10.25121 % | The Vanguard Group, Inc. | 7,043,603 | 381,738 | 8/30/2024 |
9.78968 % | EcoR1 Capital, LLC | 6,726,491 | 0 | 6/30/2024 |
7.39670 % | BlackRock Institutional Trust Company, N.A. | 5,082,270 | 684,350 | 6/30/2024 |
5.62522 % | T. Rowe Price Associates, Inc. | 3,865,089 | -397,469 | 6/30/2024 |
5.03248 % | Pfizer Inc | 3,457,815 | 3,457,815 | 3/31/2024 |
4.34849 % | Avidity Partners Management LP | 2,987,845 | 2,655 | 6/30/2024 |
4.31945 % | RTW Investments L.P. | 2,967,897 | -330,000 | 6/30/2024 |
3.84151 % | Citadel Advisors LLC | 2,639,499 | 358,886 | 6/30/2024 |
3.54846 % | Paradigm BioCapital Advisors LP | 2,438,149 | -176,786 | 6/30/2024 |
3.47955 % | Bellevue Asset Management AG | 2,390,800 | 0 | 6/30/2024 |
2.74248 % | Commodore Capital LP | 1,884,361 | 609,361 | 6/30/2024 |
2.47371 % | State Street Global Advisors (US) | 1,699,688 | 317,521 | 6/30/2024 |
2.24383 % | Geode Capital Management, L.L.C. | 1,541,737 | 228,421 | 6/30/2024 |
2.21219 % | Fidelity Management & Research Company LLC | 1,519,994 | 327,235 | 6/30/2024 |
2.04977 % | Nextech Invest, Ltd. | 1,408,394 | 0 | 6/30/2024 |
1.87676 % | New Leaf Venture Partners LLC | 1,289,521 | 0 | 6/30/2024 |
1.85471 % | JP Morgan Asset Management | 1,274,370 | 285,234 | 6/30/2024 |
1.78537 % | ArrowMark Colorado Holdings, LLC | 1,226,727 | 21,159 | 6/30/2024 |
1.68723 % | Fidelity Institutional Asset Management | 1,159,293 | -36,902 | 6/30/2024 |
1.56927 % | Norges Bank Investment Management (NBIM) | 1,078,246 | 200,538 | 6/30/2024 |
1.49578 % | Perceptive Advisors LLC | 1,027,749 | -208,854 | 6/30/2024 |
1.26001 % | Houston (John G) | 865,750 | -188,441 | 3/31/2024 |
0.94166 % | BlackRock Financial Management, Inc. | 647,013 | 12,037 | 6/30/2024 |
0.91368 % | VR Adviser, LLC | 627,788 | 0 | 6/30/2024 |
0.91124 % | JPMorgan Asset Management U.K. Limited | 626,116 | -27,572 | 6/30/2024 |
0.88846 % | Candriam Belgium S.A. | 610,458 | 147,904 | 6/30/2024 |
0.88577 % | Boxer Capital, L.L.C. | 608,614 | 0 | 6/30/2024 |
0.84690 % | Morgan Stanley & Co. LLC | 581,908 | 23,097 | 6/30/2024 |
0.83595 % | Finepoint Capital LP | 574,378 | 35,278 | 6/30/2024 |
0.80774 % | Opaleye Management Inc. | 555,000 | 225,000 | 6/30/2024 |
0.79247 % | Charles Schwab Investment Management, Inc. | 544,503 | 16,448 | 6/30/2024 |
0.78039 % | Candriam Luxembourg S.A. | 536,205 | 0 | 9/30/2024 |
0.75277 % | Braidwell LP | 517,230 | 517,230 | 6/30/2024 |
0.74728 % | Goldman Sachs & Company, Inc. | 513,457 | 19,407 | 6/30/2024 |
0.67521 % | Dimensional Fund Advisors, L.P. | 463,935 | 29,635 | 6/30/2024 |
0.65558 % | Northern Trust Investments, Inc. | 450,451 | -11,992 | 6/30/2024 |
0.62402 % | Aquilo Capital Management, LLC | 428,766 | 23,000 | 6/30/2024 |
0.61581 % | Woodline Partners LP | 423,124 | 920 | 6/30/2024 |
0.61323 % | RA Capital Management, LP | 421,348 | 0 | 6/30/2024 |
0.47386 % | American Century Investment Management, Inc. | 325,590 | 72 | 6/30/2024 |
0.46010 % | Brown Advisory | 316,138 | 41,963 | 6/30/2024 |
0.43625 % | Qube Research & Technologies Ltd | 299,745 | 185,344 | 6/30/2024 |
0.41527 % | Frazier Life Sciences Management, L.P. | 285,331 | 0 | 6/30/2024 |
0.41493 % | Gilder Gagnon Howe & Co. LLC | 285,099 | -39,745 | 6/30/2024 |
0.40086 % | Wasatch Global Investors Inc | 275,433 | 68,007 | 6/30/2024 |
0.40082 % | Renaissance Technologies LLC | 275,400 | -86,573 | 6/30/2024 |
0.37354 % | PanAgora Asset Management Inc. | 256,658 | 93,568 | 6/30/2024 |
0.37310 % | UBS Financial Services, Inc. | 256,359 | -37,685 | 6/30/2024 |
0.34598 % | Schonfeld Strategic Advisors LLC | 237,724 | -43,373 | 6/30/2024 |
0.34373 % | Nordea Funds Oy | 236,174 | -40,308 | 6/30/2024 |
0.33474 % | Rhenman & Partners Asset Management AB | 230,000 | 60,000 | 6/30/2024 |
0.32652 % | D. E. Shaw & Co., L.P. | 224,351 | -79,287 | 6/30/2024 |
0.32022 % | Two Sigma Investments, LP | 220,026 | 66,707 | 6/30/2024 |
0.31301 % | BlackRock Advisors (UK) Limited | 215,070 | 348 | 9/30/2024 |
0.31116 % | UBS Asset Management (UK) Ltd. | 213,798 | 182,472 | 6/30/2024 |
0.30906 % | Kennedy Capital Management LLC | 212,354 | 144,651 | 6/30/2024 |
0.29137 % | Millennium Management LLC | 200,199 | -43,468 | 6/30/2024 |
0.28923 % | BlackRock Asset Management Ireland Limited | 198,731 | 1,794 | 6/30/2024 |
0.28855 % | Nuveen LLC | 198,262 | -94,577 | 6/30/2024 |
0.27804 % | Amundi Asset Management US, Inc. | 191,044 | -2,297 | 6/30/2024 |
0.26197 % | Tang Capital Management, LLC | 180,000 | 0 | 6/30/2024 |
0.25666 % | Federated MDTA LLC | 176,352 | 4,389 | 6/30/2024 |
0.25114 % | BlackRock Investment Management, LLC | 172,561 | 43,501 | 6/30/2024 |
0.24407 % | Voloridge Investment Management, LLC | 167,703 | -211,673 | 6/30/2024 |
0.24388 % | Cassidy (Sean A) | 167,572 | -19,135 | 3/31/2024 |
0.23260 % | BNY Mellon Asset Management | 159,819 | 36,321 | 6/30/2024 |
0.22333 % | Hudson Bay Capital Management LP | 153,448 | 153,448 | 6/30/2024 |
0.22012 % | Neuberger Berman, LLC | 151,245 | 94,875 | 6/30/2024 |
0.20721 % | BofA Global Research (US) | 142,375 | -12,111 | 6/30/2024 |
0.20338 % | Assenagon Asset Management S.A. | 139,741 | 111,795 | 9/30/2024 |
0.18811 % | Jane Street Capital, L.L.C. | 129,248 | 19,570 | 6/30/2024 |
0.18216 % | Parkman Healthcare Partners LLC | 125,161 | 182 | 6/30/2024 |
0.18015 % | T. Rowe Price International Ltd | 123,780 | 17,920 | 6/30/2024 |
0.17585 % | Banque Pictet & Cie S.A. | 120,824 | 38,455 | 9/30/2024 |
0.17354 % | UBS Asset Management (Americas), Inc. | 119,236 | -887 | 6/30/2024 |
0.17304 % | Squarepoint Capital LLP | 118,899 | 37,028 | 6/30/2024 |
0.15783 % | Schroder Investment Management Ltd. (SIM) | 108,444 | 91,444 | 6/30/2024 |
0.15303 % | Nordea Investment Management AB (Denmark) | 105,146 | -6,082 | 8/31/2024 |
0.14861 % | Parametric Portfolio Associates LLC | 102,107 | -5,419 | 6/30/2024 |
0.14554 % | Wanjia Asset Management Co., Ltd. | 100,000 | -50,000 | 6/30/2024 |
0.14554 % | Saint Olive Gestion | 100,000 | 0 | 7/31/2024 |
0.14380 % | BlackRock Investment Management (UK) Ltd. | 98,803 | 27,094 | 6/30/2024 |
0.13842 % | Manulife Investment Management (North America) Limited | 95,105 | -24,376 | 6/30/2024 |
0.13776 % | Columbia Threadneedle Investments (US) | 94,658 | 20,265 | 6/30/2024 |
0.13681 % | Schweizerische Nationalbank | 94,000 | -20,100 | 6/30/2024 |
0.13670 % | Taylor (Ian) | 93,928 | -56,279 | 3/31/2024 |
0.13498 % | Morgan Stanley Investment Management Inc. (US) | 92,745 | 87,661 | 6/30/2024 |
0.13324 % | TD Asset Management Inc. | 91,548 | -107,800 | 6/30/2024 |
0.13295 % | Verition Fund Management LLC | 91,351 | 15,800 | 6/30/2024 |
0.13132 % | Rhumbline Advisers Ltd. Partnership | 90,229 | 19,024 | 6/30/2024 |
0.12343 % | DWS Investments UK Limited | 84,812 | -12,760 | 6/30/2024 |
0.12326 % | BNP Paribas Securities Corp. North America | 84,692 | -62,563 | 6/30/2024 |
0.11992 % | Exome Asset Management LLC | 82,400 | 82,400 | 6/30/2024 |
0.11905 % | Zacks Investment Management, Inc. | 81,798 | 5,977 | 6/30/2024 |
0.11784 % | Goldman Sachs Asset Management, L.P. | 80,968 | -11,960 | 6/30/2024 |
0.11437 % | abrdn Inc. | 78,585 | 17,093 | 9/30/2024 |
0.10915 % | Ghost Tree Capital, LLC | 75,000 | 35,000 | 6/30/2024 |
0.10729 % | AllianceBernstein L.P. | 73,720 | 17,250 | 6/30/2024 |
0.10680 % | Citi Investment Research (US) | 73,382 | 56,213 | 6/30/2024 |
0.10262 % | Mellon Investments Corporation | 70,513 | 21,679 | 6/30/2024 |