15.31122 % | RA Capital Management, LP | 10,805,129 | 0 | 6/30/2024 |
5.88215 % | Commodore Capital LP | 4,151,034 | 986,034 | 6/30/2024 |
5.38351 % | Deerfield Management Company, L.P. | 3,799,143 | -1,394,944 | 6/30/2024 |
5.33943 % | Samsara BioCapital, LLC | 3,768,035 | 0 | 6/30/2024 |
5.13345 % | BlackRock Institutional Trust Company, N.A. | 3,622,676 | 1,119,858 | 6/30/2024 |
5.10132 % | Adage Capital Management, L.P. | 3,600,000 | -200,000 | 6/30/2024 |
5.05708 % | New Enterprise Associates (NEA) | 3,568,781 | 0 | 6/30/2024 |
4.87970 % | Boxer Capital, L.L.C. | 3,443,606 | -2,163,744 | 10/10/2024 |
4.72344 % | SR One Capital Management, LP | 3,333,333 | 0 | 6/30/2024 |
4.47985 % | GSK plc | 3,161,432 | 3,161,432 | 3/27/2024 |
4.42884 % | Citadel Advisors LLC | 3,125,434 | 2,703,200 | 6/30/2024 |
4.18928 % | The Vanguard Group, Inc. | 2,956,374 | 990,103 | 6/30/2024 |
4.01947 % | EQT Life Sciences | 2,836,539 | 2,836,539 | 2/8/2024 |
1.97330 % | Wasatch Global Investors Inc | 1,392,555 | 224,063 | 6/30/2024 |
1.67348 % | Columbia Threadneedle Investments (UK) | 1,180,973 | 72,437 | 6/30/2024 |
1.61131 % | Geode Capital Management, L.L.C. | 1,137,099 | 322,691 | 6/30/2024 |
1.53393 % | State Street Global Advisors (US) | 1,082,493 | 453,338 | 6/30/2024 |
1.29713 % | Alyeska Investment Group, L.P. | 915,382 | 377,802 | 6/30/2024 |
1.29357 % | Renaissance Technologies LLC | 912,872 | 98,000 | 6/30/2024 |
1.24132 % | Superstring Capital Management LP | 875,999 | -313,194 | 6/30/2024 |
1.14576 % | T. Rowe Price Investment Management, Inc. | 808,566 | -546,755 | 6/30/2024 |
1.13363 % | OrbiMed Advisors, LLC | 800,000 | 0 | 6/30/2024 |
0.89008 % | Woodline Partners LP | 628,129 | 3,000 | 6/30/2024 |
0.77937 % | Tang Capital Management, LLC | 550,000 | 0 | 6/30/2024 |
0.64655 % | Two Sigma Investments, LP | 456,267 | 208,120 | 6/30/2024 |
0.62346 % | Marshall Wace LLP | 439,973 | 254,104 | 6/30/2024 |
0.43001 % | Acadian Asset Management LLC | 303,461 | 300,767 | 6/30/2024 |
0.42938 % | Northern Trust Investments, Inc. | 303,015 | 31,293 | 6/30/2024 |
0.39915 % | Millennium Management LLC | 281,677 | 245,251 | 6/30/2024 |
0.39531 % | JPMorgan Asset Management U.K. Limited | 278,969 | -53,606 | 6/30/2024 |
0.38435 % | Nuveen LLC | 271,235 | 39,306 | 6/30/2024 |
0.37717 % | BlackRock Financial Management, Inc. | 266,168 | 38,612 | 6/30/2024 |
0.35697 % | Cubist Systematic Strategies, LLC | 251,914 | 251,914 | 6/30/2024 |
0.35426 % | Jefferies LLC | 250,000 | 200,000 | 6/30/2024 |
0.34009 % | Octagon Capital Advisors LP | 240,000 | 0 | 6/30/2024 |
0.33469 % | Blackstone Alternative Asset Management, L.P. | 236,190 | 236,190 | 6/30/2024 |
0.28341 % | Affinity Asset Advisors LLC | 200,000 | 200,000 | 6/30/2024 |
0.25392 % | Squarepoint Capital LLP | 179,194 | 81,998 | 6/30/2024 |
0.24558 % | Wellington Management Company, LLP | 173,306 | 43,932 | 6/30/2024 |
0.24014 % | Bridgeway Capital Management, LLC | 169,467 | 0 | 6/30/2024 |
0.22714 % | BlackRock Investment Management, LLC | 160,296 | 75,860 | 6/30/2024 |
0.22493 % | AQR Capital Management, LLC | 158,736 | 158,736 | 6/30/2024 |
0.22320 % | Morgan Stanley & Co. LLC | 157,509 | 114,851 | 6/30/2024 |
0.20594 % | Charles Schwab Investment Management, Inc. | 145,332 | 55,904 | 6/30/2024 |
0.20541 % | Trager (James) | 144,959 | -456 | 6/18/2024 |
0.19835 % | State of Wisconsin Investment Board | 139,975 | 91,875 | 6/30/2024 |
0.19828 % | Goldman Sachs & Company, Inc. | 139,923 | 113,182 | 6/30/2024 |
0.19691 % | Innovis Asset Management LLC | 138,962 | 138,962 | 9/30/2023 |
0.19272 % | Abaris Investment Management AG | 136,000 | 116,000 | 12/31/2023 |
0.19138 % | Parametric Portfolio Associates LLC | 135,059 | 9,832 | 6/30/2024 |
0.18774 % | Federated MDTA LLC | 132,488 | 132,013 | 6/30/2024 |
0.18748 % | Dimensional Fund Advisors, L.P. | 132,306 | 35,643 | 6/30/2024 |
0.16589 % | D. E. Shaw & Co., L.P. | 117,070 | 117,070 | 6/30/2024 |
0.16297 % | BofA Global Research (US) | 115,009 | 74,637 | 6/30/2024 |
0.16252 % | BNY Mellon Asset Management | 114,691 | 46,039 | 6/30/2024 |
0.15357 % | Jane Street Capital, L.L.C. | 108,377 | -13,650 | 6/30/2024 |
0.12606 % | Barclays Bank PLC | 88,958 | 49,832 | 6/30/2024 |
0.12031 % | Davis (Aaron I) | 84,900 | 84,900 | 1/8/2024 |
0.11905 % | Rhumbline Advisers Ltd. Partnership | 84,011 | 33,117 | 6/30/2024 |
0.11546 % | Goldman Sachs Asset Management, L.P. | 81,481 | 55,614 | 6/30/2024 |
0.11434 % | AllianceBernstein L.P. | 80,690 | 13,870 | 6/30/2024 |
0.11300 % | Brandenberger (Ralph Erik) | 79,743 | -229 | 6/18/2024 |
0.11110 % | Stifel, Nicolaus & Company, Incorporated | 78,401 | -15,533 | 6/30/2024 |
0.10331 % | UBS Financial Services, Inc. | 72,903 | 41,388 | 6/30/2024 |
0.10232 % | American Century Investment Management, Inc. | 72,205 | 24,033 | 6/30/2024 |
0.09889 % | Hastings (Paul J) | 69,787 | -1,770 | 6/18/2024 |
0.09709 % | Schonfeld Strategic Advisors LLC | 68,517 | -331,583 | 6/30/2024 |
0.09572 % | Fidelity Management & Research Company LLC | 67,549 | 2,601 | 6/30/2024 |
0.09523 % | Jump Financial, LLC | 67,205 | 67,205 | 6/30/2024 |
0.08371 % | Dimensional Fund Advisors, Ltd. | 59,074 | 7,228 | 9/30/2024 |
0.08144 % | Mellon Investments Corporation | 57,471 | 30,573 | 6/30/2024 |
0.07794 % | ACCI Capital Investments SGIIC, SA | 55,000 | 5,000 | 7/31/2024 |
0.07458 % | Citi Investment Research (US) | 52,634 | 3,253 | 6/30/2024 |
0.07326 % | Jennison Associates LLC | 51,700 | 0 | 8/31/2024 |
0.06904 % | Hager (Alicia J) | 48,719 | -3,396 | 7/16/2024 |
0.06399 % | Avantis Investors | 45,155 | 18,824 | 3/31/2024 |
0.06256 % | PGIM Quantitative Solutions LLC | 44,150 | 44,150 | 6/30/2024 |
0.05810 % | Bellecapital AG | 41,000 | 24,000 | 3/31/2024 |
0.05712 % | Northern Trust Global Investments | 40,307 | -5,198 | 6/30/2024 |
0.05597 % | T. Rowe Price Japan, Inc. | 39,498 | 39,498 | 8/31/2023 |
0.05575 % | Shook (David M.D.) | 39,342 | 1,352 | 8/21/2024 |
0.05312 % | Simplicity Wealth, LLC | 37,486 | 21,659 | 6/30/2024 |
0.05002 % | Verition Fund Management LLC | 35,298 | 35,298 | 6/30/2024 |
0.04421 % | MetLife Investment Management, LLC | 31,197 | 15,228 | 6/30/2024 |
0.04347 % | Mahmood (Nadir Ahmeduddin) | 30,676 | -526 | 6/20/2023 |
0.04108 % | abrdn Inc. | 28,988 | 0 | 9/30/2024 |
0.04034 % | Corebridge Financial Inc | 28,466 | 28,466 | 6/30/2024 |
0.03294 % | Wells Fargo Bank, N.A. | 23,248 | 12,563 | 6/30/2024 |
0.03282 % | Alpine Global Management, LLC | 23,161 | 23,161 | 6/30/2024 |
0.03261 % | State Street Global Advisors Ireland Limited | 23,015 | -84 | 4/30/2023 |
0.03195 % | JPMorgan Private Bank (United States) | 22,549 | 10,694 | 6/30/2024 |
0.02958 % | Y-Intercept (Hong Kong) Ltd | 20,872 | 20,872 | 6/30/2024 |
0.02935 % | Manulife Investment Management (North America) Limited | 20,710 | 9,975 | 6/30/2024 |
0.02919 % | SG Americas Securities, L.L.C. | 20,597 | 20,597 | 9/30/2024 |
0.02622 % | Susquehanna International Group, LLP | 18,500 | -17,910 | 6/30/2024 |
0.02550 % | Voya Investment Management LLC | 17,994 | 11,388 | 6/30/2024 |
0.02399 % | T. Rowe Price International Ltd | 16,928 | 16,928 | 6/30/2024 |
0.02166 % | Bleakley Financial Group LLC | 15,284 | -22,202 | 9/30/2024 |
0.02154 % | Holistic Planning, L.L.C. | 15,200 | 0 | 6/30/2024 |
0.02123 % | Bayesian Capital Management, LP | 14,979 | 14,979 | 6/30/2024 |