11.39730 % | Janus Henderson Investors | 2,485,751 | -115,531 | 6/30/2024 |
9.42483 % | Avoro Capital Advisors LLC | 2,055,555 | 111,111 | 6/30/2024 |
9.05360 % | Baker Bros. Advisors LP | 1,974,590 | 4,792 | 6/30/2024 |
8.78433 % | RTW Investments L.P. | 1,915,862 | 1,518,815 | 6/30/2024 |
8.48235 % | Paulson & Co. Inc. | 1,850,000 | 75,000 | 6/30/2024 |
8.27190 % | The Vanguard Group, Inc. | 1,804,102 | 137,898 | 6/30/2024 |
5.80662 % | BlackRock Institutional Trust Company, N.A. | 1,266,424 | 183,195 | 6/30/2024 |
4.99680 % | Taub (Rebecca A) | 1,089,802 | 650,804 | 4/22/2024 |
4.20389 % | Friedman (Paul A) | 916,868 | 714 | 6/25/2024 |
3.85727 % | T. Rowe Price Associates, Inc. | 841,271 | 53,080 | 6/30/2024 |
3.41455 % | State Street Global Advisors (US) | 744,714 | 119,776 | 6/30/2024 |
3.09025 % | Fidelity Management & Research Company LLC | 673,983 | 68,468 | 6/30/2024 |
3.00569 % | SQN, L.L.C. | 655,540 | 0 | 4/22/2024 |
1.99513 % | Craves (Frederick B) | 435,138 | -15,000 | 9/13/2024 |
1.83335 % | Geode Capital Management, L.L.C. | 399,854 | 52,997 | 6/30/2024 |
1.58223 % | Artisan Partners Limited Partnership | 345,085 | -56,624 | 6/30/2024 |
1.21320 % | Perceptive Advisors LLC | 264,600 | -165,353 | 6/30/2024 |
1.12563 % | Rock Springs Capital Management LP | 245,499 | -40,432 | 6/30/2024 |
0.85921 % | ArrowMark Colorado Holdings, LLC | 187,393 | 153,174 | 6/30/2024 |
0.68776 % | Armistice Capital LLC | 150,000 | -18,000 | 6/30/2024 |
0.68447 % | TCG Crossover Management, LLC | 149,283 | 0 | 6/30/2024 |
0.63588 % | BofA Global Research (US) | 138,686 | 105,463 | 6/30/2024 |
0.63418 % | Charles Schwab Investment Management, Inc. | 138,314 | 15,622 | 6/30/2024 |
0.63415 % | Woodline Partners LP | 138,309 | 118,609 | 6/30/2024 |
0.62941 % | Pictet Asset Management Ltd. | 137,275 | -46,888 | 6/30/2024 |
0.62467 % | UBS Financial Services, Inc. | 136,240 | 10,825 | 6/30/2024 |
0.62001 % | Morgan Stanley & Co. LLC | 135,224 | -72,014 | 6/30/2024 |
0.59848 % | Tao Capital Management LP | 130,529 | 0 | 6/30/2024 |
0.57451 % | Polar Capital LLP | 125,300 | 95 | 6/30/2024 |
0.55347 % | Northern Trust Investments, Inc. | 120,712 | -145 | 6/30/2024 |
0.55012 % | Invesco Advisers, Inc. | 119,982 | 54,331 | 6/30/2024 |
0.53199 % | Norges Bank Investment Management (NBIM) | 116,027 | -29,562 | 6/30/2024 |
0.52737 % | Fidelity Institutional Asset Management | 115,020 | 6,621 | 6/30/2024 |
0.52136 % | Fiera Capital Inc. | 113,709 | 113,709 | 6/30/2024 |
0.50946 % | American Century Investment Management, Inc. | 111,113 | 13,361 | 6/30/2024 |
0.50436 % | Affinity Asset Advisors LLC | 110,000 | -5,000 | 6/30/2024 |
0.49445 % | Goldman Sachs & Company, Inc. | 107,839 | 38,878 | 6/30/2024 |
0.46976 % | Fred Alger Management, LLC | 102,455 | 37,879 | 6/30/2024 |
0.45491 % | Rheos Capital Works Inc. | 99,215 | -11,000 | 9/30/2024 |
0.42496 % | Managed Account Advisors LLC | 92,683 | 14,387 | 6/30/2024 |
0.42041 % | Mirae Asset Global Investments (USA) LLC | 91,691 | -562 | 6/30/2024 |
0.41371 % | Pictet Asset Management (Japan) Ltd. | 90,230 | 34,875 | 4/30/2024 |
0.38787 % | AlpInvest Partners B.V. | 84,595 | -21,149 | 6/30/2024 |
0.38227 % | Ensign Peak Advisors, Inc. | 83,373 | -8,845 | 6/30/2024 |
0.38084 % | Connor, Clark & Lunn Investment Management Ltd. | 83,062 | -10,535 | 6/30/2024 |
0.35029 % | Group One Trading, L.P. | 76,399 | 33,228 | 6/30/2024 |
0.34388 % | EcoR1 Capital, LLC | 75,000 | 0 | 6/30/2024 |
0.32639 % | MPM BioImpact LLC | 71,185 | 9,786 | 6/30/2024 |
0.32119 % | BlackRock Financial Management, Inc. | 70,051 | 19,642 | 6/30/2024 |
0.31977 % | Nuveen LLC | 69,741 | 9,288 | 6/30/2024 |
0.29964 % | Tri Locum Partners LP | 65,352 | 11,997 | 6/30/2024 |
0.29166 % | Goldman Sachs Asset Management, L.P. | 63,612 | 40,784 | 6/30/2024 |
0.27210 % | Morgan Stanley Smith Barney LLC | 59,345 | -1,560 | 6/30/2024 |
0.25624 % | Sibold (William John) | 55,887 | -6,363 | 9/9/2024 |
0.25552 % | TD Asset Management Inc. | 55,730 | 5,400 | 6/30/2024 |
0.22445 % | Emerald Advisers LLC | 48,952 | -123,571 | 9/30/2024 |
0.21295 % | New York State Common Retirement Fund | 46,445 | -4,728 | 9/30/2024 |
0.20967 % | University of Wisconsin Foundation | 45,730 | -10,646 | 6/30/2024 |
0.20706 % | BlackRock Investment Management, LLC | 45,159 | 9,730 | 6/30/2024 |
0.20436 % | AllianceBernstein L.P. | 44,570 | 16,670 | 6/30/2024 |
0.20365 % | Sofinnova Investments, Inc | 44,417 | 25,388 | 6/30/2024 |
0.20224 % | Bessemer Trust Company, N.A. (US) | 44,109 | -10,360 | 7/31/2024 |
0.19730 % | Propel Bio Management, LLC | 43,032 | 0 | 6/30/2024 |
0.19725 % | Voya Investment Management LLC | 43,020 | 25,493 | 6/30/2024 |
0.19695 % | BNY Mellon Asset Management | 42,954 | 8,609 | 6/30/2024 |
0.18779 % | Point72 Asset Management, L.P. | 40,958 | -52,613 | 6/30/2024 |
0.17716 % | DWS Investment GmbH | 38,638 | 0 | 6/30/2024 |
0.17596 % | Gilder Gagnon Howe & Co. LLC | 38,377 | -706 | 6/30/2024 |
0.17326 % | JP Morgan Asset Management | 37,787 | -351 | 6/30/2024 |
0.16965 % | UBS Switzerland AG | 37,000 | 37,000 | 6/30/2024 |
0.16698 % | Rafferty Asset Management LLC | 36,418 | 501 | 6/30/2024 |
0.16600 % | Jane Street Capital, L.L.C. | 36,204 | 11,053 | 6/30/2024 |
0.16359 % | Manulife Investment Management (North America) Limited | 35,678 | 4,937 | 6/30/2024 |
0.16099 % | SEB Investment Management AB | 35,112 | 0 | 6/30/2024 |
0.14901 % | Handelsbanken Kapitalf¿rvaltning AB | 32,500 | 900 | 9/30/2024 |
0.13779 % | CIBC Private Wealth Management | 30,051 | 1 | 6/30/2024 |
0.13743 % | PFM Health Sciences, LP | 29,973 | 0 | 6/30/2024 |
0.13067 % | Macquarie Investment Management | 28,500 | -30,457 | 6/30/2024 |
0.12918 % | Mellon Investments Corporation | 28,174 | 7,313 | 6/30/2024 |
0.12150 % | Rhenman & Partners Asset Management AB | 26,500 | -10,000 | 6/30/2024 |
0.11758 % | T. Rowe Price Investment Management, Inc. | 25,644 | -17,342 | 6/30/2024 |
0.11624 % | Rhumbline Advisers Ltd. Partnership | 25,351 | 4,209 | 6/30/2024 |
0.11371 % | Schweizerische Nationalbank | 24,800 | 1,400 | 6/30/2024 |
0.11215 % | Schonfeld Strategic Advisors LLC | 24,460 | 24,460 | 6/30/2024 |
0.11188 % | Erste Asset Management GmbH | 24,400 | 0 | 8/31/2024 |
0.11010 % | Wells Fargo Advisors | 24,012 | 11,742 | 6/30/2024 |
0.10843 % | Rokos Capital Management LLP | 23,649 | -14,113 | 6/30/2024 |
0.10689 % | Simplify Asset Management Inc | 23,313 | 19 | 6/30/2024 |
0.10671 % | BlackRock Advisors (UK) Limited | 23,274 | 585 | 9/30/2024 |
0.10207 % | California Public Employees' Retirement System | 22,262 | 2,072 | 6/30/2024 |
0.09798 % | Wintrust Investments, LLC | 21,370 | 2,100 | 6/30/2024 |
0.09275 % | BlackRock Asset Management Ireland Limited | 20,229 | 1,340 | 6/30/2024 |
0.09037 % | Parametric Portfolio Associates LLC | 19,710 | 4,141 | 6/30/2024 |
0.08910 % | Raymond James & Associates, Inc. | 19,433 | -888 | 9/30/2024 |
0.08752 % | Rockefeller Capital Management | 19,088 | -16,073 | 6/30/2024 |
0.08674 % | Hennion & Walsh Asset Management, Inc. | 18,917 | -1,420 | 9/30/2024 |
0.08391 % | International Biotechnology Trust PLC | 18,300 | 0 | 9/30/2023 |
0.08021 % | T. Rowe Price International Ltd | 17,494 | 2,472 | 6/30/2024 |
0.07365 % | Citi Investment Research (US) | 16,062 | -16,728 | 6/30/2024 |
0.07244 % | Cutler Group, LP | 15,800 | 2,300 | 3/31/2024 |