13.53207 % | Frazier Life Sciences Management, L.P. | 6,495,392 | 0 | 6/30/2024 |
10.39322 % | Janus Henderson Investors | 4,988,747 | 2,221,537 | 6/30/2024 |
9.10422 % | BVF Partners L.P. | 4,370,024 | 0 | 6/30/2024 |
7.53087 % | Eventide Asset Management, LLC | 3,614,820 | 314,420 | 6/30/2024 |
6.11390 % | BlackRock Institutional Trust Company, N.A. | 2,934,672 | 680,132 | 6/30/2024 |
5.08164 % | The Vanguard Group, Inc. | 2,439,185 | 233,265 | 6/30/2024 |
3.69175 % | Rock Springs Capital Management LP | 1,772,038 | -84,526 | 6/30/2024 |
3.30338 % | Citadel Advisors LLC | 1,585,624 | 193,118 | 6/30/2024 |
3.12500 % | Novo Holdings A/S | 1,500,000 | 0 | 9/30/2024 |
3.11712 % | State Street Global Advisors (US) | 1,496,217 | -1,326,255 | 6/30/2024 |
2.68147 % | Tang Capital Management, LLC | 1,287,107 | 100,000 | 6/30/2024 |
2.57317 % | Cadian Capital Management LP | 1,235,121 | -1,057,446 | 6/30/2024 |
2.43999 % | T. Rowe Price Associates, Inc. | 1,171,197 | -413,444 | 6/30/2024 |
2.28188 % | Medical Strategy GmbH | 1,095,302 | -31,500 | 6/30/2024 |
1.95600 % | Franklin Advisers, Inc. | 938,881 | 0 | 6/30/2024 |
1.88996 % | Geode Capital Management, L.L.C. | 907,180 | 210,041 | 6/30/2024 |
1.82315 % | Pictet Asset Management Ltd. | 875,113 | -80,801 | 6/30/2024 |
1.54385 % | Polar Capital LLP | 741,049 | 116,049 | 6/30/2024 |
1.52313 % | Avidity Partners Management LP | 731,104 | -411,746 | 6/30/2024 |
1.51384 % | Goldman Sachs & Company, Inc. | 726,645 | 60,085 | 6/30/2024 |
1.46541 % | First Turn Management, LLC | 703,398 | -255,256 | 6/30/2024 |
1.45819 % | ClearBridge Investments, LLC | 699,933 | 436,349 | 6/30/2024 |
1.41237 % | William Blair Investment Management, LLC | 677,939 | 50,667 | 6/30/2024 |
1.28213 % | Norges Bank Investment Management (NBIM) | 615,421 | -111,161 | 6/30/2024 |
1.09856 % | Morgan Stanley & Co. LLC | 527,308 | 184,709 | 6/30/2024 |
1.09100 % | Boone Capital Management LLC | 523,679 | 71,781 | 6/30/2024 |
1.05932 % | Candriam Belgium S.A. | 508,475 | 508,475 | 6/30/2024 |
1.05932 % | Candriam Luxembourg S.A. | 508,475 | 0 | 9/30/2024 |
1.02619 % | MPM BioImpact LLC | 492,569 | 492,569 | 6/30/2024 |
0.88748 % | AXA Investment Managers UK Ltd. | 425,992 | -167,794 | 6/30/2024 |
0.85774 % | Lord, Abbett & Co. LLC | 411,713 | -359 | 8/31/2024 |
0.80316 % | Nuveen LLC | 385,515 | 76,207 | 6/30/2024 |
0.79781 % | Grey (Michael G) | 382,948 | 0 | 2/15/2024 |
0.71550 % | Two Sigma Investments, LP | 343,440 | -8,913 | 6/30/2024 |
0.69865 % | Peetz (Christopher) | 335,353 | 34,013 | 7/23/2024 |
0.65583 % | Prosight Capital | 314,800 | -150,200 | 6/30/2024 |
0.64794 % | Charles Schwab Investment Management, Inc. | 311,012 | 39,358 | 6/30/2024 |
0.60289 % | BofA Global Research (US) | 289,386 | -6,080 | 6/30/2024 |
0.58778 % | Invesco Advisers, Inc. | 282,133 | 244,801 | 6/30/2024 |
0.55301 % | Millennium Management LLC | 265,443 | -274,223 | 6/30/2024 |
0.52217 % | Northern Trust Investments, Inc. | 250,642 | -2,002 | 6/30/2024 |
0.51699 % | DWS Investments UK Limited | 248,153 | 5,168 | 6/30/2024 |
0.50565 % | Rice Hall James & Associates, LLC | 242,711 | 12,981 | 9/30/2024 |
0.50240 % | PENN Capital Management Company, Inc. | 241,151 | -4,545 | 6/30/2024 |
0.47645 % | Barclays Bank PLC | 228,694 | -46,172 | 6/30/2024 |
0.47573 % | New York State Common Retirement Fund | 228,351 | 38,226 | 9/30/2024 |
0.46378 % | Ensign Peak Advisors, Inc. | 222,614 | 0 | 6/30/2024 |
0.45935 % | Silvercrest Asset Management Group LLC | 220,490 | 57,673 | 6/30/2024 |
0.44272 % | Citi Investment Research (US) | 212,504 | -158,547 | 6/30/2024 |
0.42442 % | Woodline Partners LP | 203,720 | -29,547 | 6/30/2024 |
0.39683 % | Baker Bros. Advisors LP | 190,476 | 0 | 6/30/2024 |
0.37500 % | Ardsley Advisory Partners LP | 180,000 | -65,000 | 6/30/2024 |
0.33333 % | Adage Capital Management, L.P. | 160,000 | 0 | 6/30/2024 |
0.33098 % | AXA Investment Managers Paris | 158,870 | 0 | 8/31/2024 |
0.32292 % | Affinity Asset Advisors LLC | 155,000 | -5,000 | 6/30/2024 |
0.28673 % | Raymond James & Associates, Inc. | 137,628 | -6,586 | 9/30/2024 |
0.27969 % | Rhenman & Partners Asset Management AB | 134,250 | 42,000 | 6/30/2024 |
0.26111 % | BlackRock Financial Management, Inc. | 125,332 | 57,231 | 6/30/2024 |
0.25621 % | Highlander Partners, L.P. | 122,980 | 0 | 6/30/2024 |
0.25555 % | Jane Street Capital, L.L.C. | 122,664 | 8,059 | 6/30/2024 |
0.24178 % | Hennion & Walsh Asset Management, Inc. | 116,054 | 11,284 | 9/30/2024 |
0.22822 % | Raymond James Financial Services Advisors, Inc. | 109,545 | 10,662 | 9/30/2024 |
0.22104 % | Nan Fung Life Sciences | 106,100 | 10,000 | 6/30/2024 |
0.21847 % | Knights of Columbus | 104,865 | 2,587 | 6/30/2024 |
0.21830 % | BlackRock Investment Management, LLC | 104,786 | 42,873 | 6/30/2024 |
0.21751 % | Longpre (Lara) | 104,407 | -847 | 2/2/2024 |
0.21622 % | Vig (Pamela) | 103,785 | 0 | 6/24/2024 |
0.20642 % | BNY Mellon Asset Management | 99,080 | 32,658 | 6/30/2024 |
0.16499 % | SilverArc Capital Management, LLC | 79,194 | 0 | 6/30/2024 |
0.15712 % | Wellington Management Company, LLP | 75,416 | 4,974 | 6/30/2024 |
0.15667 % | Healthinvest Partners AB | 75,200 | -47,800 | 6/30/2024 |
0.14345 % | Rafferty Asset Management LLC | 68,858 | -197,404 | 6/30/2024 |
0.14063 % | International Biotechnology Trust PLC | 67,500 | 0 | 9/30/2023 |
0.14046 % | Squarepoint Capital LLP | 67,421 | 26,154 | 6/30/2024 |
0.13500 % | Schweizerische Nationalbank | 64,800 | 5,500 | 6/30/2024 |
0.13479 % | Palo Alto Investors LP | 64,700 | 0 | 6/30/2024 |
0.13333 % | LifeSci Fund Management LLC | 64,000 | -30,000 | 6/30/2024 |
0.12583 % | Phocas Financial Corporation | 60,399 | -1,137 | 6/30/2024 |
0.11780 % | BlackRock Advisors (UK) Limited | 56,542 | 862 | 9/30/2024 |
0.11763 % | State of Wisconsin Investment Board | 56,464 | 10,647 | 6/30/2024 |
0.11024 % | Rhumbline Advisers Ltd. Partnership | 52,916 | 17,279 | 6/30/2024 |
0.10571 % | UBS Financial Services, Inc. | 50,743 | -106,168 | 6/30/2024 |
0.09980 % | Boston Advisors, LLC | 47,902 | 0 | 8/31/2024 |
0.09552 % | Connor, Clark & Lunn Investment Management Ltd. | 45,849 | 45,849 | 6/30/2024 |
0.09375 % | AlphaCentric Advisors LLC. | 45,000 | -19,000 | 9/30/2024 |
0.09186 % | Arctic Fund Management AS | 44,095 | -1,500 | 4/30/2024 |
0.09135 % | Mellon Investments Corporation | 43,849 | 16,754 | 6/30/2024 |
0.09114 % | ExodusPoint Capital Management, LP | 43,747 | -20,672 | 6/30/2024 |
0.08875 % | BMO Capital Markets (US) | 42,600 | -2,400 | 6/30/2024 |
0.08709 % | BlackRock Asset Management Ireland Limited | 41,803 | 1,428 | 6/30/2024 |
0.08593 % | NEOS Investment Management, LLC | 41,244 | 14,041 | 6/30/2024 |
0.08552 % | AllianceBernstein L.P. | 41,050 | 16,950 | 6/30/2024 |
0.08333 % | SBI Okasan Asset Management Co., Ltd. | 40,000 | -20,021 | 3/31/2024 |
0.08324 % | UBS Asset Management (Switzerland) | 39,954 | 7,280 | 6/30/2024 |
0.08201 % | PDT Partners, LLC | 39,363 | 39,363 | 6/30/2024 |
0.07935 % | UBS O'Connor LLC | 38,088 | -11,769 | 6/30/2024 |
0.07833 % | Nomura Asset Management Co., Ltd. | 37,600 | 37,600 | 11/30/2023 |
0.07795 % | Legal & General Investment Management Ltd. | 37,418 | 8,773 | 6/30/2024 |
0.07658 % | Alps Advisors, Inc. | 36,759 | 3,876 | 6/30/2024 |
0.07607 % | Secure Asset Management, L.L.C. | 36,514 | -9,390 | 9/30/2024 |