9.79824 % | EcoR1 Capital, LLC | 6,726,491 | 1,259,428 | 12/31/2023 |
7.05342 % | The Vanguard Group, Inc. | 4,842,174 | 243,167 | 12/31/2023 |
6.13763 % | RTW Investments L.P. | 4,213,483 | 4,213,483 | 12/31/2023 |
6.07150 % | BlackRock Institutional Trust Company, N.A. | 4,168,085 | 357,244 | 12/31/2023 |
5.43172 % | T. Rowe Price Associates, Inc. | 3,728,873 | 1,132,898 | 12/31/2023 |
4.34831 % | Avidity Partners Management LP | 2,985,117 | 370,157 | 12/31/2023 |
3.65292 % | Bellevue Asset Management AG | 2,507,731 | 382,531 | 12/31/2023 |
3.55423 % | Citadel Advisors LLC | 2,439,981 | 1,815,403 | 12/31/2023 |
2.46999 % | Nextech Invest, Ltd. | 1,695,645 | 1,408,394 | 12/31/2023 |
2.28681 % | ArrowMark Colorado Holdings, LLC | 1,569,895 | -517,397 | 12/31/2023 |
1.87840 % | New Leaf Venture Partners LLC | 1,289,521 | 0 | 12/31/2023 |
1.73199 % | Fidelity Institutional Asset Management | 1,189,011 | -374,164 | 12/31/2023 |
1.72829 % | State Street Global Advisors (US) | 1,186,474 | 27,022 | 12/31/2023 |
1.63529 % | Geode Capital Management, L.L.C. | 1,122,627 | 65,237 | 12/31/2023 |
1.56424 % | JP Morgan Asset Management | 1,073,854 | -138,077 | 12/31/2023 |
1.53679 % | Fidelity Management & Research Company LLC | 1,055,008 | -2,250,112 | 12/31/2023 |
1.53560 % | Houston (John G) | 1,054,191 | 119,254 | 2/23/2024 |
1.48210 % | JPMorgan Asset Management U.K. Limited | 1,017,463 | 307,192 | 12/31/2023 |
1.45666 % | Commodore Capital LP | 1,000,000 | 1,000,000 | 12/31/2023 |
1.35660 % | Paradigm BioCapital Advisors LP | 931,303 | 931,303 | 12/31/2023 |
1.27853 % | Norges Bank Investment Management (NBIM) | 877,708 | 175,953 | 12/31/2023 |
1.15001 % | Adage Capital Management, L.P. | 789,485 | 789,485 | 12/31/2023 |
1.08444 % | Holocene Advisors, LP | 744,465 | 744,465 | 12/31/2023 |
1.08336 % | BlackRock Financial Management, Inc. | 743,728 | -6,676 | 12/31/2023 |
0.91448 % | VR Adviser, LLC | 627,788 | 627,788 | 12/31/2023 |
0.88655 % | Boxer Capital, L.L.C. | 608,614 | 608,614 | 12/31/2023 |
0.82448 % | Morgan Stanley & Co. LLC | 566,003 | 245,460 | 12/31/2023 |
0.73518 % | Finepoint Capital LP | 504,700 | 0 | 12/31/2023 |
0.71650 % | Dimensional Fund Advisors, L.P. | 491,877 | 22,479 | 12/31/2023 |
0.71253 % | Aquilo Capital Management, LLC | 489,153 | 0 | 12/31/2023 |
0.71020 % | Candriam Belgium S.A. | 487,555 | 40,004 | 12/31/2023 |
0.68387 % | Charles Schwab Investment Management, Inc. | 469,474 | 39,484 | 12/31/2023 |
0.67376 % | Candriam Luxembourg S.A. | 462,536 | -25,000 | 2/29/2024 |
0.64459 % | Northern Trust Investments, Inc. | 442,512 | 24,794 | 12/31/2023 |
0.61376 % | RA Capital Management, LP | 421,348 | 421,348 | 12/31/2023 |
0.57592 % | American Century Investment Management, Inc. | 395,367 | -418,102 | 12/31/2023 |
0.56465 % | Woodline Partners LP | 387,630 | 215,030 | 12/31/2023 |
0.52267 % | Millennium Management LLC | 358,813 | -469,314 | 12/31/2023 |
0.51697 % | Nuveen LLC | 354,898 | 17,738 | 12/31/2023 |
0.51578 % | Perceptive Advisors LLC | 354,082 | 354,082 | 12/31/2023 |
0.48583 % | Gilder Gagnon Howe & Co. LLC | 333,524 | 162,674 | 12/31/2023 |
0.45108 % | Voloridge Investment Management, LLC | 309,663 | 309,663 | 12/31/2023 |
0.41563 % | Frazier Healthcare Partners | 285,331 | 0 | 12/31/2023 |
0.40603 % | Nordea Funds Oy | 278,737 | -6,317 | 12/31/2023 |
0.38664 % | Brown Advisory | 265,431 | -170,163 | 12/31/2023 |
0.38412 % | Opaleye Management Inc. | 263,700 | 263,700 | 12/31/2023 |
0.37434 % | UBS Financial Services, Inc. | 256,986 | -62,752 | 12/31/2023 |
0.35815 % | Schonfeld Strategic Advisors LLC | 245,868 | 181,874 | 12/31/2023 |
0.34606 % | Renaissance Technologies LLC | 237,573 | 123,873 | 12/31/2023 |
0.34098 % | Great Point Partners, LLC | 234,082 | 234,082 | 12/31/2023 |
0.31424 % | Goldman Sachs & Company, Inc. | 215,728 | 115,219 | 12/31/2023 |
0.30432 % | BlackRock Advisors (UK) Limited | 208,919 | 10,242 | 3/31/2024 |
0.30215 % | Wasatch Global Investors Inc | 207,426 | -15,516 | 3/31/2024 |
0.28704 % | BNP Paribas Securities Corp. North America | 197,052 | 97,661 | 12/31/2023 |
0.28510 % | Amundi Asset Management US, Inc. | 195,720 | 4,423 | 12/31/2023 |
0.27197 % | Cassidy (Sean A) | 186,707 | -1,702 | 2/23/2024 |
0.25492 % | Integral Health Asset Management, LLC | 175,000 | 175,000 | 12/31/2023 |
0.25452 % | BlackRock Asset Management Ireland Limited | 174,728 | 974 | 12/31/2023 |
0.24326 % | Parkman Healthcare Partners LLC | 167,001 | 62,884 | 12/31/2023 |
0.22597 % | UBS Asset Management (Americas), Inc. | 155,129 | 45,932 | 12/31/2023 |
0.22584 % | BofA Global Research (US) | 155,036 | 47,492 | 12/31/2023 |
0.21925 % | Invesco Capital Management LLC | 150,516 | 129,312 | 12/31/2023 |
0.21880 % | Taylor (Ian) | 150,207 | 37,549 | 2/23/2024 |
0.21850 % | Wanjia Asset Management Co., Ltd. | 150,000 | 0 | 6/30/2023 |
0.21721 % | BlackRock Investment Management, LLC | 149,116 | 26,694 | 12/31/2023 |
0.21405 % | TD Asset Management Inc. | 146,948 | 52,076 | 12/31/2023 |
0.20906 % | Yale University | 143,522 | 143,522 | 12/31/2023 |
0.20700 % | Credit Suisse Funds AG | 142,108 | 86,845 | 12/31/2023 |
0.20198 % | Citi Investment Research (US) | 138,656 | 133,966 | 12/31/2023 |
0.20106 % | Federated MDTA LLC | 138,028 | 33,770 | 12/31/2023 |
0.19823 % | BNY Mellon Asset Management | 136,085 | -2,556 | 12/31/2023 |
0.19559 % | Rhenman & Partners Asset Management AB | 134,270 | 49,270 | 12/31/2023 |
0.19154 % | Nordea Investment Management AB (Denmark) | 131,494 | 55 | 2/29/2024 |
0.16621 % | First Trust Advisors L.P. | 114,105 | 1,569 | 2/29/2024 |
0.16567 % | Goldman Sachs Asset Management, L.P. | 113,731 | 19,590 | 12/31/2023 |
0.15040 % | T. Rowe Price International Ltd | 103,250 | 10,554 | 12/31/2023 |
0.15021 % | Putnam Investment Management, L.L.C. | 103,118 | 87,671 | 12/31/2023 |
0.14833 % | Parametric Portfolio Associates LLC | 101,826 | 36,189 | 12/31/2023 |
0.14161 % | Jane Street Capital, L.L.C. | 97,217 | 46,894 | 12/31/2023 |
0.13537 % | Banque Pictet & Cie S.A. | 92,933 | 92,933 | 12/31/2023 |
0.13275 % | UBS O'Connor LLC | 91,132 | -19,050 | 12/31/2023 |
0.13037 % | Schweizerische Nationalbank | 89,500 | -10,200 | 12/31/2023 |
0.12998 % | Manulife Investment Management (North America) Limited | 89,228 | 21,911 | 12/31/2023 |
0.12372 % | D. E. Shaw & Co., L.P. | 84,931 | 64,131 | 12/31/2023 |
0.12181 % | Barclays Bank PLC | 83,621 | 49,824 | 12/31/2023 |
0.11747 % | Shannon (Timothy M) | 80,643 | 0 | 3/31/2023 |
0.11653 % | Tang Capital Management, LLC | 80,000 | 0 | 12/31/2023 |
0.10862 % | Algert Global LLC | 74,571 | -98,847 | 12/31/2023 |
0.10779 % | HOOPP Investment Management | 74,000 | 74,000 | 12/31/2023 |
0.10776 % | Columbia Threadneedle Investments (US) | 73,975 | 15,190 | 12/31/2023 |
0.10444 % | Zacks Investment Management, Inc. | 71,695 | 64,306 | 12/31/2023 |
0.10425 % | CastleArk Management, LLC | 71,570 | 71,570 | 12/31/2023 |
0.10286 % | JPMorgan Private Bank (United States) | 70,612 | 22,263 | 12/31/2023 |
0.10035 % | Rhumbline Advisers Ltd. Partnership | 68,890 | -110 | 12/31/2023 |
0.09853 % | Conestoga Capital Advisors, LLC | 67,640 | -1,837 | 2/29/2024 |
0.09614 % | Bank Vontobel AG | 66,000 | 66,000 | 12/31/2023 |
0.09614 % | Sectoral Asset Management Inc. | 66,000 | 58,990 | 12/31/2023 |
0.09243 % | Berkowitz (Noah) | 63,452 | 63,452 | 3/18/2024 |
0.09011 % | Hennion & Walsh Asset Management, Inc. | 61,862 | 25,778 | 3/31/2024 |
0.08921 % | Trexquant Investment LP | 61,243 | 61,243 | 12/31/2023 |