9.26080 % | The Vanguard Group, Inc. | 17,069,500 | 2,183,617 | 12/31/2024 |
7.18788 % | Farallon Capital Management, L.L.C. | 13,248,692 | 1,931,000 | 12/31/2024 |
6.85477 % | BlackRock Institutional Trust Company, N.A. | 12,634,707 | 1,077,411 | 12/31/2024 |
5.87114 % | Wellington Management Company, LLP | 10,821,691 | -579,703 | 12/31/2024 |
5.14540 % | Janus Henderson Investors | 9,483,999 | 3,346,755 | 12/31/2024 |
4.30608 % | Baker Bros. Advisors LP | 7,936,972 | 367,882 | 12/31/2024 |
4.12385 % | Nextech Invest, Ltd. | 7,601,087 | 1,304,347 | 12/31/2024 |
3.55529 % | Paradigm BioCapital Advisors LP | 6,553,111 | 1,239,022 | 12/31/2024 |
3.54198 % | Fidelity Management & Research Company LLC | 6,528,585 | 653,676 | 12/31/2024 |
3.14223 % | State Street Global Advisors (US) | 5,791,752 | 512,168 | 12/31/2024 |
3.10216 % | T. Rowe Price Associates, Inc. | 5,717,900 | 565,461 | 12/31/2024 |
2.38005 % | Bellevue Asset Management AG | 4,386,900 | -484,460 | 12/31/2024 |
2.32176 % | Boxer Capital Management, LLC | 4,279,464 | 4,279,464 | 12/31/2024 |
2.26843 % | BVF Partners L.P. | 4,181,179 | 702,567 | 12/31/2024 |
2.24245 % | Alphabet, Inc. | 4,133,277 | -122,898 | 12/31/2024 |
2.21690 % | Geode Capital Management, L.L.C. | 4,086,199 | 459,174 | 12/31/2024 |
2.10813 % | Woodline Partners LP | 3,885,713 | 452,000 | 12/31/2024 |
2.00699 % | Casdin Capital, LLC | 3,699,283 | -415,000 | 12/31/2024 |
1.76776 % | Deerfield Management Company, L.P. | 3,258,332 | 345,640 | 12/31/2024 |
1.62582 % | Holocene Advisors, LP | 2,996,710 | 847,149 | 12/31/2024 |
1.54211 % | JP Morgan Asset Management | 2,842,424 | -413,223 | 12/31/2024 |
1.49117 % | Andreessen Horowitz | 2,748,523 | 0 | 12/31/2024 |
1.26440 % | Borisy (Alexis) | 2,330,542 | 4,248 | 6/20/2024 |
1.19151 % | Lunate Holding RSC Ltd | 2,196,200 | 2,196,200 | 12/31/2024 |
1.07352 % | Lord, Abbett & Co. LLC | 1,978,720 | 146,699 | 12/31/2024 |
1.04770 % | Charles Schwab Investment Management, Inc. | 1,931,114 | 167,997 | 12/31/2024 |
0.99948 % | Goldman Sachs & Company, Inc. | 1,842,236 | 137,268 | 12/31/2024 |
0.94512 % | Norges Bank Investment Management (NBIM) | 1,742,039 | -106,608 | 12/31/2024 |
0.91061 % | Hood River Capital Management LLC | 1,678,434 | 345,622 | 12/31/2024 |
0.81641 % | Marshall Wace LLP | 1,504,801 | 439,802 | 12/31/2024 |
0.79480 % | Northern Trust Investments, Inc. | 1,464,978 | 273,175 | 12/31/2024 |
0.78668 % | Logos Global Management LLC | 1,450,000 | 250,000 | 12/31/2024 |
0.70684 % | Balyasny Asset Management LP | 1,302,848 | -348,957 | 12/31/2024 |
0.65823 % | Rock Springs Capital Management LP | 1,213,257 | 203,312 | 12/31/2024 |
0.54621 % | Columbia Threadneedle Investments (UK) | 1,006,773 | 328,691 | 12/31/2024 |
0.54115 % | Frazier Life Sciences Management, L.P. | 997,455 | 0 | 9/30/2024 |
0.50140 % | BlackRock Financial Management, Inc. | 924,186 | -77,336 | 12/31/2024 |
0.42485 % | Candriam Luxembourg S.A. | 783,079 | 68,495 | 12/31/2024 |
0.41997 % | Goldman Sachs Asset Management, L.P. | 774,082 | 137,740 | 12/31/2024 |
0.40726 % | Polar Capital LLP | 750,665 | 750,665 | 12/31/2024 |
0.38661 % | Pictet Asset Management Ltd. | 712,596 | 696,759 | 12/31/2024 |
0.38534 % | Finepoint Capital LP | 710,260 | -21,700 | 12/31/2024 |
0.35630 % | Candriam Belgium S.A. | 656,740 | 92,958 | 12/31/2024 |
0.35338 % | Goldsmith Mark A | 651,341 | 19,132 | 12/18/2024 |
0.35265 % | Adage Capital Management, L.P. | 650,000 | 360,000 | 12/31/2024 |
0.34812 % | American Century Investment Management, Inc. | 641,646 | 64,238 | 12/31/2024 |
0.34243 % | Dafna Capital Management, LLC | 631,176 | 113,182 | 12/31/2024 |
0.31008 % | Invus Public Equities Advisors, LLC | 571,548 | -182,053 | 12/31/2024 |
0.30548 % | Morgan Stanley & Co. LLC | 563,061 | 109,294 | 12/31/2024 |
0.29839 % | Integral Health Asset Management, LLC | 550,000 | 200,000 | 12/31/2024 |
0.27592 % | MIC Capital Management UK LLP | 508,569 | 0 | 12/31/2024 |
0.25752 % | BlackRock Advisors (UK) Limited | 474,664 | -1,934 | 1/31/2025 |
0.25608 % | JPMorgan Asset Management U.K. Limited | 472,001 | -24,545 | 12/31/2024 |
0.24873 % | Pzena Investment Management, LLC | 458,454 | -56,147 | 12/31/2024 |
0.24468 % | BlackRock Asset Management Ireland Limited | 451,003 | -6,304 | 12/31/2024 |
0.24354 % | BlackRock Investment Management, LLC | 448,902 | 24,088 | 12/31/2024 |
0.24208 % | Avidity Partners Management LP | 446,200 | -343,800 | 12/31/2024 |
0.23354 % | Victory Capital Management Inc. | 430,462 | -7,288 | 12/31/2024 |
0.22897 % | Nuveen LLC | 422,041 | 15,896 | 12/31/2024 |
0.22809 % | Columbia Wanger Asset Management, LLC | 420,414 | 0 | 12/31/2024 |
0.22058 % | Barclays Bank PLC | 406,575 | 114,017 | 12/31/2024 |
0.21914 % | First Turn Management, LLC | 403,915 | 403,915 | 12/31/2024 |
0.21038 % | Dimensional Fund Advisors, L.P. | 387,775 | -6,698 | 12/31/2024 |
0.20591 % | J.P. Morgan Securities LLC | 379,533 | 258,848 | 12/31/2024 |
0.20195 % | Eventide Asset Management, LLC | 372,229 | -150,822 | 12/31/2024 |
0.18348 % | Partners HealthCare System, Inc | 338,191 | 0 | 9/30/2024 |
0.17452 % | AHL Partners LLP | 321,673 | 65,749 | 12/31/2024 |
0.17449 % | Raymond James Financial Inc | 321,611 | 321,611 | 12/31/2024 |
0.17274 % | JPMorgan Asset Management (Europe) S.à.r.l. | 318,387 | -4,162 | 12/31/2024 |
0.17146 % | Voya Investment Management LLC | 316,028 | 3,901 | 12/31/2024 |
0.17026 % | MPM BioImpact LLC | 313,817 | 22,426 | 12/31/2024 |
0.16863 % | BofA Global Research (US) | 310,813 | -85,306 | 12/31/2024 |
0.16557 % | Ensign Peak Advisors, Inc. | 305,172 | 265,389 | 12/31/2024 |
0.15990 % | UBS Financial Services, Inc. | 294,728 | 111,025 | 12/31/2024 |
0.15983 % | BNY Mellon Asset Management | 294,598 | 17,789 | 12/31/2024 |
0.15418 % | Artia Global Partners LP | 284,190 | 188,305 | 12/31/2024 |
0.15266 % | TD Asset Management Inc. | 281,386 | 37,852 | 12/31/2024 |
0.14565 % | Citi Investment Research (US) | 268,454 | 150,516 | 12/31/2024 |
0.14556 % | California Public Employees' Retirement System | 268,289 | 39,475 | 12/31/2024 |
0.13949 % | Ghisallo Capital Management LLC | 257,100 | 257,100 | 12/31/2024 |
0.13643 % | Rhumbline Advisers Ltd. Partnership | 251,465 | 24,473 | 12/31/2024 |
0.13554 % | HSBC Global Asset Management (France) S.A. | 249,828 | -19,031 | 12/31/2024 |
0.13554 % | HSBC Private Bank (Suisse) S.A. | 249,828 | 17,527 | 12/31/2024 |
0.13548 % | Mellon Investments Corporation | 249,708 | 17,763 | 12/31/2024 |
0.13473 % | BNP Paribas Securities Corp. North America | 248,326 | 248,326 | 12/31/2024 |
0.13214 % | Bessemer Trust Company, N.A. (US) | 243,558 | 0 | 12/31/2024 |
0.12887 % | Manulife Investment Management (North America) Limited | 237,539 | 24,698 | 12/31/2024 |
0.12746 % | AllianceBernstein L.P. | 234,929 | -15,932 | 12/31/2024 |
0.12524 % | Qube Research & Technologies Ltd | 230,845 | 87,771 | 12/31/2024 |
0.12475 % | Schweizerische Nationalbank | 229,931 | 4,400 | 12/31/2024 |
0.12398 % | Susquehanna Fundamental Investments, LLC | 228,513 | 0 | 12/31/2024 |
0.12261 % | Decheng Capital LLC | 226,000 | 224,000 | 12/31/2024 |
0.12078 % | Parametric Portfolio Associates LLC | 222,630 | 37,596 | 12/31/2024 |
0.11583 % | Fidelity Institutional Asset Management | 213,498 | 212,514 | 12/31/2024 |
0.11537 % | Walleye Capital LLC | 212,656 | -111,076 | 12/31/2024 |
0.11393 % | Checkpoint Capital L.P. | 210,000 | 210,000 | 12/31/2024 |
0.11306 % | Connor, Clark & Lunn Investment Management Ltd. | 208,401 | 181,500 | 12/31/2024 |
0.10910 % | Soleus Capital Management, L.P. | 201,084 | -503,500 | 12/31/2024 |
0.10500 % | StemPoint Capital LP | 193,535 | 176,881 | 12/31/2024 |
0.10336 % | Raymond James & Associates, Inc. | 190,505 | 116,135 | 9/30/2024 |