12.13451 % | State Street Global Advisors (US) | 16,002,989 | 2,260,435 | 12/31/2022 |
6.68261 % | BVF Partners L.P. | 8,813,021 | 0 | 12/31/2022 |
4.87271 % | BlackRock Institutional Trust Company, N.A. | 6,426,136 | 405,152 | 12/31/2022 |
4.20730 % | The Vanguard Group, Inc. | 5,548,591 | 762,568 | 12/31/2022 |
3.74136 % | Stonepine Capital Management, LLC | 4,934,100 | -735,288 | 12/31/2022 |
3.61144 % | Millennium Management LLC | 4,762,769 | 8,641 | 12/31/2022 |
3.49297 % | Sofinnova Investments, Inc | 4,606,527 | 994,151 | 12/31/2022 |
2.95248 % | Bleichroeder LP | 3,893,730 | -50,000 | 12/31/2022 |
2.86420 % | Bain Capital Life Sciences Investors, LLC | 3,777,308 | 3,777,308 | 12/31/2022 |
2.80759 % | Lion Point Capital, L.P. | 3,702,651 | -686,895 | 12/31/2022 |
2.79472 % | New Enterprise Associates (NEA) | 3,685,683 | 0 | 12/31/2022 |
2.09198 % | Wellington Management Company, LLP | 2,758,903 | -60,760 | 12/31/2022 |
1.94735 % | Medical Strategy GmbH | 2,568,167 | 0 | 9/30/2022 |
1.45113 % | Geode Capital Management, L.L.C. | 1,913,754 | 134,785 | 12/31/2022 |
1.40279 % | Ghost Tree Capital, LLC | 1,850,000 | -150,000 | 12/31/2022 |
1.33288 % | Point72 Asset Management, L.P. | 1,757,800 | 1,649,890 | 12/31/2022 |
1.32514 % | Schonfeld Strategic Advisors LLC | 1,747,600 | 418,124 | 12/31/2022 |
1.11568 % | Rafferty Asset Management LLC | 1,471,357 | 378,314 | 12/31/2022 |
1.10372 % | Verition Fund Management LLC | 1,455,589 | 214,278 | 12/31/2022 |
1.06812 % | Parkman Healthcare Partners LLC | 1,408,642 | 198,497 | 12/31/2022 |
1.00551 % | Ensign Peak Advisors, Inc. | 1,326,062 | 619,785 | 12/31/2022 |
0.98844 % | Nuveen LLC | 1,303,552 | -49,957 | 12/31/2022 |
0.94143 % | Two Sigma Investments, LP | 1,241,564 | 101,702 | 12/31/2022 |
0.86019 % | Goldman Sachs & Company, Inc. | 1,134,419 | -213,286 | 12/31/2022 |
0.80378 % | AIGH Capital Management, LLC. | 1,060,023 | 1,060,023 | 12/31/2022 |
0.74333 % | Sectoral Asset Management Inc. | 980,300 | 12,000 | 12/31/2022 |
0.73476 % | JP Morgan Asset Management | 969,004 | -33,191 | 12/31/2022 |
0.70243 % | BofA Global Research (US) | 926,363 | 211,300 | 12/31/2022 |
0.70239 % | UBS Financial Services, Inc. | 926,309 | 782,053 | 12/31/2022 |
0.66076 % | Balyasny Asset Management LP | 871,409 | 871,409 | 12/31/2022 |
0.59477 % | Northern Trust Investments, Inc. | 784,389 | 57,217 | 12/31/2022 |
0.57504 % | Barclays Bank PLC | 758,361 | 79,748 | 12/31/2022 |
0.48690 % | Citi Investment Research (US) | 642,121 | -347,325 | 12/31/2022 |
0.48295 % | J. Goldman & Co., L.P. | 636,920 | 372,507 | 12/31/2022 |
0.42970 % | Knott Partners Management, LLC | 566,687 | 0 | 12/31/2022 |
0.37011 % | Norges Bank Investment Management (NBIM) | 488,100 | 488,100 | 12/31/2022 |
0.34122 % | Altium Capital Management LP | 450,000 | 23,000 | 12/31/2022 |
0.32306 % | Morgan Stanley & Co. LLC | 426,046 | 134,548 | 12/31/2022 |
0.32082 % | Susquehanna International Group, LLP | 423,104 | -220,888 | 12/31/2022 |
0.27676 % | Worth Venture Partners, LLC | 364,995 | 364,995 | 12/31/2022 |
0.25023 % | Sio Capital Management, LLC | 330,000 | 330,000 | 12/31/2022 |
0.23416 % | ExodusPoint Capital Management, LP | 308,813 | 308,813 | 12/31/2022 |
0.22748 % | Tang Capital Management, LLC | 300,000 | 0 | 12/31/2022 |
0.22430 % | BlackRock Investment Management, LLC | 295,807 | -6,506 | 12/31/2022 |
0.20986 % | BlackRock Financial Management, Inc. | 276,767 | 28,717 | 12/31/2022 |
0.20758 % | BNP Paribas Securities Corp. North America | 273,763 | -56,043 | 12/31/2022 |
0.20481 % | Charles Schwab Investment Management, Inc. | 270,101 | 12,405 | 12/31/2022 |
0.19801 % | BNY Mellon Asset Management | 261,142 | 15,190 | 12/31/2022 |
0.19287 % | SilverArc Capital Management, LLC | 254,361 | -729,155 | 12/31/2022 |
0.16758 % | Schweizerische Nationalbank | 221,000 | 221,000 | 12/31/2022 |
0.15713 % | BG Fund Management Luxembourg S.A. | 207,226 | 47,847 | 12/31/2022 |
0.14647 % | Walleye Capital LLC | 193,170 | -203,802 | 12/31/2022 |
0.14622 % | Gyon Technologies Capital Management, LP | 192,831 | 111,891 | 12/31/2022 |
0.13785 % | Allspring Global Investments, LLC | 181,791 | -921 | 12/31/2022 |
0.13567 % | Parametric Portfolio Associates LLC | 178,919 | -202,220 | 12/31/2022 |
0.13389 % | Kennedy Capital Management, Inc. | 176,571 | -135 | 12/31/2022 |
0.12634 % | Nomura Securities Co., Ltd. | 166,622 | 165,612 | 12/31/2022 |
0.11374 % | Islet Management, LP | 150,000 | -475,000 | 12/31/2022 |
0.10949 % | Rhumbline Advisers Ltd. Partnership | 144,396 | 2,481 | 12/31/2022 |
0.10741 % | Capital Fund Management S.A. | 141,656 | 141,656 | 12/31/2022 |
0.10448 % | Cubist Systematic Strategies, LLC | 137,794 | -126,162 | 12/31/2022 |
0.10410 % | JPMorgan Private Bank (United States) | 137,292 | 377 | 12/31/2022 |
0.10040 % | William Blair & Company, L.L.C. (Research) | 132,413 | -43,785 | 12/31/2022 |
0.09058 % | California State Teachers Retirement System | 119,460 | 79,936 | 12/31/2022 |
0.08356 % | AllianceBernstein L.P. | 110,200 | 0 | 12/31/2022 |
0.08110 % | Boothbay Fund Management, LLC | 106,949 | 106,949 | 12/31/2022 |
0.07225 % | Lakeside Advisors, Inc. | 95,280 | 0 | 12/31/2022 |
0.07120 % | SEB Investment Management AB | 93,903 | -5,442 | 12/31/2022 |
0.06954 % | State of Wisconsin Investment Board | 91,714 | 91,714 | 12/31/2022 |
0.06954 % | Mackenzie Financial Corporation | 91,714 | 80,801 | 12/31/2022 |
0.06953 % | Jump Financial, LLC | 91,693 | 58,204 | 12/31/2022 |
0.06824 % | Candriam Belgium S.A. | 90,000 | 90,000 | 12/31/2022 |
0.06824 % | Candriam Luxembourg S.A. | 90,000 | 0 | 1/31/2023 |
0.06061 % | Jane Street Capital, L.L.C. | 79,936 | -302,750 | 12/31/2022 |
0.06035 % | J.P. Morgan Securities LLC | 79,595 | 79,595 | 12/31/2022 |
0.05970 % | GSA Capital Partners LLP | 78,729 | -55,625 | 12/31/2022 |
0.05846 % | E Fund Management Co. Ltd. | 77,101 | 1,968 | 12/31/2022 |
0.05705 % | Northern Trust Global Investments | 75,232 | -2,115 | 12/31/2022 |
0.05621 % | Credit Suisse Asset Management | 74,129 | 74,129 | 12/31/2022 |
0.05458 % | Hightower Advisors, LLC | 71,982 | 1,500 | 12/31/2022 |
0.05436 % | Mellon Investments Corporation | 71,692 | 581 | 12/31/2022 |
0.04978 % | Goldman Sachs Asset Management, L.P. | 65,654 | -122,185 | 12/31/2022 |
0.04910 % | New York State Common Retirement Fund | 64,753 | 53 | 12/31/2022 |
0.04724 % | Bayesian Capital Management, LP | 62,300 | 62,300 | 12/31/2022 |
0.04108 % | State Street Global Advisors Ireland Limited | 54,175 | 3,400 | 11/30/2022 |
0.03991 % | Apo Asset Management GmbH | 52,627 | 0 | 1/31/2023 |
0.03920 % | UBS Asset Management (Switzerland) | 51,700 | 51,700 | 12/31/2022 |
0.03908 % | Virtus Etf Advisers LLC | 51,542 | 8,172 | 12/31/2022 |
0.03908 % | LifeSci Index Partners, LLC | 51,542 | 0 | 2/28/2023 |
0.03891 % | Citadel Advisors LLC | 51,311 | -439,486 | 12/31/2022 |
0.03816 % | HRT Financial LP | 50,326 | 50,326 | 12/31/2022 |
0.03791 % | Caption Management, LLC | 50,000 | 50,000 | 12/31/2022 |
0.03727 % | SG Americas Securities, L.L.C. | 49,149 | -2,555 | 12/31/2022 |
0.03692 % | MetLife Investment Management, LLC | 48,688 | 0 | 12/31/2022 |
0.03688 % | Tuckson (Reed Vaughn M.D.) | 48,639 | -43,785 | 12/16/2022 |
0.03592 % | SunAmerica Asset Management, LLC | 47,365 | -172 | 12/31/2022 |
0.03329 % | Seeley (Bruce J) | 43,905 | 0 | 3/21/2022 |
0.03271 % | Perry Matthew D | 43,139 | 0 | 8/9/2022 |
0.03231 % | DWS Investments UK Limited | 42,610 | 668 | 12/31/2022 |
0.02986 % | Manulife Investment Management (North America) Limited | 39,378 | 1,652 | 12/31/2022 |