9,65933 % | Fidelity Management & Research Company LLC | 8.160.206 | 7.271.997 | 31/1/2024 |
5,62893 % | BlackRock Institutional Trust Company, N.A. | 4.755.318 | 752.470 | 31/12/2023 |
4,59706 % | Federated Hermes Global Investment Management Corp. | 3.883.600 | 500.000 | 31/12/2023 |
4,20442 % | Janus Henderson Investors | 3.551.891 | 1.828.731 | 31/12/2023 |
4,16903 % | T. Rowe Price Associates, Inc. | 3.521.999 | 523.472 | 31/12/2023 |
4,10191 % | The Vanguard Group, Inc. | 3.465.297 | 504.275 | 31/12/2023 |
3,54155 % | State Street Global Advisors (US) | 2.991.899 | 844.399 | 31/12/2023 |
3,46247 % | Adage Capital Management, L.P. | 2.925.094 | 638.133 | 31/12/2023 |
3,11351 % | Deerfield Management Company, L.P. | 2.630.292 | 361.664 | 31/12/2023 |
2,60750 % | Boxer Capital, L.L.C. | 2.202.812 | 0 | 31/12/2023 |
2,34004 % | Capital Research Global Investors | 1.976.870 | 600.000 | 31/12/2023 |
2,13068 % | Logos Global Management LLC | 1.800.000 | -450.000 | 31/12/2023 |
2,04669 % | BVF Partners L.P. | 1.729.043 | -3.554.446 | 31/12/2023 |
2,01247 % | Holocene Advisors, LP | 1.700.135 | 667.204 | 31/12/2023 |
1,94519 % | Citadel Advisors LLC | 1.643.293 | 898.193 | 31/12/2023 |
1,79924 % | Avidity Partners Management LP | 1.520.000 | -624.971 | 31/12/2023 |
1,72690 % | Sofinnova Investments, Inc | 1.458.881 | 421.694 | 31/12/2023 |
1,59959 % | Geode Capital Management, L.L.C. | 1.351.337 | 190.232 | 31/12/2023 |
1,52261 % | Dimensional Fund Advisors, L.P. | 1.286.300 | 144.058 | 31/12/2023 |
1,25725 % | Baker Bros. Advisors LP | 1.062.123 | 0 | 31/12/2023 |
1,16933 % | Morgan Stanley & Co. LLC | 987.851 | 844.492 | 31/12/2023 |
1,10779 % | Redmile Group, LLC | 935.863 | 935.863 | 31/12/2023 |
1,08048 % | Driehaus Capital Management, LLC | 912.786 | 215.325 | 31/12/2023 |
1,03663 % | Pictet Asset Management Ltd. | 875.747 | 211.657 | 31/12/2023 |
0,80242 % | Hata (Yujiro S.) | 677.887 | 0 | 9/2/2024 |
0,78402 % | Platinum Asset Management | 662.343 | -104.339 | 31/12/2023 |
0,66844 % | Soleus Capital Management, L.P. | 564.700 | 564.700 | 31/12/2023 |
0,63920 % | Candriam Luxembourg S.A. | 540.000 | 145.000 | 29/2/2024 |
0,63882 % | Fisher Investments | 539.676 | 508.151 | 31/12/2023 |
0,62970 % | Boone Capital Management LLC | 531.967 | -38.715 | 31/12/2023 |
0,62678 % | D. E. Shaw & Co., L.P. | 529.506 | 93.148 | 31/12/2023 |
0,61120 % | Dafna Capital Management, LLC | 516.341 | 16.521 | 31/12/2023 |
0,60601 % | Northern Trust Investments, Inc. | 511.956 | 61.264 | 31/12/2023 |
0,58766 % | Charles Schwab Investment Management, Inc. | 496.456 | 59.100 | 31/12/2023 |
0,58007 % | Ensign Peak Advisors, Inc. | 490.039 | 126.255 | 31/12/2023 |
0,55193 % | Balyasny Asset Management LP | 466.271 | 466.271 | 31/12/2023 |
0,53267 % | Cormorant Asset Management, LP | 450.000 | -150.000 | 31/12/2023 |
0,49013 % | Woodline Partners LP | 414.059 | 173.631 | 31/12/2023 |
0,46759 % | Candriam Belgium S.A. | 395.019 | -35.000 | 31/12/2023 |
0,45263 % | First Turn Management, LLC | 382.382 | 382.382 | 31/12/2023 |
0,44589 % | Nuveen LLC | 376.692 | -169.061 | 31/12/2023 |
0,41364 % | Medical Strategy GmbH | 349.447 | -3400 | 31/12/2023 |
0,41014 % | Victory Capital Management Inc. | 346.490 | 346.490 | 31/12/2023 |
0,40918 % | First Light Asset Management, LLC | 345.674 | 345.674 | 31/12/2023 |
0,39654 % | Eventide Asset Management, LLC | 335.000 | 0 | 31/12/2023 |
0,36873 % | Opaleye Management Inc. | 311.500 | 0 | 31/12/2023 |
0,36574 % | BlackRock Financial Management, Inc. | 308.979 | 61.814 | 31/12/2023 |
0,29746 % | Superstring Capital Management LP | 251.295 | 251.295 | 31/12/2023 |
0,28797 % | AXA Investment Managers UK Ltd. | 243.280 | -100.475 | 31/12/2023 |
0,26532 % | Columbia Threadneedle Investments (US) | 224.141 | -49.332 | 31/12/2023 |
0,26037 % | Voya Investment Management LLC | 219.957 | -71.119 | 31/12/2023 |
0,24671 % | Goldman Sachs & Company, Inc. | 208.417 | -109.529 | 31/12/2023 |
0,24590 % | BNP Paribas Securities Corp. North America | 207.735 | 155.179 | 31/12/2023 |
0,23661 % | Walleye Capital LLC | 199.891 | 115.928 | 31/12/2023 |
0,23240 % | UBS Asset Management (Americas), Inc. | 196.329 | -2262 | 31/12/2023 |
0,23069 % | Invesco Capital Management LLC | 194.886 | -72.891 | 31/12/2023 |
0,22888 % | Rafferty Asset Management LLC | 193.356 | 64.280 | 31/12/2023 |
0,21626 % | BofA Global Research (US) | 182.695 | 100.942 | 31/12/2023 |
0,20885 % | Barclays Bank PLC | 176.440 | 90.114 | 31/12/2023 |
0,19846 % | BlackRock Investment Management, LLC | 167.656 | 22.622 | 31/12/2023 |
0,18582 % | Morgan Stanley Investment Management Inc. (US) | 156.983 | 155.836 | 31/12/2023 |
0,18172 % | BNY Mellon Asset Management | 153.513 | 11.507 | 31/12/2023 |
0,17839 % | UBS Financial Services, Inc. | 150.702 | 94.167 | 31/12/2023 |
0,16489 % | Nantahala Capital Management, LLC | 139.298 | -6562 | 31/12/2023 |
0,16364 % | Jennison Associates LLC | 138.241 | 37.345 | 31/3/2024 |
0,16299 % | TD Asset Management Inc. | 137.690 | 24.034 | 31/12/2023 |
0,15856 % | BlackRock Advisors (UK) Limited | 133.952 | 9014 | 31/3/2024 |
0,15420 % | Parkman Healthcare Partners LLC | 130.265 | -2436 | 31/12/2023 |
0,15015 % | HighVista Strategies LLC | 126.845 | 0 | 31/12/2023 |
0,14277 % | First Trust Advisors L.P. | 120.614 | 1076 | 31/12/2023 |
0,14023 % | Two Sigma Investments, LP | 118.469 | -90.839 | 31/12/2023 |
0,13062 % | Nicholas Investment Partners, L.P. | 110.351 | 94.094 | 31/12/2023 |
0,12962 % | Allianz Global Investors GmbH | 109.505 | 0 | 31/1/2024 |
0,12797 % | EAM Investors, LLC | 108.110 | 20.448 | 31/12/2023 |
0,12699 % | BlackRock Asset Management Ireland Limited | 107.277 | 7750 | 31/12/2023 |
0,11074 % | Northern Trust Global Investments | 93.555 | -2641 | 31/12/2023 |
0,10942 % | Manulife Investment Management (North America) Limited | 92.438 | 14.028 | 31/12/2023 |
0,10618 % | Citi Investment Research (US) | 89.698 | 34.444 | 31/12/2023 |
0,10176 % | Rhumbline Advisers Ltd. Partnership | 85.966 | 7172 | 31/12/2023 |
0,10073 % | Schweizerische Nationalbank | 85.100 | -21.900 | 31/12/2023 |
0,10002 % | Hudson Bay Capital Management LP | 84.500 | 49.500 | 31/12/2023 |
0,09941 % | Wellington Management Company, LLP | 83.984 | 83.984 | 31/12/2023 |
0,09176 % | Qube Research & Technologies Ltd | 77.516 | 42.162 | 31/12/2023 |
0,09139 % | Parametric Portfolio Associates LLC | 77.204 | -397 | 31/12/2023 |
0,08828 % | UBS O'Connor LLC | 74.575 | -51.574 | 31/12/2023 |
0,08404 % | HOOPP Investment Management | 71.000 | 71.000 | 31/12/2023 |
0,08256 % | Goldman Sachs Asset Management, L.P. | 69.749 | -32.327 | 31/12/2023 |
0,07694 % | MFS Investment Management | 65.001 | -11.145 | 29/2/2024 |
0,07411 % | Credit Suisse Funds AG | 62.610 | 1300 | 31/12/2023 |
0,07247 % | Campbell & Company, Inc. | 61.226 | 29.536 | 31/12/2023 |
0,07102 % | DWS Investment GmbH | 60.000 | 57.038 | 31/12/2023 |
0,06828 % | AllianceBernstein L.P. | 57.680 | 7140 | 31/12/2023 |
0,06636 % | UBS Asset Management (Switzerland) | 56.062 | 5356 | 31/12/2023 |
0,06539 % | Capstone Investment Advisors, LLC | 55.239 | 55.239 | 31/12/2023 |
0,06477 % | Mellon Investments Corporation | 54.717 | 7896 | 31/12/2023 |
0,06271 % | State of Wisconsin Investment Board | 52.976 | -11.134 | 31/12/2023 |
0,05919 % | Deka Vermögensmanagement GmbH | 50.000 | 0 | 31/12/2023 |
0,05854 % | Legal & General Investment Management Ltd. | 49.452 | -1122 | 31/12/2023 |
0,05738 % | Dimensional Fund Advisors, Ltd. | 48.478 | 3106 | 31/1/2024 |
0,05724 % | California State Teachers Retirement System | 48.359 | -6659 | 31/12/2023 |