٦٠٨ % | TwinBeech Capital LP | ٣٧٬١٧٧ | -٢٥٬٤٠٦ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥٥٢٧ % | Northern Trust Global Investments | ٣٦٬٦٣٧ | -٥٠٬١٦٩ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥٥٠٤ % | T. Rowe Price International Ltd | ٣٦٬٤٨٤ | ٢٬٠٥٢ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥٢٩٩ % | Martin (Samuel Bates) | ٣٥٬١٢٨ | ١٠٬٧٥٠ | ٢/١/٢٠٢٤ |
٠٫٠٥٢٨٠ % | PFM Health Sciences, LP | ٣٥٬٠٠٠ | ٣٥٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥١٥٠ % | JP Morgan Asset Management | ٣٤٬١٣٩ | -٢٣٬٩٣٧ | ٣١/١٢/٢٠٢٣ |
٠٫٠٤٩٣٢ % | Kentucky Teachers' Retirement System | ٣٢٬٦٩٧ | 0 | ٣١/١٢/٢٠٢٣ |