9,77004 % | Wellington Management Company, LLP | 6 476 561 | 1 044 728 | 2023-12-31 |
9,16151 % | Fidelity Management & Research Company LLC | 6 073 162 | −200 884 | 2023-12-31 |
5,47596 % | Eventide Asset Management, LLC | 3 630 013 | 2 030 013 | 2023-12-31 |
5,22432 % | RTW Investments L.P. | 3 463 201 | 0 | 2023-12-31 |
4,99849 % | BlackRock Institutional Trust Company, N.A. | 3 313 502 | 429 668 | 2023-12-31 |
4,73053 % | Polar Capital LLP | 3 135 871 | 709 115 | 2023-12-31 |
4,57939 % | The Vanguard Group, Inc. | 3 035 675 | 425 500 | 2023-12-31 |
4,53448 % | Kynam Capital Management LP | 3 005 904 | −194 096 | 2023-12-31 |
4,15767 % | Point72 Asset Management, L.P. | 2 756 122 | −866 014 | 2023-12-31 |
3,64504 % | Bellevue Asset Management AG | 2 416 296 | 516 296 | 2023-12-31 |
3,58625 % | State Street Global Advisors (US) | 2 377 326 | 84 475 | 2023-12-31 |
3,35714 % | Pictet Asset Management Ltd. | 2 225 448 | 374 478 | 2023-12-31 |
1,93104 % | Marshall Wace LLP | 1 280 084 | 741 765 | 2023-12-31 |
1,68652 % | Geode Capital Management, L.L.C. | 1 117 994 | 117 569 | 2023-12-31 |
1,49917 % | Redmile Group, LLC | 993 803 | −642 135 | 2023-12-31 |
1,47420 % | Fidelity Institutional Asset Management | 977 247 | 162 173 | 2023-12-31 |
1,46273 % | Rock Springs Capital Management LP | 969 646 | 469 545 | 2023-12-31 |
1,27321 % | Sofinnova Investments, Inc | 844 008 | 419 749 | 2023-12-31 |
1,13759 % | Eversept Partners, LP | 754 107 | 165 964 | 2023-12-31 |
1,06732 % | Octagon Capital Advisors LP | 707 526 | −52 372 | 2023-12-31 |
1,05893 % | Commodore Capital LP | 701 967 | −4 698 | 2023-12-31 |
0,93953 % | Morgan Stanley & Co. LLC | 622 813 | 119 544 | 2023-12-31 |
0,75014 % | 5AM Ventures | 497 270 | 187 000 | 2023-12-31 |
0,61758 % | Charles Schwab Investment Management, Inc. | 409 391 | 47 844 | 2023-12-31 |
0,60358 % | Northern Trust Investments, Inc. | 400 112 | 27 920 | 2023-12-31 |
0,60341 % | Affinity Asset Advisors LLC | 400 000 | 250 000 | 2023-12-31 |
0,58592 % | Goldman Sachs & Company, Inc. | 388 404 | 12 964 | 2023-12-31 |
0,58478 % | Woodline Partners LP | 387 652 | 280 156 | 2023-12-31 |
0,58200 % | T. Rowe Price Associates, Inc. | 385 809 | −47 814 | 2023-12-31 |
0,47897 % | Candriam Luxembourg S.A. | 317 509 | 0 | 2024-02-29 |
0,47897 % | Candriam Belgium S.A. | 317 509 | −5 000 | 2023-12-31 |
0,47616 % | Sphera Funds Management Ltd. | 315 644 | 135 644 | 2023-12-31 |
0,37939 % | TSP Capital Management Group, LLC | 251 495 | −200 | 2023-12-31 |
0,37358 % | Baker Bros. Advisors LP | 247 644 | 247 644 | 2023-12-31 |
0,37293 % | SilverArc Capital Management, LLC | 247 215 | 247 215 | 2023-12-31 |
0,36799 % | Medical Strategy GmbH | 243 942 | 6 400 | 2023-12-31 |
0,35543 % | Invesco Capital Management LLC | 235 612 | 217 783 | 2023-12-31 |
0,34767 % | Dimensional Fund Advisors, L.P. | 230 471 | −110 879 | 2023-12-31 |
0,32604 % | BofA Global Research (US) | 216 133 | 4 695 | 2023-12-31 |
0,27095 % | Ensign Peak Advisors, Inc. | 179 611 | 87 482 | 2023-12-31 |
0,25534 % | Walleye Capital LLC | 169 268 | 10 275 | 2023-12-31 |
0,24665 % | Nomura Asset Management Co., Ltd. | 163 501 | 163 501 | 2023-11-30 |
0,24295 % | American Century Investment Management, Inc. | 161 051 | 191 | 2023-12-31 |
0,23849 % | UBS Financial Services, Inc. | 158 092 | 136 897 | 2023-12-31 |
0,22328 % | Rafferty Asset Management LLC | 148 009 | −16 781 | 2023-12-31 |
0,21775 % | Barclays Bank PLC | 144 345 | 2 295 | 2023-12-31 |
0,21447 % | AXA Investment Managers UK Ltd. | 142 170 | −3 439 | 2023-12-31 |
0,20969 % | BlackRock Financial Management, Inc. | 139 006 | 3 916 | 2023-12-31 |
0,20898 % | Laurion Capital Management LP | 138 531 | 138 531 | 2023-12-31 |
0,20607 % | BNP Paribas Securities Corp. North America | 136 601 | 44 878 | 2023-12-31 |
0,19693 % | Schonfeld Strategic Advisors LLC | 130 542 | 130 542 | 2023-12-31 |
0,19430 % | MacKay Shields LLC | 128 803 | 0 | 2022-08-31 |
0,19333 % | Jane Street Capital, L.L.C. | 128 161 | 68 747 | 2023-12-31 |
0,19284 % | BNY Mellon Asset Management | 127 836 | 4 661 | 2023-12-31 |
0,19057 % | Citadel Advisors LLC | 126 328 | 120 403 | 2023-12-31 |
0,18614 % | BlackRock Investment Management, LLC | 123 393 | 1 115 | 2023-12-31 |
0,18114 % | Nuveen LLC | 120 076 | −204 | 2023-12-31 |
0,16790 % | Exome Asset Management LLC | 111 300 | 111 300 | 2023-12-31 |
0,15803 % | Mirador Capital Partners LP | 104 759 | −3 151 | 2024-03-31 |
0,15117 % | Monashee Investment Management, LLC | 100 209 | 100 209 | 2023-12-31 |
0,14633 % | Schweizerische Nationalbank | 97 000 | 8 700 | 2023-12-31 |
0,14225 % | Polar Asset Management Partners Inc. | 94 300 | −38 100 | 2023-12-31 |
0,12104 % | UBS Switzerland AG | 80 235 | 0 | 2023-12-31 |
0,11468 % | Rhumbline Advisers Ltd. Partnership | 76 022 | −652 | 2023-12-31 |
0,10469 % | Acuta Capital Partners, LLC | 69 400 | −52 941 | 2023-12-31 |
0,10144 % | Crestline Investors, Inc. | 67 243 | 4 133 | 2023-12-31 |
0,09633 % | BlackRock Advisors (UK) Limited | 63 854 | 1 366 | 2024-03-31 |
0,09404 % | Citi Investment Research (US) | 62 341 | −7 014 | 2023-12-31 |
0,09379 % | Kennedy Capital Management LLC | 62 172 | −25 222 | 2023-12-31 |
0,08870 % | OrbiMed Advisors, LLC | 58 800 | 58 800 | 2023-12-31 |
0,08158 % | AllianceBernstein L.P. | 54 080 | −39 201 | 2023-12-31 |
0,07893 % | TD Asset Management Inc. | 52 322 | −12 600 | 2023-12-31 |
0,07846 % | Legal & General Investment Management Ltd. | 52 012 | 11 168 | 2023-12-31 |
0,07822 % | Wellington Management Japan Pte Ltd | 51 854 | −16 384 | 2023-06-30 |
0,07765 % | California State Teachers Retirement System | 51 474 | 5 721 | 2023-12-31 |
0,07543 % | HBM Partners AG | 50 000 | 0 | 2023-09-30 |
0,07445 % | Goldman Sachs Asset Management, L.P. | 49 355 | 12 961 | 2023-12-31 |
0,07375 % | Susquehanna International Group, LLP | 48 888 | −8 572 | 2023-12-31 |
0,07256 % | International Biotechnology Trust PLC | 48 099 | 0 | 2023-09-30 |
0,07256 % | Schroder Investment Management Ltd. (SIM) | 48 099 | 48 099 | 2023-12-31 |
0,07241 % | Credit Suisse Funds AG | 47 998 | 8 352 | 2023-12-31 |
0,07107 % | Young (Diane C) | 47 115 | 0 | 2023-04-05 |
0,07063 % | BlackRock Asset Management Ireland Limited | 46 821 | 3 562 | 2023-12-31 |
0,06952 % | SG Americas Securities, L.L.C. | 46 083 | −31 928 | 2023-12-31 |
0,06861 % | Monarch Partners Asset Management LLC | 45 479 | 45 479 | 2022-12-31 |
0,06784 % | Qube Research & Technologies Ltd | 44 968 | 40 669 | 2023-12-31 |
0,06551 % | Manulife Investment Management (North America) Limited | 43 427 | −6 405 | 2023-12-31 |
0,06235 % | JPMorgan Private Bank (United States) | 41 331 | 36 735 | 2023-12-31 |
0,06223 % | Mellon Investments Corporation | 41 252 | 321 | 2023-12-31 |
0,06167 % | Atom Investors LP | 40 882 | 40 882 | 2023-12-31 |
0,06112 % | State of Wisconsin Investment Board | 40 518 | 8 569 | 2023-12-31 |
0,05989 % | Caption Management, LLC | 39 700 | 26 700 | 2023-12-31 |
0,05679 % | Alps Advisors, Inc. | 37 645 | 2 797 | 2023-12-31 |
0,05608 % | TwinBeech Capital LP | 37 177 | −25 406 | 2023-12-31 |
0,05527 % | Northern Trust Global Investments | 36 637 | −50 169 | 2023-12-31 |
0,05504 % | T. Rowe Price International Ltd | 36 484 | 2 052 | 2023-12-31 |
0,05299 % | Martin (Samuel Bates) | 35 128 | 10 750 | 2024-01-02 |
0,05280 % | PFM Health Sciences, LP | 35 000 | 35 000 | 2023-12-31 |
0,05150 % | JP Morgan Asset Management | 34 139 | −23 937 | 2023-12-31 |
0,04932 % | Kentucky Teachers' Retirement System | 32 697 | 0 | 2023-12-31 |