| 7,37190 % | RTW Investments L.P. | 3.111.680 | -204.352 | 30/6/2025 |
| 7,37041 % | BlackRock Institutional Trust Company, N.A. | 3.111.048 | 281.380 | 30/6/2025 |
| 7,05070 % | Paradigm BioCapital Advisors LP | 2.976.099 | 365.902 | 30/6/2025 |
| 6,17053 % | Jennison Associates LLC | 2.604.580 | 136.582 | 30/9/2025 |
| 5,81568 % | Tang Capital Management, LLC | 2.454.797 | 0 | 30/6/2025 |
| 5,57441 % | Deep Track Capital LP | 2.352.960 | 602.960 | 21/7/2025 |
| 5,42479 % | The Vanguard Group, Inc. | 2.289.805 | 69.637 | 30/6/2025 |
| 4,31823 % | Morgan Stanley & Co. LLC | 1.822.725 | 79.491 | 30/6/2025 |
| 4,28085 % | Janus Henderson Investors | 1.806.947 | 1.293.987 | 30/6/2025 |
| 3,31089 % | Frazier Life Sciences Management, L.P. | 1.397.527 | 0 | 30/6/2025 |
| 2,95654 % | Assenagon Asset Management S.A. | 1.247.954 | 250.367 | 30/9/2025 |
| 2,37376 % | TD Securities, Inc. | 1.001.962 | -872.783 | 30/6/2025 |
| 2,35827 % | Lord, Abbett & Co. LLC | 995.425 | -336.276 | 30/6/2025 |
| 2,32378 % | State Street Investment Management (US) | 980.868 | 70.152 | 30/6/2025 |
| 2,24793 % | Macquarie Investment Management | 948.850 | 56.069 | 30/6/2025 |
| 2,21374 % | Geode Capital Management, L.L.C. | 934.420 | 68.986 | 30/6/2025 |
| 2,08022 % | Medical Strategy GmbH | 878.062 | 0 | 31/7/2025 |
| 2,07946 % | Azamian (Bobak R) | 877.741 | 21.179 | 31/3/2025 |
| 2,07663 % | Driehaus Capital Management, LLC | 876.547 | 158.694 | 30/6/2025 |
| 1,80015 % | Invesco Advisers, Inc. | 759.842 | 111.689 | 30/6/2025 |
| 1,71330 % | D. E. Shaw & Co., L.P. | 723.183 | 312.507 | 30/6/2025 |
| 1,28643 % | Adage Capital Management, L.P. | 543.000 | 33.000 | 30/6/2025 |
| 1,27767 % | Artisan Partners Limited Partnership | 539.303 | -63.911 | 30/6/2025 |
| 1,15449 % | Ensign Peak Advisors, Inc. | 487.310 | 0 | 30/6/2025 |
| 1,11669 % | Norges Bank Investment Management (NBIM) | 471.354 | 471.354 | 30/6/2025 |
| 1,08845 % | Qube Research & Technologies Ltd | 459.436 | 212.592 | 30/6/2025 |
| 1,05307 % | ClearBridge Investments, LLC | 444.502 | 444.502 | 30/6/2025 |
| 0,96173 % | BofA Global Research (US) | 405.947 | 6.070 | 30/6/2025 |
| 0,92772 % | BlackRock Financial Management, Inc. | 391.589 | 290.492 | 30/6/2025 |
| 0,88545 % | Rock Springs Capital Management LP | 373.750 | 19.374 | 30/6/2025 |
| 0,86367 % | J. Goldman & Co., L.P. | 364.557 | 224.269 | 30/6/2025 |
| 0,86003 % | Goldman Sachs & Company, Inc. | 363.017 | 96.625 | 30/6/2025 |
| 0,83280 % | T. Rowe Price Associates, Inc. | 351.525 | -52.319 | 30/6/2025 |
| 0,80904 % | MPM BioImpact LLC | 341.496 | 341.496 | 30/6/2025 |
| 0,78014 % | Charles Schwab Investment Management, Inc. | 329.297 | 38.979 | 30/6/2025 |
| 0,77165 % | Nuveen LLC | 325.712 | 72.228 | 30/6/2025 |
| 0,76804 % | Northern Trust Investments, Inc. | 324.189 | -9.499 | 30/6/2025 |
| 0,71073 % | Cormorant Asset Management, LP | 300.000 | -100.000 | 30/6/2025 |
| 0,59228 % | Polygon Management Ltd. | 250.000 | 71.530 | 30/6/2025 |
| 0,57356 % | Capitolis Liquid Global Markets LLC | 242.100 | 242.100 | 30/6/2025 |
| 0,56863 % | Capricorn Fund Managers Ltd | 240.020 | 240.020 | 30/9/2025 |
| 0,56176 % | Jump Financial, LLC | 237.117 | 188.317 | 30/6/2025 |
| 0,54311 % | Citadel Advisors LLC | 229.246 | -763.396 | 30/6/2025 |
| 0,48567 % | Cutter Capital Management, LP | 205.000 | 92.500 | 31/3/2025 |
| 0,47382 % | Integral Health Asset Management, LLC | 200.000 | 0 | 30/6/2025 |
| 0,46885 % | OrbiMed Advisors, LLC | 197.900 | -455.843 | 30/6/2025 |
| 0,46561 % | Ikarian Capital LLC | 196.536 | -288.485 | 30/6/2025 |
| 0,42089 % | Tri Locum Partners LP | 177.656 | 177.656 | 30/6/2025 |
| 0,41459 % | PGIM Securities Investment Trust Enterprise | 175.000 | 57.000 | 30/6/2025 |
| 0,40275 % | Sands Capital Ventures LLC | 170.000 | 0 | 30/6/2025 |
| 0,38615 % | Jefferies LLC | 162.996 | 84.188 | 30/6/2025 |
| 0,37310 % | Invesco Capital Management LLC | 157.487 | -20.883 | 30/6/2025 |
| 0,36084 % | BNP Paribas Securities Corp. North America | 152.309 | 76.601 | 30/6/2025 |
| 0,35958 % | Link (William J) | 151.778 | -29.116 | 16/9/2025 |
| 0,34607 % | Morgan Stanley Investment Management Inc. (US) | 146.077 | -37.991 | 30/6/2025 |
| 0,34409 % | Russell Investments Trust Company | 145.240 | 10.623 | 30/6/2025 |
| 0,32698 % | Balyasny Asset Management LP | 138.019 | 78.345 | 30/6/2025 |
| 0,32588 % | BlackRock Investment Management, LLC | 137.553 | 42.401 | 30/6/2025 |
| 0,30499 % | Allspring Global Investments, LLC | 128.737 | -3.825 | 30/9/2025 |
| 0,29715 % | Barclays Bank PLC | 125.426 | 72.597 | 30/6/2025 |
| 0,29291 % | Wellington Management Company, LLP | 123.636 | 7.526 | 30/6/2025 |
| 0,28984 % | Mutual of America Capital Management LLC | 122.341 | -10.637 | 30/9/2025 |
| 0,28709 % | Ally Bridge Group NY LLC | 121.182 | -6.750 | 30/6/2025 |
| 0,25289 % | J.P. Morgan Securities LLC | 106.743 | 97.540 | 30/6/2025 |
| 0,24897 % | First Trust Advisors L.P. | 105.090 | -1.767 | 30/6/2025 |
| 0,24317 % | Squarepoint Capital LLP | 102.642 | 44.986 | 30/6/2025 |
| 0,24054 % | DWS Investments UK Limited | 101.532 | -49.123 | 30/6/2025 |
| 0,23726 % | Woodline Partners LP | 100.149 | 0 | 30/6/2025 |
| 0,22417 % | Trexquant Investment LP | 94.624 | 94.624 | 30/6/2025 |
| 0,21828 % | Dimensional Fund Advisors, L.P. | 92.134 | -216.096 | 30/6/2025 |
| 0,21699 % | Universal-Investment-Gesellschaft mbH | 91.590 | 39.838 | 30/9/2025 |
| 0,19005 % | Pictet Asset Management Ltd. | 80.220 | -4.477 | 30/6/2025 |
| 0,18878 % | Neervannan (Seshadri) | 79.682 | 14.915 | 31/3/2025 |
| 0,18508 % | Pictet Asset Management (Japan) Ltd. | 78.122 | 78.122 | 30/4/2025 |
| 0,18281 % | Gilder Gagnon Howe & Co. LLC | 77.164 | -339.647 | 30/6/2025 |
| 0,17929 % | BNY Mellon Asset Management | 75.680 | 4.999 | 30/6/2025 |
| 0,17893 % | Lisanti Capital Growth, LLC | 75.525 | 5.345 | 30/6/2025 |
| 0,17038 % | Wells Fargo Advisors | 71.918 | 29.861 | 30/6/2025 |
| 0,17033 % | Baird Investment Management | 71.895 | -20.802 | 31/3/2025 |
| 0,15862 % | Commonwealth Financial Network | 66.954 | -12.897 | 30/9/2025 |
| 0,15052 % | Schweizerische Nationalbank | 63.533 | 8.000 | 30/6/2025 |
| 0,14932 % | PDT Partners, LLC | 63.026 | 63.026 | 30/6/2025 |
| 0,14744 % | Victory Capital Management Inc. | 62.235 | 17.915 | 30/6/2025 |
| 0,14614 % | BlackRock Advisors (UK) Limited | 61.685 | 470 | 30/9/2025 |
| 0,14613 % | Robert W. Baird & Co. Inc. | 61.681 | -49.111 | 30/6/2025 |
| 0,14593 % | abrdn Inc. | 61.597 | 9.728 | 30/6/2025 |
| 0,14415 % | Parametric Portfolio Associates LLC | 60.846 | -4.417 | 30/6/2025 |
| 0,14332 % | Connor, Clark & Lunn Investment Management Ltd. | 60.495 | 60.495 | 30/6/2025 |
| 0,14294 % | Managed Account Advisors LLC | 60.333 | 31.066 | 30/6/2025 |
| 0,13886 % | Voloridge Investment Management, LLC | 58.613 | 58.613 | 30/6/2025 |
| 0,13774 % | Millennium Management LLC | 58.141 | -189.054 | 30/6/2025 |
| 0,13658 % | Rhumbline Advisers Ltd. Partnership | 57.650 | 5.968 | 30/6/2025 |
| 0,13038 % | Wells Fargo Bank, N.A. | 55.035 | 37.249 | 30/6/2025 |
| 0,12942 % | Federated MDTA LLC | 54.627 | 258 | 30/6/2025 |
| 0,12790 % | UBS Asset Management (Switzerland) | 53.987 | 25.995 | 30/6/2025 |
| 0,12691 % | AQR Capital Management, LLC | 53.568 | 37.344 | 30/6/2025 |
| 0,12563 % | Manulife Investment Management (North America) Limited | 53.028 | -2.809 | 30/6/2025 |
| 0,12398 % | Susquehanna International Group, LLP | 52.334 | -8.523 | 30/6/2025 |
| 0,12130 % | BlackRock Asset Management Ireland Limited | 51.199 | 2.284 | 30/6/2025 |
| 0,11631 % | Wahl (Bryan) | 49.095 | 9.527 | 20/3/2025 |