٦٫٢٤٦٢٤ % | Boxer Capital, L.L.C. | ٤٬٤٠٧٬٣٥٠ | ٢٬٩٦٧٬٣٥٠ | ٨/١/٢٠٢٤ |
٥٫٣٤٠١٩ % | Samsara BioCapital, LLC | ٣٬٧٦٨٬٠٣٥ | ٩٠٠٬٠٠٠ | ٢٩/٣/٢٠٢٤ |
٥٫٠٥٧٨٠ % | New Enterprise Associates (NEA) | ٣٬٥٦٨٬٧٨١ | 0 | ٢٧/٣/٢٠٢٤ |
٤٫٨٨٩٤٦ % | Adage Capital Management, L.P. | ٣٬٤٥٠٬٠٠٠ | -٢٥٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٤٫٨١٨٥٩ % | Deerfield Management Company, L.P. | ٣٬٤٠٠٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٣ |
٤٫٤٨٠٤٩ % | GSK plc | ٣٬١٦١٬٤٣٢ | ٣٬١٦١٬٤٣٢ | ٢٧/٣/٢٠٢٤ |
٤٫٠٢٠٠٤ % | EQT Life Sciences | ٢٬٨٣٦٬٥٣٩ | ٢٬٨٣٦٬٥٣٩ | ٨/٢/٢٠٢٤ |
٣٫٨٦٩٠٥ % | Commodore Capital LP | ٢٬٧٣٠٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٣ |
٣٫١٣٠٦٥ % | BlackRock Institutional Trust Company, N.A. | ٢٬٢٠٨٬٩٩٠ | -١٩٣٬٨٣٥ | ٣١/١٢/٢٠٢٣ |
٢٫٢١١٦٢ % | The Vanguard Group, Inc. | ١٬٥٦٠٬٥١٨ | ٦١٬٧٧٨ | ٣١/١٢/٢٠٢٣ |
١٫٨٨٩٦٤ % | SR One Capital Management, LP | ١٬٣٣٣٬٣٣٣ | 0 | ٣١/١٢/٢٠٢٣ |
١٫٦٥٦٠٣ % | Wasatch Global Investors Inc | ١٬١٦٨٬٤٩٢ | -٩٣١٬٢٠٧ | ٣١/٣/٢٠٢٤ |
١٥٫٣١٣٣٩ % | RA Capital Management, LP | ١٠٬٨٠٥٬١٢٩ | ٣٬٠٠٠٬٠٠٠ | ٢٧/٣/٢٠٢٤ |
٠٫٩٣٢٢٢ % | Renaissance Technologies LLC | ٦٥٧٬٧٧٢ | ١٤٥٬٢٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٩٢٦٥٠ % | Geode Capital Management, L.L.C. | ٦٥٣٬٧٤٠ | ٢١٬٠١٣ | ٣١/١٢/٢٠٢٣ |
٠٫٨٦٧١٣ % | State Street Global Advisors (US) | ٦١١٬٨٤٩ | ٤٬٥٤٥ | ٣١/١٢/٢٠٢٣ |
٠٫٧٧٩٤٨ % | Tang Capital Management, LLC | ٥٥٠٬٠٠٠ | -٥٥٣٬٦٣٨ | ٣١/١٢/٢٠٢٣ |
٠٫٦٥٥٩٥ % | T. Rowe Price Investment Management, Inc. | ٤٦٢٬٨٣٨ | ٣٢٬٤٨٨ | ٣١/١٢/٢٠٢٣ |
٠٫٦٣٨٧٩ % | Alyeska Investment Group, L.P. | ٤٥٠٬٧٣١ | -٥٤٩٬٢٦٩ | ٣١/١٢/٢٠٢٣ |
٠٫٥٩٢٤٤ % | Columbia Threadneedle Investments (UK) | ٤١٨٬٠٢٤ | ٤١٨٬٠٢٤ | ٢٩/٢/٢٠٢٤ |
٠٫٥٣٧٧٩ % | Bridgeway Capital Management, LLC | ٣٧٩٬٤٦٧ | -٢٢٥٬٧٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٤٩٢٣٢ % | Superstring Capital Management LP | ٣٤٧٬٣٨١ | ٣٤٧٬٣٨١ | ٣١/١٢/٢٠٢٣ |
٠٫٤٧٨٤٧ % | JPMorgan Asset Management U.K. Limited | ٣٣٧٬٦٠٧ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٤١٦١١ % | BlackRock Financial Management, Inc. | ٢٩٣٬٦٠٦ | -٢٠٬٧٥٩ | ٣١/١٢/٢٠٢٣ |
٠٫٣٩١٧٧ % | Northern Trust Investments, Inc. | ٢٧٦٬٤٣١ | -١٬٩٦٤ | ٣١/١٢/٢٠٢٣ |
٠٫٣٥٥٢٥ % | Marshall Wace LLP | ٢٥٠٬٦٦٧ | ٢٥٠٬٦٦٧ | ٣١/١٢/٢٠٢٣ |
٠٫٣٥٤٣١ % | Jefferies LLC | ٢٥٠٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٢٩٣٧٤ % | Stifel, Nicolaus & Company, Incorporated | ٢٠٧٬٢٦٤ | -٣١٩٬٣٦٢ | ٣١/١٢/٢٠٢٣ |
٠٫٢٧٤٣٨ % | Invesco Capital Management LLC | ١٩٣٬٦٠٢ | -٧١٬٧٦٧ | ٣١/١٢/٢٠٢٣ |
٠٫٢١٣٥٠ % | Two Sigma Investments, LP | ١٥٠٬٦٤٥ | ٧٢٬٥٤٥ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠٧٢٤ % | Jane Street Capital, L.L.C. | ١٤٦٬٢٣١ | ١٤٦٬٢٣١ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠٦٠٩ % | Trager (James) | ١٤٥٬٤١٥ | -٤٬١٤٣ | ١٢/٢/٢٠٢٤ |
٠٫١٩٦٩٤ % | Innovis Asset Management LLC | ١٣٨٬٩٦٢ | ١٣٨٬٩٦٢ | ٣٠/٩/٢٠٢٣ |
٠٫١٩٦٥٩ % | Fidelity Management & Research Company LLC | ١٣٨٬٧١٣ | ١٣٤٬٣٥٥ | ٣١/١٢/٢٠٢٣ |
٠٫١٧٣١١ % | BofA Global Research (US) | ١٢٢٬١٤٥ | ١٠٬٣٦٧ | ٣١/١٢/٢٠٢٣ |
٠٫١٧١٨٨ % | Hastings (Paul J) | ١٢١٬٢٨٠ | -١٥٠٬٠٠٠ | ٤/٣/٢٠٢٤ |
٠٫١٦٢٩٧ % | Parametric Portfolio Associates LLC | ١١٤٬٩٩١ | -٣٧٬٩٠٦ | ٣١/١٢/٢٠٢٣ |
٠٫١٥٧٢٨ % | Shook (David M.D.) | ١١٠٬٩٨٠ | ٥٢٬٤٤٨ | ١٦/١/٢٠٢٤ |
٠٫١٥٣٢٥ % | Medical Strategy GmbH | ١٠٨٬١٣٦ | 0 | ٣٠/٩/٢٠٢٣ |
٠٫١٥٠٠٤ % | Millennium Management LLC | ١٠٥٬٨٦٩ | ٩١٬٧٠٧ | ٣١/١٢/٢٠٢٣ |
٠٫١٤١٧٢ % | ACCI Capital Investments SGIIC, SA | ١٠٠٬٠٠٠ | -٢٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٣٨٤١ % | IndexIQ Advisors LLC | ٩٧٬٦٦٠ | -٢٬٦٣٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٣٥٥١ % | BlackRock Investment Management, LLC | ٩٥٬٦١٦ | -٧٨٨ | ٣١/١٢/٢٠٢٣ |
٠٫١٢٩٧٩ % | Morgan Stanley & Co. LLC | ٩١٬٥٨١ | ٣١٬٣٥١ | ٣١/١٢/٢٠٢٣ |
٠٫١٢٨٦٤ % | Nuveen LLC | ٩٠٬٧٦٧ | ٩٬٣٧٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٢٨٥٠ % | Acadian Asset Management LLC | ٩٠٬٦٦٩ | ٢٦٬١٢٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٢٠٣٢ % | Davis (Aaron I) | ٨٤٬٩٠٠ | ٨٤٬٩٠٠ | ٨/١/٢٠٢٤ |
٠٫١١٧٢٤ % | BNY Mellon Asset Management | ٨٢٬٧٢٨ | -١٬٠٩٣ | ٣١/١٢/٢٠٢٣ |
٠٫١١٤٩٩ % | Barclays Bank PLC | ٨١٬١٣٩ | ٣٥٬٩٩٧ | ٣١/١٢/٢٠٢٣ |
٠٫١١٣٣٤ % | Brandenberger (Ralph Erik) | ٧٩٬٩٧٢ | -١٬٦٠٤ | ١/٣/٢٠٢٤ |
٠٫٠٩٧٩٤ % | Charles Schwab Investment Management, Inc. | ٦٩٬١٠٩ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٠٩٤٧٠ % | AllianceBernstein L.P. | ٦٦٬٨٢٠ | -٤٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٩٦٨ % | PGIM Quantitative Solutions LLC | ٦٣٬٢٨٠ | -١٩٬٨٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٢٧٣ % | Goldman Sachs & Company, Inc. | ٥٨٬٣٧١ | ١٢٬٨٣٦ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٠٢٠ % | Dimensional Fund Advisors, L.P. | ٥٦٬٥٨٧ | ٣٢٬١٧٢ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧٩٣٧ % | Levin (Alyssa) | ٥٦٬٠٠٠ | ٥٦٬٠٠٠ | ٤/١/٢٠٢٤ |
٠٫٠٧٧٧٣ % | Leo Wealth, LLC | ٥٤٬٨٤٨ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٠٧٤٨٩ % | Hager (Alicia J) | ٥٢٬٨٤٢ | ٥١٬٤٤٦ | ١٦/١/٢٠٢٤ |
٠٫٠٦٩٩١ % | Rhumbline Advisers Ltd. Partnership | ٤٩٬٣٣٠ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٠٦٤٣٨ % | Connor, Clark & Lunn Investment Management Ltd. | ٤٥٬٤٢٦ | ٣٠٬٩٩٥ | ٣١/١٢/٢٠٢٣ |
٠٫٠٦٤٠٠ % | Avantis Investors | ٤٥٬١٥٥ | ١٨٬٨٢٤ | ٣١/٣/٢٠٢٤ |
٠٫٠٦٢٨١ % | Northern Trust Global Investments | ٤٤٬٣١٨ | ٨١ | ٣١/١٢/٢٠٢٣ |
٠٫٠٦١٠٢ % | Dimensional Fund Advisors, Ltd. | ٤٣٬٠٥٤ | ٢٬٧٦٣ | ٣١/١/٢٠٢٤ |
٠٫٠٥٥٩٨ % | T. Rowe Price Japan, Inc. | ٣٩٬٤٩٨ | ٣٩٬٤٩٨ | ٣١/٨/٢٠٢٣ |
٠٫٠٥١٩٣ % | Squarepoint Capital LLP | ٣٦٬٦٤٢ | ٣٦٬٦٤٢ | ٣١/١٢/٢٠٢٣ |
٠٫٠٤٨٥٩ % | UBS Financial Services, Inc. | ٣٤٬٢٨٤ | ١٩٬٩٧٨ | ٣١/١٢/٢٠٢٣ |
٠٫٠٤٦٠٢ % | Amundi Asset Management, SAS | ٣٢٬٤٦٩ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٠٤٣٤٨ % | Mahmood (Nadir Ahmeduddin) | ٣٠٬٦٧٦ | -٥٢٦ | ٢٠/٦/٢٠٢٣ |
٠٫٠٤١٥٩ % | American Century Investment Management, Inc. | ٢٩٬٣٤٨ | ٧٬٥٣١ | ٣١/١٢/٢٠٢٣ |
٠٫٠٤١٠٨ % | Tekla Capital Management LLC_NLE | ٢٨٬٩٨٨ | 0 | ٣٠/٦/٢٠٢٣ |
٠٫٠٤١٠٨ % | abrdn Inc. | ٢٨٬٩٨٨ | ٢٨٬٩٨٨ | ٣١/١٢/٢٠٢٣ |
٠٫٠٣٧٥٦ % | Denali Advisors, LLC | ٢٦٬٥٠٠ | ٢٦٬٥٠٠ | ٣١/٣/٢٠٢٤ |
٠٫٠٣٦٠٠ % | DWS Investments UK Limited | ٢٥٬٤٠١ | ٢٥٬٤٠١ | ٣١/١٢/٢٠٢٣ |
٠٫٠٣٣١٨ % | Susquehanna Portfolio Strategies, LLC | ٢٣٬٤١١ | ٢٣٬٤١١ | ٣١/١٢/٢٠٢٣ |
٠٫٠٣٢٩٤ % | Mellon Investments Corporation | ٢٣٬٢٤٤ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٠٣٢٦٢ % | State Street Global Advisors Ireland Limited | ٢٣٬٠١٥ | -٨٤ | ٣٠/٤/٢٠٢٣ |
٠٫٠٣١٨٩ % | T. Rowe Price International Ltd | ٢٢٬٥٠٢ | 0 | ٣١/١/٢٠٢٤ |
٠٫٠٣٠٠٥ % | Holistic Planning, L.L.C. | ٢١٬٢٠٠ | ٢١٬٢٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٢٩٤٧ % | Goldman Sachs Asset Management, L.P. | ٢٠٬٧٩٧ | -٥٬١٦٦ | ٣١/١٢/٢٠٢٣ |
٠٫٠٢٩٤٣ % | Forefront Analytics, LLC | ٢٠٬٧٦٧ | -١٨٬٨٩٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٢٨٣٤ % | Abaris Investment Management AG | ٢٠٬٠٠٠ | ٢٠٬٠٠٠ | ٣٠/٦/٢٠٢٣ |
٠٫٠٢٧٧٨ % | JPMorgan Private Bank (United States) | ١٩٬٥٩٩ | ١٩٬٥٩٩ | ٣١/١٢/٢٠٢٣ |
٠٫٠٢٦٧٠ % | HSBC Global Asset Management (UK) Limited | ١٨٬٨٣٧ | ٢٤ | ٣١/١٢/٢٠٢٣ |
٠٫٠٢٥٩١ % | Susquehanna International Group, LLP | ١٨٬٢٨٥ | -٢٣٦٬٨٣٨ | ٣١/١٢/٢٠٢٣ |
٠٫٠٢٥٣٤ % | Simplex Trading, LLC | ١٧٬٨٧٧ | ٦٬٦٠٢ | ٣١/١٢/٢٠٢٣ |
٠٫٠٢٢٨٤ % | Bailard, Inc. | ١٦٬١١٣ | -١٨٬٣٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٢٢٣٨ % | Principal Global Investors (Equity) | ١٥٬٧٩٣ | ١٬٢٨٨ | ٣١/١٢/٢٠٢٣ |
٠٫٠٢١٣٠ % | SunAmerica Asset Management, LLC | ١٥٬٠٣٠ | -٦١ | ٣١/١٢/٢٠٢٣ |
٠٫٠٢٠١٦ % | Vanguard Personalized Indexing Management, LLC | ١٤٬٢٢٦ | ٢٬٦١٣ | ٣١/١٢/٢٠٢٣ |
٠٫٠١٩١٠ % | Mariner Wealth Advisors | ١٣٬٤٧٤ | -١٧٬٤٧٤ | ٣١/١٢/٢٠٢٣ |
٠٫٠١٦٧٢ % | Sierra Summit Advisors LLC | ١١٬٨٠١ | ١١٬٨٠١ | ٣١/١٢/٢٠٢٣ |
٠٫٠١٦٧١ % | Vaughan Nelson Investment Management, L.P. | ١١٬٧٨٩ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٠١٥٣٩ % | SG Americas Securities, L.L.C. | ١٠٬٨٥٧ | ١٠٬٨٥٧ | ٣١/١٢/٢٠٢٣ |
٠٫٠١٥٣١ % | Wellington Management Company, LLP | ١٠٬٨٠٦ | -٦٥ | ٢٩/٢/٢٠٢٤ |
٠٫٠١٥٠٣ % | Sawtooth Asset Management, Inc. | ١٠٬٦٠٨ | ١٠٬٦٠٨ | ٣١/١٢/٢٠٢٣ |
٠٫٠١٥٠٣ % | Bleakley Financial Group LLC | ١٠٬٦٠٨ | ١٠٬٦٠٨ | ٣١/١٢/٢٠٢٣ |
٠٫٠١٤٥٦ % | Columbia Threadneedle Investments (US) | ١٠٬٢٧٦ | -١٢٧ | ٣١/١٢/٢٠٢٣ |
٠٫٠١٣٢٠ % | Wells Fargo Bank, N.A. | ٩٬٣١٤ | ١٬٨٤٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠١١٥٥ % | Invesco Advisers, Inc. | ٨٬١٥٠ | ٨٬١٥٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠١١٠٣ % | Morgan Stanley Smith Barney LLC | ٧٬٧٨٦ | ١٬٧٠١ | ٣١/١٢/٢٠٢٣ |