2,53991 % | Matrix Capital Management Company, LP | 38 974 185 | 0 | |
1,78590 % | EcoR1 Capital, LLC | 27 404 070 | 0 | |
1,11307 % | New Enterprise Associates (NEA) | 17 079 778 | 0 | |
0,98726 % | Baillie Gifford & Co. | 15 149 203 | −722 672 | |
0,80460 % | Long Focus Capital Management LLC | 12 346 417 | 1 662 184 | |
0,68559 % | PFM Health Sciences, LP | 10 520 231 | 97 096 | |
0,36204 % | MPM Capital Inc. | 5 555 461 | 0 | |
0,33210 % | MPM BioImpact LLC | 5 095 912 | 0 | |
0,30325 % | BofA Global Research (US) | 4 653 325 | −14 462 | |
0,15807 % | Rock Springs Capital Management LP | 2 425 468 | 0 | |
0,15274 % | Baker Bros. Advisors LP | 2 343 695 | −8 443 327 | |
0,11641 % | Renaissance Technologies LLC | 1 786 341 | 394 566 | |
0,11363 % | Tang Capital Management, LLC | 1 743 619 | 300 000 | |
0,11017 % | Fidelity Management & Research Company LLC | 1 690 481 | −42 084 | |
0,10347 % | Baillie Gifford Overseas Ltd. | 1 587 784 | 0 | |
0,05081 % | Millennium Management LLC | 779 615 | −45 564 | |
0,05015 % | JPMorgan Asset Management U.K. Limited | 769 586 | −144 803 | |
0,04904 % | Bellecapital AG | 752 458 | 0 | |
0,04664 % | Redmile Group, LLC | 715 607 | 0 | |
0,03527 % | Acuitas Investments LLC | 541 201 | 2 880 | |
0,02821 % | Rathbones Investment Management Limited | 432 818 | 0 | |
0,02547 % | State Street Global Advisors (US) | 390 901 | 78 363 | |
0,02301 % | Morgan Stanley Smith Barney LLC | 353 084 | 32 554 | |
0,02223 % | Dafna Capital Management, LLC | 341 064 | 0 | |
0,01740 % | J.P. Morgan Securities LLC | 267 011 | 267 011 | |
0,01732 % | Rawcliffe Adrian | 265 806 | 184 025 | |
0,01664 % | Key Client Fiduciary Advisors, LLC | 255 359 | −8 630 | |
0,01578 % | Susquehanna International Group, LLP | 242 144 | 185 806 | |
0,01442 % | ACCI Capital Investments SGIIC, SA | 221 290 | −78 710 | |
0,01368 % | Menzel (Garry E) | 209 931 | 47 702 | |
0,01296 % | LPL Financial LLC | 198 856 | 90 000 | |
0,01070 % | Bertrand William C Jr | 164 158 | 81 805 | |
0,00944 % | Marshall Wace LLP | 144 880 | −109 133 | |
0,00931 % | Citadel Advisors LLC | 142 891 | −100 800 | |
0,00887 % | Lunger (John) | 136 156 | 87 639 | |
0,00768 % | Geode Capital Management, L.L.C. | 117 909 | 0 | |
0,00617 % | Norry (Elliot) | 94 638 | 80 721 | |
0,00575 % | BlackRock Financial Management, Inc. | 88 208 | 0 | |
0,00570 % | Morgan Stanley & Co. LLC | 87 463 | 34 997 | |
0,00541 % | CAPTRUST Financial Advisors | 83 041 | −28 911 | |
0,00536 % | BlackRock Institutional Trust Company, N.A. | 82 187 | 1 160 | |
0,00516 % | Virtu Americas LLC | 79 239 | 79 239 | |
0,00493 % | Jane Street Capital, L.L.C. | 75 576 | 75 576 | |
0,00415 % | Wells Fargo Advisors | 63 672 | 9 500 | |
0,00391 % | Renta 4 Gestora, S.G.I.I.C., S.A. | 60 026 | −10 020 | |
0,00326 % | Barclays Bank PLC | 50 061 | 0 | |
0,00289 % | AllianceBernstein L.P. | 44 364 | 2 520 | |
0,00280 % | Bank Vontobel AG | 43 000 | 30 000 | |
0,00256 % | Oppenheimer Asset Management Inc. | 39 298 | −4 534 | |
0,00228 % | FullCircle Wealth LLC | 35 000 | 35 000 | |
0,00228 % | Northern Trust Investments, Inc. | 34 969 | −1 710 | |
0,00226 % | Invesco Capital Management LLC | 34 743 | 34 743 | |
0,00222 % | Group One Trading, L.P. | 34 037 | 11 670 | |
0,00217 % | Two Sigma Investments, LP | 33 337 | −27 274 | |
0,00205 % | COLUMBIA ADVISORY PARTNERS LLC | 31 420 | 3 333 | |
0,00203 % | Main Street Financial Solutions, LLC | 31 190 | 0 | |
0,00200 % | CSS, LLC | 30 702 | 0 | |
0,00199 % | DLK Investment Management, LLC | 30 512 | 0 | |
0,00198 % | Simon Quick Advisors, LLC | 30 452 | 452 | |
0,00196 % | Janney Montgomery Scott LLC | 30 000 | 0 | |
0,00194 % | Piccina (Cintia) | 29 828 | −24 531 | |
0,00180 % | Stifel, Nicolaus & Company, Incorporated | 27 619 | 3 822 | |
0,00173 % | Prosperity Wealth Management, Inc. | 26 620 | 0 | |
0,00170 % | HSBC Global Asset Management (UK) Limited | 26 064 | 0 | |
0,00156 % | Alleva (Lawrence M) | 23 894 | 0 | |
0,00150 % | Hunter Associates Investment Management LLC | 23 000 | 0 | |
0,00110 % | Northern Trust Global Investments | 16 892 | −3 929 | |
0,00109 % | Ballentine Partners, LLC | 16 758 | 16 758 | |
0,00109 % | Rhumbline Advisers Ltd. Partnership | 16 721 | 9 599 | |
0,00105 % | Goldman Sachs & Company, Inc. | 16 119 | −91 443 | |
0,00104 % | Wood (Gavin) | 16 000 | 0 | |
0,00104 % | Aperio Group, LLC | 15 939 | −97 091 | |
0,00099 % | Osaic Holdings, Inc. | 15 258 | −4 000 | |
0,00088 % | Commonwealth Financial Network | 13 433 | −6 762 | |
0,00081 % | Brewer (Joanna Elizabeth) | 12 442 | 0 | |
0,00081 % | XTX Markets LLC | 12 399 | −3 553 | |
0,00077 % | Greenleaf Trust | 11 856 | 11 856 | |
0,00073 % | X-Square Capital, LLC | 11 180 | −12 | |
0,00070 % | Wealth Enhancement Advisory Services, LLC | 10 816 | −24 286 | |
0,00065 % | Sigal Family Investments, LLC | 10 000 | 0 | |
0,00048 % | BlackRock Investment Management (UK) Ltd. | 7 423 | 0 | |
0,00045 % | BlackRock Fund Advisors | 6 958 | 6 958 | |
0,00043 % | Signaturefd, LLC | 6 620 | 6 620 | |
0,00043 % | Goldman Sachs Asset Management International | 6 547 | 0 | |
0,00039 % | Global Retirement Partners, LLC | 6 000 | 0 | |
0,00038 % | Putnam Investment Management, L.L.C. | 5 801 | −19 595 | |
0,00030 % | Lindbrook Capital, LLC | 4 610 | −2 135 | |
0,00021 % | Quadrant Family Wealth Advisors | 3 218 | −3 035 | |
0,00020 % | Independent Financial Partners | 3 023 | 3 023 | |
0,00020 % | CIBC Private Wealth Management | 3 023 | −73 698 | |
0,00012 % | UBS Financial Services, Inc. | 1 817 | −3 879 | |
0,00007 % | Sandy Spring Bank | 1 050 | 0 | |
0,00005 % | Desjardins Securities Inc. | 785 | 0 | |
0,00004 % | J.P. Morgan Securities plc | 641 | 0 | |
0,00003 % | Carmichael Hill & Associates Inc | 525 | 0 | |
0,00002 % | HighMark Wealth Management LLC | 287 | 0 | |
0,00002 % | Parametric Portfolio Associates LLC | 285 | 0 | |
0,00002 % | Guggenheim Investments | 273 | 0 | |
0,00002 % | Parallel Advisors, LLC | 250 | 250 | |
0,00001 % | BNP Paribas Securities Corp. North America | 213 | 0 | |