8.28697 % | EcoR1 Capital, LLC | 6,995,861 | 0 | 12/31/2023 |
7.95824 % | BlackRock Institutional Trust Company, N.A. | 6,718,342 | 220,477 | 12/31/2023 |
7.01848 % | JPM Partner LLC | 5,925,000 | 0 | 12/31/2023 |
6.47012 % | BML Capital Management LLC | 5,462,079 | 662,079 | 12/31/2023 |
6.33814 % | Fidelity Management & Research Company LLC | 5,350,659 | -1,101,891 | 12/31/2023 |
5.44860 % | The Vanguard Group, Inc. | 4,599,710 | 26,270 | 12/31/2023 |
4.82912 % | Tang Capital Management, LLC | 4,076,741 | 43,278 | 12/31/2023 |
2.94437 % | Bain Capital Life Sciences Investors, LLC | 2,485,638 | 0 | 12/31/2023 |
2.41221 % | BlackRock Financial Management, Inc. | 2,036,389 | 786,617 | 12/31/2023 |
2.14157 % | Geode Capital Management, L.L.C. | 1,807,912 | 82,183 | 12/31/2023 |
1.93087 % | State Street Global Advisors (US) | 1,630,037 | 123,800 | 12/31/2023 |
1.77245 % | Renaissance Technologies LLC | 1,496,303 | 141,762 | 12/31/2023 |
1.49254 % | Tyrus Capital S.A.M. | 1,260,000 | 0 | 9/30/2023 |
1.14008 % | Acadian Asset Management LLC | 962,458 | -25,458 | 12/31/2023 |
0.99445 % | Stonepine Capital Management, LLC | 839,514 | -880,486 | 12/31/2023 |
0.92200 % | Berger (Franklin Milan) | 778,353 | 0 | 4/19/2023 |
0.78362 % | Corcoran (Andrea J) | 661,528 | -15,843 | 2/1/2024 |
0.74832 % | Northern Trust Investments, Inc. | 631,729 | 27,486 | 12/31/2023 |
0.70563 % | Federated MDTA LLC | 595,692 | -13,094 | 12/31/2023 |
0.69217 % | Charles Schwab Investment Management, Inc. | 584,326 | 2,093 | 12/31/2023 |
0.65748 % | Jacobs Levy Equity Management, Inc. | 555,045 | -2,840 | 12/31/2023 |
0.60231 % | Newtyn Management, LLC | 508,474 | 108,474 | 12/31/2023 |
0.56978 % | Two Sigma Investments, LP | 481,009 | 221,013 | 12/31/2023 |
0.40876 % | Banque Pictet & Cie S.A. | 345,077 | 0 | 12/31/2023 |
0.39830 % | BlackRock Investment Management, LLC | 336,245 | 113,791 | 12/31/2023 |
0.34292 % | Nuveen LLC | 289,493 | 0 | 12/31/2023 |
0.31983 % | CM Management, LLC | 270,000 | -5,000 | 12/31/2023 |
0.28870 % | BofA Global Research (US) | 243,724 | 147,292 | 12/31/2023 |
0.27614 % | Sommadossi (Jean-Pierre) | 233,114 | -56,910 | 2/1/2024 |
0.27305 % | Morgan Stanley & Co. LLC | 230,512 | 139,143 | 12/31/2023 |
0.26739 % | BlackRock Investment Management (UK) Ltd. | 225,727 | 94,302 | 12/31/2023 |
0.23346 % | Barclays Bank PLC | 197,087 | 171,468 | 12/31/2023 |
0.23254 % | Invesco Capital Management LLC | 196,308 | 2,464 | 12/31/2023 |
0.21941 % | BNY Mellon Asset Management | 185,227 | -741 | 12/31/2023 |
0.21935 % | D. E. Shaw & Co., L.P. | 185,177 | 115,228 | 12/31/2023 |
0.21366 % | HSBC Global Asset Management (UK) Limited | 180,371 | 168,273 | 12/31/2023 |
0.21127 % | Cubist Systematic Strategies, LLC | 178,353 | 39,280 | 12/31/2023 |
0.20967 % | Auour Investments LLC | 177,000 | 0 | 12/31/2023 |
0.20494 % | Citadel Advisors LLC | 173,014 | -411,674 | 12/31/2023 |
0.20267 % | Acuitas Investments LLC | 171,098 | 47,671 | 12/31/2023 |
0.19133 % | Diametric Capital | 161,524 | -38,476 | 12/31/2023 |
0.18797 % | Parametric Portfolio Associates LLC | 158,686 | 7,050 | 12/31/2023 |
0.18054 % | RBF Capital, LLC | 152,416 | 0 | 12/31/2023 |
0.17754 % | GSA Capital Partners LLP | 149,878 | -128,408 | 12/31/2023 |
0.17427 % | Rhumbline Advisers Ltd. Partnership | 147,116 | 12,808 | 12/31/2023 |
0.17016 % | Goldman Sachs & Company, Inc. | 143,647 | 87,084 | 12/31/2023 |
0.16584 % | Leonard (Braden Michael) | 140,000 | 140,000 | 12/31/2023 |
0.15387 % | State of Wisconsin Investment Board | 129,900 | 6,700 | 12/31/2023 |
0.14301 % | AllianceBernstein L.P. | 120,730 | -3,890 | 12/31/2023 |
0.13043 % | PGIM Quantitative Solutions LLC | 110,105 | -3,900 | 12/31/2023 |
0.12751 % | UBS Financial Services, Inc. | 107,646 | 50,605 | 12/31/2023 |
0.12322 % | Vavricka (John) | 104,023 | -11,819 | 2/1/2024 |
0.12211 % | IndexIQ Advisors LLC | 103,087 | -3,194 | 12/31/2023 |
0.11928 % | State Teachers Retirement System of Ohio | 100,700 | 0 | 12/31/2023 |
0.11203 % | Avantis Investors | 94,575 | 30,504 | 3/31/2024 |
0.10939 % | Dimensional Fund Advisors, L.P. | 92,351 | 0 | 12/31/2023 |
0.10405 % | Conestoga Capital Advisors, LLC | 87,838 | 34,899 | 2/29/2024 |
0.10092 % | Goldman Sachs Asset Management, L.P. | 85,193 | -119,267 | 12/31/2023 |
0.09864 % | Susquehanna Portfolio Strategies, LLC | 83,275 | 83,275 | 12/31/2023 |
0.09329 % | American Century Investment Management, Inc. | 78,754 | 22,861 | 12/31/2023 |
0.09328 % | Jane Street Capital, L.L.C. | 78,743 | 63,935 | 12/31/2023 |
0.08292 % | Macquarie Investment Management | 70,000 | 0 | 12/31/2023 |
0.08261 % | Mellon Investments Corporation | 69,736 | -59,513 | 12/31/2023 |
0.07462 % | Northern Trust Global Investments | 62,997 | 1,088 | 12/31/2023 |
0.06999 % | BlackRock Japan Co., Ltd. | 59,087 | 47,693 | 12/31/2023 |
0.06922 % | Alps Advisors, Inc. | 58,436 | -3,137 | 12/31/2023 |
0.06797 % | Assenagon Asset Management S.A. | 57,380 | 4,151 | 2/29/2024 |
0.06535 % | T. Rowe Price International Ltd | 55,169 | 12,927 | 12/31/2023 |
0.06465 % | Prelude Capital Management, LLC | 54,578 | -9,630 | 12/31/2023 |
0.06336 % | Columbia Threadneedle Investments (US) | 53,489 | 11,601 | 12/31/2023 |
0.06319 % | Susquehanna International Group, LLP | 53,344 | -164,530 | 12/31/2023 |
0.06283 % | Qube Research & Technologies Ltd | 53,038 | 13,422 | 12/31/2023 |
0.06175 % | Connor, Clark & Lunn Investment Management Ltd. | 52,132 | -38,826 | 12/31/2023 |
0.06163 % | JPMorgan Private Bank (United States) | 52,024 | 52,024 | 12/31/2023 |
0.05939 % | Shay Capital LLC | 50,139 | 1,504 | 12/31/2023 |
0.05923 % | Lucidi (Bruno) | 50,000 | 0 | 4/19/2023 |
0.05923 % | Polsky (Bruce) | 50,000 | 0 | 4/19/2023 |
0.05595 % | MetLife Investment Management, LLC | 47,234 | 0 | 12/31/2023 |
0.05587 % | Marquette Wealth Management | 47,166 | 22,301 | 12/31/2023 |
0.05301 % | BlackRock Advisors (UK) Limited | 44,747 | 2,145 | 3/31/2024 |
0.05037 % | SG Americas Securities, L.L.C. | 42,521 | 8,024 | 12/31/2023 |
0.04920 % | T. Rowe Price Associates, Inc. | 41,532 | 11,645 | 12/31/2023 |
0.04911 % | BlackRock Asset Management Ireland Limited | 41,458 | 740 | 12/31/2023 |
0.04558 % | DWS Investments UK Limited | 38,475 | -1,315 | 12/31/2023 |
0.04521 % | Dimensional Fund Advisors, Ltd. | 38,170 | 18,404 | 1/31/2024 |
0.04514 % | SunAmerica Asset Management, LLC | 38,104 | -154 | 12/31/2023 |
0.04371 % | Algert Global LLC | 36,900 | -13,610 | 12/31/2023 |
0.04288 % | Norges Bank Investment Management (NBIM) | 36,200 | -168,000 | 12/31/2023 |
0.04094 % | Vaughan Nelson Investment Management, L.P. | 34,560 | 4,975 | 12/31/2023 |
0.03943 % | Voya Investment Management LLC | 33,286 | 0 | 12/31/2023 |
0.03907 % | Manulife Investment Management (North America) Limited | 32,985 | 0 | 12/31/2023 |
0.03882 % | Hammond (Janet MJ) | 32,771 | -14,029 | 2/1/2024 |
0.03594 % | Tower Research Capital LLC | 30,340 | 17,042 | 12/31/2023 |
0.03253 % | Principal Global Investors (Equity) | 27,462 | -2,930 | 12/31/2023 |
0.03134 % | ETF Managers Group, LLC | 26,460 | 5,695 | 3/31/2023 |
0.03046 % | Brevan Howard Capital Management LP | 25,717 | 25,717 | 12/31/2023 |
0.03040 % | Horga (Maria Arantxa) | 25,664 | -15,870 | 2/1/2024 |
0.03033 % | Aperio Group, LLC | 25,601 | -4,080 | 12/31/2023 |
0.02992 % | Invesco Advisers, Inc. | 25,257 | 6,990 | 12/31/2023 |
0.02797 % | Wells Fargo Bank, N.A. | 23,614 | 4,662 | 12/31/2023 |