٨٫١٩ % | EcoR1 Capital, LLC | ٥٬٧٤٨٬٣٩٩ | ٥٬٧٤٨٬٣٩٩ | ٢٢/٩/٢٠٢٣ |
٧٫٩٢ % | Avoro Capital Advisors LLC | ٥٬٥٥٥٬٥٥٥ | 0 | ٣٠/٦/٢٠٢٣ |
٧٫٠٨ % | The Vanguard Group, Inc. | ٤٬٩٦٩٬٨٠٦ | -٧٢٬٢٩٥ | ٣٠/٦/٢٠٢٣ |
٦٫٣٨ % | RTW Investments L.P. | ٤٬٤٧٢٬٩٨٥ | ٨٢٩٬٨٧١ | ٣٠/٦/٢٠٢٣ |
٥٫٦٧ % | Armistice Capital LLC | ٣٬٩٧٨٬٠٠٠ | ٢٨٦٬٠٠٠ | ٣٠/٦/٢٠٢٣ |
٤٫٨٣ % | Wellington Management Company, LLP | ٣٬٣٨٨٬٣٦٥ | ٦٩٢٬٢٧٣ | ٣٠/٦/٢٠٢٣ |
٤٫٥٦ % | Boxer Capital, L.L.C. | ٣٬٢٠١٬٤٤٠ | 0 | ٨/١٠/٢٠٢٣ |
٤٫٤٧ % | Aviva Holdings Ltd. | ٣٬١٣٥٬٩٦٦ | 0 | ٨/١٠/٢٠٢٣ |
٣٫٩٧ % | Morgan Stanley & Co. LLC | ٢٬٧٨٣٬٨٦٩ | ١٬٠٢٣٬٠٥٨ | ٣٠/٦/٢٠٢٣ |
٣٫٦٨ % | State Street Global Advisors (US) | ٢٬٥٨١٬٧٣٩ | ٢٧١٬٩١٩ | ٣٠/٦/٢٠٢٣ |
٣٫٠٣ % | BlackRock Institutional Trust Company, N.A. | ٢٬١٢٧٬٥٨٩ | -٢٬٥٠١ | ٣٠/٦/٢٠٢٣ |
٢٫٩٣ % | Invus Public Equities Advisors, LLC | ٢٬٠٥٥٬١٨١ | ٥١٧٬٤٧٢ | ٣٠/٦/٢٠٢٣ |
٢٫٥٧ % | Camber Capital Management LP | ١٬٨٠٠٬٠٠٠ | ٤٠٠٬٠٠٠ | ٣٠/٦/٢٠٢٣ |
٢٫٥٠ % | T. Rowe Price Associates, Inc. | ١٬٧٥٢٬٠٣٣ | ٦٬٠١٦ | ٣٠/٦/٢٠٢٣ |
٢٫٠٦ % | Paradigm BioCapital Advisors LP | ١٬٤٤٣٬٧٦٢ | ٤٦٬٩٨٣ | ٣٠/٦/٢٠٢٣ |
٢٫٠١ % | Baker Bros. Advisors LP | ١٬٤٠٩٬٧٨٤ | 0 | ٣٠/٦/٢٠٢٣ |
١٫٦٠ % | Rock Springs Capital Management LP | ١٬١٢١٬٦٤٧ | ٥٦٬٣٨٦ | ٣٠/٦/٢٠٢٣ |
١٫٣٠ % | OrbiMed Advisors, LLC | ٩١٣٬٦٥٠ | 0 | ٣٠/٦/٢٠٢٣ |
١٫٢٧ % | Candriam Luxembourg S.A. | ٨٩٣٬٧٣٨ | ٢٠٬٠٠٠ | ٣١/٨/٢٠٢٣ |
١٫٢٥ % | Candriam Belgium S.A. | ٨٧٣٬٧٦٣ | ١٠٩٬٤٩٨ | ٣٠/٦/٢٠٢٣ |
١٫١٥ % | Assenagon Asset Management S.A. | ٨٠٨٬٨٢٠ | ٥٥٢٬٨٦٠ | ٣٠/٦/٢٠٢٣ |
١٫٠٩ % | Geode Capital Management, L.L.C. | ٧٦٤٬٤٨٣ | ٢٩٬١٩٥ | ٣٠/٦/٢٠٢٣ |
١٫٠٧ % | Octagon Capital Advisors LP | ٧٥٠٬٠٠٠ | 0 | ٣٠/٦/٢٠٢٣ |
١٫٠٣ % | Perceptive Advisors LLC | ٧١٩٬١٠٣ | -٨٥٥٬٠٣١ | ٣٠/٦/٢٠٢٣ |
٠٫٩٩ % | Fiera Capital Corporation | ٦٩٢٬٠٣٣ | -١٧٬٤٩٤ | ٣٠/٦/٢٠٢٣ |
٠٫٩٢ % | Franklin Advisers, Inc. | ٦٤٦٬٨٣٧ | -٥ | ٣٠/٦/٢٠٢٣ |
٠٫٨٦ % | Eventide Asset Management, LLC | ٦٠٠٬٠٠٠ | ٢٢٨٬٨٩٨ | ٣٠/٦/٢٠٢٣ |
٠٫٨٥ % | BlackRock Financial Management, Inc. | ٥٩٣٬٠٨٧ | ٦٠٬٩٩٧ | ٣٠/٦/٢٠٢٣ |
٠٫٨٣ % | Marshall Wace LLP | ٥٨٤٬٣٢٣ | ٣١٬٧٠٩ | ٣٠/٦/٢٠٢٣ |
٠٫٧٦ % | Credit Suisse Funds AG | ٥٢٩٬٦٩٠ | ٦٬٣٣٥ | ٣٠/٦/٢٠٢٣ |
٠٫٧٢ % | Millennium Management LLC | ٥٠٥٬٣٠٩ | ٤٨٦٬٢٧٥ | ٣٠/٦/٢٠٢٣ |
٠٫٦٩ % | Citadel Advisors LLC | ٤٨١٬٨١٨ | ٣٩١٬١٧٤ | ٣٠/٦/٢٠٢٣ |
٠٫٦٨ % | Norges Bank Investment Management (NBIM) | ٤٧٥٬٩٩٢ | ٦٢٬٠٠٣ | ٣١/١٢/٢٠٢٢ |
٠٫٦٧ % | Dimensional Fund Advisors, L.P. | ٤٧٢٬٤٦٨ | ١٦٧٬٨٧٤ | ٣٠/٦/٢٠٢٣ |
٠٫٦٢ % | Charles Schwab Investment Management, Inc. | ٤٣٦٬٠٤٨ | ٥٬٥٥٤ | ٣٠/٦/٢٠٢٣ |
٠٫٥٨ % | Voloridge Investment Management, LLC | ٤٠٦٬٠٣٥ | -٢٧٢٬٦٢٣ | ٣٠/٦/٢٠٢٣ |
٠٫٥٣ % | Woodline Partners LP | ٣٧٣٬٣٣٢ | ١٠٧٬٢٣٢ | ٣٠/٦/٢٠٢٣ |
٠٫٤١ % | MVA Investors LLC | ٢٨٧٬٨٦٦ | 0 | ٨/١٠/٢٠٢٣ |
٠٫٣٧ % | D. E. Shaw & Co., L.P. | ٢٦٢٬٩٣٨ | ١٧٬٣٥٢ | ٣٠/٦/٢٠٢٣ |
٠٫٣٧ % | International Biotechnology Trust PLC | ٢٦٠٬٠٠٠ | ١٦٬٠٠٠ | ٣٠/٦/٢٠٢٣ |
٠٫٣٧ % | UBS Asset Management (Switzerland) | ٢٥٧٬٠٠١ | ٦٣٬٢٦٥ | ٣١/٣/٢٠٢٣ |
٠٫٣٦ % | BlackRock Investment Management (UK) Ltd. | ٢٥٤٬٠٣٢ | -٦٬٧٤٨ | ٣٠/٦/٢٠٢٣ |
٠٫٣٥ % | BlackRock Asset Management Ireland Limited | ٢٤٢٬٧١٥ | ٦٬٢٩٤ | ٣٠/٦/٢٠٢٣ |
٠٫٣٤ % | Braidwell LP | ٢٤٠٬٦٢٥ | -٢١١٬٣٧٥ | ٣٠/٦/٢٠٢٣ |
٠٫٣٣ % | New York State Common Retirement Fund | ٢٣٢٬٨٦٠ | ٦٤٣ | ٣٠/٦/٢٠٢٣ |
٠٫٣٣ % | Nuveen LLC | ٢٣١٬٨٨٥ | -٢٨٬٥٢٤ | ٣٠/٦/٢٠٢٣ |
٠٫٣٣ % | Jane Street Capital, L.L.C. | ٢٢٩٬٨٨٣ | ٨٠٬٧٥٥ | ٣٠/٦/٢٠٢٣ |
٠٫٣٢ % | Susquehanna International Group, LLP | ٢٢٥٬١٠١ | -١٣٧٬٥١١ | ٣٠/٦/٢٠٢٣ |
٠٫٣٢ % | Allspring Global Investments, LLC | ٢٢٢٬٧٣٧ | -١٠٬٣٠٢ | ٣٠/٦/٢٠٢٣ |
٠٫٣٢ % | Jacobs Levy Equity Management, Inc. | ٢٢١٬٧٦٣ | ١٣٬٠٠٠ | ٣٠/٦/٢٠٢٣ |
٠٫٣١ % | Rafferty Asset Management LLC | ٢١٨٬٦٣٩ | ٤٥٬١٢٣ | ٣٠/٦/٢٠٢٣ |
٠٫٢٩ % | Dissanayake (Shehan Bharath) | ٢٠٣٬٧٥٤ | 0 | ٨/١٠/٢٠٢٣ |
٠٫٢٩ % | Ghost Tree Capital, LLC | ٢٠٠٬٠٠٠ | ٦٠٬٠٠٠ | ٣٠/٦/٢٠٢٣ |
٠٫٢٩ % | DWS Investment GmbH | ٢٠٠٬٠٠٠ | -١٥٬٦٥٤ | ٣٠/٦/٢٠٢٣ |
٠٫٢٨ % | BofA Global Research (US) | ١٩٧٬٢٦٧ | -٥٩٬٥٥٣ | ٣٠/٦/٢٠٢٣ |
٠٫٢٧ % | 5AM Ventures | ١٩٢٬٥٠٠ | ١٩٢٬٥٠٠ | ٣٠/٦/٢٠٢٣ |
٠٫٢٦ % | Edmond de Rothschild Asset Management (France) S.A. | ١٨٤٬٠٦٠ | 0 | ٣٠/٦/٢٠٢٣ |
٠٫٢٥ % | Northern Trust Investments, Inc. | ١٧٨٬٢٥٩ | ٣٬٠٥٢ | ٣٠/٦/٢٠٢٣ |
٠٫٢٢ % | Oracle Investment Management, Inc. | ١٥٢٬٦٠٠ | -٤٨٬٨٠٠ | ٣٠/٦/٢٠٢٣ |
٠٫٢١ % | Sectoral Asset Management Inc. | ١٤٨٬٥٥٣ | ٢٠٬١٤٧ | ٣٠/٦/٢٠٢٣ |
٠٫٢١ % | Baum (Charles M) | ١٤٨٬٢٦٨ | ٥٤٬٠٥٤ | ٩/٨/٢٠٢٣ |
٠٫٢١ % | Granahan Investment Management, Inc. | ١٤٥٬٢٨٧ | ١٦٬١٩٧ | ٣٠/٦/٢٠٢٣ |
٠٫٢٠ % | Jefferies LLC | ١٤٢٬٩٦٩ | ٩٢٬٥٤٩ | ٣٠/٦/٢٠٢٣ |
٠٫٢٠ % | Rhenman & Partners Asset Management AB | ١٤٠٬٠٠٠ | -٧٥٬٠٠٠ | ٣٠/٦/٢٠٢٣ |
٠٫٢٠ % | AllianceBernstein L.P. | ١٣٩٬٥٠١ | ٦٧٬٨٥٨ | ٣٠/٦/٢٠٢٣ |
٠٫١٩ % | Managed Account Advisors LLC | ١٣٠٬٤٨٩ | ١٬٠٥٩ | ٣٠/٦/٢٠٢٣ |
٠٫١٨ % | Schonfeld Strategic Advisors LLC | ١٢٩٬٦٣٦ | ١٠٦٬٨٣٧ | ٣٠/٦/٢٠٢٣ |
٠٫١٨ % | UBS Financial Services, Inc. | ١٢٤٬٧٦٨ | ٤٣٬٣٣٦ | ٣٠/٦/٢٠٢٣ |
٠٫١٨ % | Fidelity Management & Research Company LLC | ١٢٣٬٧٨٣ | -٥٤٬٣٠٠ | ٣٠/٦/٢٠٢٣ |
٠٫١٧ % | Connor, Clark & Lunn Investment Management Ltd. | ١١٧٬١٥١ | -١٩٬٣٣٥ | ٣٠/٦/٢٠٢٣ |
٠٫١٦ % | Numeric Investors LLC | ١٠٩٬٤٩١ | ٨٩٬٦٨١ | ٣٠/٦/٢٠٢٣ |
٠٫١٥ % | Barclays Bank PLC | ١٠٣٬٢٠٦ | -٢٢٬١٧٣ | ٣٠/٦/٢٠٢٣ |
٠٫١٥ % | Stelzer (Laurie D) | ١٠٢٬٣١٢ | ٢٢٬٢٩٧ | ٩/٨/٢٠٢٣ |
٠٫١٤ % | ExodusPoint Capital Management, LP | ٩٨٬٧٣٨ | -٦٥٬٠٠٤ | ٣٠/٦/٢٠٢٣ |
٠٫١٤ % | Polar Asset Management Partners Inc. | ٩٨٬٥٠٠ | ٩٨٬٥٠٠ | ٣٠/٦/٢٠٢٣ |
٠٫١٣ % | Dafna Capital Management, LLC | ٩٤٬٧٠٠ | ٢١٬١٠٠ | ٣٠/٦/٢٠٢٣ |
٠٫١٣ % | SilverArc Capital Management, LLC | ٩١٬٢١٣ | ٩١٬٢١٣ | ٣٠/٦/٢٠٢٣ |
٠٫١٣ % | BNY Mellon Asset Management | ٩٠٬٠٧١ | ٧٬٦١١ | ٣٠/٦/٢٠٢٣ |
٠٫١٣ % | Schweizerische Nationalbank | ٨٨٬٦٠٠ | ١٬٦٠٠ | ٣٠/٦/٢٠٢٣ |
٠٫١٢ % | Mellon Investments Corporation | ٨٤٬٠٢٨ | -٢٬٢٥٦ | ٣٠/٦/٢٠٢٣ |
٠٫١١ % | Tang Capital Management, LLC | ٨٠٬٠٠٠ | ٨٠٬٠٠٠ | ٣٠/٦/٢٠٢٣ |
٠٫١٠ % | Algert Global LLC | ٧٣٬٥١٦ | ١٠٬٢٩٢ | ٣٠/٦/٢٠٢٣ |
٠٫١٠ % | HRT Financial LP | ٧٣٬٢٧٦ | -٨٬٠٣٠ | ٣٠/٦/٢٠٢٣ |
٠٫١٠ % | TD Asset Management Inc. | ٧٢٬١٠٥ | ٤٬٧٠٠ | ٣٠/٦/٢٠٢٣ |
٠٫١٠ % | Christensen (James G) | ٧١٬٦٨٥ | -٢٬٣٨٨ | ٨/٩/٢٠٢٣ |
٠٫١٠ % | Moriarty (John B) | ٧١٬٦٦٠ | ٢٢٬٢٩٧ | ٩/٨/٢٠٢٣ |
٠٫١٠ % | Wells Fargo Advisors | ٧٠٬٦٤٢ | -١٬٨٨٨ | ٣٠/٦/٢٠٢٣ |
٠٫١٠ % | California Public Employees' Retirement System | ٦٩٬٤٥٤ | 0 | ٣٠/٦/٢٠٢٣ |
٠٫١٠ % | Citi Investment Research (US) | ٦٧٬٧٠٤ | -٩١٬٢٨٩ | ٣٠/٦/٢٠٢٣ |
٠٫٠٩ % | Tekla Capital Management LLC | ٦٥٬٤٩٠ | 0 | ٣٠/٦/٢٠٢٣ |
٠٫٠٩ % | Florida State Board of Administration | ٦٢٬٥٠٦ | -١٬٣٦٦ | ٣٠/٦/٢٠٢٣ |
٠٫٠٩ % | Lombard Odier Asset Management (Europe) Ltd | ٦٢٬٣٣٤ | -٩٬٠٥٦ | ٣١/١٠/٢٠٢٢ |
٠٫٠٩ % | Sandler (Alan B.) | ٦٢٬٢٩٧ | ٢٢٬٢٩٧ | ٩/٨/٢٠٢٣ |
٠٫٠٩ % | Macquarie Investment Management | ٦٠٬٠٠٠ | 0 | ٣٠/٦/٢٠٢٣ |
٠٫٠٩ % | UBS O'Connor LLC | ٥٩٬٦٩٨ | ١٢٬٤٤٨ | ٣٠/٦/٢٠٢٣ |
٠٫٠٨ % | Clearline Capital LP | ٥٦٬٣٤١ | ٥٦٬٣٤١ | ٣٠/٦/٢٠٢٣ |
٠٫٠٨ % | Manulife Investment Management (North America) Limited | ٥٥٬١٤٨ | ٣٬٧٦٩ | ٣٠/٦/٢٠٢٣ |
٠٫٠٨ % | Fidelity International | ٥٣٬٤٣٤ | ٥٣٬٤٣٤ | ٣٠/٦/٢٠٢٣ |
٠٫٠٨ % | Aperio Group, LLC | ٥٣٬٤١٤ | ٢٢٬١٥٧ | ٣٠/٦/٢٠٢٣ |
٠٫٠٧ % | Wellington International Management Company Pte. Ltd. | ٥٢٬٠٥٠ | ١٣٬٩٨٦ | ٣١/١٢/٢٠٢٢ |