6.24624 % | Boxer Capital, L.L.C. | 4,407,350 | 2,967,350 | 1/8/2024 |
5.34019 % | Samsara BioCapital, LLC | 3,768,035 | 900,000 | 3/29/2024 |
5.05780 % | New Enterprise Associates (NEA) | 3,568,781 | 0 | 3/27/2024 |
4.88946 % | Adage Capital Management, L.P. | 3,450,000 | -250,000 | 12/31/2023 |
4.81859 % | Deerfield Management Company, L.P. | 3,400,000 | 0 | 12/31/2023 |
4.48049 % | GSK plc | 3,161,432 | 3,161,432 | 3/27/2024 |
4.02004 % | EQT Life Sciences | 2,836,539 | 2,836,539 | 2/8/2024 |
3.86905 % | Commodore Capital LP | 2,730,000 | 0 | 12/31/2023 |
3.13065 % | BlackRock Institutional Trust Company, N.A. | 2,208,990 | -193,835 | 12/31/2023 |
2.21162 % | The Vanguard Group, Inc. | 1,560,518 | 61,778 | 12/31/2023 |
15.31339 % | RA Capital Management, LP | 10,805,129 | 3,000,000 | 3/27/2024 |
1.88964 % | SR One Capital Management, LP | 1,333,333 | 0 | 12/31/2023 |
1.65603 % | Wasatch Global Investors Inc | 1,168,492 | -931,207 | 3/31/2024 |
0.93222 % | Renaissance Technologies LLC | 657,772 | 145,200 | 12/31/2023 |
0.92650 % | Geode Capital Management, L.L.C. | 653,740 | 21,013 | 12/31/2023 |
0.86713 % | State Street Global Advisors (US) | 611,849 | 4,545 | 12/31/2023 |
0.77948 % | Tang Capital Management, LLC | 550,000 | -553,638 | 12/31/2023 |
0.65595 % | T. Rowe Price Investment Management, Inc. | 462,838 | 32,488 | 12/31/2023 |
0.63879 % | Alyeska Investment Group, L.P. | 450,731 | -549,269 | 12/31/2023 |
0.59244 % | Columbia Threadneedle Investments (UK) | 418,024 | 418,024 | 2/29/2024 |
0.53779 % | Bridgeway Capital Management, LLC | 379,467 | -225,700 | 12/31/2023 |
0.49232 % | Superstring Capital Management LP | 347,381 | 347,381 | 12/31/2023 |
0.47847 % | JPMorgan Asset Management U.K. Limited | 337,607 | 0 | 12/31/2023 |
0.41611 % | BlackRock Financial Management, Inc. | 293,606 | -20,759 | 12/31/2023 |
0.39177 % | Northern Trust Investments, Inc. | 276,431 | -1,964 | 12/31/2023 |
0.35525 % | Marshall Wace LLP | 250,667 | 250,667 | 12/31/2023 |
0.35431 % | Jefferies LLC | 250,000 | 0 | 12/31/2023 |
0.29374 % | Stifel, Nicolaus & Company, Incorporated | 207,264 | -319,362 | 12/31/2023 |
0.27438 % | Invesco Capital Management LLC | 193,602 | -71,767 | 12/31/2023 |
0.21350 % | Two Sigma Investments, LP | 150,645 | 72,545 | 12/31/2023 |
0.20724 % | Jane Street Capital, L.L.C. | 146,231 | 146,231 | 12/31/2023 |
0.20609 % | Trager (James) | 145,415 | -4,143 | 2/12/2024 |
0.19694 % | Innovis Asset Management LLC | 138,962 | 138,962 | 9/30/2023 |
0.19659 % | Fidelity Management & Research Company LLC | 138,713 | 134,355 | 12/31/2023 |
0.17311 % | BofA Global Research (US) | 122,145 | 10,367 | 12/31/2023 |
0.17188 % | Hastings (Paul J) | 121,280 | -150,000 | 3/4/2024 |
0.16297 % | Parametric Portfolio Associates LLC | 114,991 | -37,906 | 12/31/2023 |
0.15728 % | Shook (David M.D.) | 110,980 | 52,448 | 1/16/2024 |
0.15325 % | Medical Strategy GmbH | 108,136 | 0 | 9/30/2023 |
0.15004 % | Millennium Management LLC | 105,869 | 91,707 | 12/31/2023 |
0.14172 % | ACCI Capital Investments SGIIC, SA | 100,000 | -20,000 | 12/31/2023 |
0.13841 % | IndexIQ Advisors LLC | 97,660 | -2,634 | 12/31/2023 |
0.13551 % | BlackRock Investment Management, LLC | 95,616 | -788 | 12/31/2023 |
0.12979 % | Morgan Stanley & Co. LLC | 91,581 | 31,351 | 12/31/2023 |
0.12864 % | Nuveen LLC | 90,767 | 9,374 | 12/31/2023 |
0.12850 % | Acadian Asset Management LLC | 90,669 | 26,120 | 12/31/2023 |
0.12032 % | Davis (Aaron I) | 84,900 | 84,900 | 1/8/2024 |
0.11724 % | BNY Mellon Asset Management | 82,728 | -1,093 | 12/31/2023 |
0.11499 % | Barclays Bank PLC | 81,139 | 35,997 | 12/31/2023 |
0.11334 % | Brandenberger (Ralph Erik) | 79,972 | -1,604 | 3/1/2024 |
0.09794 % | Charles Schwab Investment Management, Inc. | 69,109 | 0 | 12/31/2023 |
0.09470 % | AllianceBernstein L.P. | 66,820 | -4,000 | 12/31/2023 |
0.08968 % | PGIM Quantitative Solutions LLC | 63,280 | -19,800 | 12/31/2023 |
0.08273 % | Goldman Sachs & Company, Inc. | 58,371 | 12,836 | 12/31/2023 |
0.08020 % | Dimensional Fund Advisors, L.P. | 56,587 | 32,172 | 12/31/2023 |
0.07937 % | Levin (Alyssa) | 56,000 | 56,000 | 1/4/2024 |
0.07773 % | Leo Wealth, LLC | 54,848 | 0 | 12/31/2023 |
0.07489 % | Hager (Alicia J) | 52,842 | 51,446 | 1/16/2024 |
0.06991 % | Rhumbline Advisers Ltd. Partnership | 49,330 | 0 | 12/31/2023 |
0.06438 % | Connor, Clark & Lunn Investment Management Ltd. | 45,426 | 30,995 | 12/31/2023 |
0.06400 % | Avantis Investors | 45,155 | 18,824 | 3/31/2024 |
0.06281 % | Northern Trust Global Investments | 44,318 | 81 | 12/31/2023 |
0.06102 % | Dimensional Fund Advisors, Ltd. | 43,054 | 2,763 | 1/31/2024 |
0.05598 % | T. Rowe Price Japan, Inc. | 39,498 | 39,498 | 8/31/2023 |
0.05193 % | Squarepoint Capital LLP | 36,642 | 36,642 | 12/31/2023 |
0.04859 % | UBS Financial Services, Inc. | 34,284 | 19,978 | 12/31/2023 |
0.04602 % | Amundi Asset Management, SAS | 32,469 | 0 | 12/31/2023 |
0.04348 % | Mahmood (Nadir Ahmeduddin) | 30,676 | -526 | 6/20/2023 |
0.04159 % | American Century Investment Management, Inc. | 29,348 | 7,531 | 12/31/2023 |
0.04108 % | Tekla Capital Management LLC_NLE | 28,988 | 0 | 6/30/2023 |
0.04108 % | abrdn Inc. | 28,988 | 28,988 | 12/31/2023 |
0.03756 % | Denali Advisors, LLC | 26,500 | 26,500 | 3/31/2024 |
0.03600 % | DWS Investments UK Limited | 25,401 | 25,401 | 12/31/2023 |
0.03318 % | Susquehanna Portfolio Strategies, LLC | 23,411 | 23,411 | 12/31/2023 |
0.03294 % | Mellon Investments Corporation | 23,244 | 0 | 12/31/2023 |
0.03262 % | State Street Global Advisors Ireland Limited | 23,015 | -84 | 4/30/2023 |
0.03189 % | T. Rowe Price International Ltd | 22,502 | 0 | 1/31/2024 |
0.03005 % | Holistic Planning, L.L.C. | 21,200 | 21,200 | 12/31/2023 |
0.02947 % | Goldman Sachs Asset Management, L.P. | 20,797 | -5,166 | 12/31/2023 |
0.02943 % | Forefront Analytics, LLC | 20,767 | -18,890 | 12/31/2023 |
0.02834 % | Abaris Investment Management AG | 20,000 | 20,000 | 6/30/2023 |
0.02778 % | JPMorgan Private Bank (United States) | 19,599 | 19,599 | 12/31/2023 |
0.02670 % | HSBC Global Asset Management (UK) Limited | 18,837 | 24 | 12/31/2023 |
0.02591 % | Susquehanna International Group, LLP | 18,285 | -236,838 | 12/31/2023 |
0.02534 % | Simplex Trading, LLC | 17,877 | 6,602 | 12/31/2023 |
0.02284 % | Bailard, Inc. | 16,113 | -18,300 | 12/31/2023 |
0.02238 % | Principal Global Investors (Equity) | 15,793 | 1,288 | 12/31/2023 |
0.02130 % | SunAmerica Asset Management, LLC | 15,030 | -61 | 12/31/2023 |
0.02016 % | Vanguard Personalized Indexing Management, LLC | 14,226 | 2,613 | 12/31/2023 |
0.01910 % | Mariner Wealth Advisors | 13,474 | -17,474 | 12/31/2023 |
0.01672 % | Sierra Summit Advisors LLC | 11,801 | 11,801 | 12/31/2023 |
0.01671 % | Vaughan Nelson Investment Management, L.P. | 11,789 | 0 | 12/31/2023 |
0.01539 % | SG Americas Securities, L.L.C. | 10,857 | 10,857 | 12/31/2023 |
0.01531 % | Wellington Management Company, LLP | 10,806 | -65 | 2/29/2024 |
0.01503 % | Sawtooth Asset Management, Inc. | 10,608 | 10,608 | 12/31/2023 |
0.01503 % | Bleakley Financial Group LLC | 10,608 | 10,608 | 12/31/2023 |
0.01456 % | Columbia Threadneedle Investments (US) | 10,276 | -127 | 12/31/2023 |
0.01320 % | Wells Fargo Bank, N.A. | 9,314 | 1,840 | 12/31/2023 |
0.01155 % | Invesco Advisers, Inc. | 8,150 | 8,150 | 12/31/2023 |
0.01103 % | Morgan Stanley Smith Barney LLC | 7,786 | 1,701 | 12/31/2023 |