13.03791 % | Skorpios Trust | 6,906,181 | -2,000,000 | 12/31/2024 |
9.79270 % | Lynx1 Capital Advisors LLC | 5,187,191 | 0 | 12/31/2024 |
9.67250 % | RTW Investments L.P. | 5,123,525 | 471,240 | 12/31/2024 |
8.74804 % | Baker Bros. Advisors LP | 4,633,838 | 265,395 | 12/31/2024 |
8.67213 % | Redmile Group, LLC | 4,593,629 | -119,880 | 12/31/2024 |
5.99067 % | TD Securities, Inc. | 3,173,258 | 3,173,258 | 12/31/2024 |
5.59165 % | Morgan Stanley & Co. LLC | 2,961,896 | -551,359 | 12/31/2024 |
5.34054 % | BlackRock Institutional Trust Company, N.A. | 2,828,882 | 288,009 | 12/31/2024 |
5.14263 % | The Vanguard Group, Inc. | 2,724,051 | -28,049 | 12/31/2024 |
3.77572 % | Invus Public Equities Advisors, LLC | 2,000,000 | 2,000,000 | 12/31/2024 |
3.54033 % | Harrison (Seth Loring) | 1,875,313 | 0 | 3/31/2024 |
3.40286 % | BlackRock Financial Management, Inc. | 1,802,495 | -5,826 | 12/31/2024 |
2.99729 % | State Street Global Advisors (US) | 1,587,663 | -141,225 | 12/31/2024 |
2.55036 % | Assenagon Asset Management S.A. | 1,350,925 | 38,446 | 12/31/2024 |
2.45715 % | Goldman Sachs & Company, Inc. | 1,301,552 | 2,167 | 12/31/2024 |
1.90167 % | BlackRock Investment Management (UK) Ltd. | 1,007,316 | 3,510 | 12/31/2024 |
1.79617 % | Marshall Wace LLP | 951,432 | -719,301 | 12/31/2024 |
1.65583 % | Geode Capital Management, L.L.C. | 877,095 | 6,264 | 12/31/2024 |
1.29474 % | MPM BioImpact LLC | 685,826 | 206,374 | 12/31/2024 |
1.07172 % | Granahan Investment Management, LLC | 567,689 | -77,281 | 12/31/2024 |
1.01737 % | Dimensional Fund Advisors, L.P. | 538,900 | 273,890 | 12/31/2024 |
0.87731 % | Morgan Stanley Investment Management Inc. (US) | 464,713 | -219,100 | 12/31/2024 |
0.76405 % | Krainer (Adrian R) | 404,718 | 0 | 3/31/2024 |
0.66033 % | DWS Investments UK Limited | 349,779 | -111,861 | 12/31/2024 |
0.65269 % | Northern Trust Investments, Inc. | 345,730 | 40,918 | 12/31/2024 |
0.64589 % | Charles Schwab Investment Management, Inc. | 342,129 | 25,995 | 12/31/2024 |
0.59430 % | Norges Bank Investment Management (NBIM) | 314,800 | 290,100 | 12/31/2024 |
0.57653 % | Checkpoint Capital L.P. | 305,387 | 147,873 | 12/31/2024 |
0.56636 % | Tang Capital Management, LLC | 300,000 | 300,000 | 12/31/2024 |
0.55087 % | Schonfeld Strategic Advisors LLC | 291,795 | 291,795 | 12/31/2024 |
0.47982 % | Cormorant Asset Management, LP | 254,161 | -173,002 | 12/31/2024 |
0.39645 % | Birchview Capital, LP | 210,000 | 0 | 12/31/2024 |
0.35650 % | Victory Capital Management Inc. | 188,838 | 7,757 | 12/31/2024 |
0.35474 % | Susquehanna International Group, LLP | 187,908 | 53,767 | 12/31/2024 |
0.33574 % | UBS Financial Services, Inc. | 177,844 | 102,005 | 12/31/2024 |
0.32301 % | Dafna Capital Management, LLC | 171,097 | -36,330 | 12/31/2024 |
0.31187 % | Fidelity Management & Research Company LLC | 165,196 | -157,753 | 12/31/2024 |
0.27063 % | BlackRock Investment Management, LLC | 143,355 | -19 | 12/31/2024 |
0.25451 % | Wellington Management Company, LLP | 134,812 | -2,163 | 12/31/2024 |
0.24362 % | Renaissance Technologies LLC | 129,043 | 129,043 | 12/31/2024 |
0.23761 % | Palo Alto Investors LP | 125,861 | 0 | 12/31/2024 |
0.22700 % | Squarepoint Capital LLP | 120,242 | 7,575 | 12/31/2024 |
0.21351 % | Exome Asset Management LLC | 113,096 | -63,504 | 12/31/2024 |
0.19711 % | Group One Trading, L.P. | 104,411 | 2,637 | 12/31/2024 |
0.19685 % | PanAgora Asset Management Inc. | 104,272 | 104,272 | 12/31/2024 |
0.19565 % | Bellecapital AG | 103,634 | 0 | 7/31/2024 |
0.19451 % | Trexquant Investment LP | 103,031 | -58,718 | 12/31/2024 |
0.19263 % | Nuveen LLC | 102,034 | 0 | 12/31/2024 |
0.18291 % | Kaye (Edward M) | 96,885 | 69,885 | 12/30/2024 |
0.17916 % | Woodline Partners LP | 94,903 | 521 | 12/31/2024 |
0.17478 % | Citadel Advisors LLC | 92,580 | 85,630 | 12/31/2024 |
0.17471 % | Gilder Gagnon Howe & Co. LLC | 92,546 | 1,791 | 12/31/2024 |
0.16403 % | Voloridge Investment Management, LLC | 86,888 | -36,261 | 12/31/2024 |
0.15743 % | BlackRock Asset Management Ireland Limited | 83,389 | 22,677 | 12/31/2024 |
0.15733 % | BlackRock Advisors (UK) Limited | 83,338 | -51 | 1/31/2025 |
0.15124 % | Barclays Bank PLC | 80,112 | 372 | 12/31/2024 |
0.14504 % | Millennium Management LLC | 76,829 | 61,994 | 12/31/2024 |
0.14240 % | Fort Point Capital Partners, LLC | 75,429 | 0 | 12/31/2024 |
0.13255 % | UBS Asset Management (Switzerland) | 70,213 | 52,813 | 12/31/2024 |
0.12727 % | Goldman Sachs Asset Management, L.P. | 67,415 | -26,960 | 12/31/2024 |
0.12705 % | Schweizerische Nationalbank | 67,300 | 11,400 | 12/31/2024 |
0.12692 % | Rafferty Asset Management LLC | 67,227 | -15,561 | 12/31/2024 |
0.11060 % | BNY Mellon Asset Management | 58,585 | -324 | 12/31/2024 |
0.10975 % | Citi Investment Research (US) | 58,133 | 32,467 | 12/31/2024 |
0.10185 % | Two Sigma Investments, LP | 53,950 | -77,228 | 12/31/2024 |
0.09321 % | Rhumbline Advisers Ltd. Partnership | 49,374 | 2,787 | 12/31/2024 |
0.08447 % | Ticho (Baruch S) | 44,746 | 42,261 | 12/9/2024 |
0.08200 % | Los Angeles Capital Management LLC | 43,438 | -59,567 | 12/31/2024 |
0.08086 % | Alps Advisors, Inc. | 42,830 | 42,830 | 12/31/2024 |
0.07670 % | AllianceBernstein L.P. | 40,630 | 0 | 12/31/2024 |
0.07287 % | UBS Asset Management (UK) Ltd. | 38,600 | 28,000 | 11/30/2024 |
0.07210 % | Dimensional Fund Advisors, Ltd. | 38,191 | -2,294 | 11/30/2024 |
0.07071 % | T. Rowe Price International Ltd | 37,455 | 2,215 | 12/31/2024 |
0.06673 % | Legal & General Investment Management Ltd. | 35,347 | -2,139 | 12/31/2024 |
0.06054 % | California State Teachers Retirement System | 32,068 | 4,468 | 12/31/2024 |
0.06035 % | Entrypoint Capital LLC | 31,968 | 31,968 | 12/31/2024 |
0.05992 % | Tzianabos (Arthur) | 31,739 | 0 | 3/31/2024 |
0.05988 % | State of Wisconsin Investment Board | 31,716 | -7,398 | 12/31/2024 |
0.05725 % | Mellon Investments Corporation | 30,324 | 1,654 | 12/31/2024 |
0.05574 % | Prelude Capital Management, LLC | 29,528 | -20,372 | 12/31/2024 |
0.05484 % | Avantis Investors | 29,048 | 8,696 | 3/31/2024 |
0.05294 % | D. E. Shaw & Co., L.P. | 28,043 | -143,203 | 12/31/2024 |
0.04775 % | UBS Fund Management (Switzerland) AG | 25,292 | 0 | 12/31/2024 |
0.04721 % | Engineers Gate Manager, L.P. | 25,005 | 800 | 12/31/2024 |
0.04720 % | Opaleye Management Inc. | 25,000 | 25,000 | 12/31/2024 |
0.04679 % | Mirae Asset Global Investments (USA) LLC | 24,783 | 2,078 | 12/31/2024 |
0.04459 % | AQR Capital Management, LLC | 23,619 | -51,470 | 12/31/2024 |
0.04438 % | Acuitas Investments LLC | 23,509 | 0 | 9/30/2024 |
0.04213 % | Franklin Advisers, Inc. | 22,314 | 0 | 12/31/2024 |
0.03928 % | MetLife Investment Management, LLC | 20,805 | 0 | 12/31/2024 |
0.03917 % | Tulipano (Stephen J) | 20,746 | 8,984 | 3/31/2024 |
0.03568 % | Janus Henderson Investors | 18,900 | 0 | 12/31/2024 |
0.03518 % | Graham Capital Management, L.P. | 18,634 | 1,453 | 12/31/2024 |
0.03447 % | Tudor Investment Corporation | 18,258 | 18,258 | 12/31/2024 |
0.03407 % | Freestone Grove Partners LP | 18,049 | 18,049 | 12/31/2024 |
0.03394 % | Levin (Arthur A.) | 17,979 | 0 | 3/31/2024 |
0.03372 % | Corebridge Financial Inc. | 17,861 | -1,155 | 12/31/2024 |
0.03368 % | BlackRock (Netherlands) B.V. | 17,839 | 17,523 | 12/31/2024 |
0.03169 % | Wells Fargo Bank, N.A. | 16,786 | 5,833 | 12/31/2024 |
0.03127 % | Allan (Jonathan) | 16,565 | 16,565 | 12/9/2024 |