8,19444 % | EcoR1 Capital, LLC | 5 748 399 | 5 748 399 | 2023-09-22 |
7,91954 % | Avoro Capital Advisors LLC | 5 555 555 | 0 | 2023-06-30 |
7,08454 % | The Vanguard Group, Inc. | 4 969 806 | −72 295 | 2023-06-30 |
6,37632 % | RTW Investments L.P. | 4 472 985 | 829 871 | 2023-06-30 |
5,67071 % | Armistice Capital LLC | 3 978 000 | 286 000 | 2023-06-30 |
4,83017 % | Wellington Management Company, LLP | 3 388 365 | 692 273 | 2023-06-30 |
4,56371 % | Boxer Capital, L.L.C. | 3 201 440 | 0 | 2023-10-08 |
4,47037 % | Aviva Holdings Ltd. | 3 135 966 | 0 | 2023-10-08 |
3,96845 % | Morgan Stanley & Co. LLC | 2 783 869 | 1 023 058 | 2023-06-30 |
3,68031 % | State Street Global Advisors (US) | 2 581 739 | 271 919 | 2023-06-30 |
3,03291 % | BlackRock Institutional Trust Company, N.A. | 2 127 589 | −2 501 | 2023-06-30 |
2,92969 % | Invus Public Equities Advisors, LLC | 2 055 181 | 517 472 | 2023-06-30 |
2,56593 % | Camber Capital Management LP | 1 800 000 | 400 000 | 2023-06-30 |
2,49755 % | T. Rowe Price Associates, Inc. | 1 752 033 | 6 016 | 2023-06-30 |
2,05811 % | Paradigm BioCapital Advisors LP | 1 443 762 | 46 983 | 2023-06-30 |
2,00967 % | Baker Bros. Advisors LP | 1 409 784 | 0 | 2023-06-30 |
1,59893 % | Rock Springs Capital Management LP | 1 121 647 | 56 386 | 2023-06-30 |
1,30242 % | OrbiMed Advisors, LLC | 913 650 | 0 | 2023-06-30 |
1,27404 % | Candriam Luxembourg S.A. | 893 738 | 20 000 | 2023-08-31 |
1,24556 % | Candriam Belgium S.A. | 873 763 | 109 498 | 2023-06-30 |
1,15299 % | Assenagon Asset Management S.A. | 808 820 | 552 860 | 2023-06-30 |
1,08978 % | Geode Capital Management, L.L.C. | 764 483 | 29 195 | 2023-06-30 |
1,06914 % | Octagon Capital Advisors LP | 750 000 | 0 | 2023-06-30 |
1,02509 % | Perceptive Advisors LLC | 719 103 | −855 031 | 2023-06-30 |
0,98650 % | Fiera Capital Corporation | 692 033 | −17 494 | 2023-06-30 |
0,92208 % | Franklin Advisers, Inc. | 646 837 | −5 | 2023-06-30 |
0,85531 % | Eventide Asset Management, LLC | 600 000 | 228 898 | 2023-06-30 |
0,84546 % | BlackRock Financial Management, Inc. | 593 087 | 60 997 | 2023-06-30 |
0,83296 % | Marshall Wace LLP | 584 323 | 31 709 | 2023-06-30 |
0,75508 % | Credit Suisse Funds AG | 529 690 | 6 335 | 2023-06-30 |
0,72033 % | Millennium Management LLC | 505 309 | 486 275 | 2023-06-30 |
0,68684 % | Citadel Advisors LLC | 481 818 | 391 174 | 2023-06-30 |
0,67853 % | Norges Bank Investment Management (NBIM) | 475 992 | 62 003 | 2022-12-31 |
0,67351 % | Dimensional Fund Advisors, L.P. | 472 468 | 167 874 | 2023-06-30 |
0,62159 % | Charles Schwab Investment Management, Inc. | 436 048 | 5 554 | 2023-06-30 |
0,57881 % | Voloridge Investment Management, LLC | 406 035 | −272 623 | 2023-06-30 |
0,53219 % | Woodline Partners LP | 373 332 | 107 232 | 2023-06-30 |
0,41036 % | MVA Investors LLC | 287 866 | 0 | 2023-10-08 |
0,37482 % | D. E. Shaw & Co., L.P. | 262 938 | 17 352 | 2023-06-30 |
0,37063 % | International Biotechnology Trust PLC | 260 000 | 16 000 | 2023-06-30 |
0,36636 % | UBS Asset Management (Switzerland) | 257 001 | 63 265 | 2023-03-31 |
0,36213 % | BlackRock Investment Management (UK) Ltd. | 254 032 | −6 748 | 2023-06-30 |
0,34599 % | BlackRock Asset Management Ireland Limited | 242 715 | 6 294 | 2023-06-30 |
0,34301 % | Braidwell LP | 240 625 | −211 375 | 2023-06-30 |
0,33195 % | New York State Common Retirement Fund | 232 860 | 643 | 2023-06-30 |
0,33056 % | Nuveen LLC | 231 885 | −28 524 | 2023-06-30 |
0,32770 % | Jane Street Capital, L.L.C. | 229 883 | 80 755 | 2023-06-30 |
0,32089 % | Susquehanna International Group, LLP | 225 101 | −137 511 | 2023-06-30 |
0,31752 % | Allspring Global Investments, LLC | 222 737 | −10 302 | 2023-06-30 |
0,31613 % | Jacobs Levy Equity Management, Inc. | 221 763 | 13 000 | 2023-06-30 |
0,31167 % | Rafferty Asset Management LLC | 218 639 | 45 123 | 2023-06-30 |
0,29045 % | Dissanayake (Shehan Bharath) | 203 754 | 0 | 2023-10-08 |
0,28510 % | Ghost Tree Capital, LLC | 200 000 | 60 000 | 2023-06-30 |
0,28510 % | DWS Investment GmbH | 200 000 | −15 654 | 2023-06-30 |
0,28121 % | BofA Global Research (US) | 197 267 | −59 553 | 2023-06-30 |
0,27441 % | 5AM Ventures | 192 500 | 192 500 | 2023-06-30 |
0,26238 % | Edmond de Rothschild Asset Management (France) S.A. | 184 060 | 0 | 2023-06-30 |
0,25411 % | Northern Trust Investments, Inc. | 178 259 | 3 052 | 2023-06-30 |
0,21753 % | Oracle Investment Management, Inc. | 152 600 | −48 800 | 2023-06-30 |
0,21176 % | Sectoral Asset Management Inc. | 148 553 | 20 147 | 2023-06-30 |
0,21136 % | Baum (Charles M) | 148 268 | 54 054 | 2023-08-09 |
0,20711 % | Granahan Investment Management, Inc. | 145 287 | 16 197 | 2023-06-30 |
0,20380 % | Jefferies LLC | 142 969 | 92 549 | 2023-06-30 |
0,19957 % | Rhenman & Partners Asset Management AB | 140 000 | −75 000 | 2023-06-30 |
0,19886 % | AllianceBernstein L.P. | 139 501 | 67 858 | 2023-06-30 |
0,18601 % | Managed Account Advisors LLC | 130 489 | 1 059 | 2023-06-30 |
0,18480 % | Schonfeld Strategic Advisors LLC | 129 636 | 106 837 | 2023-06-30 |
0,17786 % | UBS Financial Services, Inc. | 124 768 | 43 336 | 2023-06-30 |
0,17645 % | Fidelity Management & Research Company LLC | 123 783 | −54 300 | 2023-06-30 |
0,16700 % | Connor, Clark & Lunn Investment Management Ltd. | 117 151 | −19 335 | 2023-06-30 |
0,15608 % | Numeric Investors LLC | 109 491 | 89 681 | 2023-06-30 |
0,14712 % | Barclays Bank PLC | 103 206 | −22 173 | 2023-06-30 |
0,14585 % | Stelzer (Laurie D) | 102 312 | 22 297 | 2023-08-09 |
0,14075 % | ExodusPoint Capital Management, LP | 98 738 | −65 004 | 2023-06-30 |
0,14041 % | Polar Asset Management Partners Inc. | 98 500 | 98 500 | 2023-06-30 |
0,13500 % | Dafna Capital Management, LLC | 94 700 | 21 100 | 2023-06-30 |
0,13003 % | SilverArc Capital Management, LLC | 91 213 | 91 213 | 2023-06-30 |
0,12840 % | BNY Mellon Asset Management | 90 071 | 7 611 | 2023-06-30 |
0,12630 % | Schweizerische Nationalbank | 88 600 | 1 600 | 2023-06-30 |
0,11978 % | Mellon Investments Corporation | 84 028 | −2 256 | 2023-06-30 |
0,11404 % | Tang Capital Management, LLC | 80 000 | 80 000 | 2023-06-30 |
0,10480 % | Algert Global LLC | 73 516 | 10 292 | 2023-06-30 |
0,10446 % | HRT Financial LP | 73 276 | −8 030 | 2023-06-30 |
0,10279 % | TD Asset Management Inc. | 72 105 | 4 700 | 2023-06-30 |
0,10219 % | Christensen (James G) | 71 685 | −2 388 | 2023-09-08 |
0,10215 % | Moriarty (John B) | 71 660 | 22 297 | 2023-08-09 |
0,10070 % | Wells Fargo Advisors | 70 642 | −1 888 | 2023-06-30 |
0,09901 % | California Public Employees' Retirement System | 69 454 | 0 | 2023-06-30 |
0,09651 % | Citi Investment Research (US) | 67 704 | −91 289 | 2023-06-30 |
0,09336 % | Tekla Capital Management LLC | 65 490 | 0 | 2023-06-30 |
0,08910 % | Florida State Board of Administration | 62 506 | −1 366 | 2023-06-30 |
0,08886 % | Lombard Odier Asset Management (Europe) Ltd | 62 334 | −9 056 | 2022-10-31 |
0,08881 % | Sandler (Alan B.) | 62 297 | 22 297 | 2023-08-09 |
0,08553 % | Macquarie Investment Management | 60 000 | 0 | 2023-06-30 |
0,08510 % | UBS O'Connor LLC | 59 698 | 12 448 | 2023-06-30 |
0,08032 % | Clearline Capital LP | 56 341 | 56 341 | 2023-06-30 |
0,07861 % | Manulife Investment Management (North America) Limited | 55 148 | 3 769 | 2023-06-30 |
0,07617 % | Fidelity International | 53 434 | 53 434 | 2023-06-30 |
0,07614 % | Aperio Group, LLC | 53 414 | 22 157 | 2023-06-30 |
0,07420 % | Wellington International Management Company Pte. Ltd. | 52 050 | 13 986 | 2022-12-31 |