9,17555 % | EcoR1 Capital, LLC | 11.173.068 | 273.209 | 31. 12. 2023. |
9,12467 % | Avoro Capital Advisors LLC | 11.111.111 | 0 | 31. 12. 2023. |
7,83257 % | The Vanguard Group, Inc. | 9.537.719 | 85.701 | 31. 12. 2023. |
5,17663 % | T. Rowe Price Investment Management, Inc. | 6.303.584 | −215.887 | 31. 12. 2023. |
3,96886 % | BlackRock Institutional Trust Company, N.A. | 4.832.877 | 92.717 | 31. 12. 2023. |
2,69025 % | Jennison Associates LLC | 3.275.922 | −266.287 | 31. 12. 2023. |
2,39420 % | State Street Global Advisors (US) | 2.915.422 | −322.692 | 31. 12. 2023. |
2,30515 % | Octagon Capital Advisors LP | 2.806.980 | −323.020 | 31. 12. 2023. |
2,29551 % | Morgan Stanley & Co. LLC | 2.795.240 | 1.601.542 | 31. 12. 2023. |
13,50521 % | Wellington Management Company, LLP | 16.445.290 | 1.278.246 | 31. 12. 2023. |
10,51683 % | Morningside Venture Investments, Ltd. | 12.806.342 | 0 | 31. 03. 2023. |
1,96998 % | T. Rowe Price Associates, Inc. | 2.398.842 | 669.759 | 31. 12. 2023. |
1,76152 % | Assenagon Asset Management S.A. | 2.145.004 | 1.121.497 | 31. 12. 2023. |
1,71837 % | Fidelity Management & Research Company LLC | 2.092.464 | −167.086 | 31. 12. 2023. |
1,41743 % | Boxer Capital, L.L.C. | 1.726.000 | 0 | 31. 12. 2023. |
1,40927 % | JP Morgan Asset Management | 1.716.070 | 70.134 | 31. 12. 2023. |
1,33912 % | Geode Capital Management, L.L.C. | 1.630.642 | 75.816 | 31. 12. 2023. |
1,16724 % | Invus Public Equities Advisors, LLC | 1.421.346 | −243.226 | 31. 12. 2023. |
1,10418 % | Pictet Asset Management Ltd. | 1.344.563 | 610.413 | 31. 12. 2023. |
0,87320 % | Deschatelets (Pascal) | 1.063.301 | 0 | 08. 04. 2024. |
0,86511 % | Polar Capital LLP | 1.053.440 | −435 | 31. 12. 2023. |
0,78016 % | Logos Global Management LLC | 950.000 | 200.000 | 31. 12. 2023. |
0,77705 % | Norges Bank Investment Management (NBIM) | 946.213 | −101.241 | 31. 12. 2023. |
0,75733 % | OrbiMed Advisors, LLC | 922.200 | −338.300 | 31. 12. 2023. |
0,75478 % | Fiera Capital Corporation | 919.090 | −600 | 31. 12. 2023. |
0,74272 % | Charles Schwab Investment Management, Inc. | 904.409 | 25.052 | 31. 12. 2023. |
0,72692 % | Frazier Healthcare Partners | 885.165 | 271.122 | 31. 12. 2023. |
0,67488 % | Bellevue Asset Management AG | 821.800 | 27.959 | 31. 12. 2023. |
0,63960 % | Machiels (Alec) | 778.844 | 3.341 | 01. 01. 2024. |
0,53660 % | Francois (Cedric G) | 653.418 | 0 | 01. 03. 2024. |
0,51326 % | Cormorant Asset Management, LP | 625.000 | −1.375.000 | 31. 12. 2023. |
0,50610 % | Victory Capital Management Inc. | 616.272 | −122.239 | 31. 12. 2023. |
0,50246 % | JPMorgan Asset Management U.K. Limited | 611.840 | 137.145 | 31. 12. 2023. |
0,47912 % | Macquarie Investment Management | 583.429 | −493.119 | 31. 12. 2023. |
0,40627 % | Invesco Advisers, Inc. | 494.709 | 2.597 | 31. 12. 2023. |
0,40201 % | Columbia Threadneedle Investments (US) | 489.522 | 213.188 | 31. 12. 2023. |
0,39691 % | TD Asset Management Inc. | 483.322 | 112.465 | 31. 12. 2023. |
0,39542 % | Driehaus Capital Management, LLC | 481.501 | 300.177 | 31. 12. 2023. |
0,38146 % | Candriam Luxembourg S.A. | 464.507 | 95.000 | 29. 02. 2024. |
0,36626 % | Eagle Asset Management, Inc. | 446.000 | −3.970 | 31. 12. 2023. |
0,35699 % | Jane Street Capital, L.L.C. | 434.701 | 161.475 | 31. 12. 2023. |
0,33028 % | Dunlop (Sinclair Andrew) | 402.185 | 1.500 | 12. 04. 2024. |
0,32277 % | Caption Management, LLC | 393.031 | 119.781 | 31. 12. 2023. |
0,31834 % | Northern Trust Investments, Inc. | 387.643 | 18.292 | 31. 12. 2023. |
0,31439 % | Susquehanna International Group, LLP | 382.832 | 10.047 | 31. 12. 2023. |
0,30263 % | BMO Capital Markets (US) | 368.510 | −62.000 | 31. 12. 2023. |
0,29558 % | DWS Investments UK Limited | 359.928 | 356.000 | 31. 12. 2023. |
0,27963 % | New York State Common Retirement Fund | 340.507 | −62.437 | 31. 12. 2023. |
0,27717 % | Candriam Belgium S.A. | 337.507 | 11.000 | 31. 12. 2023. |
0,26608 % | PGIM Securities Investment Trust Enterprise | 324.000 | 23.000 | 31. 12. 2023. |
0,23414 % | Citadel Advisors LLC | 285.117 | 270.370 | 31. 12. 2023. |
0,23188 % | Medical Strategy GmbH | 282.365 | −6.200 | 31. 12. 2023. |
0,21905 % | Nuveen LLC | 266.739 | −6.439 | 31. 12. 2023. |
0,21067 % | Voya Investment Management LLC | 256.533 | 174.366 | 31. 12. 2023. |
0,20851 % | Group One Trading, L.P. | 253.905 | 27.221 | 31. 12. 2023. |
0,20166 % | Ensign Peak Advisors, Inc. | 245.566 | 60.000 | 31. 12. 2023. |
0,19923 % | Fiduciary Trust Company | 242.607 | −22.600 | 31. 12. 2023. |
0,19822 % | Amundi Asset Management US, Inc. | 241.371 | 135.315 | 31. 12. 2023. |
0,18960 % | Marshall Wace LLP | 230.876 | 61.582 | 31. 12. 2023. |
0,18857 % | Franklin Advisers, Inc. | 229.622 | 229.622 | 31. 12. 2023. |
0,17229 % | Eventide Asset Management, LLC | 209.794 | 209.794 | 31. 12. 2023. |
0,17095 % | Great Lakes Advisors, LLC | 208.163 | 208.163 | 31. 12. 2023. |
0,16569 % | Managed Account Advisors LLC | 201.764 | −138.260 | 31. 12. 2023. |
0,15998 % | Barclays Bank PLC | 194.813 | −133.008 | 31. 12. 2023. |
0,15722 % | Goldman Sachs Asset Management, L.P. | 191.449 | −31.387 | 31. 12. 2023. |
0,15676 % | DWS Investment S.A. | 190.889 | 190.889 | 31. 12. 2023. |
0,15479 % | DWS Investment GmbH | 188.493 | −15.577 | 31. 12. 2023. |
0,15374 % | BNY Mellon Asset Management | 187.210 | 3.829 | 31. 12. 2023. |
0,15293 % | Woodline Partners LP | 186.224 | 186.224 | 31. 12. 2023. |
0,15160 % | BlackRock Financial Management, Inc. | 184.605 | −347 | 31. 12. 2023. |
0,14227 % | Tekla Capital Management LLC_NLE | 173.248 | 38.124 | 30. 06. 2023. |
0,13883 % | abrdn Inc. | 169.051 | 169.051 | 31. 12. 2023. |
0,13754 % | BNP Paribas Securities Corp. North America | 167.488 | −68.867 | 31. 12. 2023. |
0,13443 % | Mellon Investments Corporation | 163.694 | −2.386 | 31. 12. 2023. |
0,13337 % | Schweizerische Nationalbank | 162.400 | −16.800 | 31. 12. 2023. |
0,12499 % | Altitude Crest Partners Inc | 152.200 | 152.200 | 31. 12. 2023. |
0,12440 % | Morgan Stanley Smith Barney LLC | 151.483 | −120.351 | 31. 12. 2023. |
0,12343 % | BlackRock Asset Management Ireland Limited | 150.301 | 4.920 | 31. 12. 2023. |
0,12318 % | Ally Bridge Group NY LLC | 150.000 | −31.805 | 31. 12. 2023. |
0,12127 % | Walleye Capital LLC | 147.674 | 13.691 | 31. 12. 2023. |
0,11976 % | California Public Employees' Retirement System | 145.833 | −38.011 | 31. 12. 2023. |
0,11936 % | J.P. Morgan Securities plc | 145.342 | 145.342 | 31. 12. 2023. |
0,11753 % | Rafferty Asset Management LLC | 143.118 | −71.043 | 31. 12. 2023. |
0,11737 % | Saturn V Capital Management LLC | 142.927 | 142.927 | 31. 12. 2023. |
0,10970 % | Rhumbline Advisers Ltd. Partnership | 133.586 | 1.292 | 31. 12. 2023. |
0,10791 % | Pictet Asset Management (Japan) Ltd. | 131.404 | 131.404 | 31. 10. 2023. |
0,10766 % | Lombard Odier Asset Management (Europe) Ltd | 131.098 | −38.956 | 30. 09. 2022. |
0,10676 % | 683 Capital Management LLC | 130.000 | −110.000 | 31. 12. 2023. |
0,10282 % | Wells Fargo Advisors | 125.206 | 15.309 | 31. 12. 2023. |
0,09826 % | PNC Investments LLC | 119.653 | 57 | 31. 12. 2023. |
0,09774 % | BofA Global Research (US) | 119.017 | −245.914 | 31. 12. 2023. |
0,09481 % | Allspring Global Investments, LLC | 115.453 | 56.178 | 31. 03. 2024. |
0,09428 % | Goldman Sachs & Company, Inc. | 114.810 | 5.853 | 31. 12. 2023. |
0,09368 % | LMR Partners LLP | 114.069 | 56.940 | 31. 12. 2023. |
0,08869 % | Cutter Capital Management, LP | 108.000 | 108.000 | 31. 12. 2023. |
0,08705 % | Manulife Investment Management (North America) Limited | 106.002 | 51.737 | 31. 12. 2023. |
0,08274 % | Parametric Portfolio Associates LLC | 100.752 | 14.566 | 31. 12. 2023. |
0,08245 % | Rhenman & Partners Asset Management AB | 100.400 | −114.600 | 31. 12. 2023. |
0,08196 % | BMO Nesbitt Burns Inc. | 99.800 | 99.800 | 31. 12. 2023. |
0,08025 % | Thrivent Asset Management, LLC | 97.716 | 18.255 | 31. 12. 2023. |