7,60022 % | Fidelity Management & Research Company LLC | 5.203.110 | 3.540.565 | 30-6-2024 |
6,09026 % | RTW Investments L.P. | 4.169.393 | 60.000 | 30-6-2024 |
4,67426 % | Commodore Capital LP | 3.200.000 | -1.160.000 | 30-6-2024 |
4,01607 % | Deerfield Management Company, L.P. | 2.749.401 | 100.000 | 30-6-2024 |
3,50394 % | Federated Hermes Global Investment Management Corp. | 2.398.800 | 150.000 | 30-6-2024 |
3,39497 % | Samlyn Capital, LLC | 2.324.195 | 247.605 | 30-6-2024 |
3,07649 % | Franklin Advisers, Inc. | 2.106.163 | 241.915 | 30-6-2024 |
2,95036 % | Paradigm BioCapital Advisors LP | 2.019.814 | 2.019.814 | 30-6-2024 |
2,77534 % | Boxer Capital, L.L.C. | 1.900.000 | 0 | 30-6-2024 |
2,42907 % | Wellington Management Company, LLP | 1.662.941 | 414.301 | 30-6-2024 |
2,29896 % | Holocene Advisors, LP | 1.573.866 | 634.290 | 30-6-2024 |
2,26411 % | Driehaus Capital Management, LLC | 1.550.009 | 323.518 | 30-6-2024 |
2,16928 % | Morgan Stanley & Co. LLC | 1.485.092 | 556.281 | 30-6-2024 |
2,11953 % | Two Sigma Investments, LP | 1.451.027 | 20.418 | 30-6-2024 |
2,02339 % | T. Rowe Price Associates, Inc. | 1.385.216 | 199.862 | 30-6-2024 |
1,97926 % | Avoro Capital Advisors LLC | 1.355.000 | 466.112 | 30-6-2024 |
1,86832 % | BVF Partners L.P. | 1.279.049 | 106.800 | 30-6-2024 |
1,85079 % | Polar Capital LLP | 1.267.052 | 1.267.052 | 30-6-2024 |
1,84519 % | VR Adviser, LLC | 1.263.214 | -527.000 | 30-6-2024 |
1,76265 % | Lynx1 Capital Advisors LLC | 1.206.707 | -302.300 | 30-6-2024 |
1,49258 % | Fidelity Institutional Asset Management | 1.021.822 | 1.021.822 | 30-6-2024 |
1,48555 % | Janus Henderson Investors | 1.017.007 | 474.427 | 30-6-2024 |
1,47250 % | Incyte Corp | 1.008.076 | -2.996.468 | 30-6-2024 |
1,46227 % | Rock Springs Capital Management LP | 1.001.073 | -145.487 | 30-6-2024 |
1,40048 % | Woodline Partners LP | 958.769 | 287.970 | 30-6-2024 |
1,39929 % | Marshall Wace LLP | 957.952 | 853.060 | 30-6-2024 |
1,24160 % | Logos Global Management LLC | 850.000 | 850.000 | 30-6-2024 |
1,23353 % | Pictet Asset Management Ltd. | 844.474 | 214.799 | 30-6-2024 |
1,22699 % | Cormorant Asset Management, LP | 840.000 | 125.000 | 30-6-2024 |
1,12474 % | Adage Capital Management, L.P. | 770.000 | 445.000 | 30-6-2024 |
1,11066 % | Invus Public Equities Advisors, LLC | 760.355 | 305.274 | 30-6-2024 |
1,08417 % | BlackRock Financial Management, Inc. | 742.225 | 3.033 | 30-6-2024 |
1,05270 % | T. Rowe Price Investment Management, Inc. | 720.676 | -8.339 | 30-6-2024 |
1,02249 % | Novo Holdings A/S | 700.000 | 25.000 | 30-9-2024 |
1,01957 % | Candriam Luxembourg S.A. | 697.997 | 0 | 30-9-2024 |
0,99039 % | AllianceBernstein L.P. | 678.021 | 594.761 | 30-6-2024 |
0,91094 % | SilverArc Capital Management, LLC | 623.628 | 57.341 | 30-6-2024 |
0,85455 % | Balyasny Asset Management LP | 585.024 | 585.024 | 30-6-2024 |
0,84716 % | Invesco Advisers, Inc. | 579.967 | 578.811 | 30-6-2024 |
0,76437 % | Great Point Partners, LLC | 523.288 | 300.000 | 30-6-2024 |
0,76152 % | D. E. Shaw & Co., L.P. | 521.339 | 247.813 | 30-6-2024 |
0,62583 % | BlackRock Institutional Trust Company, N.A. | 428.443 | 26.103 | 30-6-2024 |
0,59808 % | Dafna Capital Management, LLC | 409.445 | 30.450 | 30-6-2024 |
0,57796 % | Lord, Abbett & Co. LLC | 395.672 | 71.042 | 30-6-2024 |
0,54969 % | Soleus Capital Management, L.P. | 376.321 | 180.744 | 30-6-2024 |
0,54499 % | Frazier Life Sciences Management, L.P. | 373.100 | -373.379 | 30-6-2024 |
0,49009 % | Tri Locum Partners LP | 335.514 | 49.192 | 30-6-2024 |
0,48134 % | Medical Strategy GmbH | 329.522 | 18.321 | 30-6-2024 |
0,47021 % | First Turn Management, LLC | 321.906 | 321.906 | 30-6-2024 |
0,43821 % | Perceptive Advisors LLC | 300.000 | 300.000 | 30-6-2024 |
0,43821 % | Baker Bros. Advisors LP | 300.000 | 300.000 | 30-6-2024 |
0,42166 % | StemPoint Capital LP | 288.668 | 54.797 | 30-6-2024 |
0,38690 % | State Street Global Advisors (US) | 264.873 | 20.197 | 30-6-2024 |
0,35533 % | Millennium Management LLC | 243.257 | 92.987 | 30-6-2024 |
0,31382 % | Voloridge Investment Management, LLC | 214.838 | 149.137 | 30-6-2024 |
0,30514 % | Handelsbanken Kapitalf¿rvaltning AB | 208.900 | 34.200 | 30-9-2024 |
0,30267 % | Goldman Sachs & Company, Inc. | 207.209 | 102.495 | 30-6-2024 |
0,29666 % | BlackRock Advisors (UK) Limited | 203.092 | 675 | 30-9-2024 |
0,28104 % | BlackRock Asset Management Ireland Limited | 192.397 | -7.721 | 30-6-2024 |
0,26617 % | TimesSquare Capital Management, LLC | 182.220 | 174.216 | 30-6-2024 |
0,26563 % | Citadel Advisors LLC | 181.853 | -170.355 | 30-6-2024 |
0,26161 % | Decheng Capital LLC | 179.098 | 77.300 | 30-6-2024 |
0,25540 % | Ally Bridge Group NY LLC | 174.844 | -81.084 | 30-6-2024 |
0,24955 % | BNP Paribas Securities Corp. North America | 170.844 | 67.959 | 30-6-2024 |
0,24069 % | Saturn V Capital Management LP | 164.773 | -211.856 | 30-6-2024 |
0,22802 % | OrbiMed Advisors, LLC | 156.100 | 156.100 | 30-6-2024 |
0,22789 % | Liu (Hui) | 156.016 | 98.085 | 15-3-2024 |
0,22678 % | The Vanguard Group, Inc. | 155.257 | 8.232 | 30-6-2024 |
0,22354 % | State of Wisconsin Investment Board | 153.038 | 130.307 | 30-6-2024 |
0,22213 % | Lundberg (Sven Ante) | 152.071 | 0 | 15-3-2024 |
0,21634 % | Aquilo Capital Management, LLC | 148.109 | -107.000 | 30-6-2024 |
0,21565 % | Sphera Funds Management Ltd. | 147.633 | -1.700 | 30-6-2024 |
0,19475 % | Algert Global LLC | 133.323 | 35.549 | 30-6-2024 |
0,18632 % | TD Asset Management Inc. | 127.554 | -23.620 | 30-6-2024 |
0,18469 % | BlackRock Investment Management (UK) Ltd. | 126.442 | 40.537 | 30-6-2024 |
0,18259 % | Affinity Asset Advisors LLC | 125.000 | 125.000 | 30-6-2024 |
0,17752 % | Invesco Capital Management LLC | 121.529 | -5.564 | 30-6-2024 |
0,17534 % | Nan Fung Life Sciences | 120.038 | 30.522 | 30-6-2024 |
0,17049 % | HighVista Strategies LLC | 116.718 | -4.962 | 30-6-2024 |
0,16652 % | Ensign Peak Advisors, Inc. | 114.000 | 114.000 | 30-6-2024 |
0,16068 % | DWS Investment GmbH | 110.000 | 0 | 30-6-2024 |
0,14607 % | Integral Health Asset Management, LLC | 100.000 | -65.000 | 30-6-2024 |
0,14607 % | Tang Capital Management, LLC | 100.000 | 100.000 | 30-6-2024 |
0,13219 % | Rhenman & Partners Asset Management AB | 90.500 | 90.500 | 30-6-2024 |
0,13043 % | Wellington Management Singapore Pte. Ltd. | 89.295 | 89.295 | 31-3-2024 |
0,13043 % | Wellington Management Japan Pte Ltd | 89.295 | -61.818 | 30-6-2023 |
0,12740 % | abrdn Inc. | 87.215 | 87.215 | 30-9-2024 |
0,12708 % | Nomura Asset Management Co., Ltd. | 87.000 | 87.000 | 30-11-2023 |
0,12278 % | Voya Investment Management LLC | 84.055 | 54.205 | 30-6-2024 |
0,11813 % | BofA Global Research (US) | 80.873 | 25.690 | 30-6-2024 |
0,11759 % | Nicholas Investment Partners, L.P. | 80.503 | 62.818 | 30-6-2024 |
0,11431 % | Schweizerische Nationalbank | 78.254 | 4.200 | 30-6-2024 |
0,11291 % | First Trust Advisors L.P. | 77.296 | 26.233 | 30-6-2024 |
0,10888 % | Jane Street Capital, L.L.C. | 74.542 | 61.764 | 30-6-2024 |
0,10769 % | Platinum Asset Management | 73.722 | -25.768 | 30-6-2024 |
0,10747 % | Iwicki (Mark T.) | 73.576 | 73.576 | 15-3-2024 |
0,10594 % | Principal Global Investors (Equity) | 72.526 | 3.740 | 31-8-2024 |
0,10320 % | J.P. Morgan Securities LLC | 70.652 | -26.024 | 30-6-2024 |
0,09710 % | Eversept Partners, LP | 66.474 | -53.008 | 30-6-2024 |
0,09176 % | Fred Alger Management, LLC | 62.816 | 42.219 | 30-6-2024 |