9,61 % | The Vanguard Group, Inc. | 28.450.070 | 1.360.613 | 31/12/2023 |
9,47 % | Perceptive Advisors LLC | 28.057.456 | 364.539 | 31/12/2023 |
9,25 % | Avoro Capital Advisors LLC | 27.400.000 | 0 | 31/12/2023 |
6,97 % | BlackRock Institutional Trust Company, N.A. | 20.651.163 | 1.971.281 | 31/12/2023 |
5,13 % | Wellington Management Company, LLP | 15.190.024 | 7.666.335 | 31/12/2023 |
5,01 % | Redmile Group, LLC | 14.828.321 | -2.116.300 | 31/12/2023 |
4,44 % | State Street Global Advisors (US) | 13.163.085 | 1.790.649 | 31/12/2023 |
3,94 % | JP Morgan Asset Management | 11.670.883 | 4.804.623 | 31/12/2023 |
3,93 % | William Blair Investment Management, LLC | 11.647.026 | 1.270.263 | 31/12/2023 |
3,88 % | Janus Henderson Investors | 11.507.129 | -3.426.892 | 31/12/2023 |
3,84 % | Morgan Stanley & Co. LLC | 11.380.117 | 1.254.072 | 31/12/2023 |
3,50 % | Palo Alto Investors LP | 10.373.715 | -150.307 | 31/12/2023 |
2,44 % | Macquarie Investment Management | 7.215.010 | 2358 | 31/12/2023 |
2,36 % | Pictet Asset Management Ltd. | 6.994.597 | -1.402.914 | 31/12/2023 |
2,01 % | Geode Capital Management, L.L.C. | 5.951.295 | 345.129 | 31/12/2023 |
1,80 % | JPMorgan Asset Management U.K. Limited | 5.323.591 | -143.025 | 31/12/2023 |
1,71 % | Fiera Capital Corporation | 5.061.644 | -24.227 | 31/12/2023 |
1,55 % | American Century Investment Management, Inc. | 4.582.067 | 238.197 | 31/12/2023 |
1,33 % | DWS Investments UK Limited | 3.951.977 | 3.818.630 | 31/12/2023 |
0,85 % | Norges Bank Investment Management (NBIM) | 2.531.000 | -2.869.086 | 31/12/2023 |
0,84 % | Novo Holdings A/S | 2.500.000 | 404.100 | 31/12/2023 |
0,84 % | Northern Trust Investments, Inc. | 2.492.674 | 97.960 | 31/12/2023 |
0,82 % | MFS Investment Management | 2.415.090 | 593.131 | 31/12/2023 |
0,77 % | Charles Schwab Investment Management, Inc. | 2.268.886 | 90.195 | 31/12/2023 |
0,74 % | Fidelity Management & Research Company LLC | 2.194.460 | -583.703 | 31/12/2023 |
0,68 % | Invus Public Equities Advisors, LLC | 2.026.364 | -2.036.203 | 31/12/2023 |
0,61 % | DWS Investment S.A. | 1.812.149 | 1.812.149 | 31/12/2023 |
0,59 % | Victory Capital Management Inc. | 1.752.687 | -1.196.519 | 31/12/2023 |
0,59 % | Goldman Sachs & Company, Inc. | 1.741.597 | -88.568 | 31/12/2023 |
0,57 % | Pictet Asset Management (Japan) Ltd. | 1.692.993 | 439.503 | 31/10/2023 |
0,53 % | Balyasny Asset Management LP | 1.556.540 | -1.828.892 | 31/12/2023 |
0,50 % | Finepoint Capital LP | 1.489.025 | 0 | 31/12/2023 |
0,50 % | New York State Common Retirement Fund | 1.475.212 | 1039 | 31/12/2023 |
0,47 % | PanAgora Asset Management Inc. | 1.397.312 | -33.112 | 31/12/2023 |
0,47 % | Nuveen LLC | 1.392.742 | 152.535 | 31/12/2023 |
0,43 % | Great Point Partners, LLC | 1.280.500 | 423.500 | 31/12/2023 |
0,42 % | Clarus Ventures, LLC | 1.233.552 | 1.233.552 | 31/12/2023 |
0,42 % | Blackstone Alternative Credit Advisors LP | 1.233.552 | 1.233.552 | 31/12/2023 |
0,41 % | T. Rowe Price Associates, Inc. | 1.228.659 | -23.851 | 31/12/2023 |
0,39 % | Managed Account Advisors LLC | 1.143.052 | -472.002 | 31/12/2023 |
0,37 % | PRIMECAP Management Company | 1.094.200 | 0 | 31/12/2023 |
0,37 % | BlackRock Financial Management, Inc. | 1.093.483 | 68.591 | 31/12/2023 |
0,36 % | Rice Hall James & Associates, LLC | 1.065.965 | -12.900 | 31/12/2023 |
0,36 % | Rock Springs Capital Management LP | 1.063.806 | 0 | 31/12/2023 |
0,36 % | BofA Global Research (US) | 1.062.845 | 433.266 | 31/12/2023 |
0,36 % | Morgan Stanley Investment Management Inc. (US) | 1.055.476 | 1.050.060 | 31/12/2023 |
0,33 % | Voya Investment Management LLC | 970.313 | 239.792 | 31/12/2023 |
0,32 % | Cutter Capital Management, LP | 947.418 | 947.418 | 31/12/2023 |
0,31 % | BNP Paribas Securities Corp. North America | 923.045 | 536.480 | 31/12/2023 |
0,29 % | StemPoint Capital LP | 862.815 | 862.815 | 31/12/2023 |
0,29 % | abrdn Inc. | 861.508 | 861.508 | 29/2/2024 |
0,28 % | UBS Financial Services, Inc. | 824.708 | 303.038 | 31/12/2023 |
0,27 % | OrbiMed Advisors, LLC | 806.000 | 806.000 | 31/12/2023 |
0,27 % | Rafferty Asset Management LLC | 795.351 | 87.112 | 31/12/2023 |
0,26 % | Candriam Luxembourg S.A. | 759.823 | 0 | 29/2/2024 |
0,25 % | BNY Mellon Asset Management | 749.242 | 1737 | 31/12/2023 |
0,25 % | Voloridge Investment Management, LLC | 734.867 | 734.867 | 31/12/2023 |
0,24 % | Barclays Bank PLC | 724.227 | 315.439 | 31/12/2023 |
0,24 % | Neuberger Berman, LLC | 717.714 | 171.029 | 31/12/2023 |
0,24 % | BioImpact Capital LLC | 715.883 | -256 | 31/12/2023 |
0,24 % | BlackRock Investment Management, LLC | 715.574 | 13.306 | 31/12/2023 |
0,24 % | M&G Investment Management Ltd. | 710.557 | 509.632 | 31/12/2023 |
0,22 % | Medical Strategy GmbH | 654.742 | 0 | 31/12/2023 |
0,20 % | Peregrine Capital Management, LLC | 605.348 | -123.337 | 31/12/2023 |
0,19 % | Candriam Belgium S.A. | 553.879 | -25.000 | 31/12/2023 |
0,17 % | JPMorgan Private Bank (United States) | 515.649 | 206.395 | 31/12/2023 |
0,17 % | Schroder Investment Management Ltd. (SIM) | 510.000 | 510.000 | 31/12/2023 |
0,17 % | Wells Fargo Advisors | 495.047 | -14.688 | 31/12/2023 |
0,17 % | Columbia Threadneedle Investments (US) | 489.756 | 109.622 | 31/12/2023 |
0,16 % | Campbell (Bradley Lewis) | 473.777 | 0 | 1/4/2024 |
0,16 % | Citi Investment Research (US) | 471.318 | 96.651 | 31/12/2023 |
0,15 % | CM Management, LLC | 450.000 | 0 | 31/12/2023 |
0,14 % | Schweizerische Nationalbank | 424.400 | -44.800 | 31/12/2023 |
0,14 % | Envestnet Asset Management, Inc. | 415.382 | 21.654 | 31/12/2023 |
0,14 % | Rhumbline Advisers Ltd. Partnership | 402.640 | -13.480 | 31/12/2023 |
0,13 % | Mellon Investments Corporation | 387.065 | 3294 | 31/12/2023 |
0,13 % | Conestoga Capital Advisors, LLC | 375.202 | -10.180 | 29/2/2024 |
0,13 % | ExodusPoint Capital Management, LP | 372.380 | -569.053 | 31/12/2023 |
0,12 % | Goldman Sachs Asset Management, L.P. | 367.757 | -295.357 | 31/12/2023 |
0,12 % | Hudson Bay Capital Management LP | 360.000 | 185.000 | 31/12/2023 |
0,12 % | Silvercrest Asset Management Group LLC | 358.925 | -74 | 31/12/2023 |
0,11 % | AllianceBernstein L.P. | 340.349 | 3000 | 31/12/2023 |
0,11 % | Parametric Portfolio Associates LLC | 339.971 | 14.794 | 31/12/2023 |
0,11 % | BlackRock Advisors (UK) Limited | 336.870 | 12.488 | 31/3/2024 |
0,11 % | Credit Suisse Funds AG | 326.217 | 4816 | 31/12/2023 |
0,11 % | J.P. Morgan Securities LLC | 320.034 | -20.380 | 31/12/2023 |
0,11 % | HOOPP Investment Management | 318.500 | 43.000 | 31/12/2023 |
0,10 % | Transcend Capital Advisors, LLC | 309.978 | 23.474 | 31/12/2023 |
0,10 % | Caption Management, LLC | 299.500 | 272.500 | 31/12/2023 |
0,10 % | Hillsdale Investment Management Inc. | 294.300 | 23.640 | 31/12/2023 |
0,10 % | D. E. Shaw & Co., L.P. | 286.224 | -73.967 | 31/12/2023 |
0,09 % | Northern Trust Global Investments | 273.054 | -47.039 | 31/12/2023 |
0,09 % | Ambassador Advisors, LLC | 270.993 | -1180 | 31/12/2023 |
0,09 % | BlackRock Asset Management Ireland Limited | 266.911 | 20.636 | 31/12/2023 |
0,09 % | Jane Street Capital, L.L.C. | 262.333 | 129.730 | 31/12/2023 |
0,09 % | Allianz Global Investors GmbH | 262.332 | 7478 | 31/12/2023 |
0,09 % | FundLogic SAS | 260.870 | 194.317 | 31/12/2023 |
0,09 % | New Jersey Division of Investment | 253.532 | 46.541 | 31/12/2023 |
0,09 % | Simplex Trading, LLC | 251.989 | 220.670 | 31/12/2023 |
0,08 % | Quimi (Daphne) | 249.991 | -14.605 | 12/4/2023 |