9,20473 % | Kynam Capital Management LP | 4 420 349 | 2 747 308 | 2022-12-31 |
7,55686 % | BVF Partners L.P. | 3 629 000 | 0 | 2022-12-31 |
3,97934 % | The Vanguard Group, Inc. | 1 910 984 | 69 214 | 2022-12-31 |
3,60744 % | Nantahala Capital Management, LLC | 1 732 388 | −54 771 | 2022-12-31 |
3,00220 % | Millennium Management LLC | 1 441 735 | 122 227 | 2022-12-31 |
2,89718 % | Citadel Advisors LLC | 1 391 302 | 269 873 | 2022-12-31 |
2,79098 % | Point72 Asset Management, L.P. | 1 340 300 | 1 069 700 | 2022-12-31 |
2,72452 % | BofA Global Research (US) | 1 308 386 | 4 391 | 2022-12-31 |
2,69838 % | Ingalls & Snyder LLC (Asset Management) | 1 295 833 | −34 600 | 2022-12-31 |
2,50608 % | Parkman Healthcare Partners LLC | 1 203 484 | 65 897 | 2022-12-31 |
2,46141 % | BlackRock Institutional Trust Company, N.A. | 1 182 032 | 380 848 | 2022-12-31 |
2,39471 % | Tang Capital Management, LLC | 1 150 000 | 146 983 | 2022-12-31 |
2,26622 % | RA Capital Management, LP | 1 088 296 | 0 | 2022-12-31 |
2,08815 % | Sphera Funds Management Ltd. | 1 002 783 | 50 000 | 2022-12-31 |
2,03927 % | Medical Strategy GmbH | 979 309 | 0 | 2022-09-30 |
1,61366 % | Dimensional Fund Advisors, L.P. | 774 922 | 112 822 | 2022-12-31 |
1,60203 % | Assenagon Asset Management S.A. | 769 336 | −140 554 | 2022-12-31 |
1,56830 % | Acadian Asset Management LLC | 753 140 | 123 841 | 2022-12-31 |
1,38822 % | AWM Investment Company, Inc. | 666 661 | 0 | 2022-12-31 |
1,14145 % | Barclays Bank PLC | 548 155 | 97 922 | 2022-12-31 |
1,14009 % | NewEdge Wealth, LLC | 547 501 | 0 | 2022-12-31 |
1,13113 % | BMO Capital Markets (US) | 543 200 | 543 200 | 2022-12-31 |
1,12151 % | Alyeska Investment Group, L.P. | 538 579 | 38 579 | 2022-12-31 |
1,09038 % | Goldman Sachs & Company, Inc. | 523 630 | 189 551 | 2022-12-31 |
1,08237 % | Morgan Stanley & Co. LLC | 519 782 | −32 140 | 2022-12-31 |
1,04883 % | Schonfeld Strategic Advisors LLC | 503 674 | 244 574 | 2022-12-31 |
1,04244 % | Renaissance Technologies LLC | 500 605 | −142 000 | 2022-12-31 |
1,02265 % | Two Sigma Investments, LP | 491 105 | −365 147 | 2022-12-31 |
0,95823 % | IndexIQ Advisors LLC | 460 165 | 460 165 | 2023-02-28 |
0,87013 % | Geode Capital Management, L.L.C. | 417 858 | 9 369 | 2022-12-31 |
0,60512 % | Connor, Clark & Lunn Investment Management Ltd. | 290 595 | −9 763 | 2022-12-31 |
0,57106 % | J.P. Morgan Securities LLC | 274 240 | 186 915 | 2022-12-31 |
0,50016 % | Susquehanna International Group, LLP | 240 190 | 202 781 | 2022-12-31 |
0,43866 % | Stuart Nancy | 210 654 | −6 048 | 2023-02-15 |
0,43006 % | Pura Vida Investments, LLC | 206 525 | 206 525 | 2022-12-31 |
0,41814 % | International Biotechnology Trust PLC | 200 800 | 0 | 2022-12-31 |
0,40416 % | Citi Investment Research (US) | 194 090 | 73 373 | 2022-12-31 |
0,31849 % | Manulife Investment Management (North America) Limited | 152 947 | 151 883 | 2023-01-31 |
0,30860 % | Bridgeway Capital Management, LLC | 148 200 | 0 | 2022-12-31 |
0,29340 % | State Street Global Advisors (US) | 140 898 | 20 300 | 2022-12-31 |
0,23707 % | D. E. Shaw & Co., L.P. | 113 848 | 113 848 | 2022-12-31 |
0,23656 % | Aberdeen Asset Managers Ltd. | 113 600 | −105 700 | 2023-02-28 |
0,22506 % | Northern Trust Investments, Inc. | 108 079 | −437 | 2022-12-31 |
0,21511 % | ClariVest Asset Management LLC | 103 300 | −1 500 | 2022-12-31 |
0,20824 % | BZ Bank AG (Asset Management) | 100 000 | 0 | 2022-11-30 |
0,18408 % | Florida State Board of Administration | 88 400 | 88 400 | 2022-09-30 |
0,18396 % | Ensign Peak Advisors, Inc. | 88 341 | 0 | 2022-12-31 |
0,18158 % | City National Rochdale, LLC | 87 200 | 87 200 | 2022-12-31 |
0,17490 % | Caxton Associates LP | 83 993 | −40 122 | 2022-12-31 |
0,15524 % | Walleye Capital LLC | 74 548 | 74 548 | 2022-12-31 |
0,14785 % | Black Diamond Financial, LLC | 71 000 | 0 | 2022-12-31 |
0,14622 % | Morgan Stanley Smith Barney LLC | 70 221 | 0 | 2022-12-31 |
0,12513 % | BG Fund Management Luxembourg S.A. | 60 092 | 0 | 2022-12-31 |
0,12202 % | Kensington Investment Counsel, LLC | 58 599 | −18 202 | 2022-12-31 |
0,10229 % | RBF Capital, LLC | 49 122 | −15 781 | 2022-12-31 |
0,09816 % | Qube Research & Technologies Ltd | 47 137 | 13 399 | 2022-12-31 |
0,09614 % | Cubist Systematic Strategies, LLC | 46 167 | −26 901 | 2022-12-31 |
0,08168 % | Aldrich (Richard H) | 39 226 | −358 500 | 2023-03-06 |
0,08057 % | Cassella (James V) | 38 690 | −3 762 | 2023-02-15 |
0,07925 % | 683 Capital Management LLC | 38 058 | 38 058 | 2022-12-31 |
0,07689 % | van Heek (Christine) | 36 926 | 26 926 | 2022-06-09 |
0,07371 % | Lake Street Advisors | 35 398 | 0 | 2022-12-31 |
0,06771 % | Alps Advisors, Inc. | 32 516 | 6 319 | 2022-12-31 |
0,06395 % | BlackRock Advisors (UK) Limited | 30 710 | 8 243 | 2023-02-28 |
0,06247 % | ACCI Capital Investments SGIIC, SA | 30 000 | −10 000 | 2022-12-31 |
0,06123 % | Jane Street Capital, L.L.C. | 29 404 | 18 992 | 2022-12-31 |
0,06084 % | Dimensional Fund Advisors, Ltd. | 29 215 | 4 867 | 2023-01-31 |
0,06045 % | Marshall Wace LLP | 29 030 | 29 030 | 2022-12-31 |
0,06018 % | Auchincloss (Thomas G Jr) | 28 900 | 22 400 | 2022-06-09 |
0,05875 % | Apo Asset Management GmbH | 28 215 | 0 | 2023-01-31 |
0,05411 % | AHL Partners LLP | 25 987 | 25 987 | 2022-12-31 |
0,05085 % | Occudo Quantitative Strategies LP | 24 418 | −38 386 | 2022-12-31 |
0,05073 % | Hutt (Peter Barton) | 24 363 | 0 | 2022-10-14 |
0,05052 % | BlackRock Financial Management, Inc. | 24 259 | 8 692 | 2022-12-31 |
0,04963 % | Barclays Capital Inc. | 23 835 | 21 314 | 2022-12-31 |
0,04720 % | BlackRock Asset Management Ireland Limited | 22 668 | 22 668 | 2022-12-31 |
0,04334 % | Northern Trust Global Investments | 20 813 | −5 | 2022-12-31 |
0,04320 % | Lighthouse Partners | 20 746 | 20 746 | 2022-12-31 |
0,04240 % | SG Americas Securities, L.L.C. | 20 361 | 3 352 | 2022-12-31 |
0,04165 % | Birchview Capital, LP | 20 000 | 0 | 2022-12-31 |
0,03834 % | Boothbay Fund Management, LLC | 18 414 | 18 414 | 2022-12-31 |
0,03830 % | Becker (Marc A) | 18 392 | −3 762 | 2023-02-15 |
0,03598 % | BNY Mellon Asset Management | 17 278 | 0 | 2022-12-31 |
0,03540 % | Alpine Associates Management Inc. | 17 000 | −17 700 | 2023-02-28 |
0,03415 % | Hoeiland (Jesper) | 16 400 | 16 400 | 2022-06-09 |
0,03415 % | Jaeger (Wilfred E) | 16 400 | 16 400 | 2022-06-09 |
0,03290 % | Acuitas Investments LLC | 15 800 | −600 | 2022-12-31 |
0,03266 % | Charles Schwab Investment Management, Inc. | 15 686 | 0 | 2022-12-31 |
0,03242 % | HSBC Global Asset Management (UK) Limited | 15 571 | 0 | 2022-12-31 |
0,03209 % | Tung (Roger D) | 15 411 | −814 343 | 2023-03-06 |
0,03209 % | Mirabella Financial Services LLP | 15 410 | 15 410 | 2022-12-31 |
0,03002 % | Jump Financial, LLC | 14 418 | −21 782 | 2022-12-31 |
0,02499 % | Cantor Fitzgerald, L.P | 12 000 | −30 100 | 2022-12-31 |
0,02155 % | Flagship Harbor Advisors LLC | 10 350 | 0 | 2022-12-31 |
0,02082 % | Roanoke Asset Management Corp. | 10 000 | 0 | 2022-12-31 |
0,02041 % | Blackstone Alternative Investment Advisors LLC | 9 800 | 8 000 | 2022-09-30 |
0,01664 % | Lord, Abbett & Co. LLC | 7 992 | 0 | 2023-01-31 |
0,01664 % | BlackRock Investment Management, LLC | 7 992 | 242 | 2022-12-31 |
0,01541 % | Tower Research Capital LLC | 7 398 | 5 351 | 2022-12-31 |
0,01520 % | UBS Financial Services, Inc. | 7 301 | −6 560 | 2022-12-31 |