9.67951 % | Avoro Capital Advisors LLC | 11,111,111 | 811,111 | 12/31/2023 |
7.56710 % | BlackRock Institutional Trust Company, N.A. | 8,686,279 | 1,687,923 | 12/31/2023 |
6.04582 % | RA Capital Management, LP | 6,940,000 | 0 | 12/31/2023 |
5.47826 % | The Vanguard Group, Inc. | 6,288,497 | 558,562 | 12/31/2023 |
5.31736 % | Janus Henderson Investors | 6,103,797 | -699,687 | 12/31/2023 |
3.81025 % | T. Rowe Price Associates, Inc. | 4,373,789 | 2,522,030 | 12/31/2023 |
3.50588 % | Perceptive Advisors LLC | 4,024,400 | -18,791 | 12/31/2023 |
3.47827 % | Jennison Associates LLC | 3,992,711 | 437,437 | 12/31/2023 |
2.82804 % | Franklin Advisers, Inc. | 3,246,308 | -22,592 | 12/31/2023 |
2.60819 % | Holocene Advisors, LP | 2,993,945 | -123,740 | 12/31/2023 |
2.43742 % | State Street Global Advisors (US) | 2,797,916 | 511,972 | 12/31/2023 |
2.32925 % | Octagon Capital Advisors LP | 2,673,750 | -400,000 | 12/31/2023 |
2.28940 % | Adage Capital Management, L.P. | 2,628,000 | -1,497,000 | 12/31/2023 |
2.24209 % | Point72 Asset Management, L.P. | 2,573,700 | 143,776 | 12/31/2023 |
2.07344 % | Geode Capital Management, L.L.C. | 2,380,105 | 304,549 | 12/31/2023 |
2.02511 % | Fidelity Management & Research Company LLC | 2,324,620 | 755,672 | 12/31/2023 |
1.71431 % | Fred Alger Management, LLC | 1,967,858 | -204,451 | 12/31/2023 |
1.69609 % | Emerald Advisers LLC | 1,946,936 | 153,423 | 12/31/2023 |
1.56808 % | Cormorant Asset Management, LP | 1,800,000 | -2,050,000 | 12/31/2023 |
1.55684 % | Foresite Capital Management, LLC | 1,787,094 | 0 | 9/30/2023 |
1.42158 % | Medical Strategy GmbH | 1,631,828 | 140,650 | 9/30/2023 |
1.41563 % | Vestal Point Capital, LP | 1,625,000 | 1,625,000 | 12/31/2023 |
1.30441 % | First Turn Management, LLC | 1,497,331 | 1,497,331 | 12/31/2023 |
1.22987 % | Sofinnova Investments, Inc | 1,411,769 | 1,411,769 | 12/31/2023 |
1.15099 % | Lord, Abbett & Co. LLC | 1,321,219 | 1,302,682 | 12/31/2023 |
1.13378 % | Norges Bank Investment Management (NBIM) | 1,301,465 | 1,301,465 | 12/31/2023 |
1.01225 % | Dimensional Fund Advisors, L.P. | 1,161,964 | 0 | 12/31/2023 |
0.94994 % | Affinity Asset Advisors LLC | 1,090,441 | -38,935 | 12/31/2023 |
0.84562 % | Northern Trust Investments, Inc. | 970,683 | 117,963 | 12/31/2023 |
0.80262 % | Millennium Management LLC | 921,330 | 777,926 | 12/31/2023 |
0.78404 % | Novo Holdings A/S | 900,000 | -666,521 | 12/31/2023 |
0.74351 % | Charles Schwab Investment Management, Inc. | 853,475 | 54,920 | 12/31/2023 |
0.73323 % | Driehaus Capital Management, LLC | 841,677 | 348,712 | 12/31/2023 |
0.71343 % | DWS Investment S.A. | 818,946 | 818,946 | 12/31/2023 |
0.65358 % | Saturn V Capital Management LLC | 750,250 | -374,209 | 12/31/2023 |
0.65019 % | Assenagon Asset Management S.A. | 746,353 | 684,901 | 12/31/2023 |
0.64804 % | Nuveen LLC | 743,886 | 44,494 | 12/31/2023 |
0.64237 % | Fidelity Institutional Asset Management | 737,376 | 737,376 | 12/31/2023 |
0.60986 % | Westfield Capital Management Company, L.P. | 700,056 | 700,056 | 12/31/2023 |
0.60075 % | Victory Capital Management Inc. | 689,603 | -347,830 | 12/31/2023 |
0.59333 % | Invesco Capital Management LLC | 681,088 | -210,576 | 12/31/2023 |
0.55727 % | Morgan Stanley & Co. LLC | 639,694 | 443,502 | 12/31/2023 |
0.55484 % | D. E. Shaw & Co., L.P. | 636,897 | -161,112 | 12/31/2023 |
0.53243 % | BioImpact Capital LLC | 611,181 | 411 | 12/31/2023 |
0.51076 % | Jefferies LLC | 586,298 | 586,298 | 12/31/2023 |
0.46346 % | Woodline Partners LP | 532,002 | 121,287 | 12/31/2023 |
0.45235 % | Hood River Capital Management LLC | 519,249 | 6,838 | 12/31/2023 |
0.44739 % | Goldman Sachs & Company, Inc. | 513,557 | 64,228 | 12/31/2023 |
0.42874 % | Acuta Capital Partners, LLC | 492,155 | 74,155 | 12/31/2023 |
0.42681 % | Ally Bridge Group NY LLC | 489,938 | 489,938 | 12/31/2023 |
0.37852 % | Nicholas Investment Partners, L.P. | 434,507 | -1,405,507 | 12/31/2023 |
0.32308 % | DWS Investment GmbH | 370,861 | -29,139 | 12/31/2023 |
0.30490 % | Tang Capital Management, LLC | 350,000 | 150,000 | 12/31/2023 |
0.30468 % | AllianceBernstein L.P. | 349,739 | 248,739 | 12/31/2023 |
0.28769 % | Citadel Advisors LLC | 330,234 | 216,927 | 12/31/2023 |
0.26448 % | Invus Public Equities Advisors, LLC | 303,600 | 303,600 | 12/31/2023 |
0.25764 % | BNY Mellon Asset Management | 295,742 | 45,213 | 12/31/2023 |
0.25207 % | BlackRock Investment Management, LLC | 289,354 | 37,699 | 12/31/2023 |
0.24579 % | Parametric Portfolio Associates LLC | 282,141 | -13,203 | 12/31/2023 |
0.24356 % | BlackRock Financial Management, Inc. | 279,580 | 22,808 | 12/31/2023 |
0.23308 % | Shah (Sujal A) | 267,551 | 96,250 | 1/24/2024 |
0.23207 % | Two Sigma Investments, LP | 266,389 | -547,938 | 12/31/2023 |
0.22773 % | Moody Aldrich Partners, LLC | 261,415 | -64,562 | 12/31/2023 |
0.19688 % | PGIM Securities Investment Trust Enterprise | 226,000 | -9,000 | 12/31/2023 |
0.19076 % | SilverArc Capital Management, LLC | 218,975 | -371,025 | 12/31/2023 |
0.18046 % | EAM Investors, LLC | 207,152 | -174,412 | 12/31/2023 |
0.17665 % | Wellington Management Company, LLP | 202,782 | 202,782 | 12/31/2023 |
0.16985 % | Jane Street Capital, L.L.C. | 194,968 | 136,320 | 12/31/2023 |
0.16822 % | BlackRock Advisors (UK) Limited | 193,101 | 8,714 | 1/31/2024 |
0.16128 % | Barclays Bank PLC | 185,132 | 141,494 | 12/31/2023 |
0.15914 % | DWS Investments UK Limited | 182,676 | 131,239 | 12/31/2023 |
0.15878 % | StemPoint Capital LP | 182,258 | 182,258 | 12/31/2023 |
0.15637 % | MFS Investment Management | 179,499 | 2,250 | 12/31/2023 |
0.15629 % | ArrowMark Colorado Holdings, LLC | 179,400 | 0 | 12/31/2023 |
0.15426 % | ExodusPoint Capital Management, LP | 177,072 | 163,441 | 12/31/2023 |
0.14730 % | BNP Paribas Securities Corp. North America | 169,082 | 104,776 | 12/31/2023 |
0.14635 % | BlackRock Asset Management Ireland Limited | 167,998 | 27,475 | 12/31/2023 |
0.14456 % | J. Goldman & Co., L.P. | 165,937 | 26,988 | 12/31/2023 |
0.13968 % | HighVista Strategies LLC | 160,334 | -19,971 | 12/31/2023 |
0.13934 % | Renaissance Technologies LLC | 159,950 | 46,500 | 12/31/2023 |
0.13726 % | TD Asset Management Inc. | 157,556 | 65,600 | 12/31/2023 |
0.13538 % | Schweizerische Nationalbank | 155,400 | -26,100 | 12/31/2023 |
0.13133 % | Credit Suisse Funds AG | 150,752 | -10,913 | 12/31/2023 |
0.13082 % | Rhumbline Advisers Ltd. Partnership | 150,169 | 20,665 | 12/31/2023 |
0.12632 % | Atika Capital Management LLC | 145,000 | 29,000 | 12/31/2023 |
0.12043 % | UBS Financial Services, Inc. | 138,241 | 5,741 | 12/31/2023 |
0.11570 % | Qube Research & Technologies Ltd | 132,809 | 132,809 | 12/31/2023 |
0.11262 % | Manulife Investment Management (North America) Limited | 129,280 | 29,844 | 12/31/2023 |
0.10715 % | Voya Investment Management LLC | 122,998 | 83,293 | 12/31/2023 |
0.10208 % | Goldman Sachs Asset Management, L.P. | 117,178 | 5,746 | 12/31/2023 |
0.09921 % | Raymond James Financial Services Advisors, Inc. | 113,883 | 12,554 | 12/31/2023 |
0.09904 % | Von Emster (Kurt Konrad Hans III) | 113,683 | 5,367 | 3/15/2023 |
0.09670 % | Altium Capital Management LP | 111,000 | -689,000 | 12/31/2023 |
0.08990 % | Arctic Fund Management AS | 103,199 | 46,763 | 12/31/2023 |
0.08623 % | Advisory Research, Inc. | 98,985 | -5,555 | 12/31/2023 |
0.08407 % | ClariVest Asset Management LLC | 96,505 | 24 | 12/31/2023 |
0.08328 % | LPL Financial LLC | 95,601 | -27,763 | 12/31/2023 |
0.08280 % | New York State Common Retirement Fund | 95,043 | 30,639 | 12/31/2023 |
0.08174 % | Russell Investments Trust Company | 93,834 | 93,011 | 12/31/2023 |
0.08113 % | Squarepoint Capital LLP | 93,133 | 9,232 | 12/31/2023 |