5.97 % | Abingworth Management Limited | 3,496,808 | 0 | 12/31/2023 |
4.94 % | Invesco Advisers, Inc. | 2,892,757 | -240,804 | 12/31/2023 |
4.77 % | Takeda Pharmaceutical Co Ltd | 2,790,480 | -362,737 | 4/9/2024 |
4.07 % | BlackRock Institutional Trust Company, N.A. | 2,384,358 | 205,229 | 12/31/2023 |
3.89 % | Ensign Peak Advisors, Inc. | 2,280,000 | 547,828 | 12/31/2023 |
3.35 % | New Enterprise Associates (NEA) | 1,960,169 | 683,574 | 12/31/2023 |
3.33 % | The Vanguard Group, Inc. | 1,949,896 | 33,767 | 12/31/2023 |
2.94 % | Avidity Partners Management LP | 1,721,580 | 104,280 | 12/31/2023 |
2.49 % | Gilder Gagnon Howe & Co. LLC | 1,455,132 | 145,084 | 12/31/2023 |
2.19 % | 683 Capital Management LLC | 1,280,000 | 180,000 | 12/31/2023 |
2.09 % | Socks (David A) | 1,220,756 | 9,000 | 5/25/2023 |
17.27 % | Frazier Healthcare Partners | 10,109,279 | 0 | 12/31/2023 |
12.75 % | Medicxi Ventures (UK) LLP | 7,464,572 | 0 | 3/31/2024 |
1.87 % | Woodline Partners LP | 1,096,121 | 356,100 | 12/31/2023 |
1.52 % | Jennison Associates LLC | 892,270 | 474,848 | 3/31/2024 |
1.45 % | Decheng Capital LLC | 850,000 | 0 | 12/31/2023 |
1.33 % | Nabulsi (Azmi) | 776,539 | 32,500 | 11/1/2023 |
1.26 % | Geode Capital Management, L.L.C. | 735,273 | 52,703 | 12/31/2023 |
1.23 % | Catalys Pacific, LLC | 721,962 | 721,962 | 12/31/2023 |
1.17 % | State Street Global Advisors (US) | 687,837 | 20,241 | 12/31/2023 |
1.10 % | Newtyn Management, LLC | 646,760 | 146,760 | 12/31/2023 |
1.05 % | Jacobs Levy Equity Management, Inc. | 617,365 | 327,513 | 12/31/2023 |
0.98 % | Kennedy Capital Management LLC | 571,976 | -489,769 | 12/31/2023 |
0.96 % | GW&K Investment Management, LLC | 561,490 | -15,960 | 12/31/2023 |
0.76 % | Propel Bio Management, LLC | 443,047 | 205,112 | 12/31/2023 |
0.72 % | StepStone Group LP | 422,085 | 0 | 12/31/2023 |
0.66 % | Ghost Tree Capital, LLC | 385,241 | -9,759 | 12/31/2023 |
0.61 % | Checkpoint Capital L.P. | 359,446 | 359,446 | 12/31/2023 |
0.52 % | Nuveen LLC | 302,809 | 14,975 | 12/31/2023 |
0.49 % | Two Sigma Investments, LP | 289,557 | 205,494 | 12/31/2023 |
0.47 % | Invesco Canada Ltd. | 273,560 | -10,707 | 12/31/2023 |
0.45 % | Northern Trust Investments, Inc. | 264,574 | 24,732 | 12/31/2023 |
0.45 % | Charles Schwab Investment Management, Inc. | 262,524 | 15,843 | 12/31/2023 |
0.41 % | Curran (Terrie) | 240,068 | -16,851 | 3/22/2024 |
0.41 % | Simplify Asset Management Inc | 237,935 | 0 | 12/31/2023 |
0.38 % | Medical Strategy GmbH | 222,722 | 39,780 | 12/31/2023 |
0.35 % | Walleye Capital LLC | 202,154 | 116,782 | 12/31/2023 |
0.34 % | EcoR1 Capital, LLC | 198,480 | -501,520 | 12/31/2023 |
0.31 % | Goldman Sachs & Company, Inc. | 179,796 | 74,192 | 12/31/2023 |
0.29 % | Millennium Management LLC | 170,044 | 30,696 | 12/31/2023 |
0.27 % | Saturn V Capital Management LLC | 160,075 | 160,075 | 12/31/2023 |
0.26 % | Wellington Management Company, LLP | 154,391 | 54,581 | 12/31/2023 |
0.22 % | D. E. Shaw & Co., L.P. | 129,389 | -1,175 | 12/31/2023 |
0.19 % | JP Morgan Asset Management | 113,049 | -21,090 | 12/31/2023 |
0.18 % | Azimut Capital Management Sgr SpA | 106,866 | 4,222 | 2/29/2024 |
0.17 % | Moore Capital Management, LP | 100,000 | 20,000 | 12/31/2023 |
0.17 % | Morgan Stanley & Co. LLC | 99,100 | 44,405 | 12/31/2023 |
0.16 % | BlackRock Advisors (UK) Limited | 95,563 | 3,255 | 3/31/2024 |
0.15 % | BlackRock Financial Management, Inc. | 89,863 | 2,494 | 12/31/2023 |
0.14 % | BlackRock Investment Management, LLC | 84,860 | 7,404 | 12/31/2023 |
0.14 % | BNY Mellon Asset Management | 82,849 | 8,803 | 12/31/2023 |
0.14 % | Columbia Threadneedle Investments (US) | 82,244 | 70,842 | 12/31/2023 |
0.14 % | BofA Global Research (US) | 81,793 | 28,235 | 12/31/2023 |
0.14 % | BlackRock Asset Management Ireland Limited | 81,781 | 23,356 | 12/31/2023 |
0.12 % | BioImpact Capital LLC | 70,000 | -277,332 | 12/31/2023 |
0.11 % | Renaissance Technologies LLC | 65,600 | 65,600 | 12/31/2023 |
0.11 % | Jane Street Capital, L.L.C. | 65,254 | -5,530 | 12/31/2023 |
0.11 % | Penn Mutual Asset Management, LLC | 62,802 | 0 | 12/31/2023 |
0.10 % | Schonfeld Strategic Advisors LLC | 61,000 | 22,256 | 12/31/2023 |
0.10 % | Schweizerische Nationalbank | 56,000 | -4,200 | 12/31/2023 |
0.09 % | Susquehanna International Group, LLP | 52,313 | 52,313 | 12/31/2023 |
0.09 % | Octagon Capital Advisors LP | 50,000 | 50,000 | 12/31/2023 |
0.08 % | Barclays Bank PLC | 49,672 | 36,437 | 12/31/2023 |
0.08 % | Rhumbline Advisers Ltd. Partnership | 48,502 | -8,035 | 12/31/2023 |
0.08 % | State of Wisconsin Investment Board | 47,314 | -36,442 | 12/31/2023 |
0.07 % | UBS O'Connor LLC | 43,209 | -74,071 | 12/31/2023 |
0.07 % | UBS Financial Services, Inc. | 39,432 | 5,732 | 12/31/2023 |
0.07 % | Assenagon Asset Management S.A. | 38,863 | 2,828 | 2/29/2024 |
0.07 % | Ohio Public Employees Retirement System | 38,569 | 29,669 | 12/31/2023 |
0.06 % | Credit Suisse Funds AG | 38,036 | -2 | 12/31/2023 |
0.06 % | AllianceBernstein L.P. | 37,700 | 0 | 12/31/2023 |
0.06 % | Inspirion Wealth Advisors, LLC | 35,134 | 0 | 3/31/2024 |
0.06 % | Legal & General Investment Management Ltd. | 34,253 | 251 | 12/31/2023 |
0.06 % | Parikh (Asit) | 32,500 | 7,500 | 11/8/2023 |
0.05 % | California State Teachers Retirement System | 30,590 | -396 | 12/31/2023 |
0.05 % | Goldman Sachs Asset Management, L.P. | 30,415 | -2,481 | 12/31/2023 |
0.05 % | Occidental Asset Management, LLC | 29,672 | 0 | 3/31/2024 |
0.05 % | Dimensional Fund Advisors, L.P. | 27,321 | 165 | 1/31/2024 |
0.04 % | Parametric Portfolio Associates LLC | 23,810 | 1,379 | 12/31/2023 |
0.04 % | FBB Capital Partners | 23,579 | 23,579 | 12/31/2023 |
0.04 % | Mellon Investments Corporation | 23,470 | 2,451 | 12/31/2023 |
0.04 % | Allworth Financial, L.P. | 22,580 | 3,000 | 12/31/2023 |
0.04 % | JPMorgan Private Bank (United States) | 22,223 | 22,223 | 12/31/2023 |
0.04 % | Creative Planning, Inc. | 21,352 | 877 | 12/31/2023 |
0.04 % | Graham Capital Management, L.P. | 20,619 | 20,619 | 12/31/2023 |
0.03 % | Northern Trust Global Investments | 19,242 | -1,440 | 12/31/2023 |
0.03 % | AQR Capital Management, LLC | 18,427 | -4,408 | 12/31/2023 |
0.03 % | Tocqueville Asset Management LP | 18,100 | 18,100 | 12/31/2023 |
0.03 % | SG Americas Securities, L.L.C. | 18,070 | 5,906 | 12/31/2023 |
0.03 % | Henderson (Molly) | 17,675 | -3,435 | 4/8/2024 |
0.03 % | T. Rowe Price International Ltd | 17,401 | 4,007 | 12/31/2023 |
0.03 % | DWS Investments UK Limited | 16,628 | 4,870 | 12/31/2023 |
0.03 % | Aperio Group, LLC | 16,586 | 3,705 | 12/31/2023 |
0.03 % | Topper (James N) | 16,508 | 0 | 5/26/2023 |
0.03 % | MetLife Investment Management, LLC | 16,471 | 0 | 12/31/2023 |
0.03 % | BlackRock Investment Management (UK) Ltd. | 16,360 | -3,744 | 12/31/2023 |
0.03 % | SunAmerica Asset Management, LLC | 15,938 | 529 | 12/31/2023 |
0.03 % | Arctic Fund Management AS | 15,700 | 15,700 | 2/29/2024 |
0.03 % | Russell Investments Trust Company | 15,678 | 10,478 | 12/31/2023 |
0.03 % | Apo Asset Management GmbH | 15,301 | 0 | 2/29/2024 |