8,43569 % | The Vanguard Group, Inc. | 3.218.215 | 21.201 | 31-12-2023 |
7,51056 % | Fidelity Management & Research Company LLC | 2.865.278 | -2.691.695 | 31-12-2023 |
7,10257 % | T. Rowe Price Investment Management, Inc. | 2.709.629 | -32.828 | 31-12-2023 |
5,03766 % | T. Rowe Price Associates, Inc. | 1.921.869 | -777.197 | 31-12-2023 |
4,44435 % | BlackRock Institutional Trust Company, N.A. | 1.695.518 | 50.701 | 31-12-2023 |
4,01458 % | PureTech Health, L.L.C. | 1.531.564 | -125.000 | 12-8-2022 |
3,62031 % | Sofinnova Investments, Inc | 1.381.149 | 0 | 17-1-2024 |
2,97260 % | Wellington Management Company, LLP | 1.134.046 | -151.462 | 31-12-2023 |
2,79476 % | Pentwater Capital Management LP | 1.066.200 | 1.037.700 | 31-12-2023 |
2,58640 % | General Atlantic LLC | 986.710 | 0 | 31-12-2023 |
2,55477 % | State Street Global Advisors (US) | 974.643 | 45.673 | 31-12-2023 |
2,08914 % | Pivotal Bioventure Partners Investment Advisor LLC | 797.008 | 0 | 31-12-2023 |
1,49337 % | Geode Capital Management, L.L.C. | 569.722 | 24.649 | 31-12-2023 |
1,35000 % | Rock Springs Capital Management LP | 515.024 | 9.591 | 31-12-2023 |
1,17658 % | Capital International Investors | 448.866 | -3.778.236 | 31-1-2024 |
1,10663 % | UBS Financial Services, Inc. | 422.178 | 419.217 | 31-12-2023 |
0,98861 % | AllianceBernstein L.P. | 377.155 | 13.787 | 31-12-2023 |
0,93702 % | Woodline Partners LP | 357.473 | 334.751 | 31-12-2023 |
0,87325 % | Brown Advisory | 333.144 | 11.059 | 31-12-2023 |
0,85994 % | Norges Bank Investment Management (NBIM) | 328.067 | 16.582 | 31-12-2023 |
0,82803 % | Balyasny Asset Management LP | 315.892 | 208.093 | 31-12-2023 |
0,77939 % | Invesco Advisers, Inc. | 297.336 | -15.709 | 31-12-2023 |
0,75239 % | First Light Asset Management, LLC | 287.037 | -16.100 | 31-12-2023 |
0,65531 % | Boxer Capital, L.L.C. | 250.000 | 0 | 31-12-2023 |
0,62295 % | Fiera Capital Corporation | 237.656 | 199 | 31-12-2023 |
0,59158 % | Nan Fung Life Sciences | 225.688 | 0 | 31-12-2023 |
0,58993 % | Charles Schwab Investment Management, Inc. | 225.060 | 6.721 | 31-12-2023 |
0,58453 % | Alpine Associates Management Inc. | 223.000 | 223.000 | 31-12-2023 |
0,53997 % | Avidity Partners Management LP | 206.000 | -80.700 | 31-12-2023 |
0,52992 % | Magnetar Capital Partners LP | 202.165 | 198.264 | 31-12-2023 |
0,52701 % | Kryger Capital Limited | 201.053 | 201.053 | 31-12-2023 |
0,49901 % | Goldman Sachs Asset Management, L.P. | 190.371 | 169.488 | 31-12-2023 |
0,49803 % | Eventide Asset Management, LLC | 190.000 | -149.840 | 31-12-2023 |
0,49630 % | TD Asset Management Inc. | 189.340 | -38.378 | 31-12-2023 |
0,46880 % | Eagle Asset Management, Inc. | 178.849 | -26.930 | 31-12-2023 |
0,45660 % | SG Americas Securities, L.L.C. | 174.193 | 167.448 | 31-12-2023 |
0,42724 % | Millennium Management LLC | 162.991 | 64.988 | 31-12-2023 |
0,41419 % | Citadel Advisors LLC | 158.012 | -31.585 | 31-12-2023 |
0,38599 % | AQR Capital Management, LLC | 147.256 | 143.172 | 31-12-2023 |
0,38392 % | Ensign Peak Advisors, Inc. | 146.467 | 5.129 | 31-12-2023 |
0,37153 % | Citi Investment Research (US) | 141.738 | 104.913 | 31-12-2023 |
0,35946 % | Northern Trust Investments, Inc. | 137.134 | 6.670 | 31-12-2023 |
0,34153 % | PFM Health Sciences, LP | 130.293 | -7.916 | 31-12-2023 |
0,33451 % | Nuveen LLC | 127.614 | -22.405 | 31-12-2023 |
0,33082 % | Twin Capital Management, LLC | 126.206 | 126.206 | 31-12-2023 |
0,33029 % | BlackRock Financial Management, Inc. | 126.004 | -168 | 31-12-2023 |
0,32765 % | Avoro Capital Advisors LLC | 125.000 | 125.000 | 31-12-2023 |
0,32146 % | Franklin Advisers, Inc. | 122.636 | -77.897 | 31-12-2023 |
0,31679 % | BlackRock Asset Management Ireland Limited | 120.857 | -2.911 | 31-12-2023 |
0,31405 % | Bank of Nova Scotia | 119.810 | 119.810 | 31-12-2023 |
0,31164 % | Morgan Stanley & Co. LLC | 118.890 | 93.499 | 31-12-2023 |
0,29106 % | Mellon Investments Corporation | 111.039 | -8.865 | 31-12-2023 |
0,29068 % | Paul (Steven M) | 110.895 | -804 | 9-2-2024 |
0,27727 % | ClearBridge Investments, LLC | 105.780 | 11.390 | 31-12-2023 |
0,27374 % | UBS Asset Management (Switzerland) | 104.432 | -18.731 | 31-12-2023 |
0,26759 % | Allspring Global Investments, LLC | 102.086 | 1.057 | 31-12-2023 |
0,26518 % | Westchester Capital Management, LLC | 101.166 | 101.166 | 31-12-2023 |
0,25275 % | Driehaus Capital Management, LLC | 96.424 | 5.745 | 31-12-2023 |
0,24401 % | New York State Common Retirement Fund | 93.089 | -4.694 | 31-12-2023 |
0,23591 % | Logos Global Management LLC | 90.000 | -25.000 | 31-12-2023 |
0,23591 % | Carlson Capital, L.P. | 90.000 | 90.000 | 31-12-2023 |
0,22901 % | First Turn Management, LLC | 87.369 | 87.369 | 31-12-2023 |
0,22890 % | Water Island Capital, LLC | 87.325 | 87.325 | 31-12-2023 |
0,22068 % | Gabelli Funds, LLC | 84.190 | 84.190 | 31-12-2023 |
0,20408 % | Ignelzi (Troy A) | 77.855 | 56.018 | 17-1-2024 |
0,20408 % | Catalyst Private Wealth, L.L.C. | 77.855 | 56.018 | 31-12-2023 |
0,19558 % | Segantii Capital Management Limited | 74.613 | 74.613 | 31-12-2023 |
0,18194 % | Glazer Capital, LLC | 69.410 | 69.410 | 31-12-2023 |
0,18181 % | BNY Mellon Asset Management | 69.359 | -161 | 31-12-2023 |
0,18152 % | The Clarius Group, LLC | 69.248 | -29.973 | 31-12-2023 |
0,17956 % | Corient Private Wealth LLC | 68.504 | 19.912 | 31-12-2023 |
0,16941 % | Point72 Asset Management, L.P. | 64.630 | -283.170 | 31-12-2023 |
0,16847 % | SEB Investment Management AB | 64.273 | 55.374 | 31-12-2023 |
0,16540 % | Schweizerische Nationalbank | 63.100 | -6.900 | 31-12-2023 |
0,16514 % | P. Schoenfeld Asset Management LP | 63.000 | 63.000 | 31-12-2023 |
0,16182 % | Barclays Bank PLC | 61.734 | 33.152 | 31-12-2023 |
0,15697 % | Fidelity International | 59.885 | 0 | 31-12-2023 |
0,15625 % | AQR Arbitrage, LLC | 59.608 | 59.608 | 31-12-2023 |
0,15354 % | Tekla Capital Management LLC | 58.577 | 5.125 | 30-6-2023 |
0,15335 % | Neuberger Berman, LLC | 58.503 | 57.215 | 31-12-2023 |
0,14994 % | Candriam Belgium S.A. | 57.201 | -4.000 | 31-12-2023 |
0,14994 % | Candriam Luxembourg S.A. | 57.201 | 0 | 31-12-2023 |
0,14417 % | Picton Mahoney Asset Management | 55.000 | 55.000 | 31-12-2023 |
0,13966 % | BioImpact Capital LLC | 53.279 | 69 | 31-12-2023 |
0,13602 % | Dimensional Fund Advisors, L.P. | 51.891 | 10.334 | 31-12-2023 |
0,13289 % | California Public Employees' Retirement System | 50.696 | 0 | 31-12-2023 |
0,13179 % | HSBC Global Asset Management (UK) Limited | 50.277 | 50.277 | 31-12-2023 |
0,13157 % | Melqart Asset Management (UK) Limited | 50.194 | 50.194 | 31-12-2023 |
0,13151 % | Rice Hall James & Associates, LLC | 50.171 | 10.790 | 31-12-2023 |
0,13028 % | DWS Investment GmbH | 49.700 | 0 | 31-12-2023 |
0,12620 % | Dafna Capital Management, LLC | 48.145 | -4.728 | 31-12-2023 |
0,12558 % | Summit Partners Public Asset Management, LLC | 47.910 | -49.467 | 31-12-2023 |
0,12366 % | Rhumbline Advisers Ltd. Partnership | 47.175 | -312 | 31-12-2023 |
0,12320 % | Decheng Capital LLC | 47.000 | 47.000 | 31-12-2023 |
0,11812 % | American Century Investment Management, Inc. | 45.064 | 823 | 31-12-2023 |
0,11453 % | Rafferty Asset Management LLC | 43.693 | -4.667 | 31-12-2023 |
0,11194 % | BofA Global Research (US) | 42.705 | 22 | 31-12-2023 |
0,11153 % | Florida State Board of Administration | 42.548 | 1.485 | 31-12-2023 |
0,11085 % | Connor, Clark & Lunn Investment Management Ltd. | 42.289 | -10.401 | 31-12-2023 |
0,10940 % | Ostrum Asset Management | 41.737 | 41.737 | 31-12-2023 |