8,19 % | EcoR1 Capital, LLC | 5.748.399 | 5.748.399 | 22/09/2023 |
7,92 % | Avoro Capital Advisors LLC | 5.555.555 | 0 | 30/06/2023 |
7,08 % | The Vanguard Group, Inc. | 4.969.806 | -72.295 | 30/06/2023 |
6,38 % | RTW Investments L.P. | 4.472.985 | 829.871 | 30/06/2023 |
5,67 % | Armistice Capital LLC | 3.978.000 | 286.000 | 30/06/2023 |
4,83 % | Wellington Management Company, LLP | 3.388.365 | 692.273 | 30/06/2023 |
4,56 % | Boxer Capital, L.L.C. | 3.201.440 | 0 | 08/10/2023 |
4,47 % | Aviva Holdings Ltd. | 3.135.966 | 0 | 08/10/2023 |
3,97 % | Morgan Stanley & Co. LLC | 2.783.869 | 1.023.058 | 30/06/2023 |
3,68 % | State Street Global Advisors (US) | 2.581.739 | 271.919 | 30/06/2023 |
3,03 % | BlackRock Institutional Trust Company, N.A. | 2.127.589 | -2.501 | 30/06/2023 |
2,93 % | Invus Public Equities Advisors, LLC | 2.055.181 | 517.472 | 30/06/2023 |
2,57 % | Camber Capital Management LP | 1.800.000 | 400.000 | 30/06/2023 |
2,50 % | T. Rowe Price Associates, Inc. | 1.752.033 | 6.016 | 30/06/2023 |
2,06 % | Paradigm BioCapital Advisors LP | 1.443.762 | 46.983 | 30/06/2023 |
2,01 % | Baker Bros. Advisors LP | 1.409.784 | 0 | 30/06/2023 |
1,60 % | Rock Springs Capital Management LP | 1.121.647 | 56.386 | 30/06/2023 |
1,30 % | OrbiMed Advisors, LLC | 913.650 | 0 | 30/06/2023 |
1,27 % | Candriam Luxembourg S.A. | 893.738 | 20.000 | 31/08/2023 |
1,25 % | Candriam Belgium S.A. | 873.763 | 109.498 | 30/06/2023 |
1,15 % | Assenagon Asset Management S.A. | 808.820 | 552.860 | 30/06/2023 |
1,09 % | Geode Capital Management, L.L.C. | 764.483 | 29.195 | 30/06/2023 |
1,07 % | Octagon Capital Advisors LP | 750.000 | 0 | 30/06/2023 |
1,03 % | Perceptive Advisors LLC | 719.103 | -855.031 | 30/06/2023 |
0,99 % | Fiera Capital Corporation | 692.033 | -17.494 | 30/06/2023 |
0,92 % | Franklin Advisers, Inc. | 646.837 | -5 | 30/06/2023 |
0,86 % | Eventide Asset Management, LLC | 600.000 | 228.898 | 30/06/2023 |
0,85 % | BlackRock Financial Management, Inc. | 593.087 | 60.997 | 30/06/2023 |
0,83 % | Marshall Wace LLP | 584.323 | 31.709 | 30/06/2023 |
0,76 % | Credit Suisse Funds AG | 529.690 | 6.335 | 30/06/2023 |
0,72 % | Millennium Management LLC | 505.309 | 486.275 | 30/06/2023 |
0,69 % | Citadel Advisors LLC | 481.818 | 391.174 | 30/06/2023 |
0,68 % | Norges Bank Investment Management (NBIM) | 475.992 | 62.003 | 31/12/2022 |
0,67 % | Dimensional Fund Advisors, L.P. | 472.468 | 167.874 | 30/06/2023 |
0,62 % | Charles Schwab Investment Management, Inc. | 436.048 | 5.554 | 30/06/2023 |
0,58 % | Voloridge Investment Management, LLC | 406.035 | -272.623 | 30/06/2023 |
0,53 % | Woodline Partners LP | 373.332 | 107.232 | 30/06/2023 |
0,41 % | MVA Investors LLC | 287.866 | 0 | 08/10/2023 |
0,37 % | D. E. Shaw & Co., L.P. | 262.938 | 17.352 | 30/06/2023 |
0,37 % | International Biotechnology Trust PLC | 260.000 | 16.000 | 30/06/2023 |
0,37 % | UBS Asset Management (Switzerland) | 257.001 | 63.265 | 31/03/2023 |
0,36 % | BlackRock Investment Management (UK) Ltd. | 254.032 | -6.748 | 30/06/2023 |
0,35 % | BlackRock Asset Management Ireland Limited | 242.715 | 6.294 | 30/06/2023 |
0,34 % | Braidwell LP | 240.625 | -211.375 | 30/06/2023 |
0,33 % | New York State Common Retirement Fund | 232.860 | 643 | 30/06/2023 |
0,33 % | Nuveen LLC | 231.885 | -28.524 | 30/06/2023 |
0,33 % | Jane Street Capital, L.L.C. | 229.883 | 80.755 | 30/06/2023 |
0,32 % | Susquehanna International Group, LLP | 225.101 | -137.511 | 30/06/2023 |
0,32 % | Allspring Global Investments, LLC | 222.737 | -10.302 | 30/06/2023 |
0,32 % | Jacobs Levy Equity Management, Inc. | 221.763 | 13.000 | 30/06/2023 |
0,31 % | Rafferty Asset Management LLC | 218.639 | 45.123 | 30/06/2023 |
0,29 % | Dissanayake (Shehan Bharath) | 203.754 | 0 | 08/10/2023 |
0,29 % | Ghost Tree Capital, LLC | 200.000 | 60.000 | 30/06/2023 |
0,29 % | DWS Investment GmbH | 200.000 | -15.654 | 30/06/2023 |
0,28 % | BofA Global Research (US) | 197.267 | -59.553 | 30/06/2023 |
0,27 % | 5AM Ventures | 192.500 | 192.500 | 30/06/2023 |
0,26 % | Edmond de Rothschild Asset Management (France) S.A. | 184.060 | 0 | 30/06/2023 |
0,25 % | Northern Trust Investments, Inc. | 178.259 | 3.052 | 30/06/2023 |
0,22 % | Oracle Investment Management, Inc. | 152.600 | -48.800 | 30/06/2023 |
0,21 % | Sectoral Asset Management Inc. | 148.553 | 20.147 | 30/06/2023 |
0,21 % | Baum (Charles M) | 148.268 | 54.054 | 09/08/2023 |
0,21 % | Granahan Investment Management, Inc. | 145.287 | 16.197 | 30/06/2023 |
0,20 % | Jefferies LLC | 142.969 | 92.549 | 30/06/2023 |
0,20 % | Rhenman & Partners Asset Management AB | 140.000 | -75.000 | 30/06/2023 |
0,20 % | AllianceBernstein L.P. | 139.501 | 67.858 | 30/06/2023 |
0,19 % | Managed Account Advisors LLC | 130.489 | 1.059 | 30/06/2023 |
0,18 % | Schonfeld Strategic Advisors LLC | 129.636 | 106.837 | 30/06/2023 |
0,18 % | UBS Financial Services, Inc. | 124.768 | 43.336 | 30/06/2023 |
0,18 % | Fidelity Management & Research Company LLC | 123.783 | -54.300 | 30/06/2023 |
0,17 % | Connor, Clark & Lunn Investment Management Ltd. | 117.151 | -19.335 | 30/06/2023 |
0,16 % | Numeric Investors LLC | 109.491 | 89.681 | 30/06/2023 |
0,15 % | Barclays Bank PLC | 103.206 | -22.173 | 30/06/2023 |
0,15 % | Stelzer (Laurie D) | 102.312 | 22.297 | 09/08/2023 |
0,14 % | ExodusPoint Capital Management, LP | 98.738 | -65.004 | 30/06/2023 |
0,14 % | Polar Asset Management Partners Inc. | 98.500 | 98.500 | 30/06/2023 |
0,13 % | Dafna Capital Management, LLC | 94.700 | 21.100 | 30/06/2023 |
0,13 % | SilverArc Capital Management, LLC | 91.213 | 91.213 | 30/06/2023 |
0,13 % | BNY Mellon Asset Management | 90.071 | 7.611 | 30/06/2023 |
0,13 % | Schweizerische Nationalbank | 88.600 | 1.600 | 30/06/2023 |
0,12 % | Mellon Investments Corporation | 84.028 | -2.256 | 30/06/2023 |
0,11 % | Tang Capital Management, LLC | 80.000 | 80.000 | 30/06/2023 |
0,10 % | Algert Global LLC | 73.516 | 10.292 | 30/06/2023 |
0,10 % | HRT Financial LP | 73.276 | -8.030 | 30/06/2023 |
0,10 % | TD Asset Management Inc. | 72.105 | 4.700 | 30/06/2023 |
0,10 % | Christensen (James G) | 71.685 | -2.388 | 08/09/2023 |
0,10 % | Moriarty (John B) | 71.660 | 22.297 | 09/08/2023 |
0,10 % | Wells Fargo Advisors | 70.642 | -1.888 | 30/06/2023 |
0,10 % | California Public Employees' Retirement System | 69.454 | 0 | 30/06/2023 |
0,10 % | Citi Investment Research (US) | 67.704 | -91.289 | 30/06/2023 |
0,09 % | Tekla Capital Management LLC | 65.490 | 0 | 30/06/2023 |
0,09 % | Florida State Board of Administration | 62.506 | -1.366 | 30/06/2023 |
0,09 % | Lombard Odier Asset Management (Europe) Ltd | 62.334 | -9.056 | 31/10/2022 |
0,09 % | Sandler (Alan B.) | 62.297 | 22.297 | 09/08/2023 |
0,09 % | Macquarie Investment Management | 60.000 | 0 | 30/06/2023 |
0,09 % | UBS O'Connor LLC | 59.698 | 12.448 | 30/06/2023 |
0,08 % | Clearline Capital LP | 56.341 | 56.341 | 30/06/2023 |
0,08 % | Manulife Investment Management (North America) Limited | 55.148 | 3.769 | 30/06/2023 |
0,08 % | Fidelity International | 53.434 | 53.434 | 30/06/2023 |
0,08 % | Aperio Group, LLC | 53.414 | 22.157 | 30/06/2023 |
0,07 % | Wellington International Management Company Pte. Ltd. | 52.050 | 13.986 | 31/12/2022 |