14,29871 % | Frazier Life Sciences Management, L.P. | 6 795 121 | 3 065 901 | 2025-03-31 |
10,51874 % | Janus Henderson Investors | 4 998 777 | 232 668 | 2025-04-30 |
6,34707 % | BlackRock Institutional Trust Company, N.A. | 3 016 291 | −81 874 | 2025-03-31 |
5,88460 % | BVF Partners L.P. | 2 796 513 | 0 | 2025-03-31 |
5,32907 % | The Vanguard Group, Inc. | 2 532 513 | 115 327 | 2025-03-31 |
5,31747 % | Eventide Asset Management, LLC | 2 527 000 | −79 938 | 2025-03-31 |
3,15639 % | Novo Holdings A/S | 1 500 000 | 0 | 2025-03-31 |
3,14496 % | State Street Global Advisors (US) | 1 494 566 | 112 939 | 2025-03-31 |
3,04275 % | Citadel Advisors LLC | 1 445 995 | −65 188 | 2025-03-31 |
2,90662 % | T. Rowe Price Associates, Inc. | 1 381 300 | −8 294 | 2025-03-31 |
2,60320 % | Tang Capital Management, LLC | 1 237 107 | 0 | 2025-03-31 |
2,47251 % | Polar Capital LLP | 1 175 000 | 500 000 | 2025-03-31 |
2,05811 % | ClearBridge Investments, LLC | 978 067 | 70 750 | 2025-03-31 |
2,02780 % | Geode Capital Management, L.L.C. | 963 665 | 20 321 | 2025-03-31 |
2,00276 % | Rock Springs Capital Management LP | 951 765 | −519 799 | 2025-03-31 |
1,71160 % | Lord, Abbett & Co. LLC | 813 398 | 31 044 | 2025-03-31 |
1,63763 % | Pictet Asset Management Ltd. | 778 244 | −81 852 | 2025-03-31 |
1,60519 % | Medical Strategy GmbH | 762 828 | 151 493 | 2024-11-30 |
1,32221 % | Nuveen LLC | 628 349 | −61 731 | 2025-03-31 |
1,26954 % | Boone Capital Management LLC | 603 318 | 21 475 | 2025-03-31 |
1,24711 % | Franklin Advisers, Inc. | 592 660 | 2 693 | 2025-03-31 |
1,19158 % | Woodline Partners LP | 566 271 | 161 867 | 2025-03-31 |
1,19134 % | Loomis, Sayles & Company, L.P. | 566 155 | −11 869 | 2025-03-31 |
1,18924 % | Morgan Stanley & Co. LLC | 565 158 | 237 910 | 2025-03-31 |
1,14320 % | D. E. Shaw & Co., L.P. | 543 277 | 385 925 | 2025-03-31 |
1,05847 % | First Turn Management, LLC | 503 014 | −3 894 | 2025-03-31 |
1,05041 % | BNP Paribas Securities Corp. North America | 499 183 | 237 539 | 2025-03-31 |
1,00857 % | Millennium Management LLC | 479 299 | −47 675 | 2025-03-31 |
0,98812 % | Norges Bank Investment Management (NBIM) | 469 582 | −145 839 | 2024-12-31 |
0,89945 % | Goldman Sachs & Company, Inc. | 427 440 | −87 627 | 2025-03-31 |
0,84808 % | Candriam Luxembourg S.A. | 403 032 | 20 053 | 2025-04-30 |
0,80589 % | Candriam Belgium S.A. | 382 979 | −46 752 | 2025-03-31 |
0,80325 % | Two Sigma Investments, LP | 381 726 | 80 880 | 2025-03-31 |
0,78598 % | PENN Capital Management Company, Inc. | 373 519 | 95 092 | 2025-03-31 |
0,77174 % | Macquarie Investment Management | 366 751 | 76 940 | 2025-03-31 |
0,74970 % | Connor, Clark & Lunn Investment Management Ltd. | 356 276 | 179 316 | 2025-03-31 |
0,74893 % | Northern Trust Investments, Inc. | 355 910 | −18 294 | 2025-03-31 |
0,73938 % | AXA Investment Managers UK Ltd. | 351 372 | −74 274 | 2025-03-31 |
0,73062 % | Peetz (Christopher) | 347 211 | 22 721 | 2025-03-17 |
0,72597 % | Adage Capital Management, L.P. | 345 000 | 195 000 | 2025-03-31 |
0,72245 % | Prosight Capital | 343 326 | −107 801 | 2025-03-31 |
0,71567 % | Federated MDTA LLC | 340 105 | 339 264 | 2025-03-31 |
0,68994 % | Charles Schwab Investment Management, Inc. | 327 878 | −4 761 | 2025-03-31 |
0,67436 % | BofA Global Research (US) | 320 474 | −67 275 | 2025-03-31 |
0,64048 % | Invesco Advisers, Inc. | 304 371 | 10 048 | 2025-03-31 |
0,62473 % | Cubist Systematic Strategies, LLC | 296 887 | 212 918 | 2025-03-31 |
0,58953 % | Grey (Michael G) | 280 160 | −102 788 | 2025-02-15 |
0,54788 % | New York State Common Retirement Fund | 260 366 | 32 015 | 2025-03-31 |
0,54711 % | Erste Asset Management GmbH | 260 000 | 0 | 2025-03-31 |
0,50082 % | DWS Investments UK Limited | 238 003 | 69 578 | 2025-03-31 |
0,49652 % | UBS Financial Services, Inc. | 235 957 | 51 368 | 2025-03-31 |
0,49386 % | Rice Hall James & Associates, LLC | 234 696 | −4 303 | 2025-03-31 |
0,48839 % | Point72 Asset Management, L.P. | 232 098 | 232 098 | 2025-03-31 |
0,45282 % | Russell Investments Trust Company | 215 192 | 189 232 | 2025-03-31 |
0,41105 % | Next Century Growth Investors, LLC | 195 341 | 31 089 | 2025-03-31 |
0,40646 % | JP Morgan Asset Management | 193 160 | −10 517 | 2025-03-31 |
0,39665 % | Renaissance Technologies LLC | 188 500 | 87 252 | 2025-03-31 |
0,39154 % | Columbia Threadneedle Investments (US) | 186 069 | 1 852 | 2025-03-31 |
0,38042 % | Jane Street Capital, L.L.C. | 180 784 | 8 151 | 2025-03-31 |
0,36413 % | Nicholas Investment Partners, L.P. | 173 043 | 24 200 | 2025-03-31 |
0,33430 % | AXA Investment Managers Paris | 158 870 | 0 | 2025-04-30 |
0,30973 % | Hennion & Walsh Asset Management, Inc. | 147 193 | 1 594 | 2025-03-31 |
0,30883 % | Nan Fung Life Sciences | 146 765 | 21 435 | 2025-03-31 |
0,29341 % | Qube Research & Technologies Ltd | 139 434 | 139 434 | 2025-03-31 |
0,28933 % | PDT Partners, LLC | 137 495 | 23 782 | 2025-03-31 |
0,28600 % | Silvercrest Asset Management Group LLC | 135 915 | −785 | 2025-03-31 |
0,28191 % | Ensign Peak Advisors, Inc. | 133 973 | −84 615 | 2025-03-31 |
0,28138 % | Citi Investment Research (US) | 133 721 | −72 | 2025-03-31 |
0,27278 % | First Trust Advisors L.P. | 129 634 | −4 547 | 2025-03-31 |
0,26895 % | Raymond James Financial Services Advisors, Inc. | 127 811 | 5 551 | 2025-03-31 |
0,26850 % | Mellon Investments Corporation | 127 600 | 79 400 | 2025-03-31 |
0,25878 % | Highlander Partners, L.P. | 122 980 | 0 | 2025-03-31 |
0,25660 % | BlackRock Financial Management, Inc. | 121 941 | −16 010 | 2025-03-31 |
0,25568 % | Raymond James & Associates, Inc. | 121 507 | −12 845 | 2025-03-31 |
0,24486 % | Patient Square Capital, LP | 116 362 | 51 462 | 2025-03-31 |
0,23762 % | Wellington Management Company, LLP | 112 924 | −5 277 | 2025-03-31 |
0,21970 % | Longpre (Lara) | 104 407 | −847 | 2024-02-02 |
0,21839 % | Vig (Pamela) | 103 785 | 0 | 2024-06-24 |
0,21809 % | BlackRock Investment Management, LLC | 103 644 | 541 | 2025-03-31 |
0,18912 % | Barrow Hanley Global Investors | 89 877 | −4 340 | 2025-02-28 |
0,17416 % | UBS Asset Management (Americas) LLC | 82 767 | 82 767 | 2025-03-31 |
0,17083 % | BNY Mellon Asset Management | 81 183 | 5 131 | 2025-03-31 |
0,16765 % | Barclays Bank PLC | 79 670 | −172 094 | 2025-03-31 |
0,16258 % | Healthinvest Partners AB | 77 263 | −39 429 | 2025-03-31 |
0,15783 % | Voloridge Investment Management, LLC | 75 005 | −96 532 | 2025-03-31 |
0,15520 % | Rhenman & Partners Asset Management AB | 73 755 | 0 | 2025-03-31 |
0,15293 % | The Informed Momentum Company LLC | 72 678 | −278 | 2025-03-31 |
0,14688 % | Schweizerische Nationalbank | 69 800 | −500 | 2025-03-31 |
0,14204 % | International Biotechnology Trust PLC | 67 500 | 0 | 2023-09-30 |
0,14048 % | Algert Global LLC | 66 761 | −1 530 | 2025-03-31 |
0,13615 % | Palo Alto Investors LP | 64 700 | 0 | 2025-03-31 |
0,12460 % | J.P. Morgan Mansart Management Limited | 59 214 | 59 214 | 2025-03-31 |
0,12236 % | Managed Account Advisors LLC | 58 148 | 3 270 | 2025-03-31 |
0,12235 % | State of Wisconsin Investment Board | 58 146 | −8 798 | 2025-03-31 |
0,12233 % | BlackRock Advisors (UK) Limited | 58 133 | 0 | 2025-05-31 |
0,11911 % | Susquehanna International Group, LLP | 56 605 | 30 861 | 2025-03-31 |
0,11805 % | BMO Capital Markets (US) | 56 100 | 4 000 | 2025-03-31 |
0,11665 % | Rhumbline Advisers Ltd. Partnership | 55 434 | 2 321 | 2025-03-31 |
0,11432 % | Fidelity Management & Research Company LLC | 54 327 | 49 512 | 2025-03-31 |
0,11033 % | Kodai Capital Management, L.P. | 52 430 | 52 430 | 2025-03-31 |