9,43 % | Federated Hermes Global Investment Management Corp. | 1 956 488 | -301 636 | 31.12.2022 |
8,47 % | Perceptive Advisors LLC | 1 757 160 | -182 563 | 31.12.2022 |
8,21 % | Deep Track Capital LP | 1 704 000 | 579 579 | 31.12.2022 |
7,15 % | Beryl Capital Management, LLC | 1 483 599 | 1 483 599 | 16.02.2023 |
6,57 % | Chicago Capital, LLC | 1 362 484 | 242 710 | 31.12.2022 |
5,59 % | BlackRock Institutional Trust Company, N.A. | 1 159 924 | 91 388 | 31.12.2022 |
5,18 % | Carlson Capital, L.P. | 1 075 000 | 1 075 000 | 17.02.2023 |
4,82 % | Millennium Management LLC | 999 363 | 611 796 | 21.02.2023 |
4,56 % | The Vanguard Group, Inc. | 945 227 | 31 052 | 31.12.2022 |
4,46 % | Franklin Advisers, Inc. | 924 773 | -487 | 31.12.2022 |
3,79 % | ArrowMark Colorado Holdings, LLC | 786 664 | -4 585 | 31.12.2022 |
3,68 % | Medical Strategy GmbH | 763 135 | 0 | 30.09.2022 |
3,06 % | GW&K Investment Management, LLC | 634 701 | -9 091 | 31.12.2022 |
3,00 % | Decheng Capital Management III (Cayman) LLC | 623 342 | 0 | 31.12.2022 |
2,48 % | Rice Hall James & Associates, LLC | 513 525 | 9 387 | 31.12.2022 |
2,35 % | Prosight Capital | 486 726 | -4 518 | 31.12.2022 |
2,24 % | Sphera Funds Management Ltd. | 463 828 | 104 828 | 31.12.2022 |
1,99 % | Tang Capital Management, LLC | 411 968 | -687 548 | 31.12.2022 |
1,68 % | State Street Global Advisors (US) | 348 114 | -2 430 | 31.12.2022 |
1,65 % | Saturn V Capital Management LLC | 341 827 | 341 827 | 31.12.2022 |
1,61 % | Geode Capital Management, L.L.C. | 333 211 | 20 467 | 31.12.2022 |
1,48 % | Platinum Asset Management | 306 834 | 39 917 | 31.12.2022 |
1,45 % | Privium Fund Management BV | 300 252 | 0 | 31.12.2022 |
1,30 % | Dimensional Fund Advisors, L.P. | 269 731 | 5 195 | 31.12.2022 |
1,29 % | Great Point Partners, LLC | 267 283 | 267 283 | 31.12.2022 |
1,28 % | MAI Capital Management, LLC | 265 364 | -141 469 | 31.12.2022 |
1,05 % | Endurant Capital Management LP | 217 209 | 44 588 | 31.12.2022 |
0,89 % | Cooper (Ronald Harold Wilfred) | 184 641 | -33 094 | 02.03.2023 |
0,76 % | Northern Trust Investments, Inc. | 157 275 | 6 165 | 31.12.2022 |
0,61 % | Fiera Capital Corporation | 126 109 | -2 377 | 31.12.2022 |
0,57 % | Streck (Paul) | 118 966 | 55 000 | 19.01.2023 |
0,56 % | Birchview Capital, LP | 117 000 | 0 | 31.12.2022 |
0,56 % | EQT Life Sciences | 116 376 | 11 500 | 30.06.2021 |
0,48 % | Samsara BioCapital, LLC | 100 000 | 0 | 31.12.2022 |
0,43 % | Renaissance Technologies LLC | 89 683 | -50 000 | 31.12.2022 |
0,42 % | BlackRock Financial Management, Inc. | 86 540 | 32 390 | 31.12.2022 |
0,40 % | Morgan Stanley & Co. LLC | 82 277 | -7 959 | 31.12.2022 |
0,36 % | Mattsson (Jan P) | 73 950 | -35 524 | 02.03.2023 |
0,31 % | Duncan (Jason G) | 64 490 | -3 296 | 02.03.2023 |
0,29 % | Parametric Portfolio Associates LLC | 60 726 | 29 482 | 31.12.2022 |
0,27 % | Stephenson (Pamela) | 56 763 | -22 242 | 02.03.2023 |
0,25 % | BNY Mellon Asset Management | 51 894 | 2 145 | 31.12.2022 |
0,25 % | Carter (Martha J) | 51 268 | -3 656 | 02.03.2023 |
0,25 % | Graham (Michelle) | 50 950 | -5 543 | 02.03.2023 |
0,24 % | Charles Schwab Investment Management, Inc. | 49 296 | 2 462 | 31.12.2022 |
0,23 % | BlackRock Investment Management, LLC | 47 565 | 1 062 | 31.12.2022 |
0,22 % | Harford Simon N R | 46 671 | -13 739 | 02.03.2023 |
0,22 % | Deka Vermögensmanagement GmbH | 45 000 | 0 | 31.12.2022 |
0,22 % | Manulife Investment Management (North America) Limited | 44 811 | 37 853 | 31.01.2023 |
0,21 % | Schweizerische Nationalbank | 42 600 | 1 700 | 31.12.2022 |
0,21 % | Jacobs Levy Equity Management, Inc. | 42 538 | 42 538 | 31.12.2022 |
0,20 % | Brandywine Global Investment Management, LLC | 42 168 | 0 | 31.12.2022 |
0,19 % | Nuveen LLC | 40 260 | -52 803 | 31.12.2022 |
0,18 % | International Biotechnology Trust PLC | 38 000 | 21 907 | 31.12.2022 |
0,17 % | Aperio Group, LLC | 35 366 | 4 138 | 31.12.2022 |
0,17 % | Weiss Multi-Strategy Advisers LLC | 35 322 | 322 | 31.12.2022 |
0,17 % | Deka Investment GmbH | 35 000 | 35 000 | 30.06.2022 |
0,14 % | Wilmington Trust Investment Advisors, Inc. | 29 524 | 4 562 | 31.12.2022 |
0,12 % | AllianceBernstein L.P. | 25 200 | 2 300 | 31.12.2022 |
0,12 % | Point72 Asset Management, L.P. | 24 200 | -53 900 | 31.12.2022 |
0,11 % | Northern Trust Global Investments | 23 841 | 719 | 31.12.2022 |
0,11 % | PDT Partners, LLC | 23 587 | 23 587 | 31.12.2022 |
0,11 % | California State Teachers Retirement System | 22 599 | 645 | 31.12.2022 |
0,11 % | Rhumbline Advisers Ltd. Partnership | 22 452 | 1 155 | 31.12.2022 |
0,09 % | ARIAD Asset Management GmbH | 19 099 | 0 | 31.12.2022 |
0,09 % | Schonfeld Strategic Advisors LLC | 18 393 | 18 393 | 31.12.2022 |
0,08 % | Granite Investment Partners, LLC | 16 162 | -734 | 31.01.2023 |
0,08 % | Apo Asset Management GmbH | 15 964 | 0 | 31.01.2023 |
0,08 % | State of Wisconsin Investment Board | 15 802 | -1 081 | 31.12.2022 |
0,07 % | William Blair & Company, L.L.C. (Research) | 15 456 | 75 | 31.12.2022 |
0,07 % | State Street Global Advisors Ireland Limited | 14 594 | 0 | 31.01.2023 |
0,07 % | Mellon Investments Corporation | 14 191 | 1 057 | 31.12.2022 |
0,07 % | Alps Advisors, Inc. | 14 058 | 3 310 | 31.12.2022 |
0,07 % | BlackRock Advisors (UK) Limited | 13 743 | 291 | 28.02.2023 |
0,06 % | Cheyne Capital Management (UK) LLP | 13 364 | 13 364 | 31.12.2022 |
0,06 % | Ensign Peak Advisors, Inc. | 13 090 | 6 450 | 31.12.2022 |
0,06 % | Fidelity Management & Research Company LLC | 13 049 | 11 657 | 31.12.2022 |
0,06 % | Goldman Sachs Asset Management, L.P. | 12 706 | 12 706 | 31.12.2022 |
0,06 % | BofA Global Research (US) | 12 342 | 6 108 | 31.12.2022 |
0,06 % | New York State Common Retirement Fund | 11 751 | -13 | 31.12.2022 |
0,06 % | Jump Financial, LLC | 11 700 | 11 700 | 31.12.2022 |
0,05 % | Credit Suisse Asset Management | 11 279 | 0 | 31.12.2022 |
0,05 % | Dimensional Fund Advisors, Ltd. | 11 256 | 0 | 31.01.2023 |
0,05 % | BlackRock Asset Management Ireland Limited | 11 164 | 513 | 31.12.2022 |
0,05 % | Two Sigma Investments, LP | 11 000 | -900 | 31.12.2022 |
0,05 % | JPMorgan Private Bank (United States) | 10 637 | 1 232 | 31.12.2022 |
0,05 % | Hopkinson (Craig C M.D.) | 10 495 | 10 495 | 01.12.2022 |
0,05 % | MetLife Investment Management, LLC | 9 864 | 0 | 31.12.2022 |
0,05 % | Connor, Clark & Lunn Investment Management Ltd. | 9 724 | -337 | 31.12.2022 |
0,04 % | Russell Investments Trust Company | 9 289 | 8 513 | 31.12.2022 |
0,04 % | Cubist Systematic Strategies, LLC | 8 640 | 4 930 | 31.12.2022 |
0,04 % | SunAmerica Asset Management, LLC | 8 613 | 442 | 31.12.2022 |
0,04 % | DWS Investments UK Limited | 7 848 | 990 | 31.12.2022 |
0,03 % | Legal & General Investment Management Ltd. | 6 990 | 434 | 31.12.2022 |
0,03 % | E Fund Management Co. Ltd. | 6 623 | 4 498 | 30.06.2022 |
0,03 % | UBS Financial Services, Inc. | 6 164 | 5 399 | 31.12.2022 |
0,03 % | Barclays Bank PLC | 6 163 | 4 160 | 31.12.2022 |
0,03 % | Horn Patrick Taylor | 6 086 | 2 066 | 01.04.2022 |
0,03 % | Perinvest (UK) Ltd. | 6 000 | 0 | 30.06.2022 |
0,03 % | Zürcher Kantonalbank (Asset Management) | 5 713 | 813 | 31.12.2022 |