9.88447 % | The Vanguard Group, Inc. | 16,579,977 | -489,523 | 3/31/2025 |
8.06896 % | Farallon Capital Management, L.L.C. | 13,534,692 | 286,000 | 3/31/2025 |
7.62253 % | BlackRock Institutional Trust Company, N.A. | 12,785,849 | 151,142 | 3/31/2025 |
7.02759 % | Wellington Management Company, LLP | 11,787,921 | 966,230 | 3/31/2025 |
6.07500 % | Janus Henderson Investors | 10,190,071 | 706,072 | 3/31/2025 |
4.73178 % | Baker Bros. Advisors LP | 7,936,972 | 0 | 3/31/2025 |
4.53153 % | Nextech Invest, Ltd. | 7,601,087 | 0 | 3/31/2025 |
4.41483 % | Fidelity Management & Research Company LLC | 7,405,341 | 876,756 | 3/31/2025 |
3.68320 % | Paradigm BioCapital Advisors LP | 6,178,111 | -375,000 | 3/31/2025 |
3.46071 % | State Street Global Advisors (US) | 5,804,919 | 13,167 | 3/31/2025 |
3.24010 % | T. Rowe Price Associates, Inc. | 5,434,868 | -283,032 | 3/31/2025 |
2.97034 % | BVF Partners L.P. | 4,982,384 | 801,205 | 3/31/2025 |
2.60782 % | Bellevue Asset Management AG | 4,374,300 | -12,600 | 3/31/2025 |
2.46958 % | Geode Capital Management, L.L.C. | 4,142,414 | 56,215 | 3/31/2025 |
2.46413 % | Alphabet, Inc. | 4,133,277 | 0 | 3/31/2025 |
2.31733 % | Woodline Partners LP | 3,887,036 | 1,323 | 3/31/2025 |
2.20459 % | Casdin Capital, LLC | 3,697,933 | -1,350 | 3/31/2025 |
2.20090 % | Holocene Advisors, LP | 3,691,744 | 695,034 | 3/31/2025 |
1.97769 % | Deerfield Management Company, L.P. | 3,317,332 | 59,000 | 3/31/2025 |
1.69668 % | JP Morgan Asset Management | 2,845,971 | 3,547 | 3/31/2025 |
1.63858 % | Andreessen Horowitz | 2,748,523 | 0 | 3/31/2025 |
1.38996 % | Borisy (Alexis) | 2,331,494 | 952 | 3/31/2025 |
1.30931 % | Lunate Capital LLC | 2,196,200 | 0 | 3/31/2025 |
1.15088 % | Charles Schwab Investment Management, Inc. | 1,930,468 | -646 | 3/31/2025 |
1.03855 % | Norges Bank Investment Management (NBIM) | 1,742,039 | -106,608 | 12/31/2024 |
1.02365 % | Hood River Capital Management LLC | 1,717,048 | 38,614 | 3/31/2025 |
0.99765 % | T. Rowe Price Investment Management, Inc. | 1,673,429 | 1,673,429 | 3/31/2025 |
0.95387 % | Logos Global Management LP | 1,600,000 | 150,000 | 3/31/2025 |
0.84478 % | Northern Trust Investments, Inc. | 1,417,022 | -47,956 | 3/31/2025 |
0.80253 % | Goldman Sachs & Company, Inc. | 1,346,144 | -496,092 | 3/31/2025 |
0.78574 % | Boxer Capital Management, LLC | 1,317,977 | -2,961,487 | 3/31/2025 |
0.76407 % | Rock Springs Capital Management LP | 1,281,640 | 68,383 | 3/31/2025 |
0.64307 % | Columbia Threadneedle Investments (UK) | 1,078,664 | 71,891 | 3/31/2025 |
0.63435 % | Westfield Capital Management Company, L.P. | 1,064,046 | 1,058,247 | 3/31/2025 |
0.59465 % | Frazier Life Sciences Management, L.P. | 997,455 | 0 | 3/31/2025 |
0.57984 % | Morgan Stanley & Co. LLC | 972,610 | 409,549 | 3/31/2025 |
0.48321 % | Goldman Sachs Asset Management, L.P. | 810,532 | 36,450 | 3/31/2025 |
0.44752 % | Polar Capital LLP | 750,665 | 0 | 3/31/2025 |
0.44567 % | Pictet Asset Management Ltd. | 747,560 | 34,964 | 3/31/2025 |
0.44227 % | American Century Investment Management, Inc. | 741,860 | 100,214 | 3/31/2025 |
0.44091 % | BlackRock Financial Management, Inc. | 739,574 | -184,612 | 3/31/2025 |
0.44026 % | Candriam Luxembourg S.A. | 738,487 | -77,530 | 4/30/2025 |
0.42037 % | Goldsmith Mark A | 705,116 | 53,775 | 3/31/2025 |
0.41211 % | Finepoint Capital LP | 691,260 | -19,000 | 3/31/2025 |
0.39119 % | Dafna Capital Management, LLC | 656,176 | 25,000 | 3/31/2025 |
0.39057 % | Candriam Belgium S.A. | 655,134 | -1,606 | 3/31/2025 |
0.36330 % | Citi Investment Research (US) | 609,388 | 340,934 | 3/31/2025 |
0.33609 % | Invus Public Equities Advisors, LLC | 563,755 | -7,793 | 3/31/2025 |
0.31265 % | BNP Paribas Securities Corp. North America | 524,428 | 276,102 | 3/31/2025 |
0.30953 % | JPMorgan Asset Management U.K. Limited | 519,192 | 47,191 | 3/31/2025 |
0.30319 % | MIC Capital Management UK LLP | 508,569 | 0 | 3/31/2025 |
0.28735 % | BlackRock Advisors (UK) Limited | 481,989 | -5,106 | 5/31/2025 |
0.28414 % | UBS Financial Services, Inc. | 476,607 | 181,879 | 3/31/2025 |
0.27777 % | BlackRock Asset Management Ireland Limited | 465,931 | 14,928 | 3/31/2025 |
0.27722 % | Caligan Partners, LP | 465,000 | 465,000 | 3/31/2025 |
0.27390 % | Nuveen LLC | 459,427 | 37,386 | 3/31/2025 |
0.26530 % | BlackRock Investment Management, LLC | 445,007 | -3,895 | 3/31/2025 |
0.25484 % | Ensign Peak Advisors, Inc. | 427,466 | 122,294 | 3/31/2025 |
0.23489 % | Adage Capital Management, L.P. | 394,000 | -256,000 | 3/31/2025 |
0.23370 % | Checkpoint Capital L.P. | 392,011 | 182,011 | 3/31/2025 |
0.23259 % | Pzena Investment Management, LLC | 390,133 | -68,321 | 3/31/2025 |
0.22282 % | Dimensional Fund Advisors, L.P. | 373,754 | -14,021 | 3/31/2025 |
0.22191 % | Eventide Asset Management, LLC | 372,229 | 0 | 3/31/2025 |
0.21917 % | Lord, Abbett & Co. LLC | 367,630 | -1,611,090 | 3/31/2025 |
0.21486 % | JPMorgan Asset Management (Europe) S.à.r.l. | 360,405 | 49,899 | 3/31/2025 |
0.20820 % | BofA Global Research (US) | 349,231 | 38,418 | 3/31/2025 |
0.20276 % | First Turn Management, LLC | 340,109 | -63,806 | 3/31/2025 |
0.20162 % | Partners HealthCare System, Inc | 338,191 | 0 | 9/30/2024 |
0.20143 % | Victory Capital Management Inc. | 337,881 | -92,581 | 3/31/2025 |
0.20115 % | Jane Street Capital, L.L.C. | 337,402 | 273,471 | 3/31/2025 |
0.19428 % | TD Asset Management Inc. | 325,876 | 44,490 | 3/31/2025 |
0.19047 % | Voya Investment Management LLC | 319,491 | 3,463 | 3/31/2025 |
0.19005 % | StemPoint Capital LP | 318,782 | 125,247 | 3/31/2025 |
0.18904 % | MPM BioImpact LLC | 317,083 | 3,266 | 3/31/2025 |
0.18143 % | BNY Mellon Asset Management | 304,330 | 9,732 | 3/31/2025 |
0.16486 % | Schweizerische Nationalbank | 276,531 | 46,600 | 3/31/2025 |
0.16468 % | Russell Investments Trust Company | 276,230 | 271,987 | 3/31/2025 |
0.16203 % | Barclays Bank PLC | 271,786 | -134,789 | 3/31/2025 |
0.15330 % | Rhumbline Advisers Ltd. Partnership | 257,150 | 5,685 | 3/31/2025 |
0.14905 % | Mellon Investments Corporation | 250,011 | 303 | 3/31/2025 |
0.14904 % | Integral Health Asset Management, LLC | 250,000 | -300,000 | 3/31/2025 |
0.14666 % | WCM Investment Management | 245,997 | 88,520 | 3/31/2025 |
0.14550 % | Susquehanna International Group, LLP | 244,053 | 97,865 | 3/31/2025 |
0.14521 % | Bessemer Trust Company, N.A. (US) | 243,571 | 13 | 3/31/2025 |
0.14314 % | Manulife Investment Management (North America) Limited | 240,095 | 2,556 | 3/31/2025 |
0.13473 % | Decheng Capital LLC | 226,000 | 0 | 3/31/2025 |
0.12860 % | Edgestream Partners, L.P. | 215,717 | 207,938 | 3/31/2025 |
0.12725 % | HSBC Private Bank (Suisse) S.A. | 213,454 | -36,374 | 3/31/2025 |
0.12725 % | HSBC Global Asset Management (France) S.A. | 213,454 | -36,374 | 3/31/2025 |
0.12698 % | Avidity Partners Management LP | 213,000 | -233,200 | 3/31/2025 |
0.12693 % | California Public Employees' Retirement System | 212,915 | -55,374 | 3/31/2025 |
0.12305 % | Columbia Threadneedle Investments (US) | 206,394 | 23,326 | 3/31/2025 |
0.11570 % | AllianceBernstein L.P. | 194,078 | -40,851 | 3/31/2025 |
0.11549 % | Comerica, Inc. | 193,719 | 193,267 | 3/31/2025 |
0.11276 % | Columbia Wanger Asset Management, LLC | 189,147 | -231,267 | 3/31/2025 |
0.11220 % | Kelsey (Stephen Michael) | 188,201 | 34,519 | 3/31/2025 |
0.11160 % | Marshall Wace LLP | 187,188 | -1,317,613 | 3/31/2025 |
0.11103 % | J.P. Morgan Securities LLC | 186,242 | -193,291 | 3/31/2025 |
0.10960 % | Parametric Portfolio Associates LLC | 183,839 | -38,791 | 3/31/2025 |
0.10918 % | Qube Research & Technologies Ltd | 183,140 | -47,705 | 3/31/2025 |