13.09729 % | Fidelity Management & Research Company LLC | 15,626,378 | 2,054,142 | 6/30/2024 |
9.04989 % | T. Rowe Price Associates, Inc. | 10,797,421 | 3,502,039 | 6/30/2024 |
6.94231 % | RTW Investments L.P. | 8,282,870 | -523,968 | 8/22/2024 |
5.98499 % | BlackRock Institutional Trust Company, N.A. | 7,140,692 | 1,669,713 | 6/30/2024 |
5.45218 % | Avoro Capital Advisors LLC | 6,505,000 | 680,000 | 6/30/2024 |
4.96703 % | The Vanguard Group, Inc. | 5,926,169 | 2,096,174 | 6/30/2024 |
4.52637 % | RA Capital Management, LP | 5,400,408 | 504,449 | 6/30/2024 |
4.29897 % | TD Cowen (Research) | 5,129,103 | -500,000 | 6/30/2024 |
4.25388 % | Bristol Myers Squibb | 5,075,304 | 5,075,304 | 11/27/2023 |
3.18668 % | Wellington Management Company, LLP | 3,802,026 | 2,573,028 | 6/30/2024 |
3.06499 % | Janus Henderson Investors | 3,656,843 | 2,414,010 | 6/30/2024 |
2.84719 % | Adage Capital Management, L.P. | 3,396,982 | 996,937 | 6/30/2024 |
2.78268 % | State Street Global Advisors (US) | 3,320,019 | -141,803 | 6/30/2024 |
1.89146 % | Geode Capital Management, L.L.C. | 2,256,697 | 657,023 | 6/30/2024 |
1.74742 % | Casdin Capital, LLC | 2,084,841 | 0 | 6/30/2024 |
1.59422 % | Artisan Partners Limited Partnership | 1,902,065 | -424,436 | 6/30/2024 |
1.44781 % | Boxer Capital, L.L.C. | 1,727,388 | 0 | 6/30/2024 |
1.00482 % | Nuveen LLC | 1,198,852 | 128,111 | 6/30/2024 |
0.93379 % | Polar Capital LLP | 1,114,101 | 1,114,101 | 6/30/2024 |
0.87855 % | Morgan Stanley & Co. LLC | 1,048,194 | -351,199 | 6/30/2024 |
0.70341 % | BlackRock Financial Management, Inc. | 839,235 | 600,535 | 6/30/2024 |
0.66475 % | Charles Schwab Investment Management, Inc. | 793,117 | 244,682 | 6/30/2024 |
0.63496 % | EcoR1 Capital, LLC | 757,576 | 0 | 6/30/2024 |
0.61943 % | D. E. Shaw & Co., L.P. | 739,039 | 707,773 | 6/30/2024 |
0.59213 % | OrbiMed Advisors, LLC | 706,475 | -287,625 | 6/30/2024 |
0.58090 % | Dimensional Fund Advisors, L.P. | 693,066 | -317,102 | 6/30/2024 |
0.57007 % | Northern Trust Investments, Inc. | 680,150 | 82,692 | 6/30/2024 |
0.54946 % | Invus Public Equities Advisors, LLC | 655,555 | 655,555 | 6/30/2024 |
0.54116 % | Woodline Partners LP | 645,658 | 59,320 | 6/30/2024 |
0.44646 % | Fidelity Institutional Asset Management | 532,669 | -136,731 | 6/30/2024 |
0.43394 % | SilverArc Capital Management, LLC | 517,734 | 28,431 | 6/30/2024 |
0.43026 % | TD Asset Management Inc. | 513,338 | 300,054 | 6/30/2024 |
0.42201 % | Alethea Capital Management, LLC | 503,504 | -257,193 | 6/30/2024 |
0.39824 % | Two Sigma Investments, LP | 475,146 | -226,054 | 6/30/2024 |
0.35621 % | Cormorant Asset Management, LP | 425,000 | 425,000 | 6/30/2024 |
0.35301 % | Goldman Sachs & Company, Inc. | 421,182 | 40,446 | 6/30/2024 |
0.34728 % | Lord, Abbett & Co. LLC | 414,340 | 414,340 | 6/30/2024 |
0.31833 % | Pictet Asset Management Ltd. | 379,802 | 368,930 | 6/30/2024 |
0.31632 % | Renaissance Technologies LLC | 377,400 | 377,400 | 6/30/2024 |
0.31508 % | Eventide Asset Management, LLC | 375,924 | 375,924 | 6/30/2024 |
0.30402 % | JPMorgan Asset Management U.K. Limited | 362,732 | -69,715 | 6/30/2024 |
0.27106 % | Candriam Luxembourg S.A. | 323,396 | 0 | 9/30/2024 |
0.26678 % | Invesco Capital Management LLC | 318,293 | -25,417 | 6/30/2024 |
0.24348 % | Norges Bank Investment Management (NBIM) | 290,500 | 205,400 | 3/31/2023 |
0.23586 % | BlackRock Investment Management, LLC | 281,410 | 75,900 | 6/30/2024 |
0.22862 % | Manulife Investment Management (North America) Limited | 272,762 | 42,636 | 6/30/2024 |
0.22521 % | Levin (Arthur A.) | 268,702 | 0 | 10/21/2024 |
0.21067 % | BNY Mellon Asset Management | 251,354 | 75,981 | 6/30/2024 |
0.18817 % | Voya Investment Management LLC | 224,503 | 199,982 | 6/30/2024 |
0.18123 % | AllianceBernstein L.P. | 216,228 | -112,298 | 6/30/2024 |
0.16777 % | UBS Asset Management (Americas), Inc. | 200,170 | 182,963 | 6/30/2024 |
0.16763 % | Darwin Global Management Ltd | 200,000 | 200,000 | 6/30/2024 |
0.16525 % | Boyce (Sarah) | 197,164 | 92,120 | 9/23/2024 |
0.16355 % | Parametric Portfolio Associates LLC | 195,131 | 59,706 | 6/30/2024 |
0.16055 % | Bessemer Trust Company, N.A. (US) | 191,553 | -123,181 | 7/31/2024 |
0.15665 % | Mirae Asset Global Investments (USA) LLC | 186,896 | 149,434 | 6/30/2024 |
0.15443 % | Mutual of America Capital Management LLC | 184,249 | 40,913 | 6/30/2024 |
0.15440 % | New York State Common Retirement Fund | 184,213 | 63,843 | 9/30/2024 |
0.15326 % | BofA Global Research (US) | 182,854 | 1,183 | 6/30/2024 |
0.14961 % | Propel Bio Management, LLC | 178,500 | 0 | 6/30/2024 |
0.13799 % | American Century Investment Management, Inc. | 164,631 | 25,663 | 6/30/2024 |
0.13581 % | Jane Street Capital, L.L.C. | 162,039 | 50,125 | 6/30/2024 |
0.13476 % | Citadel Advisors LLC | 160,777 | 57,644 | 6/30/2024 |
0.13208 % | BlackRock Advisors (UK) Limited | 157,588 | 13,939 | 9/30/2024 |
0.13139 % | Raymond James & Associates, Inc. | 156,763 | 3,131 | 9/30/2024 |
0.13109 % | Schweizerische Nationalbank | 156,400 | 15,600 | 6/30/2024 |
0.12572 % | Alyeska Investment Group, L.P. | 150,000 | 150,000 | 6/30/2024 |
0.11858 % | Rhumbline Advisers Ltd. Partnership | 141,481 | 22,604 | 6/30/2024 |
0.11067 % | Voloridge Investment Management, LLC | 132,041 | 132,041 | 6/30/2024 |
0.10508 % | Millennium Management LLC | 125,375 | -43,216 | 6/30/2024 |
0.10477 % | Simplify Asset Management Inc | 125,000 | 0 | 6/30/2024 |
0.10477 % | MPM BioImpact LLC | 125,000 | 125,000 | 6/30/2024 |
0.10402 % | BlackRock Asset Management Ireland Limited | 124,107 | 52,847 | 6/30/2024 |
0.10298 % | Goldman Sachs Asset Management, L.P. | 122,869 | -11,675 | 6/30/2024 |
0.10105 % | Rafferty Asset Management LLC | 120,557 | -146,575 | 6/30/2024 |
0.10034 % | Aperio Group, LLC | 119,720 | 3,647 | 6/30/2024 |
0.09991 % | T. Rowe Price International Ltd | 119,205 | -14,520 | 6/30/2024 |
0.09774 % | EAM Global Investors LLC | 116,615 | 116,615 | 6/30/2024 |
0.09723 % | Medical Strategy GmbH | 116,000 | -20,000 | 6/30/2024 |
0.09681 % | Squarepoint Capital LLP | 115,508 | 51,743 | 6/30/2024 |
0.09673 % | Raymond James Financial Services Advisors, Inc. | 115,403 | 3,370 | 9/30/2024 |
0.09368 % | Marshall Wace LLP | 111,770 | 9,906 | 6/30/2024 |
0.09227 % | Mellon Investments Corporation | 110,088 | 39,639 | 6/30/2024 |
0.08749 % | UBS Financial Services, Inc. | 104,383 | -91,063 | 6/30/2024 |
0.08650 % | Steward Partners Investment Advisory, LLC | 103,200 | 2,700 | 6/30/2024 |
0.08508 % | Wells Fargo Advisors | 101,512 | -30,375 | 6/30/2024 |
0.08503 % | Avantis Investors | 101,454 | 101,454 | 3/31/2024 |
0.08339 % | Driehaus Capital Management, LLC | 99,496 | 99,496 | 8/31/2024 |
0.08335 % | DWS Investment GmbH | 99,444 | 0 | 6/30/2024 |
0.08194 % | BlackRock Investment Management (UK) Ltd. | 97,768 | 35,235 | 6/30/2024 |
0.07993 % | Allianz Global Investors GmbH | 95,365 | 0 | 8/31/2024 |
0.07880 % | McCarthy (Teresa) | 94,018 | 0 | 10/16/2024 |
0.07743 % | Legal & General Investment Management Ltd. | 92,379 | 16,330 | 6/30/2024 |
0.07597 % | EAM Investors, LLC | 90,635 | 90,635 | 6/30/2024 |
0.07576 % | Barclays Bank PLC | 90,391 | -32,256 | 6/30/2024 |
0.07123 % | MacLean (Michael F.) | 84,980 | 38,490 | 9/23/2024 |
0.06987 % | Cinctive Capital Management LP | 83,362 | 83,362 | 6/30/2024 |
0.06616 % | California State Teachers Retirement System | 78,937 | 7,363 | 6/30/2024 |
0.06558 % | Hennion & Walsh Asset Management, Inc. | 78,238 | -975 | 9/30/2024 |
0.06407 % | Wilson (Troy Edward) | 76,444 | -550,000 | 4/15/2024 |