٩٫٤٣ % | Federated Hermes Global Investment Management Corp. | ١٬٩٥٦٬٤٨٨ | -٣٠١٬٦٣٦ | ٣١/١٢/٢٠٢٢ |
٨٫٤٧ % | Perceptive Advisors LLC | ١٬٧٥٧٬١٦٠ | -١٨٢٬٥٦٣ | ٣١/١٢/٢٠٢٢ |
٨٫٢١ % | Deep Track Capital LP | ١٬٧٠٤٬٠٠٠ | ٥٧٩٬٥٧٩ | ٣١/١٢/٢٠٢٢ |
٧٫١٥ % | Beryl Capital Management, LLC | ١٬٤٨٣٬٥٩٩ | ١٬٤٨٣٬٥٩٩ | ١٦/٢/٢٠٢٣ |
٦٫٥٧ % | Chicago Capital, LLC | ١٬٣٦٢٬٤٨٤ | ٢٤٢٬٧١٠ | ٣١/١٢/٢٠٢٢ |
٥٫٥٩ % | BlackRock Institutional Trust Company, N.A. | ١٬١٥٩٬٩٢٤ | ٩١٬٣٨٨ | ٣١/١٢/٢٠٢٢ |
٥٫١٨ % | Carlson Capital, L.P. | ١٬٠٧٥٬٠٠٠ | ١٬٠٧٥٬٠٠٠ | ١٧/٢/٢٠٢٣ |
٤٫٨٢ % | Millennium Management LLC | ٩٩٩٬٣٦٣ | ٦١١٬٧٩٦ | ٢١/٢/٢٠٢٣ |
٤٫٥٦ % | The Vanguard Group, Inc. | ٩٤٥٬٢٢٧ | ٣١٬٠٥٢ | ٣١/١٢/٢٠٢٢ |
٤٫٤٦ % | Franklin Advisers, Inc. | ٩٢٤٬٧٧٣ | -٤٨٧ | ٣١/١٢/٢٠٢٢ |
٣٫٧٩ % | ArrowMark Colorado Holdings, LLC | ٧٨٦٬٦٦٤ | -٤٬٥٨٥ | ٣١/١٢/٢٠٢٢ |
٣٫٦٨ % | Medical Strategy GmbH | ٧٦٣٬١٣٥ | 0 | ٣٠/٩/٢٠٢٢ |
٣٫٠٦ % | GW&K Investment Management, LLC | ٦٣٤٬٧٠١ | -٩٬٠٩١ | ٣١/١٢/٢٠٢٢ |
٣٫٠٠ % | Decheng Capital Management III (Cayman) LLC | ٦٢٣٬٣٤٢ | 0 | ٣١/١٢/٢٠٢٢ |
٢٫٤٨ % | Rice Hall James & Associates, LLC | ٥١٣٬٥٢٥ | ٩٬٣٨٧ | ٣١/١٢/٢٠٢٢ |
٢٫٣٥ % | Prosight Capital | ٤٨٦٬٧٢٦ | -٤٬٥١٨ | ٣١/١٢/٢٠٢٢ |
٢٫٢٤ % | Sphera Funds Management Ltd. | ٤٦٣٬٨٢٨ | ١٠٤٬٨٢٨ | ٣١/١٢/٢٠٢٢ |
١٫٩٩ % | Tang Capital Management, LLC | ٤١١٬٩٦٨ | -٦٨٧٬٥٤٨ | ٣١/١٢/٢٠٢٢ |
١٫٦٨ % | State Street Global Advisors (US) | ٣٤٨٬١١٤ | -٢٬٤٣٠ | ٣١/١٢/٢٠٢٢ |
١٫٦٥ % | Saturn V Capital Management LLC | ٣٤١٬٨٢٧ | ٣٤١٬٨٢٧ | ٣١/١٢/٢٠٢٢ |
١٫٦١ % | Geode Capital Management, L.L.C. | ٣٣٣٬٢١١ | ٢٠٬٤٦٧ | ٣١/١٢/٢٠٢٢ |
١٫٤٨ % | Platinum Asset Management | ٣٠٦٬٨٣٤ | ٣٩٬٩١٧ | ٣١/١٢/٢٠٢٢ |
١٫٤٥ % | Privium Fund Management BV | ٣٠٠٬٢٥٢ | 0 | ٣١/١٢/٢٠٢٢ |
١٫٣٠ % | Dimensional Fund Advisors, L.P. | ٢٦٩٬٧٣١ | ٥٬١٩٥ | ٣١/١٢/٢٠٢٢ |
١٫٢٩ % | Great Point Partners, LLC | ٢٦٧٬٢٨٣ | ٢٦٧٬٢٨٣ | ٣١/١٢/٢٠٢٢ |
١٫٢٨ % | MAI Capital Management, LLC | ٢٦٥٬٣٦٤ | -١٤١٬٤٦٩ | ٣١/١٢/٢٠٢٢ |
١٫٠٥ % | Endurant Capital Management LP | ٢١٧٬٢٠٩ | ٤٤٬٥٨٨ | ٣١/١٢/٢٠٢٢ |
٠٫٨٩ % | Cooper (Ronald Harold Wilfred) | ١٨٤٬٦٤١ | -٣٣٬٠٩٤ | ٢/٣/٢٠٢٣ |
٠٫٧٦ % | Northern Trust Investments, Inc. | ١٥٧٬٢٧٥ | ٦٬١٦٥ | ٣١/١٢/٢٠٢٢ |
٠٫٦١ % | Fiera Capital Corporation | ١٢٦٬١٠٩ | -٢٬٣٧٧ | ٣١/١٢/٢٠٢٢ |
٠٫٥٧ % | Streck (Paul) | ١١٨٬٩٦٦ | ٥٥٬٠٠٠ | ١٩/١/٢٠٢٣ |
٠٫٥٦ % | Birchview Capital, LP | ١١٧٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٥٦ % | EQT Life Sciences | ١١٦٬٣٧٦ | ١١٬٥٠٠ | ٣٠/٦/٢٠٢١ |
٠٫٤٨ % | Samsara BioCapital, LLC | ١٠٠٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٤٣ % | Renaissance Technologies LLC | ٨٩٬٦٨٣ | -٥٠٬٠٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٤٢ % | BlackRock Financial Management, Inc. | ٨٦٬٥٤٠ | ٣٢٬٣٩٠ | ٣١/١٢/٢٠٢٢ |
٠٫٤٠ % | Morgan Stanley & Co. LLC | ٨٢٬٢٧٧ | -٧٬٩٥٩ | ٣١/١٢/٢٠٢٢ |
٠٫٣٦ % | Mattsson (Jan P) | ٧٣٬٩٥٠ | -٣٥٬٥٢٤ | ٢/٣/٢٠٢٣ |
٠٫٣١ % | Duncan (Jason G) | ٦٤٬٤٩٠ | -٣٬٢٩٦ | ٢/٣/٢٠٢٣ |
٠٫٢٩ % | Parametric Portfolio Associates LLC | ٦٠٬٧٢٦ | ٢٩٬٤٨٢ | ٣١/١٢/٢٠٢٢ |
٠٫٢٧ % | Stephenson (Pamela) | ٥٦٬٧٦٣ | -٢٢٬٢٤٢ | ٢/٣/٢٠٢٣ |
٠٫٢٥ % | BNY Mellon Asset Management | ٥١٬٨٩٤ | ٢٬١٤٥ | ٣١/١٢/٢٠٢٢ |
٠٫٢٥ % | Carter (Martha J) | ٥١٬٢٦٨ | -٣٬٦٥٦ | ٢/٣/٢٠٢٣ |
٠٫٢٥ % | Graham (Michelle) | ٥٠٬٩٥٠ | -٥٬٥٤٣ | ٢/٣/٢٠٢٣ |
٠٫٢٤ % | Charles Schwab Investment Management, Inc. | ٤٩٬٢٩٦ | ٢٬٤٦٢ | ٣١/١٢/٢٠٢٢ |
٠٫٢٣ % | BlackRock Investment Management, LLC | ٤٧٬٥٦٥ | ١٬٠٦٢ | ٣١/١٢/٢٠٢٢ |
٠٫٢٢ % | Harford Simon N R | ٤٦٬٦٧١ | -١٣٬٧٣٩ | ٢/٣/٢٠٢٣ |
٠٫٢٢ % | Deka Vermögensmanagement GmbH | ٤٥٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٢٢ % | Manulife Investment Management (North America) Limited | ٤٤٬٨١١ | ٣٧٬٨٥٣ | ٣١/١/٢٠٢٣ |
٠٫٢١ % | Schweizerische Nationalbank | ٤٢٬٦٠٠ | ١٬٧٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٢١ % | Jacobs Levy Equity Management, Inc. | ٤٢٬٥٣٨ | ٤٢٬٥٣٨ | ٣١/١٢/٢٠٢٢ |
٠٫٢٠ % | Brandywine Global Investment Management, LLC | ٤٢٬١٦٨ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫١٩ % | Nuveen LLC | ٤٠٬٢٦٠ | -٥٢٬٨٠٣ | ٣١/١٢/٢٠٢٢ |
٠٫١٨ % | International Biotechnology Trust PLC | ٣٨٬٠٠٠ | ٢١٬٩٠٧ | ٣١/١٢/٢٠٢٢ |
٠٫١٧ % | Aperio Group, LLC | ٣٥٬٣٦٦ | ٤٬١٣٨ | ٣١/١٢/٢٠٢٢ |
٠٫١٧ % | Weiss Multi-Strategy Advisers LLC | ٣٥٬٣٢٢ | ٣٢٢ | ٣١/١٢/٢٠٢٢ |
٠٫١٧ % | Deka Investment GmbH | ٣٥٬٠٠٠ | ٣٥٬٠٠٠ | ٣٠/٦/٢٠٢٢ |
٠٫١٤ % | Wilmington Trust Investment Advisors, Inc. | ٢٩٬٥٢٤ | ٤٬٥٦٢ | ٣١/١٢/٢٠٢٢ |
٠٫١٢ % | AllianceBernstein L.P. | ٢٥٬٢٠٠ | ٢٬٣٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫١٢ % | Point72 Asset Management, L.P. | ٢٤٬٢٠٠ | -٥٣٬٩٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫١١ % | Northern Trust Global Investments | ٢٣٬٨٤١ | ٧١٩ | ٣١/١٢/٢٠٢٢ |
٠٫١١ % | PDT Partners, LLC | ٢٣٬٥٨٧ | ٢٣٬٥٨٧ | ٣١/١٢/٢٠٢٢ |
٠٫١١ % | California State Teachers Retirement System | ٢٢٬٥٩٩ | ٦٤٥ | ٣١/١٢/٢٠٢٢ |
٠٫١١ % | Rhumbline Advisers Ltd. Partnership | ٢٢٬٤٥٢ | ١٬١٥٥ | ٣١/١٢/٢٠٢٢ |
٠٫٠٩ % | ARIAD Asset Management GmbH | ١٩٬٠٩٩ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٠٩ % | Schonfeld Strategic Advisors LLC | ١٨٬٣٩٣ | ١٨٬٣٩٣ | ٣١/١٢/٢٠٢٢ |
٠٫٠٨ % | Granite Investment Partners, LLC | ١٦٬١٦٢ | -٧٣٤ | ٣١/١/٢٠٢٣ |
٠٫٠٨ % | Apo Asset Management GmbH | ١٥٬٩٦٤ | 0 | ٣١/١/٢٠٢٣ |
٠٫٠٨ % | State of Wisconsin Investment Board | ١٥٬٨٠٢ | -١٬٠٨١ | ٣١/١٢/٢٠٢٢ |
٠٫٠٧ % | William Blair & Company, L.L.C. (Research) | ١٥٬٤٥٦ | ٧٥ | ٣١/١٢/٢٠٢٢ |
٠٫٠٧ % | State Street Global Advisors Ireland Limited | ١٤٬٥٩٤ | 0 | ٣١/١/٢٠٢٣ |
٠٫٠٧ % | Mellon Investments Corporation | ١٤٬١٩١ | ١٬٠٥٧ | ٣١/١٢/٢٠٢٢ |
٠٫٠٧ % | Alps Advisors, Inc. | ١٤٬٠٥٨ | ٣٬٣١٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٧ % | BlackRock Advisors (UK) Limited | ١٣٬٧٤٣ | ٢٩١ | ٢٨/٢/٢٠٢٣ |
٠٫٠٦ % | Cheyne Capital Management (UK) LLP | ١٣٬٣٦٤ | ١٣٬٣٦٤ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦ % | Ensign Peak Advisors, Inc. | ١٣٬٠٩٠ | ٦٬٤٥٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦ % | Fidelity Management & Research Company LLC | ١٣٬٠٤٩ | ١١٬٦٥٧ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦ % | Goldman Sachs Asset Management, L.P. | ١٢٬٧٠٦ | ١٢٬٧٠٦ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦ % | BofA Global Research (US) | ١٢٬٣٤٢ | ٦٬١٠٨ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦ % | New York State Common Retirement Fund | ١١٬٧٥١ | -١٣ | ٣١/١٢/٢٠٢٢ |
٠٫٠٦ % | Jump Financial, LLC | ١١٬٧٠٠ | ١١٬٧٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٥ % | Credit Suisse Asset Management | ١١٬٢٧٩ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٠٥ % | Dimensional Fund Advisors, Ltd. | ١١٬٢٥٦ | 0 | ٣١/١/٢٠٢٣ |
٠٫٠٥ % | BlackRock Asset Management Ireland Limited | ١١٬١٦٤ | ٥١٣ | ٣١/١٢/٢٠٢٢ |
٠٫٠٥ % | Two Sigma Investments, LP | ١١٬٠٠٠ | -٩٠٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٥ % | JPMorgan Private Bank (United States) | ١٠٬٦٣٧ | ١٬٢٣٢ | ٣١/١٢/٢٠٢٢ |
٠٫٠٥ % | Hopkinson (Craig C M.D.) | ١٠٬٤٩٥ | ١٠٬٤٩٥ | ١/١٢/٢٠٢٢ |
٠٫٠٥ % | MetLife Investment Management, LLC | ٩٬٨٦٤ | 0 | ٣١/١٢/٢٠٢٢ |
٠٫٠٥ % | Connor, Clark & Lunn Investment Management Ltd. | ٩٬٧٢٤ | -٣٣٧ | ٣١/١٢/٢٠٢٢ |
٠٫٠٤ % | Russell Investments Trust Company | ٩٬٢٨٩ | ٨٬٥١٣ | ٣١/١٢/٢٠٢٢ |
٠٫٠٤ % | Cubist Systematic Strategies, LLC | ٨٬٦٤٠ | ٤٬٩٣٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٤ % | SunAmerica Asset Management, LLC | ٨٬٦١٣ | ٤٤٢ | ٣١/١٢/٢٠٢٢ |
٠٫٠٤ % | DWS Investments UK Limited | ٧٬٨٤٨ | ٩٩٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٣ % | Legal & General Investment Management Ltd. | ٦٬٩٩٠ | ٤٣٤ | ٣١/١٢/٢٠٢٢ |
٠٫٠٣ % | E Fund Management Co. Ltd. | ٦٬٦٢٣ | ٤٬٤٩٨ | ٣٠/٦/٢٠٢٢ |
٠٫٠٣ % | UBS Financial Services, Inc. | ٦٬١٦٤ | ٥٬٣٩٩ | ٣١/١٢/٢٠٢٢ |
٠٫٠٣ % | Barclays Bank PLC | ٦٬١٦٣ | ٤٬١٦٠ | ٣١/١٢/٢٠٢٢ |
٠٫٠٣ % | Horn Patrick Taylor | ٦٬٠٨٦ | ٢٬٠٦٦ | ١/٤/٢٠٢٢ |
٠٫٠٣ % | Perinvest (UK) Ltd. | ٦٬٠٠٠ | 0 | ٣٠/٦/٢٠٢٢ |
٠٫٠٣ % | Zürcher Kantonalbank (Asset Management) | ٥٬٧١٣ | ٨١٣ | ٣١/١٢/٢٠٢٢ |