13,95277 % | State Street Global Advisors (US) | 16 002 989 | 2 260 435 | 31.12.2022 |
7,68394 % | BVF Partners L.P. | 8 813 021 | 0 | 31.12.2022 |
5,60285 % | BlackRock Institutional Trust Company, N.A. | 6 426 136 | 405 152 | 31.12.2022 |
4,83773 % | The Vanguard Group, Inc. | 5 548 591 | 762 568 | 31.12.2022 |
4,30197 % | Stonepine Capital Management, LLC | 4 934 100 | -735 288 | 31.12.2022 |
4,15259 % | Millennium Management LLC | 4 762 769 | 8 641 | 31.12.2022 |
4,01636 % | Sofinnova Investments, Inc | 4 606 527 | 994 151 | 31.12.2022 |
3,39489 % | Bleichroeder LP | 3 893 730 | -50 000 | 31.12.2022 |
3,29338 % | Bain Capital Life Sciences Investors, LLC | 3 777 308 | 3 777 308 | 31.12.2022 |
3,22829 % | Lion Point Capital, L.P. | 3 702 651 | -686 895 | 31.12.2022 |
3,21349 % | New Enterprise Associates (NEA) | 3 685 683 | 0 | 31.12.2022 |
2,40545 % | Wellington Management Company, LLP | 2 758 903 | -60 760 | 31.12.2022 |
2,23915 % | Medical Strategy GmbH | 2 568 167 | 0 | 30.09.2022 |
1,66857 % | Geode Capital Management, L.L.C. | 1 913 754 | 134 785 | 31.12.2022 |
1,61299 % | Ghost Tree Capital, LLC | 1 850 000 | -150 000 | 31.12.2022 |
1,53260 % | Point72 Asset Management, L.P. | 1 757 800 | 1 649 890 | 31.12.2022 |
1,52371 % | Schonfeld Strategic Advisors LLC | 1 747 600 | 418 124 | 31.12.2022 |
1,28285 % | Rafferty Asset Management LLC | 1 471 357 | 378 314 | 31.12.2022 |
1,26911 % | Verition Fund Management LLC | 1 455 589 | 214 278 | 31.12.2022 |
1,22817 % | Parkman Healthcare Partners LLC | 1 408 642 | 198 497 | 31.12.2022 |
1,15617 % | Ensign Peak Advisors, Inc. | 1 326 062 | 619 785 | 31.12.2022 |
1,13655 % | Nuveen LLC | 1 303 552 | -49 957 | 31.12.2022 |
1,08250 % | Two Sigma Investments, LP | 1 241 564 | 101 702 | 31.12.2022 |
0,98908 % | Goldman Sachs & Company, Inc. | 1 134 419 | -213 286 | 31.12.2022 |
0,92422 % | AIGH Capital Management, LLC. | 1 060 023 | 1 060 023 | 31.12.2022 |
0,85471 % | Sectoral Asset Management Inc. | 980 300 | 12 000 | 31.12.2022 |
0,84486 % | JP Morgan Asset Management | 969 004 | -33 191 | 31.12.2022 |
0,80768 % | BofA Global Research (US) | 926 363 | 211 300 | 31.12.2022 |
0,80764 % | UBS Financial Services, Inc. | 926 309 | 782 053 | 31.12.2022 |
0,75977 % | Balyasny Asset Management LP | 871 409 | 871 409 | 31.12.2022 |
0,68390 % | Northern Trust Investments, Inc. | 784 389 | 57 217 | 31.12.2022 |
0,66120 % | Barclays Bank PLC | 758 361 | 79 748 | 31.12.2022 |
0,55986 % | Citi Investment Research (US) | 642 121 | -347 325 | 31.12.2022 |
0,55532 % | J. Goldman & Co., L.P. | 636 920 | 372 507 | 31.12.2022 |
0,49409 % | Knott Partners Management, LLC | 566 687 | 0 | 31.12.2022 |
0,42557 % | Norges Bank Investment Management (NBIM) | 488 100 | 488 100 | 31.12.2022 |
0,39235 % | Altium Capital Management LP | 450 000 | 23 000 | 31.12.2022 |
0,37146 % | Morgan Stanley & Co. LLC | 426 046 | 134 548 | 31.12.2022 |
0,36890 % | Susquehanna International Group, LLP | 423 104 | -220 888 | 31.12.2022 |
0,31823 % | Worth Venture Partners, LLC | 364 995 | 364 995 | 31.12.2022 |
0,28772 % | Sio Capital Management, LLC | 330 000 | 330 000 | 31.12.2022 |
0,26925 % | ExodusPoint Capital Management, LP | 308 813 | 308 813 | 31.12.2022 |
0,26157 % | Tang Capital Management, LLC | 300 000 | 0 | 31.12.2022 |
0,25791 % | BlackRock Investment Management, LLC | 295 807 | -6 506 | 31.12.2022 |
0,24131 % | BlackRock Financial Management, Inc. | 276 767 | 28 717 | 31.12.2022 |
0,23869 % | BNP Paribas Securities Corp. North America | 273 763 | -56 043 | 31.12.2022 |
0,23550 % | Charles Schwab Investment Management, Inc. | 270 101 | 12 405 | 31.12.2022 |
0,22769 % | BNY Mellon Asset Management | 261 142 | 15 190 | 31.12.2022 |
0,22177 % | SilverArc Capital Management, LLC | 254 361 | -729 155 | 31.12.2022 |
0,19269 % | Schweizerische Nationalbank | 221 000 | 221 000 | 31.12.2022 |
0,18068 % | BG Fund Management Luxembourg S.A. | 207 226 | 47 847 | 31.12.2022 |
0,16842 % | Walleye Capital LLC | 193 170 | -203 802 | 31.12.2022 |
0,16813 % | Gyon Technologies Capital Management, LP | 192 831 | 111 891 | 31.12.2022 |
0,15850 % | Allspring Global Investments, LLC | 181 791 | -921 | 31.12.2022 |
0,15600 % | Parametric Portfolio Associates LLC | 178 919 | -202 220 | 31.12.2022 |
0,15395 % | Kennedy Capital Management, Inc. | 176 571 | -135 | 31.12.2022 |
0,14528 % | Nomura Securities Co., Ltd. | 166 622 | 165 612 | 31.12.2022 |
0,13078 % | Islet Management, LP | 150 000 | -475 000 | 31.12.2022 |
0,12590 % | Rhumbline Advisers Ltd. Partnership | 144 396 | 2 481 | 31.12.2022 |
0,12351 % | Capital Fund Management S.A. | 141 656 | 141 656 | 31.12.2022 |
0,12014 % | Cubist Systematic Strategies, LLC | 137 794 | -126 162 | 31.12.2022 |
0,11970 % | JPMorgan Private Bank (United States) | 137 292 | 377 | 31.12.2022 |
0,11545 % | William Blair & Company, L.L.C. (Research) | 132 413 | -43 785 | 31.12.2022 |
0,10416 % | California State Teachers Retirement System | 119 460 | 79 936 | 31.12.2022 |
0,09608 % | AllianceBernstein L.P. | 110 200 | 0 | 31.12.2022 |
0,09325 % | Boothbay Fund Management, LLC | 106 949 | 106 949 | 31.12.2022 |
0,08307 % | Lakeside Advisors, Inc. | 95 280 | 0 | 31.12.2022 |
0,08187 % | SEB Investment Management AB | 93 903 | -5 442 | 31.12.2022 |
0,07996 % | State of Wisconsin Investment Board | 91 714 | 91 714 | 31.12.2022 |
0,07996 % | Mackenzie Financial Corporation | 91 714 | 80 801 | 31.12.2022 |
0,07995 % | Jump Financial, LLC | 91 693 | 58 204 | 31.12.2022 |
0,07847 % | Candriam Belgium S.A. | 90 000 | 90 000 | 31.12.2022 |
0,07847 % | Candriam Luxembourg S.A. | 90 000 | 0 | 31.01.2023 |
0,06970 % | Jane Street Capital, L.L.C. | 79 936 | -302 750 | 31.12.2022 |
0,06940 % | J.P. Morgan Securities LLC | 79 595 | 79 595 | 31.12.2022 |
0,06864 % | GSA Capital Partners LLP | 78 729 | -55 625 | 31.12.2022 |
0,06722 % | E Fund Management Co. Ltd. | 77 101 | 1 968 | 31.12.2022 |
0,06559 % | Northern Trust Global Investments | 75 232 | -2 115 | 31.12.2022 |
0,06463 % | Credit Suisse Asset Management | 74 129 | 74 129 | 31.12.2022 |
0,06276 % | Hightower Advisors, LLC | 71 982 | 1 500 | 31.12.2022 |
0,06251 % | Mellon Investments Corporation | 71 692 | 581 | 31.12.2022 |
0,05724 % | Goldman Sachs Asset Management, L.P. | 65 654 | -122 185 | 31.12.2022 |
0,05646 % | New York State Common Retirement Fund | 64 753 | 53 | 31.12.2022 |
0,05432 % | Bayesian Capital Management, LP | 62 300 | 62 300 | 31.12.2022 |
0,04723 % | State Street Global Advisors Ireland Limited | 54 175 | 3 400 | 30.11.2022 |
0,04588 % | Apo Asset Management GmbH | 52 627 | 0 | 31.01.2023 |
0,04508 % | UBS Asset Management (Switzerland) | 51 700 | 51 700 | 31.12.2022 |
0,04494 % | Virtus Etf Advisers LLC | 51 542 | 8 172 | 31.12.2022 |
0,04494 % | LifeSci Index Partners, LLC | 51 542 | 0 | 28.02.2023 |
0,04474 % | Citadel Advisors LLC | 51 311 | -439 486 | 31.12.2022 |
0,04388 % | HRT Financial LP | 50 326 | 50 326 | 31.12.2022 |
0,04359 % | Caption Management, LLC | 50 000 | 50 000 | 31.12.2022 |
0,04285 % | SG Americas Securities, L.L.C. | 49 149 | -2 555 | 31.12.2022 |
0,04245 % | MetLife Investment Management, LLC | 48 688 | 0 | 31.12.2022 |
0,04241 % | Tuckson (Reed Vaughn M.D.) | 48 639 | -43 785 | 16.12.2022 |
0,04130 % | SunAmerica Asset Management, LLC | 47 365 | -172 | 31.12.2022 |
0,03828 % | Seeley (Bruce J) | 43 905 | 0 | 21.03.2022 |
0,03761 % | Perry Matthew D | 43 139 | 0 | 09.08.2022 |
0,03715 % | DWS Investments UK Limited | 42 610 | 668 | 31.12.2022 |
0,03433 % | Manulife Investment Management (North America) Limited | 39 378 | 1 652 | 31.12.2022 |