18,87544 % | Fidelity Management & Research Company LLC | 5.449.340 | 176.940 | 30-9-2021 |
16,00206 % | MDV Management Company, L.L.C. | 4.619.796 | 0 | 16-2-2021 |
13,85521 % | Armistice Capital LLC | 4.000.000 | 144.000 | 30-9-2021 |
13,56057 % | Stonepine Capital Management, LLC | 3.914.938 | 1.220.643 | 30-9-2021 |
10,84841 % | Magnetar Capital Partners LP | 3.131.937 | 3.131.937 | 18-10-2021 |
6,11372 % | The Vanguard Group, Inc. | 1.765.031 | 13.211 | 30-9-2021 |
5,14375 % | Swedbank Robur Fonder AB | 1.485.000 | 0 | 30-9-2021 |
5,05715 % | Opaleye Management Inc. | 1.460.000 | -210.600 | 30-9-2021 |
3,98337 % | Point72 Asset Management, L.P. | 1.150.000 | -1.101.255 | 30-9-2021 |
3,63389 % | Medical Strategy GmbH | 1.049.103 | 0 | 30-6-2021 |
2,77139 % | Cooper Creek Partners Management LLC | 800.100 | 0 | 30-9-2021 |
2,64362 % | Renaissance Technologies LLC | 763.212 | -19.600 | 30-9-2021 |
2,43595 % | Two Sigma Investments, LP | 703.258 | -413.601 | 30-9-2021 |
2,31225 % | MAI Capital Management, LLC | 667.546 | 123.730 | 30-9-2021 |
2,16650 % | Altium Capital Management LP | 625.469 | 154.520 | 30-9-2021 |
2,16515 % | Worth Venture Partners, LLC | 625.080 | 34.350 | 30-9-2021 |
2,02017 % | BlackRock Institutional Trust Company, N.A. | 583.223 | -13.551 | 30-9-2021 |
1,82067 % | Acadian Asset Management LLC | 525.628 | -67.637 | 30-9-2021 |
1,24953 % | Geode Capital Management, L.L.C. | 360.738 | 25.632 | 30-9-2021 |
1,23398 % | McFarlane (Neil F) | 356.250 | 300.000 | 2-3-2021 |
1,01638 % | D. E. Shaw & Co., L.P. | 293.428 | -175.432 | 30-9-2021 |
0,99772 % | SilverArc Capital Management, LLC | 288.042 | -250.702 | 30-9-2021 |
0,81795 % | BMO Capital Markets (US) | 236.142 | 236.142 | 30-9-2021 |
0,79559 % | BMO Asset Management U.S. | 229.688 | -12.702 | 30-9-2021 |
0,68237 % | MacPhee (John A) | 197.000 | 5.000 | 2-6-2021 |
0,48493 % | DCF Advisers, LLC | 140.000 | 0 | 30-9-2021 |
0,39799 % | Bridgeway Capital Management, LLC | 114.900 | -150.000 | 30-9-2021 |
0,39092 % | State Street Global Advisors (US) | 112.859 | 9.700 | 30-9-2021 |
0,39065 % | Mahoney (David L) | 112.781 | 5.000 | 2-6-2021 |
0,37485 % | Prentiss (Christopher B.) | 108.219 | 72.578 | 22-3-2021 |
0,34638 % | Healthcare Value Capital, LLC | 100.000 | 0 | 30-9-2021 |
0,34568 % | Shreedhar (Vishvanath) | 99.797 | -6.200 | 21-6-2021 |
0,33907 % | Newton Investment Management North America, LLC | 97.890 | 97.890 | 30-9-2021 |
0,33061 % | Northern Trust Investments, Inc. | 95.446 | 14.876 | 30-9-2021 |
0,31629 % | Mosaic Family Wealth, LLC | 91.314 | 0 | 30-9-2021 |
0,25277 % | BlackRock Financial Management, Inc. | 72.975 | 10.338 | 30-9-2021 |
0,23900 % | Lieberburg (Ivan M) | 69.000 | 5.000 | 3-6-2020 |
0,23119 % | BofA Global Research (US) | 66.745 | 6.406 | 30-9-2021 |
0,21880 % | Principal Global Investors (Equity) | 63.167 | -474 | 30-9-2021 |
0,20824 % | Morgan Stanley & Co. LLC | 60.118 | -6.115 | 30-9-2021 |
0,15006 % | Apo Asset Management GmbH | 43.322 | 0 | 31-8-2021 |
0,13351 % | Susquehanna International Group, LLP | 38.545 | 38.545 | 30-9-2021 |
0,11802 % | SG Americas Securities, L.L.C. | 34.073 | -42 | 30-9-2021 |
0,11614 % | Jacobs Levy Equity Management, Inc. | 33.530 | -17.173 | 30-9-2021 |
0,10523 % | BNY Mellon Asset Management | 30.381 | 0 | 30-9-2021 |
0,10218 % | Campbell & Company, Inc. | 29.500 | 29.500 | 30-9-2021 |
0,09621 % | Citadel Advisors LLC | 27.776 | 12.649 | 30-9-2021 |
0,09468 % | Asset Management One Co., Ltd. | 27.333 | 33 | 31-8-2020 |
0,09006 % | T. Rowe Price Associates, Inc. | 26.000 | -7.700 | 30-9-2021 |
0,08105 % | Zebra Capital Management, LLC | 23.400 | 0 | 30-9-2021 |
0,07341 % | HighVista Strategies LLC | 21.193 | 6.437 | 30-9-2021 |
0,07265 % | Papapetropoulos (Spyridon) | 20.975 | 5.000 | 2-6-2021 |
0,06923 % | Goldman Sachs Asset Management, L.P. | 19.986 | -3.765 | 30-9-2021 |
0,06543 % | Clear Harbor Asset Management, LLC | 18.889 | -1.500 | 30-9-2021 |
0,06517 % | Goldman Sachs & Company, Inc. | 18.816 | -21.489 | 30-9-2021 |
0,06191 % | Charles Schwab Investment Management, Inc. | 17.873 | 0 | 30-9-2021 |
0,05709 % | Group One Trading, L.P. | 16.483 | 16.483 | 30-9-2021 |
0,05542 % | Dowling & Yahnke, LLC | 16.000 | 0 | 30-9-2021 |
0,05542 % | Demski (Martha J) | 16.000 | 3.000 | 7-6-2021 |
0,05520 % | Algert Global LLC | 15.936 | 15.936 | 30-9-2021 |
0,05196 % | Richo (Anna S.) | 15.000 | 5.000 | 2-6-2021 |
0,04662 % | Cubist Systematic Strategies, LLC | 13.460 | -900 | 30-9-2021 |
0,04503 % | PNC Wealth Management | 13.000 | 3.000 | 30-9-2021 |
0,04337 % | Hightower Advisors, LLC | 12.521 | 0 | 30-9-2021 |
0,03907 % | Barclays Bank PLC | 11.279 | 5.553 | 30-9-2021 |
0,03879 % | United Bank, Inc. | 11.200 | 11.200 | 30-9-2021 |
0,03817 % | Nuveen Asset Management, LLC | 11.020 | 0 | 30-4-2020 |
0,03506 % | Capstone Investment Advisors, LLC | 10.123 | 10.123 | 30-9-2021 |
0,03182 % | BlackRock Japan Co., Ltd. | 9.185 | 0 | 30-9-2021 |
0,02840 % | Blackstone Alternative Investment Advisors LLC | 8.200 | 0 | 30-6-2021 |
0,02613 % | Northern Trust Global Investments | 7.545 | 0 | 30-9-2021 |
0,02600 % | BlackRock Investment Management, LLC | 7.507 | -803 | 30-9-2021 |
0,02425 % | Morgan Stanley Smith Barney LLC | 7.000 | 0 | 30-9-2021 |
0,02212 % | BlackRock Investment Management (UK) Ltd. | 6.386 | 0 | 30-9-2021 |
0,02032 % | Mackenzie Financial Corporation | 5.865 | 5.865 | 30-6-2021 |
0,01732 % | Bigham (Michael F) | 5.000 | 5.000 | 2-6-2021 |
0,01732 % | Dier (Mardi C) | 5.000 | 5.000 | 2-6-2021 |
0,01732 % | Ericson (William) | 5.000 | 5.000 | 2-6-2021 |
0,01705 % | BlackRock Fund Advisors | 4.923 | 4.923 | 30-6-2021 |
0,01455 % | Advisor Group, Inc | 4.200 | -2.000 | 30-9-2021 |
0,01239 % | Rockefeller Capital Management | 3.576 | 0 | 30-9-2021 |
0,00786 % | UBS Financial Services, Inc. | 2.270 | 685 | 30-9-2021 |
0,00381 % | Cutler Group, LP | 1.100 | 0 | 30-9-2021 |
0,00221 % | Truvestments Capital LLC | 637 | 0 | 30-9-2021 |
0,00104 % | Clearview Wealth Advisors LLC | 300 | 0 | 30-9-2021 |
0,00104 % | Wells Fargo Advisors | 300 | 0 | 30-9-2021 |
0,00077 % | Wells Fargo Bank, N.A. | 221 | -36 | 30-9-2021 |
0,00069 % | RBC Capital Markets Wealth Management | 200 | 0 | 30-9-2021 |
0,00026 % | BNY Mellon Wealth Management | 76 | 0 | 30-9-2021 |
0,00016 % | Aperio Group, LLC | 47 | 0 | 30-9-2021 |
0,00010 % | J.P. Morgan Securities plc | 28 | 0 | 30-9-2021 |
0,00000 % | BNP Paribas Securities Corp. North America | 1 | 0 | 30-9-2021 |
0 % | Walleye Capital LLC | 0 | -16.700 | 30-6-2021 |
0 % | AIGH Capital Management, LLC. | 0 | -2.585.743 | 11-10-2021 |
0 % | Avidity Partners Management LP | 0 | -2.200.200 | 30-6-2021 |
0 % | Maven Investment Partners US Ltd. | 0 | -250.000 | 30-6-2021 |
0 % | XTX Markets LLC | 0 | -16.357 | 30-9-2021 |
0 % | Jump Financial, LLC | 0 | -23.191 | 30-9-2021 |
0 % | Voya Investment Management LLC | 0 | -40.980 | 30-6-2020 |
0 % | Franklin Mutual Advisers, LLC | 0 | -1.243 | 30-6-2020 |