٩٫٨٣ % | EcoR1 Capital, LLC | ٦٬٧٢٦٬٤٩١ | ١٬٢٥٩٬٤٢٨ | ٣١/١٢/٢٠٢٣ |
٧٫٠٨ % | The Vanguard Group, Inc. | ٤٬٨٤٢٬١٧٤ | ٢٤٣٬١٦٧ | ٣١/١٢/٢٠٢٣ |
٦٫١٦ % | RTW Investments L.P. | ٤٬٢١٣٬٤٨٣ | ٤٬٢١٣٬٤٨٣ | ٣١/١٢/٢٠٢٣ |
٦٫٠٩ % | BlackRock Institutional Trust Company, N.A. | ٤٬١٦٨٬٠٨٥ | ٣٥٧٬٢٤٤ | ٣١/١٢/٢٠٢٣ |
٥٫٤٥ % | T. Rowe Price Associates, Inc. | ٣٬٧٢٨٬٨٧٣ | ١٬١٣٢٬٨٩٨ | ٣١/١٢/٢٠٢٣ |
٤٫٣٦ % | Avidity Partners Management LP | ٢٬٩٨٥٬١١٧ | ٣٧٠٬١٥٧ | ٣١/١٢/٢٠٢٣ |
٣٫٦٦ % | Bellevue Asset Management AG | ٢٬٥٠٧٬٧٣١ | ٣٨٢٬٥٣١ | ٣١/١٢/٢٠٢٣ |
٣٫٥٧ % | Citadel Advisors LLC | ٢٬٤٣٩٬٩٨١ | ١٬٨١٥٬٤٠٣ | ٣١/١٢/٢٠٢٣ |
٢٫٤٨ % | Nextech Invest, Ltd. | ١٬٦٩٥٬٦٤٥ | ١٬٤٠٨٬٣٩٤ | ٣١/١٢/٢٠٢٣ |
٢٫٢٩ % | ArrowMark Colorado Holdings, LLC | ١٬٥٦٩٬٨٩٥ | -٥١٧٬٣٩٧ | ٣١/١٢/٢٠٢٣ |
١٫٨٨ % | New Leaf Venture Partners LLC | ١٬٢٨٩٬٥٢١ | 0 | ٣١/١٢/٢٠٢٣ |
١٫٧٤ % | Fidelity Institutional Asset Management | ١٬١٨٩٬٠١١ | -٣٧٤٬١٦٤ | ٣١/١٢/٢٠٢٣ |
١٫٧٣ % | State Street Global Advisors (US) | ١٬١٨٦٬٤٧٤ | ٢٧٬٠٢٢ | ٣١/١٢/٢٠٢٣ |
١٫٦٤ % | Geode Capital Management, L.L.C. | ١٬١٢٢٬٦٢٧ | ٦٥٬٢٣٧ | ٣١/١٢/٢٠٢٣ |
١٫٥٧ % | JP Morgan Asset Management | ١٬٠٧٣٬٨٥٤ | -١٣٨٬٠٧٧ | ٣١/١٢/٢٠٢٣ |
١٫٥٤ % | Fidelity Management & Research Company LLC | ١٬٠٥٥٬٠٠٨ | -٢٬٢٥٠٬١١٢ | ٣١/١٢/٢٠٢٣ |
١٫٥٤ % | Houston (John G) | ١٬٠٥٤٬١٩١ | ١١٩٬٢٥٤ | ٢٣/٢/٢٠٢٤ |
١٫٤٩ % | JPMorgan Asset Management U.K. Limited | ١٬٠١٧٬٤٦٣ | ٣٠٧٬١٩٢ | ٣١/١٢/٢٠٢٣ |
١٫٤٦ % | Commodore Capital LP | ١٬٠٠٠٬٠٠٠ | ١٬٠٠٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
١٫٣٦ % | Paradigm BioCapital Advisors LP | ٩٣١٬٣٠٣ | ٩٣١٬٣٠٣ | ٣١/١٢/٢٠٢٣ |
١٫٢٨ % | Norges Bank Investment Management (NBIM) | ٨٧٧٬٧٠٨ | ١٧٥٬٩٥٣ | ٣١/١٢/٢٠٢٣ |
١٫١٥ % | Adage Capital Management, L.P. | ٧٨٩٬٤٨٥ | ٧٨٩٬٤٨٥ | ٣١/١٢/٢٠٢٣ |
١٫٠٩ % | Holocene Advisors, LP | ٧٤٤٬٤٦٥ | ٧٤٤٬٤٦٥ | ٣١/١٢/٢٠٢٣ |
١٫٠٩ % | BlackRock Financial Management, Inc. | ٧٤٣٬٧٢٨ | -٦٬٦٧٦ | ٣١/١٢/٢٠٢٣ |
٠٫٩٢ % | VR Adviser, LLC | ٦٢٧٬٧٨٨ | ٦٢٧٬٧٨٨ | ٣١/١٢/٢٠٢٣ |
٠٫٨٩ % | Boxer Capital, L.L.C. | ٦٠٨٬٦١٤ | ٦٠٨٬٦١٤ | ٣١/١٢/٢٠٢٣ |
٠٫٨٣ % | Morgan Stanley & Co. LLC | ٥٦٦٬٠٠٣ | ٢٤٥٬٤٦٠ | ٣١/١٢/٢٠٢٣ |
٠٫٧٤ % | Finepoint Capital LP | ٥٠٤٬٧٠٠ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٧٢ % | Dimensional Fund Advisors, L.P. | ٤٩١٬٨٧٧ | ٢٢٬٤٧٩ | ٣١/١٢/٢٠٢٣ |
٠٫٧١ % | Aquilo Capital Management, LLC | ٤٨٩٬١٥٣ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٧١ % | Candriam Belgium S.A. | ٤٨٧٬٥٥٥ | ٤٠٬٠٠٤ | ٣١/١٢/٢٠٢٣ |
٠٫٦٩ % | Charles Schwab Investment Management, Inc. | ٤٦٩٬٤٧٤ | ٣٩٬٤٨٤ | ٣١/١٢/٢٠٢٣ |
٠٫٦٨ % | Candriam Luxembourg S.A. | ٤٦٢٬٥٣٦ | -٢٥٬٠٠٠ | ٢٩/٢/٢٠٢٤ |
٠٫٦٥ % | Northern Trust Investments, Inc. | ٤٤٢٬٥١٢ | ٢٤٬٧٩٤ | ٣١/١٢/٢٠٢٣ |
٠٫٦٢ % | RA Capital Management, LP | ٤٢١٬٣٤٨ | ٤٢١٬٣٤٨ | ٣١/١٢/٢٠٢٣ |
٠٫٥٨ % | American Century Investment Management, Inc. | ٣٩٥٬٣٦٧ | -٤١٨٬١٠٢ | ٣١/١٢/٢٠٢٣ |
٠٫٥٧ % | Woodline Partners LP | ٣٨٧٬٦٣٠ | ٢١٥٬٠٣٠ | ٣١/١٢/٢٠٢٣ |
٠٫٥٢ % | Millennium Management LLC | ٣٥٨٬٨١٣ | -٤٦٩٬٣١٤ | ٣١/١٢/٢٠٢٣ |
٠٫٥٢ % | Nuveen LLC | ٣٥٤٬٨٩٨ | ١٧٬٧٣٨ | ٣١/١٢/٢٠٢٣ |
٠٫٥٢ % | Perceptive Advisors LLC | ٣٥٤٬٠٨٢ | ٣٥٤٬٠٨٢ | ٣١/١٢/٢٠٢٣ |
٠٫٤٩ % | Gilder Gagnon Howe & Co. LLC | ٣٣٣٬٥٢٤ | ١٦٢٬٦٧٤ | ٣١/١٢/٢٠٢٣ |
٠٫٤٥ % | Voloridge Investment Management, LLC | ٣٠٩٬٦٦٣ | ٣٠٩٬٦٦٣ | ٣١/١٢/٢٠٢٣ |
٠٫٤٢ % | Frazier Healthcare Partners | ٢٨٥٬٣٣١ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٤١ % | Nordea Funds Oy | ٢٧٨٬٧٣٧ | -٦٬٣١٧ | ٣١/١٢/٢٠٢٣ |
٠٫٣٩ % | Brown Advisory | ٢٦٥٬٤٣١ | -١٧٠٬١٦٣ | ٣١/١٢/٢٠٢٣ |
٠٫٣٩ % | Opaleye Management Inc. | ٢٦٣٬٧٠٠ | ٢٦٣٬٧٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٣٨ % | UBS Financial Services, Inc. | ٢٥٦٬٩٨٦ | -٦٢٬٧٥٢ | ٣١/١٢/٢٠٢٣ |
٠٫٣٦ % | Schonfeld Strategic Advisors LLC | ٢٤٥٬٨٦٨ | ١٨١٬٨٧٤ | ٣١/١٢/٢٠٢٣ |
٠٫٣٥ % | Renaissance Technologies LLC | ٢٣٧٬٥٧٣ | ١٢٣٬٨٧٣ | ٣١/١٢/٢٠٢٣ |
٠٫٣٤ % | Great Point Partners, LLC | ٢٣٤٬٠٨٢ | ٢٣٤٬٠٨٢ | ٣١/١٢/٢٠٢٣ |
٠٫٣٢ % | Goldman Sachs & Company, Inc. | ٢١٥٬٧٢٨ | ١١٥٬٢١٩ | ٣١/١٢/٢٠٢٣ |
٠٫٣١ % | BlackRock Advisors (UK) Limited | ٢٠٨٬٩١٩ | ١٠٬٢٤٢ | ٣١/٣/٢٠٢٤ |
٠٫٣٠ % | Wasatch Global Investors Inc | ٢٠٧٬٤٢٦ | -١٥٬٥١٦ | ٣١/٣/٢٠٢٤ |
٠٫٢٩ % | BNP Paribas Securities Corp. North America | ١٩٧٬٠٥٢ | ٩٧٬٦٦١ | ٣١/١٢/٢٠٢٣ |
٠٫٢٩ % | Amundi Asset Management US, Inc. | ١٩٥٬٧٢٠ | ٤٬٤٢٣ | ٣١/١٢/٢٠٢٣ |
٠٫٢٧ % | Cassidy (Sean A) | ١٨٦٬٧٠٧ | -١٬٧٠٢ | ٢٣/٢/٢٠٢٤ |
٠٫٢٦ % | Integral Health Asset Management, LLC | ١٧٥٬٠٠٠ | ١٧٥٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٢٦ % | BlackRock Asset Management Ireland Limited | ١٧٤٬٧٢٨ | ٩٧٤ | ٣١/١٢/٢٠٢٣ |
٠٫٢٤ % | Parkman Healthcare Partners LLC | ١٦٧٬٠٠١ | ٦٢٬٨٨٤ | ٣١/١٢/٢٠٢٣ |
٠٫٢٣ % | UBS Asset Management (Americas), Inc. | ١٥٥٬١٢٩ | ٤٥٬٩٣٢ | ٣١/١٢/٢٠٢٣ |
٠٫٢٣ % | BofA Global Research (US) | ١٥٥٬٠٣٦ | ٤٧٬٤٩٢ | ٣١/١٢/٢٠٢٣ |
٠٫٢٢ % | Invesco Capital Management LLC | ١٥٠٬٥١٦ | ١٢٩٬٣١٢ | ٣١/١٢/٢٠٢٣ |
٠٫٢٢ % | Taylor (Ian) | ١٥٠٬٢٠٧ | ٣٧٬٥٤٩ | ٢٣/٢/٢٠٢٤ |
٠٫٢٢ % | Wanjia Asset Management Co., Ltd. | ١٥٠٬٠٠٠ | 0 | ٣٠/٦/٢٠٢٣ |
٠٫٢٢ % | BlackRock Investment Management, LLC | ١٤٩٬١١٦ | ٢٦٬٦٩٤ | ٣١/١٢/٢٠٢٣ |
٠٫٢١ % | TD Asset Management Inc. | ١٤٦٬٩٤٨ | ٥٢٬٠٧٦ | ٣١/١٢/٢٠٢٣ |
٠٫٢١ % | Yale University | ١٤٣٬٥٢٢ | ١٤٣٬٥٢٢ | ٣١/١٢/٢٠٢٣ |
٠٫٢١ % | Credit Suisse Funds AG | ١٤٢٬١٠٨ | ٨٦٬٨٤٥ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠ % | Citi Investment Research (US) | ١٣٨٬٦٥٦ | ١٣٣٬٩٦٦ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠ % | Federated MDTA LLC | ١٣٨٬٠٢٨ | ٣٣٬٧٧٠ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠ % | BNY Mellon Asset Management | ١٣٦٬٠٨٥ | -٢٬٥٥٦ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠ % | Rhenman & Partners Asset Management AB | ١٣٤٬٢٧٠ | ٤٩٬٢٧٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٩ % | Nordea Investment Management AB (Denmark) | ١٣١٬٤٩٤ | ٥٥ | ٢٩/٢/٢٠٢٤ |
٠٫١٧ % | First Trust Advisors L.P. | ١١٤٬١٠٥ | ١٬٥٦٩ | ٢٩/٢/٢٠٢٤ |
٠٫١٧ % | Goldman Sachs Asset Management, L.P. | ١١٣٬٧٣١ | ١٩٬٥٩٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٥ % | T. Rowe Price International Ltd | ١٠٣٬٢٥٠ | ١٠٬٥٥٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٥ % | Putnam Investment Management, L.L.C. | ١٠٣٬١١٨ | ٨٧٬٦٧١ | ٣١/١٢/٢٠٢٣ |
٠٫١٥ % | Parametric Portfolio Associates LLC | ١٠١٬٨٢٦ | ٣٦٬١٨٩ | ٣١/١٢/٢٠٢٣ |
٠٫١٤ % | Jane Street Capital, L.L.C. | ٩٧٬٢١٧ | ٤٦٬٨٩٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٤ % | Banque Pictet & Cie S.A. | ٩٢٬٩٣٣ | ٩٢٬٩٣٣ | ٣١/١٢/٢٠٢٣ |
٠٫١٣ % | UBS O'Connor LLC | ٩١٬١٣٢ | -١٩٬٠٥٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٣ % | Schweizerische Nationalbank | ٨٩٬٥٠٠ | -١٠٬٢٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٣ % | Manulife Investment Management (North America) Limited | ٨٩٬٢٢٨ | ٢١٬٩١١ | ٣١/١٢/٢٠٢٣ |
٠٫١٢ % | D. E. Shaw & Co., L.P. | ٨٤٬٩٣١ | ٦٤٬١٣١ | ٣١/١٢/٢٠٢٣ |
٠٫١٢ % | Barclays Bank PLC | ٨٣٬٦٢١ | ٤٩٬٨٢٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٢ % | Shannon (Timothy M) | ٨٠٬٦٤٣ | 0 | ٣١/٣/٢٠٢٣ |
٠٫١٢ % | Tang Capital Management, LLC | ٨٠٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫١١ % | Algert Global LLC | ٧٤٬٥٧١ | -٩٨٬٨٤٧ | ٣١/١٢/٢٠٢٣ |
٠٫١١ % | HOOPP Investment Management | ٧٤٬٠٠٠ | ٧٤٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١١ % | Columbia Threadneedle Investments (US) | ٧٣٬٩٧٥ | ١٥٬١٩٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٠ % | Zacks Investment Management, Inc. | ٧١٬٦٩٥ | ٦٤٬٣٠٦ | ٣١/١٢/٢٠٢٣ |
٠٫١٠ % | CastleArk Management, LLC | ٧١٬٥٧٠ | ٧١٬٥٧٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٠ % | JPMorgan Private Bank (United States) | ٧٠٬٦١٢ | ٢٢٬٢٦٣ | ٣١/١٢/٢٠٢٣ |
٠٫١٠ % | Rhumbline Advisers Ltd. Partnership | ٦٨٬٨٩٠ | -١١٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٠ % | Conestoga Capital Advisors, LLC | ٦٧٬٦٤٠ | -١٬٨٣٧ | ٢٩/٢/٢٠٢٤ |
٠٫١٠ % | Bank Vontobel AG | ٦٦٬٠٠٠ | ٦٦٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٠ % | Sectoral Asset Management Inc. | ٦٦٬٠٠٠ | ٥٨٬٩٩٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٩ % | Berkowitz (Noah) | ٦٣٬٤٥٢ | ٦٣٬٤٥٢ | ١٨/٣/٢٠٢٤ |
٠٫٠٩ % | Hennion & Walsh Asset Management, Inc. | ٦١٬٨٦٢ | ٢٥٬٧٧٨ | ٣١/٣/٢٠٢٤ |
٠٫٠٩ % | Trexquant Investment LP | ٦١٬٢٤٣ | ٦١٬٢٤٣ | ٣١/١٢/٢٠٢٣ |