14.96499 % | Fidelity Management & Research Company LLC | 10,678,612 | 48,951 | 6/30/2022 |
8.13684 % | The Vanguard Group, Inc. | 5,806,227 | 686,912 | 6/30/2022 |
7.27898 % | Vifor (International), Ltd | 5,194,085 | 0 | 9/13/2022 |
5.73376 % | BlackRock Institutional Trust Company, N.A. | 4,091,453 | 306,603 | 6/30/2022 |
5.67001 % | State Street Global Advisors (US) | 4,045,964 | 404,301 | 6/30/2022 |
3.35404 % | Schall (Thomas J) | 2,393,352 | 0 | 9/13/2022 |
3.32502 % | Pictet Asset Management Ltd. | 2,372,645 | 532,478 | 6/30/2022 |
2.94707 % | Wasatch Global Investors Inc | 2,102,953 | 1,027,231 | 6/30/2022 |
2.51223 % | Baker Bros. Advisors LP | 1,792,657 | 875,795 | 6/30/2022 |
2.15378 % | GW&K Investment Management, LLC | 1,536,877 | 375,530 | 6/30/2022 |
1.99699 % | Cormorant Asset Management, LP | 1,425,000 | 560,000 | 6/30/2022 |
1.96820 % | Invesco Advisers, Inc. | 1,404,451 | 34,143 | 6/30/2022 |
1.87336 % | Hood River Capital Management LLC | 1,336,776 | 1,336,776 | 6/30/2022 |
1.65218 % | Marshall Wace LLP | 1,178,948 | -219,635 | 6/30/2022 |
1.54129 % | Norges Bank Investment Management (NBIM) | 1,099,824 | 661,000 | 12/31/2021 |
1.53785 % | HealthCor Management, L.P. | 1,097,370 | 140,630 | 6/30/2022 |
1.41112 % | Geode Capital Management, L.L.C. | 1,006,934 | 6,519 | 6/30/2022 |
1.18123 % | Nuveen LLC | 842,891 | 340,858 | 6/30/2022 |
1.02076 % | Eventide Asset Management, LLC | 728,385 | 0 | 6/30/2022 |
0.92914 % | Morgan Stanley & Co. LLC | 663,007 | 262,249 | 6/30/2022 |
0.89221 % | Sofinnova Investments, Inc | 636,659 | 62,975 | 6/30/2022 |
0.84084 % | Logos Global Management LLC | 600,000 | 600,000 | 6/30/2022 |
0.81428 % | Wellington Management Company, LLP | 581,050 | -64,783 | 6/30/2022 |
0.80444 % | Integral Health Asset Management, LLC | 574,029 | 174,029 | 6/30/2022 |
0.77680 % | Principal Global Investors (Equity) | 554,300 | 249,434 | 6/30/2022 |
0.76524 % | Barclays Bank PLC | 546,057 | 505,367 | 6/30/2022 |
0.76451 % | Tri Locum Partners LP | 545,532 | 249,205 | 6/30/2022 |
0.69025 % | Northern Trust Investments, Inc. | 492,544 | 46,115 | 6/30/2022 |
0.68038 % | APG Asset Management N.V. | 485,501 | 485,501 | 3/31/2022 |
0.61897 % | Perceptive Advisors LLC | 441,680 | -1,213,399 | 6/30/2022 |
0.53568 % | Charles Schwab Investment Management, Inc. | 382,244 | 14,545 | 6/30/2022 |
0.51949 % | Millennium Management LLC | 370,692 | -930,257 | 6/30/2022 |
0.50771 % | Voloridge Investment Management, LLC | 362,291 | -301,944 | 6/30/2022 |
0.44388 % | Invesco Capital Management LLC | 316,743 | 76,060 | 6/30/2022 |
0.43899 % | Goldman Sachs & Company, Inc. | 313,253 | 62,366 | 6/30/2022 |
0.43461 % | T. Rowe Price Associates, Inc. | 310,129 | -55,505 | 6/30/2022 |
0.42662 % | Citadel Advisors LLC | 304,424 | -1,906 | 6/30/2022 |
0.39746 % | Raymond James & Associates, Inc. | 283,620 | -11,213 | 6/30/2022 |
0.36369 % | Raymond James Financial Services Advisors, Inc. | 259,519 | 12,347 | 6/30/2022 |
0.32452 % | PGIM Quantitative Solutions LLC | 231,570 | 231,570 | 6/30/2022 |
0.32154 % | Parametric Portfolio Associates LLC | 229,439 | -14,171 | 6/30/2022 |
0.31396 % | Kanaya (Susan M) | 224,034 | 0 | 9/13/2022 |
0.30925 % | Thornburg Investment Management, Inc. | 220,675 | -25,602 | 6/30/2022 |
0.27396 % | Dimensional Fund Advisors, L.P. | 195,488 | -124,852 | 6/30/2022 |
0.25918 % | Lisanti Capital Growth, LLC | 184,946 | -136,623 | 6/30/2022 |
0.25265 % | Lord, Abbett & Co. LLC | 180,285 | 169,409 | 6/30/2022 |
0.25259 % | BNY Mellon Asset Management | 180,238 | 21,793 | 6/30/2022 |
0.24858 % | BlackRock Investment Management, LLC | 177,382 | 7,809 | 6/30/2022 |
0.23596 % | BlackRock Financial Management, Inc. | 168,375 | 22,142 | 6/30/2022 |
0.23578 % | Granahan Investment Management, Inc. | 168,245 | 45,478 | 6/30/2022 |
0.23563 % | Two Sigma Investments, LP | 168,141 | -833,794 | 6/30/2022 |
0.23097 % | Goldman Sachs Asset Management, L.P. | 164,816 | 39,130 | 6/30/2022 |
0.22422 % | Altium Capital Management LP | 160,000 | 160,000 | 6/30/2022 |
0.22342 % | Citi Investment Research (US) | 159,427 | 117,029 | 6/30/2022 |
0.21638 % | Soleus Capital Management, L.P. | 154,400 | 154,400 | 6/30/2022 |
0.21603 % | Susquehanna International Group, LLP | 154,151 | -18,198 | 6/30/2022 |
0.21353 % | Rafferty Asset Management LLC | 152,368 | -73,036 | 6/30/2022 |
0.20758 % | Feczko (Joseph M) | 148,127 | 0 | 9/13/2022 |
0.20083 % | Edwards (Thomas A) | 143,306 | 0 | 9/13/2022 |
0.20007 % | Parker (Geoffrey M) | 142,763 | 0 | 9/13/2022 |
0.19510 % | Assenagon Asset Management S.A. | 139,219 | -22,556 | 6/30/2022 |
0.19176 % | Northern Trust Global Investments | 136,838 | 38,823 | 6/30/2022 |
0.19157 % | Nomura Asset Management Co., Ltd. | 136,700 | -59,499 | 11/30/2021 |
0.18952 % | BofA Global Research (US) | 135,237 | -111,166 | 6/30/2022 |
0.18919 % | BZ Bank AG (Asset Management) | 135,000 | 0 | 5/31/2022 |
0.18498 % | Schweizerische Nationalbank | 132,000 | 16,100 | 6/30/2022 |
0.17251 % | Medical Strategy GmbH | 123,100 | 7,500 | 5/31/2022 |
0.16971 % | International Biotechnology Trust PLC | 121,100 | 85,000 | 6/30/2022 |
0.16641 % | Allspring Global Investments, LLC | 118,744 | 39,199 | 6/30/2022 |
0.15954 % | Capital Fund Management S.A. | 113,844 | 113,844 | 6/30/2022 |
0.14732 % | ExodusPoint Capital Management, LP | 105,124 | 11,155 | 6/30/2022 |
0.13558 % | Ensign Peak Advisors, Inc. | 96,746 | 23,783 | 6/30/2022 |
0.13236 % | Mutual of America Capital Management LLC | 94,450 | -41,248 | 6/30/2022 |
0.13220 % | UBS Financial Services, Inc. | 94,337 | -73,833 | 6/30/2022 |
0.12468 % | Aperio Group, LLC | 88,969 | -6,250 | 6/30/2022 |
0.12284 % | Cappel (Markus J) | 87,658 | 0 | 9/13/2022 |
0.12018 % | BlackRock Advisors (UK) Limited | 85,759 | 5,091 | 8/31/2022 |
0.12003 % | Mirabella Financial Services LLP | 85,653 | 85,653 | 6/30/2022 |
0.11562 % | Rhumbline Advisers Ltd. Partnership | 82,501 | 8,950 | 6/30/2022 |
0.11300 % | Group One Trading, L.P. | 80,635 | 80,635 | 6/30/2022 |
0.10959 % | Tekla Capital Management LLC | 78,197 | 0 | 6/30/2022 |
0.10581 % | AllianceBernstein L.P. | 75,500 | 13,100 | 6/30/2022 |
0.10479 % | California State Teachers Retirement System | 74,776 | 9,871 | 6/30/2022 |
0.10427 % | BlackRock Asset Management Ireland Limited | 74,403 | 9,221 | 6/30/2022 |
0.10216 % | Jane Street Capital, L.L.C. | 72,896 | -41,935 | 6/30/2022 |
0.10195 % | McKinnell (Henry A Jr) | 72,749 | 7,726 | 5/20/2022 |
0.10122 % | Allianz Global Investors U.S. LLC | 72,225 | 7,540 | 6/30/2022 |
0.09737 % | Jump Financial, LLC | 69,484 | 60,484 | 6/30/2022 |
0.09580 % | Cahill Wealth Management, LLC | 68,358 | 23,445 | 6/30/2022 |
0.09109 % | Hudson Bay Capital Management LP | 65,000 | 10,000 | 6/30/2022 |
0.08913 % | Cubist Systematic Strategies, LLC | 63,599 | 31,059 | 6/30/2022 |
0.08856 % | EFG Asset Management (UK) Limited | 63,195 | 11,721 | 5/31/2022 |
0.08696 % | EFG Asset Management (North America) Corp | 62,051 | 8,550 | 6/30/2022 |
0.08572 % | Ohio Public Employees Retirement System | 61,171 | 26,172 | 6/30/2022 |
0.08531 % | Algert Global LLC | 60,875 | 46,740 | 6/30/2022 |
0.08156 % | Jennison Associates LLC | 58,200 | 58,200 | 6/30/2022 |
0.07689 % | State of Wisconsin Investment Board | 54,866 | -11,834 | 6/30/2022 |
0.07367 % | SEI Investments Management Corporation | 52,572 | 52,572 | 6/30/2022 |
0.07277 % | PanAgora Asset Management Inc. | 51,929 | 23,495 | 6/30/2022 |
0.07146 % | Legal & General Investment Management Ltd. | 50,994 | 8,111 | 6/30/2022 |