1,98988 % | Rubric Capital Management LP | 15 307 347 | 1 754 350 | |
1,53281 % | Adage Capital Management, L.P. | 11 791 310 | 2 462 571 | |
1,20681 % | Rock Springs Capital Management LP | 9 283 492 | 1 141 383 | |
1,13783 % | Mangrove Partners | 8 752 893 | 0 | |
1,03290 % | Janus Henderson Investors | 7 945 704 | 64 822 | |
0,87232 % | Deerfield Management Company, L.P. | 6 710 429 | 6 710 429 | |
0,64998 % | 683 Capital Management LLC | 5 000 000 | −750 000 | |
0,61073 % | Alkeon Capital Management LLC | 4 698 100 | 460 000 | |
0,57216 % | Frazier Life Sciences Management, L.P. | 4 401 371 | 4 401 371 | |
0,43246 % | Clearline Capital LP | 3 326 718 | 0 | |
0,41621 % | Millennium Management LLC | 3 201 705 | 1 022 570 | |
0,34000 % | Tejara Capital Ltd. | 2 615 458 | 145 274 | |
0,32596 % | Goldman Sachs & Company, Inc. | 2 507 513 | 263 699 | |
0,23074 % | Integral Health Asset Management, LLC | 1 775 000 | 825 000 | |
0,22905 % | Renaissance Technologies LLC | 1 762 003 | 89 694 | |
0,16292 % | Perceptive Advisors LLC | 1 253 250 | 1 253 250 | |
0,16210 % | Soleus Capital Management, L.P. | 1 246 953 | −1 370 000 | |
0,14872 % | Marshall Wace LLP | 1 144 051 | 1 144 051 | |
0,12473 % | NEOS Investment Management, LLC | 959 467 | 336 037 | |
0,11671 % | Blue Owl Capital Holdings LP | 897 809 | 897 809 | |
0,10923 % | Susquehanna International Group, LLP | 840 264 | −779 363 | |
0,10516 % | Scots-Knight (Denise) | 808 921 | 99 403 | |
0,08801 % | Acuta Capital Partners, LLC | 677 000 | 279 116 | |
0,06450 % | Eversept Partners, LP | 496 171 | 496 171 | |
0,05477 % | Artia Global Partners LP | 421 359 | 0 | |
0,05317 % | Citadel Advisors LLC | 408 989 | 365 082 | |
0,04525 % | Monaco asset management S.A.M. | 348 128 | −56 872 | |
0,03575 % | Cantor Fitzgerald, L.P | 275 000 | 275 000 | |
0,03386 % | Knoll Capital Management, LLC | 260 470 | 0 | |
0,03068 % | Knott Partners Management, LLC | 236 000 | 206 000 | |
0,02962 % | J. Goldman & Co., L.P. | 227 890 | −50 698 | |
0,02944 % | Verition Fund Management LLC | 226 494 | −258 942 | |
0,02848 % | Sermon (Charles E.) | 219 061 | 34 674 | |
0,02804 % | Two Sigma Investments, LP | 215 702 | −136 027 | |
0,02652 % | Morgan Stanley & Co. LLC | 204 040 | −1 178 630 | |
0,01895 % | Polar Asset Management Partners Inc. | 145 800 | 145 800 | |
0,01232 % | Hughes-Wilson (Alexandra) | 94 771 | 60 223 | |
0,01198 % | Geode Capital Management, L.L.C. | 92 156 | −4 474 | |
0,01161 % | Fox (Christine Ann) | 89 285 | 31 714 | |
0,01100 % | Jane Street Capital, L.L.C. | 84 593 | −2 280 | |
0,01092 % | BofA Global Research (US) | 84 018 | 5 300 | |
0,01022 % | Lewicki (John A) | 78 630 | 29 851 | |
0,00975 % | Suvretta Capital Management, LLC | 75 000 | −3 578 494 | |
0,00720 % | Adar1 Capital Management LLC | 55 400 | 55 400 | |
0,00702 % | PRIMECAP Management Company | 54 000 | 0 | |
0,00678 % | Arctic Fund Management AS | 52 160 | 0 | |
0,00641 % | Fred Alger Management, LLC | 49 304 | −145 575 | |
0,00618 % | State Street Global Advisors (US) | 47 561 | 47 561 | |
0,00581 % | AllianceBernstein L.P. | 44 657 | 2 583 | |
0,00572 % | The Vanguard Group, Inc. | 44 000 | 0 | |
0,00565 % | Clear Harbor Asset Management, LLC | 43 500 | 0 | |
0,00538 % | Simplex Trading, LLC | 41 393 | 12 151 | |
0,00493 % | Ekblom (Anders M.D., Ph.D.) | 37 940 | 0 | |
0,00471 % | Forefront Analytics, LLC | 36 231 | −7 586 | |
0,00433 % | Qube Research & Technologies Ltd | 33 287 | −76 040 | |
0,00371 % | HSBC Global Asset Management (UK) Limited | 28 577 | 0 | |
0,00355 % | Squarepoint Capital LLP | 27 297 | −20 390 | |
0,00326 % | Wyzga (Michael S) | 25 050 | 25 050 | |
0,00325 % | Centiva Capital, LP | 25 000 | 0 | |
0,00323 % | Flexible Plan Investments, Ltd. | 24 813 | 13 666 | |
0,00267 % | BNP Paribas Securities Corp. North America | 20 535 | 3 100 | |
0,00238 % | OneDigital Investment Advisors LLC | 18 300 | −213 | |
0,00236 % | Advisors Preferred, LLC | 18 188 | −6 625 | |
0,00221 % | PFG Investments, LLC | 17 000 | 0 | |
0,00218 % | Aperio Group, LLC | 16 792 | −16 051 | |
0,00190 % | Manulife Investment Management (North America) Limited | 14 621 | −104 357 | |
0,00184 % | Virtu Americas LLC | 14 152 | 14 152 | |
0,00163 % | RWA Wealth Partners, LLC | 12 550 | 12 550 | |
0,00139 % | GAMMA Investing LLC | 10 693 | 3 928 | |
0,00130 % | Level Four Advisory Services, LLC | 10 000 | −10 000 | |
0,00090 % | Rhumbline Advisers Ltd. Partnership | 6 958 | 2 887 | |
0,00084 % | Golden State Equity Partners, L.L.C | 6 500 | −18 300 | |
0,00059 % | PNC Investments LLC | 4 524 | 4 524 | |
0,00052 % | SRS Capital Advisors, Inc | 4 000 | 0 | |
0,00048 % | Morgan Stanley Smith Barney LLC | 3 696 | 3 677 | |
0,00045 % | Ariadne Wealth Management, LP | 3 499 | 3 499 | |
0,00022 % | Lindbrook Capital, LLC | 1 665 | −635 | |
0,00019 % | Allworth Financial, L.P. | 1 500 | 0 | |
0,00019 % | GPS Wealth Strategies Group, LLC | 1 500 | 1 500 | |
0,00013 % | Northern Trust Global Investments | 1 007 | 0 | |
0,00013 % | Benefit Financial Services Group, LLC | 1 000 | 0 | |
0,00013 % | Sit Investment Associates, Inc. | 970 | 0 | |
0,00009 % | Signaturefd, LLC | 679 | 0 | |
0,00005 % | Quadrant Family Wealth Advisors | 398 | −341 | |
0,00005 % | J.P. Morgan Securities plc | 365 | 0 | |
0,00004 % | New England Capital Financial Advisors LLC | 300 | 0 | |
0,00003 % | Wells Fargo Advisors | 230 | 0 | |
0,00002 % | Highlander Capital Management, LLC | 127 | 0 | |
0,00001 % | Cranbrook Wealth Management, LLC | 60 | 60 | |
0,00001 % | Plante Moran Financial Advisors, LLC | 48 | 0 | |
0,00000 % | Barclays Capital Inc. | 38 | 0 | |
0,00000 % | RBC Capital Partners | 28 | 0 | |
0,00000 % | U.S. Bancorp Asset Management, Inc. | 13 | 0 | |
0 % | Lynwood Capital Management Inc. | 0 | −25 000 | |
0 % | EAM Global Investors LLC | 0 | −195 087 | |
0 % | Tidal Investments LLC | 0 | −319 390 | |
0 % | Invus Public Equities Advisors, LLC | 0 | −1 500 000 | |
0 % | Ergoteles Capital | 0 | −132 784 | |
0 % | Worth Venture Partners, LLC | 0 | −76 513 | |
0 % | Schonfeld Strategic Advisors LLC | 0 | −50 100 | |