19,50597 % | BVF Partners L.P. | 8 291 988 | 0 | 2022-12-31 |
7,81578 % | OrbiMed Advisors, LLC | 3 322 488 | 0 | 2022-12-31 |
6,98107 % | Versant Ventures | 2 967 652 | −577 210 | 2022-12-29 |
6,58698 % | Cowen Investment Management LLC | 2 800 126 | −269 721 | 2022-12-31 |
6,41639 % | Deep Track Capital LP | 2 727 606 | −400 061 | 2022-12-31 |
6,31474 % | Redmile Group, LLC | 2 684 396 | 0 | 2022-12-31 |
5,71173 % | ARK Investment Management LLC | 2 428 055 | −203 973 | 2022-12-31 |
5,27555 % | MPM Capital Inc. | 2 242 636 | 0 | 2022-12-31 |
4,51194 % | T. Rowe Price Investment Management, Inc. | 1 918 026 | 155 283 | 2022-12-31 |
3,85756 % | BioImpact Capital LLC | 1 639 849 | 0 | 2022-12-31 |
1,64826 % | Fidelity Institutional Asset Management | 700 676 | 698 406 | 2022-12-31 |
1,64667 % | Invus Public Equities Advisors, LLC | 700 000 | 0 | 2022-12-31 |
1,50911 % | Medical Strategy GmbH | 641 524 | 0 | 2022-09-30 |
1,42387 % | Millennium Management LLC | 605 287 | 357 966 | 2022-12-31 |
0,66603 % | BlackRock Institutional Trust Company, N.A. | 283 131 | 30 064 | 2022-12-31 |
0,61371 % | BofA Global Research (US) | 260 886 | 247 926 | 2022-12-31 |
0,45278 % | Citadel Advisors LLC | 192 478 | −120 798 | 2022-12-31 |
0,42141 % | Segal (Lloyd Mitchell) | 179 143 | 78 550 | 2023-01-30 |
0,41393 % | Koehler (Maria) | 175 963 | 26 450 | 2023-01-30 |
0,41285 % | Fidelity Management & Research Company LLC | 175 502 | 542 | 2022-12-31 |
0,40939 % | Nikko Asset Management Co., Ltd. | 174 033 | −13 004 | 2022-12-31 |
0,38789 % | HighVista Strategies LLC | 164 890 | −139 291 | 2022-12-31 |
0,38438 % | Renaissance Technologies LLC | 163 400 | 28 279 | 2022-12-31 |
0,37579 % | BlackRock Advisors (UK) Limited | 159 749 | −14 | 2023-02-28 |
0,36792 % | BlackRock Asset Management Ireland Limited | 156 402 | 10 160 | 2022-12-31 |
0,31319 % | UBS Asset Management (Americas), Inc. | 133 138 | 22 986 | 2022-12-31 |
0,30233 % | BMO Private Investment Counsel Inc. | 128 519 | −5 000 | 2022-12-31 |
0,25235 % | D. E. Shaw & Co., L.P. | 107 274 | 41 890 | 2022-12-31 |
0,19902 % | Ensign Peak Advisors, Inc. | 84 603 | −6 200 | 2022-12-31 |
0,17294 % | The Vanguard Group, Inc. | 73 515 | 1 260 | 2022-12-31 |
0,17083 % | Trexquant Investment LP | 72 618 | −7 056 | 2022-12-31 |
0,16606 % | Zinda (Michael) | 70 591 | 24 550 | 2023-01-30 |
0,15227 % | Versant Venture Capital V (Canada), LP. | 64 731 | −80 148 | 2022-06-06 |
0,12545 % | State Street Global Advisors (US) | 53 330 | −145 | 2022-12-31 |
0,12511 % | Dimensional Fund Advisors, L.P. | 53 185 | 40 206 | 2022-12-31 |
0,10883 % | Parametric Portfolio Associates LLC | 46 262 | −25 315 | 2022-12-31 |
0,10703 % | Schweizerische Nationalbank | 45 500 | 1 200 | 2022-12-31 |
0,09289 % | Marshall Wace LLP | 39 489 | 39 489 | 2022-12-31 |
0,09143 % | Goldman Sachs & Company, Inc. | 38 867 | 10 762 | 2022-12-31 |
0,08133 % | Harbor Capital Advisors, Inc. | 34 572 | 32 255 | 2022-12-31 |
0,07219 % | Forte (Steve) | 30 687 | 24 530 | 2023-01-30 |
0,07102 % | Susquehanna International Group, LLP | 30 189 | 30 189 | 2022-12-31 |
0,06857 % | Tekla Capital Management LLC | 29 150 | 0 | 2022-12-31 |
0,06670 % | Algert Global LLC | 28 355 | 0 | 2022-12-31 |
0,06662 % | Versant Ophthalmic Affiliates Fund I, L.P. | 28 322 | −35 065 | 2022-06-06 |
0,06633 % | Jane Street Capital, L.L.C. | 28 197 | 28 197 | 2022-12-31 |
0,06587 % | Jump Financial, LLC | 28 000 | 9 800 | 2022-12-31 |
0,06327 % | T. Rowe Price Associates, Inc. | 26 894 | 8 567 | 2022-12-31 |
0,06244 % | Geode Capital Management, L.L.C. | 26 544 | 5 142 | 2022-12-31 |
0,06155 % | Acadian Asset Management LLC | 26 165 | 26 165 | 2022-12-31 |
0,06019 % | Versant Affiliates Fund V, L.P. | 25 587 | −31 677 | 2022-06-06 |
0,06017 % | Goldman Sachs Asset Management, L.P. | 25 577 | 4 372 | 2022-12-31 |
0,05912 % | Davis (Jerel C) | 25 131 | 4 254 | 2022-12-29 |
0,05874 % | XTX Markets LLC | 24 969 | 24 969 | 2022-12-31 |
0,05762 % | Assenagon Asset Management S.A. | 24 495 | −1 010 | 2023-02-28 |
0,05354 % | TD Asset Management Inc. | 22 758 | −6 505 | 2022-12-31 |
0,05315 % | The Blackstone Group | 22 595 | 3 427 | 2022-12-31 |
0,05300 % | HRT Financial LP | 22 529 | 22 529 | 2022-12-31 |
0,05088 % | Nuveen LLC | 21 630 | −188 | 2022-12-31 |
0,05009 % | Credit Suisse Asset Management | 21 293 | 7 043 | 2022-12-31 |
0,04718 % | Fred Alger Management, LLC | 20 055 | −4 256 | 2022-12-31 |
0,04659 % | Black (Cameron) | 19 804 | 729 | 2022-02-15 |
0,04608 % | Cubist Systematic Strategies, LLC | 19 590 | 19 590 | 2022-12-31 |
0,04363 % | Apo Asset Management GmbH | 18 545 | 0 | 2023-01-31 |
0,04268 % | Morgan Stanley & Co. LLC | 18 143 | −10 765 | 2022-12-31 |
0,04189 % | AQR Capital Management, LLC | 17 807 | 17 807 | 2022-12-31 |
0,04007 % | Tudor Investment Corporation | 17 034 | 17 034 | 2022-12-31 |
0,03855 % | California State Teachers Retirement System | 16 386 | 164 | 2022-12-31 |
0,03824 % | State of Wisconsin Investment Board | 16 256 | −1 141 | 2022-12-31 |
0,03682 % | Two Sigma Investments, LP | 15 653 | 15 653 | 2022-12-31 |
0,03626 % | Difesa Capital Management, LP | 15 416 | 0 | 2022-12-31 |
0,03621 % | Northern Trust Investments, Inc. | 15 392 | 1 046 | 2022-12-31 |
0,03434 % | Deka Investment GmbH | 14 600 | 1 300 | 2022-06-30 |
0,03434 % | Deka Vermögensmanagement GmbH | 14 600 | 0 | 2022-12-31 |
0,03399 % | BlackRock Financial Management, Inc. | 14 450 | 7 237 | 2022-12-31 |
0,02896 % | SETH KIM | 12 312 | 11 625 | 2021-12-02 |
0,02888 % | HarbourVest Partners, L.L.C. | 12 276 | 0 | 2022-12-31 |
0,02887 % | DuPont Capital Management Corporation | 12 271 | 12 271 | 2022-12-31 |
0,02780 % | Emerge Canada Inc | 11 816 | −1 204 | 2023-01-31 |
0,02655 % | UBS Asset Management (Switzerland) | 11 286 | −906 | 2022-12-31 |
0,02652 % | Morgan Stanley Smith Barney LLC | 11 273 | −35 203 | 2022-12-31 |
0,02588 % | Abaris Investment Management AG | 11 000 | 0 | 2021-12-31 |
0,02509 % | Qube Research & Technologies Ltd | 10 664 | −1 569 | 2022-12-31 |
0,02217 % | Virtus Etf Advisers LLC | 9 426 | 1 789 | 2022-12-31 |
0,01882 % | Schafer (Carol Anne) | 8 000 | 0 | 2022-03-15 |
0,01832 % | Lazard Asset Management, L.L.C. | 7 788 | 7 788 | 2022-12-31 |
0,01764 % | Civik (Thomas) | 7 500 | 0 | 2022-03-15 |
0,01599 % | Simplex Trading, LLC | 6 797 | 6 775 | 2022-12-31 |
0,01294 % | Handelsbanken Kapitalförvaltning AB | 5 500 | 0 | 2023-01-31 |
0,01186 % | UBS Financial Services, Inc. | 5 042 | 1 491 | 2022-12-31 |
0,01129 % | Morrison Briggs W | 4 800 | 0 | 2022-03-15 |
0,01090 % | Legal & General Investment Management Ltd. | 4 633 | 0 | 2022-12-31 |
0,01027 % | American Century Investment Management, Inc. | 4 367 | 2 848 | 2022-12-31 |
0,00972 % | BlackRock Investment Management (UK) Ltd. | 4 133 | 179 | 2022-12-31 |
0,00970 % | Dimensional Fund Advisors, Ltd. | 4 124 | 0 | 2023-01-31 |
0,00941 % | KLP Fondsforvaltning AS | 4 000 | 0 | 2023-01-31 |
0,00941 % | Rhoads (Ann D) | 4 000 | 0 | 2022-03-15 |
0,00936 % | Northern Trust Global Investments | 3 977 | 0 | 2022-12-31 |
0,00842 % | Northern Trust Global Investments Limited | 3 578 | 0 | 2022-12-31 |
0,00762 % | ProShare Advisors LLC | 3 239 | −345 | 2023-02-28 |