11.54700 % | Fidelity Management & Research Company LLC | 14,392,175 | -238,466 | 6/30/2024 |
7.84422 % | The Vanguard Group, Inc. | 9,777,040 | 58,630 | 6/30/2024 |
7.11562 % | Janus Henderson Investors | 8,868,907 | 1,195,039 | 6/30/2024 |
6.58196 % | RA Capital Management, LP | 8,203,754 | 0 | 6/30/2024 |
6.32651 % | BlackRock Institutional Trust Company, N.A. | 7,885,361 | 314,385 | 6/30/2024 |
3.68507 % | Wellington Management Company, LLP | 4,593,066 | -326,304 | 6/30/2024 |
3.31639 % | Capital Research Global Investors | 4,133,544 | -6,977 | 6/30/2024 |
3.22737 % | T. Rowe Price Investment Management, Inc. | 4,022,589 | 469,622 | 6/30/2024 |
2.70150 % | State Street Global Advisors (US) | 3,367,147 | 30,055 | 6/30/2024 |
2.47001 % | T. Rowe Price Associates, Inc. | 3,078,615 | -8,212 | 6/30/2024 |
1.95906 % | Geode Capital Management, L.L.C. | 2,441,772 | 154,397 | 6/30/2024 |
1.74519 % | Franklin Advisers, Inc. | 2,175,205 | 278,124 | 6/30/2024 |
1.66957 % | Darwin Global Management Ltd | 2,080,946 | -669,858 | 6/30/2024 |
1.55227 % | Driehaus Capital Management, LLC | 1,934,747 | 66,940 | 6/30/2024 |
1.54794 % | Westfield Capital Management Company, L.P. | 1,929,348 | 343,253 | 6/30/2024 |
1.49439 % | Perceptive Advisors LLC | 1,862,608 | -70,151 | 6/30/2024 |
1.42423 % | Fidelity Institutional Asset Management | 1,775,165 | 144,647 | 6/30/2024 |
1.39187 % | AllianceBernstein L.P. | 1,734,821 | -45,882 | 6/30/2024 |
1.10970 % | Jennison Associates LLC | 1,383,131 | 126,248 | 6/30/2024 |
1.05138 % | Fred Alger Management, LLC | 1,310,436 | -86,275 | 6/30/2024 |
1.04702 % | Commodore Capital LP | 1,305,000 | 445,000 | 6/30/2024 |
0.98253 % | BlackRock Financial Management, Inc. | 1,224,621 | 45,069 | 6/30/2024 |
0.88254 % | Cormorant Asset Management, LP | 1,100,000 | 415,000 | 6/30/2024 |
0.83393 % | Frazier Life Sciences Management, L.P. | 1,039,405 | -100,000 | 6/30/2024 |
0.81758 % | Invesco Advisers, Inc. | 1,019,035 | -1,858 | 6/30/2024 |
0.80499 % | JP Morgan Asset Management | 1,003,336 | 37,836 | 6/30/2024 |
0.78985 % | Norges Bank Investment Management (NBIM) | 984,464 | 68,952 | 6/30/2024 |
0.72384 % | Fidelity Investments Canada ULC | 902,197 | 7,267 | 6/30/2024 |
0.70301 % | Charles Schwab Investment Management, Inc. | 876,237 | 42,619 | 6/30/2024 |
0.67245 % | Northern Trust Investments, Inc. | 838,142 | -28,926 | 6/30/2024 |
0.64851 % | Braidwell LP | 808,303 | -404,400 | 6/30/2024 |
0.63856 % | OrbiMed Advisors, LLC | 795,900 | -270,231 | 6/30/2024 |
0.63626 % | Pivotal Bioventure Partners Investment Advisor LLC | 793,036 | 0 | 6/30/2024 |
0.60433 % | Kynam Capital Management LP | 753,240 | 8,240 | 6/30/2024 |
0.60173 % | Novo Holdings A/S | 750,000 | -200,000 | 9/30/2024 |
0.59303 % | Eventide Asset Management, LLC | 739,153 | 81,947 | 6/30/2024 |
0.56716 % | Woodline Partners LP | 706,903 | 313,199 | 6/30/2024 |
0.55192 % | Maverick Capital, Ltd. | 687,908 | 332,777 | 6/30/2024 |
0.50321 % | Paradigm BioCapital Advisors LP | 627,202 | -612,793 | 6/30/2024 |
0.46133 % | Avoro Capital Advisors LLC | 575,000 | 0 | 6/30/2024 |
0.42755 % | Pictet Asset Management Ltd. | 532,904 | -328,665 | 6/30/2024 |
0.42329 % | American Century Investment Management, Inc. | 527,594 | 65,870 | 6/30/2024 |
0.37121 % | Ensign Peak Advisors, Inc. | 462,682 | -13,018 | 6/30/2024 |
0.35487 % | Amundi Asset Management US, Inc. | 442,308 | 139,951 | 6/30/2024 |
0.34321 % | Pickering (Grant E) | 427,779 | -15,000 | 10/8/2024 |
0.34150 % | Federated Hermes Global Investment Management Corp. | 425,640 | -110 | 6/30/2024 |
0.33594 % | Balyasny Asset Management LP | 418,715 | 418,715 | 6/30/2024 |
0.30929 % | BofA Global Research (US) | 385,494 | 175,420 | 6/30/2024 |
0.30538 % | Goldman Sachs & Company, Inc. | 380,629 | -31,175 | 6/30/2024 |
0.29462 % | Brown Advisory | 367,217 | 316,734 | 6/30/2024 |
0.27900 % | Goldman Sachs Asset Management, L.P. | 347,747 | 61,059 | 6/30/2024 |
0.27878 % | Allspring Global Investments, LLC | 347,474 | 3,922 | 9/30/2024 |
0.25459 % | Nuveen LLC | 317,323 | 10,052 | 6/30/2024 |
0.25066 % | TD Asset Management Inc. | 312,426 | 31,138 | 6/30/2024 |
0.24672 % | Victory Capital Management Inc. | 307,516 | 26,641 | 6/30/2024 |
0.24256 % | BlackRock Investment Management, LLC | 302,327 | 23,446 | 6/30/2024 |
0.24069 % | EcoR1 Capital, LLC | 300,000 | 0 | 6/30/2024 |
0.24069 % | Tang Capital Management, LLC | 300,000 | 0 | 6/30/2024 |
0.23267 % | Farallon Capital Management, L.L.C. | 290,000 | -87,400 | 6/30/2024 |
0.22917 % | Putnam Investment Management, L.L.C. | 285,640 | 41,171 | 6/30/2024 |
0.22786 % | Avidity Partners Management LP | 284,000 | 0 | 6/30/2024 |
0.22722 % | BlackRock Investment Management (UK) Ltd. | 283,204 | 26,464 | 6/30/2024 |
0.22653 % | Eagle Asset Management, Inc. | 282,351 | -56,449 | 6/30/2024 |
0.22416 % | Voya Investment Management LLC | 279,398 | 96,267 | 6/30/2024 |
0.21952 % | Cercano Management LLC | 273,608 | 1,457 | 6/30/2024 |
0.21905 % | Comerica, Inc. | 273,025 | 84,941 | 6/30/2024 |
0.21495 % | BNY Mellon Asset Management | 267,915 | 20,855 | 6/30/2024 |
0.20895 % | Columbia Threadneedle Investments (US) | 260,431 | 162,012 | 6/30/2024 |
0.20883 % | First Turn Management, LLC | 260,281 | 0 | 6/30/2024 |
0.19756 % | Lord, Abbett & Co. LLC | 246,242 | -138,121 | 6/30/2024 |
0.18470 % | D. E. Shaw & Co., L.P. | 230,207 | -137,042 | 6/30/2024 |
0.17755 % | Morgan Stanley & Co. LLC | 221,296 | -72,415 | 6/30/2024 |
0.17304 % | Saturn V Capital Management LP | 215,680 | 30,505 | 6/30/2024 |
0.16346 % | Millennium Management LLC | 203,731 | -3,251 | 6/30/2024 |
0.14934 % | ClearBridge Investments, LLC | 186,141 | 186,141 | 6/30/2024 |
0.14863 % | Soleus Capital Management, L.P. | 185,250 | -22,500 | 6/30/2024 |
0.14762 % | BlackRock Advisors (UK) Limited | 183,988 | 3,293 | 9/30/2024 |
0.14567 % | Parametric Portfolio Associates LLC | 181,563 | -7,614 | 6/30/2024 |
0.14546 % | Schweizerische Nationalbank | 181,300 | 3,300 | 6/30/2024 |
0.14135 % | Mellon Investments Corporation | 176,182 | 30,003 | 6/30/2024 |
0.13302 % | Citi Investment Research (US) | 165,795 | 20,928 | 6/30/2024 |
0.13226 % | SEI Investments Management Corporation | 164,843 | 67,939 | 6/30/2024 |
0.13032 % | Segall Bryant & Hamill, LLC | 162,432 | 4,411 | 6/30/2024 |
0.12780 % | Rhumbline Advisers Ltd. Partnership | 159,295 | 11,001 | 6/30/2024 |
0.12758 % | Macquarie Investment Management | 159,012 | 39,039 | 6/30/2024 |
0.12695 % | BlackRock Asset Management Ireland Limited | 158,235 | 1,236 | 6/30/2024 |
0.12258 % | California Public Employees' Retirement System | 152,778 | -4,208 | 6/30/2024 |
0.12050 % | Parkman Healthcare Partners LLC | 150,191 | 235 | 6/30/2024 |
0.12035 % | Ghost Tree Capital, LLC | 150,000 | 55,000 | 6/30/2024 |
0.11211 % | First Light Asset Management, LLC | 139,729 | 79,445 | 6/30/2024 |
0.10570 % | Manulife Investment Management (North America) Limited | 131,749 | 12,667 | 6/30/2024 |
0.10266 % | Barclays Bank PLC | 127,952 | -1,300 | 6/30/2024 |
0.09224 % | Pier Capital, LLC | 114,969 | -12,415 | 6/30/2024 |
0.09094 % | Tri Locum Partners LP | 113,344 | 113,344 | 6/30/2024 |
0.08858 % | Acuta Capital Partners, LLC | 110,400 | 5,570 | 6/30/2024 |
0.08672 % | Neuberger Berman, LLC | 108,092 | 5,781 | 6/30/2024 |
0.08554 % | Jane Street Capital, L.L.C. | 106,611 | 90,929 | 6/30/2024 |
0.08502 % | JPMorgan Asset Management U.K. Limited | 105,974 | 1,052 | 6/30/2024 |
0.08423 % | Legal & General Investment Management Ltd. | 104,984 | 10,201 | 6/30/2024 |
0.08336 % | MFS Investment Management | 103,906 | 2,967 | 8/31/2024 |