8.05955 % | Vestal Point Capital, LP | 3,925,000 | 3,925,000 | 12/31/2023 |
7.14347 % | State Street Global Advisors (US) | 3,478,872 | 28,590 | 12/31/2023 |
6.07398 % | Nantahala Capital Management, LLC | 2,958,027 | -65,772 | 12/31/2023 |
4.90371 % | Bristol Myers Squibb | 2,388,108 | 0 | 9/15/2023 |
3.47639 % | 683 Capital Management LLC | 1,693,000 | 118,000 | 12/31/2023 |
3.00161 % | BlackRock Institutional Trust Company, N.A. | 1,461,782 | 206,012 | 12/31/2023 |
2.76776 % | OrbiMed Advisors, LLC | 1,347,900 | -716,555 | 12/31/2023 |
2.71919 % | Pictet Asset Management Ltd. | 1,324,246 | 320,552 | 12/31/2023 |
2.54928 % | Schroder Investment Management Ltd. (SIM) | 1,241,500 | 1,241,500 | 12/31/2023 |
2.54928 % | International Biotechnology Trust PLC | 1,241,500 | 1,226,000 | 9/30/2023 |
2.42149 % | Morgan Stanley & Co. LLC | 1,179,265 | -568,827 | 12/31/2023 |
1.97699 % | The Vanguard Group, Inc. | 962,796 | 18,348 | 12/31/2023 |
1.91255 % | Point72 Asset Management, L.P. | 931,410 | 886,584 | 12/31/2023 |
1.68431 % | Columbia Threadneedle Investments (US) | 820,260 | 445,795 | 12/31/2023 |
1.52754 % | Citi Investment Research (US) | 743,910 | -22,611 | 12/31/2023 |
1.45107 % | BNP Paribas Securities Corp. North America | 706,670 | 448,319 | 12/31/2023 |
1.45003 % | Macquarie Investment Management | 706,166 | 0 | 12/31/2023 |
1.42781 % | Goldman Sachs & Company, Inc. | 695,345 | 233,526 | 12/31/2023 |
1.23203 % | Tang Capital Management, LLC | 600,000 | -335,800 | 12/31/2023 |
1.16957 % | JPMorgan Asset Management U.K. Limited | 569,582 | 0 | 12/31/2023 |
1.15058 % | D. E. Shaw & Co., L.P. | 560,331 | 148,595 | 12/31/2023 |
1.13388 % | Morgan Stanley Investment Management Inc. (US) | 552,200 | -331,806 | 12/31/2023 |
0.99070 % | Pictet Asset Management (Japan) Ltd. | 482,473 | 168,042 | 10/31/2023 |
0.98496 % | Geode Capital Management, L.L.C. | 479,675 | 31,443 | 12/31/2023 |
0.93526 % | Millennium Management LLC | 455,472 | 75,712 | 12/31/2023 |
0.91201 % | Privium Fund Management BV | 444,148 | 162,542 | 12/31/2023 |
0.87269 % | Hudson Bay Capital Management LP | 425,000 | 34,800 | 12/31/2023 |
0.86453 % | LifeSci Fund Management LLC | 421,025 | 29,525 | 12/31/2023 |
0.86453 % | AlphaCentric Advisors LLC. | 421,025 | 29,525 | 12/31/2023 |
0.82234 % | abrdn Inc. | 400,480 | 400,480 | 12/31/2023 |
0.76972 % | Kapusta Matthew C | 374,853 | 150,000 | 3/1/2024 |
0.75725 % | Rafferty Asset Management LLC | 368,783 | -22,061 | 12/31/2023 |
0.74404 % | Bridger Management, LLC | 362,349 | 350,340 | 12/31/2023 |
0.73158 % | Tekla Capital Management LLC_NLE | 356,280 | -296,166 | 6/30/2023 |
0.62307 % | Verition Fund Management LLC | 303,435 | -340,207 | 12/31/2023 |
0.60584 % | Bank Vontobel AG | 295,042 | 242,214 | 12/31/2023 |
0.60080 % | Sectoral Asset Management Inc. | 292,592 | 292,592 | 12/31/2023 |
0.56441 % | BofA Global Research (US) | 274,869 | -79,157 | 12/31/2023 |
0.56355 % | Cubist Systematic Strategies, LLC | 274,448 | 77,286 | 12/31/2023 |
0.54315 % | Renaissance Technologies LLC | 264,513 | -184,599 | 12/31/2023 |
0.54045 % | Acadian Asset Management LLC | 263,199 | 263,199 | 12/31/2023 |
0.48297 % | Silvercrest Asset Management Group LLC | 235,205 | -18,462 | 12/31/2023 |
0.45665 % | Charles Schwab Investment Management, Inc. | 222,389 | -18,623 | 12/31/2023 |
0.42526 % | Norges Bank Investment Management (NBIM) | 207,100 | -566,394 | 12/31/2023 |
0.40041 % | Carlson Capital, L.P. | 195,000 | -100 | 12/31/2023 |
0.38646 % | Algert Global LLC | 188,205 | -226,036 | 12/31/2023 |
0.35703 % | BlackRock Investment Management (UK) Ltd. | 173,876 | -25,763 | 12/31/2023 |
0.35122 % | Citadel Advisors LLC | 171,044 | -370,868 | 12/31/2023 |
0.35093 % | J.P. Morgan Securities LLC | 170,904 | 156,397 | 12/31/2023 |
0.34646 % | Susquehanna International Group, LLP | 168,724 | -73,831 | 12/31/2023 |
0.34497 % | UBS Financial Services, Inc. | 168,002 | 81,533 | 12/31/2023 |
0.34253 % | Kuta (Alexander Edward III) | 166,812 | 105,581 | 9/15/2023 |
0.33881 % | Ghost Tree Capital, LLC | 165,000 | -50,000 | 12/31/2023 |
0.32313 % | Ikarian Capital LLC | 157,365 | 0 | 12/31/2023 |
0.30857 % | Two Sigma Investments, LP | 150,276 | 88,917 | 12/31/2023 |
0.29689 % | Banque Pictet & Cie S.A. | 144,585 | -16,044 | 12/31/2023 |
0.28902 % | Walleye Capital LLC | 140,755 | 14,777 | 12/31/2023 |
0.28029 % | Barclays Bank PLC | 136,502 | -56,444 | 12/31/2023 |
0.25735 % | Medical Strategy GmbH | 125,331 | 0 | 9/30/2023 |
0.25575 % | Schonfeld Strategic Advisors LLC | 124,549 | -258,080 | 12/31/2023 |
0.24943 % | BlackRock Financial Management, Inc. | 121,470 | -30,366 | 12/31/2023 |
0.23963 % | Abi-Saab (Walid) | 116,700 | 49,500 | 3/1/2024 |
0.23674 % | Squarepoint Capital LLP | 115,292 | 115,292 | 12/31/2023 |
0.22358 % | Jump Financial, LLC | 108,882 | -13,736 | 12/31/2023 |
0.21602 % | Jane Street Capital, L.L.C. | 105,202 | -187,173 | 12/31/2023 |
0.21424 % | Nomura Securities Co., Ltd. | 104,336 | 94,336 | 12/31/2023 |
0.20575 % | PDT Partners, LLC | 100,201 | -29,914 | 12/31/2023 |
0.19836 % | Potts (Jeannette) | 96,600 | 49,500 | 3/1/2024 |
0.19507 % | UBS O'Connor LLC | 95,000 | 6,035 | 12/31/2023 |
0.18752 % | Klemt (Christian) | 91,321 | 49,500 | 3/1/2024 |
0.18553 % | Mirae Asset Global Investments (USA) LLC | 90,354 | -124,332 | 12/31/2023 |
0.17438 % | Northern Trust Investments, Inc. | 84,924 | -24,194 | 12/31/2023 |
0.16453 % | RBC Capital Markets Wealth Management | 80,125 | 12,595 | 12/31/2023 |
0.16285 % | SELECTRA Management Company S.A. | 79,306 | 0 | 6/30/2023 |
0.15844 % | AQR Capital Management, LLC | 77,161 | -58,289 | 12/31/2023 |
0.14130 % | Qube Research & Technologies Ltd | 68,813 | -50,098 | 12/31/2023 |
0.13977 % | Sanders Morris LLC | 68,070 | 0 | 3/31/2024 |
0.13470 % | Pale Fire Capital SE | 65,600 | 5,500 | 12/31/2023 |
0.13030 % | Caloz (Pierre Alain) | 63,456 | 33,000 | 3/1/2024 |
0.12726 % | BlackRock Asset Management Ireland Limited | 61,976 | -38,270 | 12/31/2023 |
0.12320 % | Moore Capital Management, LP | 60,000 | 0 | 12/31/2023 |
0.11948 % | ProFund Advisors LLC | 58,187 | -5,985 | 12/31/2023 |
0.11680 % | HRT Financial LP | 56,881 | -154,765 | 12/31/2023 |
0.11126 % | Diamond Hill Capital Management Inc. | 54,185 | 29,277 | 12/31/2023 |
0.10974 % | Florida State Board of Administration | 53,443 | 53,443 | 9/30/2022 |
0.10724 % | Raymond James & Associates, Inc. | 52,224 | 3,145 | 12/31/2023 |
0.10611 % | BlackRock Advisors (UK) Limited | 51,676 | -3,159 | 3/31/2024 |
0.10547 % | Bellecapital Partners AG | 51,363 | 0 | 9/30/2023 |
0.10430 % | Engineers Gate Manager, L.P. | 50,794 | 11,990 | 12/31/2023 |
0.10399 % | Allianz Global Investors GmbH | 50,642 | -131,753 | 12/31/2023 |
0.10325 % | Group One Trading, L.P. | 50,281 | 28,713 | 12/31/2023 |
0.10267 % | Sonic GP LLC | 50,000 | 0 | 12/31/2023 |
0.10017 % | Fidelity Management & Research Company LLC | 48,782 | -147,358 | 12/31/2023 |
0.09959 % | Pennant Investors, LP | 48,500 | 48,500 | 12/31/2023 |
0.09800 % | Dolmetsch (Ricardo) | 47,728 | 12,492 | 9/18/2023 |
0.09762 % | Avantis Investors | 47,540 | 14,561 | 3/31/2024 |
0.09137 % | American Century Investment Management, Inc. | 44,496 | 11,332 | 12/31/2023 |
0.08480 % | Erste Asset Management GmbH | 41,300 | 0 | 12/31/2023 |
0.08478 % | Henry James International Management, Inc. | 41,286 | -1,307 | 12/31/2023 |
0.08090 % | Deka Investment GmbH | 39,400 | 39,400 | 12/31/2022 |